Tag: 2958-87-4

2958-87-4, 2,3,6-Trichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2958-87-4

To a solution of 2,3,6-trichloro-quinoxaline (100 mg, 0.43 mmol) in DMF (3 mL) was added N-methylpiperazine (0.47 mL, 0.43 mmol). The reaction mixture was stirred for 12 h, and then the solvent was removed in vacuo. The residue was purified by silica gel chromatography to give 47 mg of 2,6-dichloro-3-(4-methyl-piperazin-1-yl)-quinoxaline and 28 mg of 3,6-dichloro-2-(4-methyl-piperazin-1-yl)-quinoxaline. 2,6-Dichloro-3-(4-methyl-piperazin-1-yl)-quinoxaline: 1H NMR (400 MHz, CDCl3): 7.80 (d, J=2.3 Hz, 1H), 7.77 (d, J=8.8 Hz, 1H), 7.46-7.43 (dd, J=8.8, 2.3 Hz, 2H), 3.63-3.62 (m, 4H), 2.64-2.61 (m, 4H), 2.38 (s, 3H). 3,6-Dichloro-2-(4-methyl-piperazin-1-yl)-quinoxaline: 1H NMR (400 MHz, CDCl3): 7.85 (d, J=2.3 Hz, 1H), 7.75 (d, J=8.8 Hz, 1H), 7.59-7.56 (dd, J=8.8, 2.3 Hz, 2H), 3.63-3.61 (m, 4H), 2.64-2.62 (m, 4H), 2.39 (s, 3H).

As the paragraph descriping shows that 2958-87-4 is playing an increasingly important role.

Reference£º
Patent; Edwards, James P.; Venable, Jennifer D.; US2005/70527; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

2958-87-4, 2,3,6-Trichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example C 6-Chloro-2,3-dicyanoquinoxaline A mixture of 11.7 g of 2,3,6-trichloroquinoxaline, 5.39 g of sodium cyanide and 2.04 g of benzyltrimethylammonium chloride is stirred in 200 ml of DMSO at room temperature for 24 hours. With intensive stirring the reaction mixture is poured onto 520 ml of ice-water, stirred for an hour, and filtered with suction, and the solid product is washed with water. Drying at 40 C. gives 8.12 g (76% of theory) of a gray powder of a compound with the following formula MS (m/e): 215 [M+H]+, 237 [M+Na]+ H NMR (DMSO): 8.53 (d, 1H), 8.37 (d, 1H), 8.26 (dd,1H)

The synthetic route of 2958-87-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Heckmann, Heino; Metz, Hans Joachim; US2007/264600; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider