55687-05-3, 2,5-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55687-05-3, EXAMPLE 5 Preparation of N-(5-chloro-2-quinoxalinyl)benzofuran-5-sulfonamide In a manner similar to Example 4, the reaction mixture from benzofuran-5-sulfonamide (397 mg, 2.01 mmol), sodium hydride (60%, 315 mg, 7.9 mmol) and 2,5-dichloroquinoxaline (600 mg, 3.01 mmol) was poured carefully into water and washed with hexanes. The hexane-free aqueous was acidified to a pH of 1-2 by the addition of 5N hydrochloric acid solution and the resulting precipitate was collected and dried. This precipitate was washed with methylene chloride and the solid obtained by evaporation of the filtrate was purified by radial silica gel chromatography (EtOAc/hexanes) followed by silica gel flash chromatography (diethyl ether/hexanes). The resulting foam which was broken up in hexanes, collected and dried, finally under vacuum at 80 C. to yield the title product (110 mg, 15%) as a solid. Analysis of the title compound gave the following results: 1 H NMR (300 MHz, d6 -DMSO) delta7.15 (d, 1H, J=2.0 Hz, Ar-H), 7.64-8.0 (overlapping multuplets, 4H, Ar-H), 8.03 (d, 1H, J=7.3 Hz, Ar-H), 8.13 (d, 1H, J=2.0 Hz, Ar-H), 8.51 (s, 1H, Ar-H), 8.67 (s, 1H, Ar-H), 12.21 (s, 1H, exchanges with D2 O, NH); IR(KBr) 1617, 1581, 1453, 1263 and 1153 cm-1; FDMS (DMSO) m/e=359, 361 (M+). Analysis of C16 H10 ClN3 O3 S: Theory: C, 53.41; H, 2.80; N, 11.68. Found: C, 52.95; H, 2.99; N, 11.47.
As the paragraph descriping shows that 55687-05-3 is playing an increasingly important role.
Reference£º
Patent; Eli Lilly and Company; US5529999; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider