Tag: 199.0368

Etkind, Samuel I. et al. published their research in ACS Sustainable Chemistry & Engineering in 2022 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Synthetic Route of C8H4Cl2N2

Thianthrene-Based Bipolar Redox-Active Molecules Toward Symmetric All-Organic Batteries was written by Etkind, Samuel I.;Lopez, Jeffrey;Zhu, Yun Guang;Fang, Jen-Hung;Ong, Wen Jie;Shao-Horn, Yang;Swager, Timothy M.. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Synthetic Route of C8H4Cl2N2 This article mentions the following:

Bipolar redox activity is generally obtained using a single moiety that can be both oxidized and reduced or by tethering two distinct redox active mols., together with a covalent linker. Herein, we demonstrate an alternative approach using the SNAr and SNAr-type reactions of benzene-1,2-dithiols and electron-deficient aromatic halides or halogenated quinones to prepare a family of compact, thianthrene-based bifunctional mols. The potential of these mols. as electrolytes for redox flow batteries was assessed in static cells as a proof of concept. Cycling in a static cell demonstrated that the thianthrene-quinone, PQtBuTH (8), is highly stable, compared to other sym. organic active materials, with 44% capacity retention over 450 cycles (16.7 days), and an initial energy d. of 1.3Wh/L at a concentration of 0.1 M. Redox flow batteries represent a promising grid-scale energy storage technol., and the development of new sym. electrolyte systems in organic solvents can potentially mitigate issues associated with membrane crossover and provide high cell voltages. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Synthetic Route of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Synthetic Route of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Ezzat, Hany G. et al. published their research in Molecular Diversity in 2021 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Category: quinoxaline

Design, synthesis, and molecular docking studies of new [1,2,4]triazolo[4,3-a]quinoxaline derivatives as potential A2B receptor antagonists was written by Ezzat, Hany G.;Bayoumi, Ashraf H.;Sherbiny, Farag F.;El-Morsy, Ahmed M.;Ghiaty, Adel;Alswah, Mohamed;Abulkhair, Hamada S.. And the article was included in Molecular Diversity in 2021.Category: quinoxaline This article mentions the following:

Many shreds of evidence have recently correlated A2B receptor antagonism with anticancer activity. Hence, the search for an efficient A2B antagonist may help in the development of a new chemotherapeutic agent. In this article, 23 new derivatives of [1,2,4]triazolo[4,3-a]quinoxaline were designed and synthesized and its structures were confirmed by different spectral data and elemental analyses. The results of cytotoxic evaluation of these compounds showed six promising active derivatives with IC50 values ranging from 1.9 to 6.4μM on MDA-MB 231 cell line. Addnl., mol. docking for all synthesized compounds was performed to predict their binding affinity toward the homol. model of A2B receptor as a proposed mode of their cytotoxic activity. Results of mol. docking were strongly correlated with those of the cytotoxic study. Finally, structure activity relationship analyses of the new compounds were explored. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Category: quinoxaline).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Alsaif, Nawaf A. et al. published their research in Bioorganic Chemistry in 2021 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Computed Properties of C8H4Cl2N2

New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: design, molecular modeling, and synthesis was written by Alsaif, Nawaf A.;Dahab, Mohammed A.;Alanazi, Mohammed M.;Obaidullah, Ahmad J.;Al-Mehizia, Abdulrahman A.;Alanazi, Manal M.;Aldawas, Saleh;Mahdy, Hazem A.;Elkady, Hazem. And the article was included in Bioorganic Chemistry in 2021.Computed Properties of C8H4Cl2N2 This article mentions the following:

New series of [1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one I [R = Et, Ph, 3-ClC6H4, etc.; X = CH2] and [1,2,4]triazolo[4,3-a]quinoxaline derivatives I [X = SCH2] were designed, synthesized, and biol. assessed for their anti-proliferative activities against two selected tumor cell lines MCF-7 and HepG2. Comparing to sorafenib (IC50 = 2.17 ± 0.13 and 3.51 ± 0.21μM against MCF-7 and HepG2, resp.), compounds I [R = 4-ClC6H4, 2,5-di-ClC6H3, 2-HO-5-MeC6H3; X = CH2, SCH2] exhibited the highest activities against the examined cell lines with IC50 values extending from 4.1 ± 0.4 to 11.7 ± 1.1μM. Furthermore, VEGFR-2 inhibitory activities were assessed for all the synthesized compounds as potential mechanisms for their anti-proliferative activities. Compounds I [R = 4-ClC6H4, 2,5-di-ClC6H3, 2-HO-5-MeC6H3; X = CH2, SCH2] displayed prominent inhibitory efficiency vs. VEGFR-2 kinase with IC50 value ranging from 3.4 ± 0.3 to 6.8 ± 0.5 nM. Fascinatingly, the results of VEGFR-2 inhibitory assays were matched with that of the cytotoxicity data, where the most potent anti-proliferative derivatives exhibited promising VEGFR-2 inhibitory activities. Further studies displayed the ability of compound I [R = 4-ClC6H4; X = CH2] to induce apoptosis in HepG2 cells and can arrest the growth of such cells at the G2/M phase. Also, compound I [R = 4-ClC6H4; X = CH2] produced a significant increase in the level of BAX/Bcl-2 ratio (3.8-fold), caspase- 3 (1.8-fold), and caspase-9 (1.9-fold) compared to the control cells. Mol. docking studies were carried out to investigate the possible binding interaction inside the active site of the VEGFR-2. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Computed Properties of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Computed Properties of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Neri, Jannyely M. et al. published their research in Arabian Journal of Chemistry in 2020 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Related Products of 2213-63-0

2,3-Dichloroquinoxaline as a versatile building block for heteroaromatic nucleophilic substitution: A review of the last decade was written by Neri, Jannyely M.;Cavalcanti, Livia N.;Araujo, Renata M.;Menezes, Fabricio G.. And the article was included in Arabian Journal of Chemistry in 2020.Related Products of 2213-63-0 This article mentions the following:

An overview of the last decade on the remarkable versatility of DCQX as a substrate for SNAr reactions is described. Several examples in which DCQX reacts with N-, O-, S-, P- and C-nucleophiles, including controlled processes for the selective formation of mono- and disubstituted substrates are provided. Almost all polyfunctionalized quinoxalines synthesized using this approach have shown applications in different areas such as in biol. and technol. fields. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Related Products of 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Related Products of 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Hatakeyama-Sato, Kan et al. published their research in Batteries & Supercaps in 2022 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Electric Literature of C8H4Cl2N2

Quadruply Fused Aromatic Heterocycles toward 4 V-Class Robust Organic Cathode-Active Materials was written by Hatakeyama-Sato, Kan;Go, Choitsu;Akahane, Tomoki;Kaseyama, Takahiro;Yoshimoto, Takuji;Oyaizu, Kenichi. And the article was included in Batteries & Supercaps in 2022.Electric Literature of C8H4Cl2N2 This article mentions the following:

Quadruply fused aromatic heterocycles are examined as 4 V-class organic cathode-active materials. A newly synthesized dimethylfluoflavin-substituted polymer displays reversible charge/discharge at high potentials of 3.5 and 4.1 V (vs. Li/Li+) as a cathode-active material for organic secondary batteries. The robust redox-active heterocycles enable the long cycle-life (>1000) while maintaining the high potential over 4 V. The linear polymer backbone and radical spin configuration in the heterocycles are the keys to enhancing the voltages and the cycle life. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Electric Literature of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Electric Literature of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Aimoto, Yutaro et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2018 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson鈥檚, and Alzheimer鈥檚 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application of 2213-63-0

A family of molecular nickel hydrogen evolution catalysts providing tunable overpotentials using ligand-centered proton-coupled electron transfer paths was written by Aimoto, Yutaro;Koshiba, Keita;Yamauchi, Kosei;Sakai, Ken. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Application of 2213-63-0 This article mentions the following:

Two new nickel dithiolate derivatives have been examined for their electrocatalytic activity for the hydrogen evolution reaction (HER) in attempts to clarify whether the overpotential for the HER can be tuned upon varying the ligand-centered reduction potential that triggers the HER by the catalysts. We demonstrate the validity of this approach to achieve desirable tunability in the overpotential for the HER. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Application of 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson鈥檚, and Alzheimer鈥檚 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application of 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Dasari, Gouthami et al. published their research in Heterocyclic Letters in 2019 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.HPLC of Formula: 2213-63-0

Synthesis and anti microbial activity of tetrazolo quinoxaline containing pyrazole analogues was written by Dasari, Gouthami;Sontireddy, Rajitha;Bandari, Srinivas. And the article was included in Heterocyclic Letters in 2019.HPLC of Formula: 2213-63-0 This article mentions the following:

In the present work some novel substituted 5-methyl-2-(tetrazolo[1,5-a]quinoxalin-4-yl)-2,4-dihydro-3H-pyrazol- 3-ones and substituted 1-(tetrazolo[1,5-a] quinoxalin-4-yl) pyrazolidin-3,5- diones were synthesized. These derivatives were synthesized by treating 4- hydrazinyl tetrazolo[1,5-a]quinoxalines with ethylaceto acetate and di-Et malonate in acetic acid solution All the synthesized compounds were characterized by IR, 1H-NMR and Elemental Anal. All the newly synthesized derivatives were evaluated for anti-microbial activity on different micro-organisms (E.coli, S. aureus, A.niger, C.albicans) at the concentration of 10渭g/mL and 20渭g/mL by using agar disk-diffusion method. The activity was measured in terms of zone of inhibition and compared with standard drug ciprofloxacin for antibacterial and Flucanazole for antifungal activity. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0HPLC of Formula: 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.HPLC of Formula: 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Keivanloo, Ali et al. published their research in Tetrahedron in 2017 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.SDS of cas: 2213-63-0

Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions was written by Keivanloo, Ali;Soozani, Atena;Bakherad, Mohammad;Mirzaee, Mahdi;Rudbari, Hadi Amiri;Bruno, Giuseppe. And the article was included in Tetrahedron in 2017.SDS of cas: 2213-63-0 This article mentions the following:

The 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines I (R = morpholin-4-yl, pyrrolidin-1-yl, piperidin-1-yl; R1 = diethylaminyl, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl) are synthesized through multi-component reaction of 3-substituted 2-chloroquinoxalines II, propargyl bromide, and excess secondary amines such as morpholine, piperidine, diethylamine in the presence of a palladium-copper catalytic system. This one-pot process provides an unexpected synthesis of new trisubstituted pyrrolo[1,2-a]quinoxalines I by the introduction of two amine substituents onto the fused pyrrole rings in a single reaction procedure. The synthesized pyrrolo[1,2-a]quinoxaline derivatives I are also screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginos, and Bacillus subtilis. According to the obtained results, compounds I (R = piperidin-1-yl, R1 = morpholin-4-yl; R = R1 = morpholin-4-yl; R = R1 = piperidin-1-yl), are active against M. luteus, and compounds I (R = piperidin-1-yl, morpholin-4-yl; R1 = piperidin-1-yl, morpholin-4-yl) are active against Ps. Aeruginos, and only compound I (R = pyrrolidin-1-yl; R1 = piperidin-1-yl) are active against all the three bacterial strains. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0SDS of cas: 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.SDS of cas: 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Milic, Jovana V. et al. published their research in Helvetica Chimica Acta in 2019 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Synthetic Route of C8H4Cl2N2

Thioether-functionalized quinone-based resorcin[4]arene cavitands: Electroswitchable molecular actuators was written by Milic, Jovana V.;Schneeberger, Thomas;Zalibera, Michal;Milowska, Karolina Z.;Ong, Quy K.;Trapp, Nils;Ruhlmann, Laurent;Boudon, Corinne;Thilgen, Carlo;Diederich, Francois. And the article was included in Helvetica Chimica Acta in 2019.Synthetic Route of C8H4Cl2N2 This article mentions the following:

The utility of mol. actuators in nanoelectronics requires activation of mech. motion by elec. charge at the interface with conductive surfaces. We functionalized redox-active resorcin[4]arene-quinone cavitands with thioethers as surface-anchoring groups at the lower rim and investigated their propensity to act as electroswitchable actuators that can adopt two different conformations in response to changes in applied potential. Mol. design was assessed by DFT calculations and X-ray anal. Electronic properties were exptl. studied in solution and thin films electrochem., as well as by XPS on gold substrates. The redox interconversion between the oxidized (quinone, Q) and the reduced (semiquinone, SQ) state was monitored by UV-Vis-NIR spectroelectrochem. and EPR spectroscopy. Reduction to the SQ state induces a conformational change, providing the basis for potential voltage-controlled mol. actuating devices. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Synthetic Route of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Synthetic Route of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Ono, Yukari et al. published their research in Bioorganic Chemistry in 2020 | CAS: 2213-63-0

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Recommanded Product: 2213-63-0

Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein was written by Ono, Yukari;Ninomiya, Masayuki;Kaneko, Daiki;Sonawane, Amol D.;Udagawa, Taro;Tanaka, Kaori;Nishina, Atsuyoshi;Koketsu, Mamoru. And the article was included in Bioorganic Chemistry in 2020.Recommanded Product: 2213-63-0 This article mentions the following:

A series of quinoxaline-1,3,4-oxadiazole hybrids I [R = chloro, Ph, 4-methylpiperazin-1-yl, 4-phenylpiperazin-1-yl, etc.; R1 = hydroxy, amino, 2-phenylethoxy, etc.] were synthesized and assessed for their anticancer potential on human leukemia HL-60 cells. Although these hybrids I exerted significant inhibition of HL-60 cell proliferation, they showed high cytotoxicity on human normal cells (WI-38). Utilizing information from mol. modeling of the hybrids I to the anti-apoptotic Bcl-2 protein, substructures including Ph, piperazine, piperidine and morpholine rings were added to their frameworks. The designed compounds I successfully induced apoptotic response on HL-60 cells with low toxicity on WI-38 cells. Furthermore, RT-PCR anal. demonstrated that these compounds I predominantly inhibited Bcl-2 expression. These findings highlight the great potential for the development of synthetic quinoxaline-1,3,4-oxadiazole hybrid derivatives as proapoptotic anticancer agents. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Recommanded Product: 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Recommanded Product: 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider