Tag: 32601-86-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

To a suspension of NaH (33.7 mg, 842 mumol) in DMF (3 ml) at 0 under an argon atmosphere was added (6-(pyrrolidin-1-yl)pyridin-2-yl)methanol (0.1 g, 561 mumol) and 2-chloro-3-methylquinoxaline (150 mg, 842 mumol). The mixture was stirred at 0 for 2.5 hrs. At 0 water was given to the reaction mixture. The product was extracted with EtOAc, washed with water, dried over MgSO4, filtered and evaporated. The crude product was purified by column chromatography using a CH2Cl2/MeOH gradient as eluent, providing the title compound (0.15 g, 83%) as off-white solid. MS: M=321.1 (M+H)+, 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Flohr, Alexander; Zbinden, Katrin Groebke; Koerner, Matthias; Lerner, Christian; US2015/87644; (2015); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Methyl 4-hydroxybenzoate (42.1mmol, 6.4g) and K2CO3 (50.5mmol, 5.3g) were dissolved in DMF (150mL), the resulting solution was allowed to react at 85C for 12h. Compound 2a (23.5mmol, 5.0g) was added in batches, and the resulting mixture was allowed to react for additional 12hat the same condition. After completion of reaction, the reaction was quenched with cooled water (150mL) and extracted with EtOAc (2¡Á100mL). The combined organic phase was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuum to afford the crude product, which was purified by silica gel flash chromatography (PE: EA=50:1, v:v) to afford 6.6g of 3a as oily semi-solid, yield 80%. ESI-MS m/z: 295.4 [M+H]+., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Xia, Qiao-Hong; Hu, Wei; Li, Chen; Wu, Ji-Feng; Yang, Liang; Han, Xue-Mei; Shen, Yue-Mao; Li, Zhi-Yu; Li, Xun; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 311 – 325;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,32601-86-8

General procedure: Method A. To a solution of chloroheterocycles (2.5 mmol) inCHCl3 (25 mL) was added (0.69 g, 2.5 mmol) of N-cyclohexyldithiocarbamate cyclohexylammonium salt. The reaction mixture was refluxed at 61 C for 12 h. The reaction mixture wasevaporated under reduced pressure and 25 mL of ethanol wasadded to the solid residue. The yellowish-orange precipitatewas filtered to give the desired product. The crude compounds were pure enough for analytical purposes. Purification of products for analysis was achieved by crystallization from theappropriate solvent; chromatographed with the appropriateeluent or by repeated dissolution in KOH and reprecipitation byacetic acid. The filtrate was evaporated once again and the solidobtained was crystalized from ethanol water to give symmetrical dicyclohexylthiourea (3).

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fathalla, Walid; Ali, Ibrahim A. I.; Pazdera, Pavel; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 174 – 181;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example M: Preparation of N-[3-(bromomethyl)quinoxalin-2-yl]-N- (cyclopentylmethyl)ethylamine Step 1 :A suspension of 2-chloro-3-methylquinoxaline (500 mg, 2.8 mmol), N-(cyclopenthylmethyl)- N-ethylamine (900 mg, 7.1 mmol), potassium carbonate (970 mg, 7.0 mmol) in toluene (2.5 mL) is stirred at 150 0C for 14 hours. The reaction mixture is cooled to room temperature, diluted with water and ethyl acetate. The organic layer is washed with brine, dried over magnesium sulfate, filtered and concentrated. The crude product is purified by reverse phase HPLC (0.1% TFA to acetonitrile) to give N-(3-methylquinoxalin-2-yl)-N- (cyclopentylmethyl)ethylamine.1H-NMR (400MHz, CDCI3), delta (ppm): 1.15-1.20 (m, 2H), 1.19 (t, 3H), 1.45-1.73 (m, 8H), 2.21 (m, 1 H), 2.69 (s, 3H), 3.37 (d, 2H), 3.39 (q, 2H), 7.47 (ddd, 1 H), 7.55 (ddd, 1 H), 7.79 (dd, 1 H), 7.86 (dd, 1 H).

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/128568; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider