Tag: 3476-89-9

3476-89-9, 1,2,3,4-Tetrahydroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 5-(3,4,5-trimethoxyphenyl)penta-(2E,4E)-dienoyl chloride in methylene chloride (3 ml) was added dropwise to a solution of 45 mg (0.34 mmol) of 1,2,3,4-tetrahydroquinoxaline(1) in pyridine (0.5 ml) over about 5 minutes with stirring in an ice bath.. After completion of the addition, the mixture was stirred for 1 hour and water was added to conduct extraction with chloroform.. An organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure.. The resultant crude oil (254 mg) was purified by column chromatography on alumina and column chromatography on silica gel to obtain 91 mg (yield: 43%) of crude crystals of the title compound.. The crude crystals were recrystallized from chloroform-ether to obtain pale yellow fien needles. Melting point: 183-185 C. 1H-NMR (DMSO-d6, 120 C.) delta: 3.71(s,6H), 3.80(s,12H), 3.97(s,4H), 6.52(d,J=14.9 Hz,2H), 6.80(s,4H), 6.85-7.00(m,4H), 7.21-7.28(m,2H), 7.36(ddd,J=14.9,9.0,1.1 Hz,2H), 7.38-7.45(m,2H)., 3476-89-9

As the paragraph descriping shows that 3476-89-9 is playing an increasingly important role.

Reference£º
Patent; Kowa Co., Ltd.; US6340682; (2002); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

3476-89-9, 1,2,3,4-Tetrahydroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of compound 14-1 (270 mg, 2 mmol) in THF (10 mL) was added LiAlH4 (0411) (228 mg, 6 mmol) at 0 C. The resulting mixture was stirred at 0 C for 30 min then stirred at room temperature overnight. The reaction was quenched with 0.25 mL H20, 0.25 mL 5N NaOH and 1.25 mL H20. The participate was filtered off, and the filtrate was extracted with EtOAc (3 x 20 mL). The organic layers were separated, washed with brine, dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 60% EtOAc/hexane) to obtain as light yellow solid (90 mg, 34%). To a stirred solution of the intermediate afforded in last step (90 mg, 0.67 mmol) in THF was added Boc20 (146 mg, 0.67 mmol) and aqueous solution NaOH (IN, 0.67 mL) at 0 C. Then the resulting mixture was stirred at room temperature overnight. The reaction was quenched with water, extracted with EtOAc (3 x 10 mL). The organic layers were separated, washed with brine, dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 60% EtOAc/hexanes) to obtain as light yellow oil (90 mg, 57%). 1H NMR (400 MHz, CDC13) delta 7.49 (d, / = 7.7 Hz, 1H), 6.89 (td, / = 8.0, 1.4 Hz, 1H), 6.69 – 6.60 (m, 1H), 6.55 (dd, / = 8.0, 1.3 Hz, 1H), 3.94 (s, 1H), 3.83 – 3.69 (m, 2H), 3.47 – 3.34 (m, 2H), 1.52 (s, 9H).

3476-89-9 1,2,3,4-Tetrahydroquinoxaline 77028, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; SHEN, Sida; BERGMAN, Joel; (100 pag.)WO2017/142883; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider