Tag: 199.0368

Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach was written by Kaneko, Daiki;Ninomiya, Masayuki;Yoshikawa, Rina;Ono, Yukari;Sonawane, Amol D.;Tanaka, Kaori;Nishina, Atsuyoshi;Koketsu, Mamoru. And the article was included in Bioorganic Chemistry in 2020.Electric Literature of C8H4Cl2N2 This article mentions the following:

A series of [1,2,4]triazolo[4,3-a]quinoxalines I [R¹ = benzyl, anilino, styryl, etc.], EAPB0203 (N-methyl-1-(2-phenethyl)imidazo[1,2-a]quinoxalin-4-amine) incorporated with 1,3,4-oxadiazole/thiadiazoles II [X = O, S; R² = H, Me, Cl, etc.] and imiquimod incorporated with 1,3,4-oxadiazole/thiadiazoles III [Y = O, S; R³ = Me, OH, NH₂] were synthesized and assessed their antiproliferative effects against various cancer cell lines. The 1,3,4-oxadiazole derivatives demonstrated the superior effectiveness compared to imiquimod and EAPB0203. These findings highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as anticancer agents. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Electric Literature of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Visible-Light Organophotoredox-Mediated [3 + 2] Cycloaddition of Arylcyclopropylamine with Structurally Diverse Olefins for the Construction of Cyclopentylamines and Spiro[4.n] Skeletons was written by Luo, Zhengshan;Cao, Bowen;Song, Tianhang;Xing, Zequn;Ren, Jun;Wang, Zhongwen. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C8H4Cl2N2 This article mentions the following:

A visible-light-mediated [3 + 2] cycloaddition of arylcyclopropylamine with structurally diverse olefins was developed using QXPT-NPh I as a highly efficient organic photoredox catalyst. The use of various alkyl-substituted alkenes in intermol. [3 + 2] cycloadditions with cyclopropylamine was first achieved. A general and efficient strategy for the construction of compounds containing structurally diverse cyclopentane-based spiro[4.n] skeletons such as II with 1,3-difunctional groups was also developed, which broadly exist in natural products and synthetic mols. Furthermore, a hydrogen-bond mode between the arylcyclopropylamine and the photocatalyst QXPT-NPh was proposed. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Computed Properties of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Computed Properties of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions was written by Keivanloo, Ali;Soozani, Atena;Bakherad, Mohammad;Mirzaee, Mahdi;Rudbari, Hadi Amiri;Bruno, Giuseppe. And the article was included in Tetrahedron in 2017.SDS of cas: 2213-63-0 This article mentions the following:

The 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines I (R = morpholin-4-yl, pyrrolidin-1-yl, piperidin-1-yl; R¹ = diethylaminyl, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl) are synthesized through multi-component reaction of 3-substituted 2-chloroquinoxalines II, propargyl bromide, and excess secondary amines such as morpholine, piperidine, diethylamine in the presence of a palladium-copper catalytic system. This one-pot process provides an unexpected synthesis of new trisubstituted pyrrolo[1,2-a]quinoxalines I by the introduction of two amine substituents onto the fused pyrrole rings in a single reaction procedure. The synthesized pyrrolo[1,2-a]quinoxaline derivatives I are also screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginos, and Bacillus subtilis. According to the obtained results, compounds I (R = piperidin-1-yl, R¹ = morpholin-4-yl; R = R¹ = morpholin-4-yl; R = R¹ = piperidin-1-yl), are active against M. luteus, and compounds I (R = piperidin-1-yl, morpholin-4-yl; R¹ = piperidin-1-yl, morpholin-4-yl) are active against Ps. Aeruginos, and only compound I (R = pyrrolidin-1-yl; R¹ = piperidin-1-yl) are active against all the three bacterial strains. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0SDS of cas: 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.SDS of cas: 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Thioether-functionalized quinone-based resorcin[4]arene cavitands: Electroswitchable molecular actuators was written by Milic, Jovana V.;Schneeberger, Thomas;Zalibera, Michal;Milowska, Karolina Z.;Ong, Quy K.;Trapp, Nils;Ruhlmann, Laurent;Boudon, Corinne;Thilgen, Carlo;Diederich, Francois. And the article was included in Helvetica Chimica Acta in 2019.Synthetic Route of C8H4Cl2N2 This article mentions the following:

The utility of mol. actuators in nanoelectronics requires activation of mech. motion by elec. charge at the interface with conductive surfaces. We functionalized redox-active resorcin[4]arene-quinone cavitands with thioethers as surface-anchoring groups at the lower rim and investigated their propensity to act as electroswitchable actuators that can adopt two different conformations in response to changes in applied potential. Mol. design was assessed by DFT calculations and X-ray anal. Electronic properties were exptl. studied in solution and thin films electrochem., as well as by XPS on gold substrates. The redox interconversion between the oxidized (quinone, Q) and the reduced (semiquinone, SQ) state was monitored by UV-Vis-NIR spectroelectrochem. and EPR spectroscopy. Reduction to the SQ state induces a conformational change, providing the basis for potential voltage-controlled mol. actuating devices. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Synthetic Route of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Synthetic Route of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein was written by Ono, Yukari;Ninomiya, Masayuki;Kaneko, Daiki;Sonawane, Amol D.;Udagawa, Taro;Tanaka, Kaori;Nishina, Atsuyoshi;Koketsu, Mamoru. And the article was included in Bioorganic Chemistry in 2020.Recommanded Product: 2213-63-0 This article mentions the following:

A series of quinoxaline-1,3,4-oxadiazole hybrids I [R = chloro, Ph, 4-methylpiperazin-1-yl, 4-phenylpiperazin-1-yl, etc.; R¹ = hydroxy, amino, 2-phenylethoxy, etc.] were synthesized and assessed for their anticancer potential on human leukemia HL-60 cells. Although these hybrids I exerted significant inhibition of HL-60 cell proliferation, they showed high cytotoxicity on human normal cells (WI-38). Utilizing information from mol. modeling of the hybrids I to the anti-apoptotic Bcl-2 protein, substructures including Ph, piperazine, piperidine and morpholine rings were added to their frameworks. The designed compounds I successfully induced apoptotic response on HL-60 cells with low toxicity on WI-38 cells. Furthermore, RT-PCR anal. demonstrated that these compounds I predominantly inhibited Bcl-2 expression. These findings highlight the great potential for the development of synthetic quinoxaline-1,3,4-oxadiazole hybrid derivatives as proapoptotic anticancer agents. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Recommanded Product: 2213-63-0).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Recommanded Product: 2213-63-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach was written by Kaneko, Daiki;Ninomiya, Masayuki;Yoshikawa, Rina;Ono, Yukari;Sonawane, Amol D.;Tanaka, Kaori;Nishina, Atsuyoshi;Koketsu, Mamoru. And the article was included in Bioorganic Chemistry in 2020.Electric Literature of C8H4Cl2N2 This article mentions the following:

A series of [1,2,4]triazolo[4,3-a]quinoxalines I [R¹ = benzyl, anilino, styryl, etc.], EAPB0203 (N-methyl-1-(2-phenethyl)imidazo[1,2-a]quinoxalin-4-amine) incorporated with 1,3,4-oxadiazole/thiadiazoles II [X = O, S; R² = H, Me, Cl, etc.] and imiquimod incorporated with 1,3,4-oxadiazole/thiadiazoles III [Y = O, S; R³ = Me, OH, NH₂] were synthesized and assessed their antiproliferative effects against various cancer cell lines. The 1,3,4-oxadiazole derivatives demonstrated the superior effectiveness compared to imiquimod and EAPB0203. These findings highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as anticancer agents. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Electric Literature of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider