Tag: 879-65-2

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, To a solution of quinoxaline-2-carboxylic acid 5 (0.2 g, 1.14 mmol) in dichloromethane was cooled to 0 C followed by addition of triethylamine (0.18 ml, 1.2 equiv) and ethylchloroformate (0.14 ml, 1.2 equiv) into it and stirred for 30 min. This reaction mixture was then transferred to a solution in another flask containing 5-(4-aminophenyl)-10,15,20-tripyridylporphyrin 7 (0.1 g, 0.158) dissolved in dichloromethane and triethylamine (0.18 ml, 1.2 equiv) at 0 C. Stirring continued for 1 h at the same temperature and allowed to reach at room temperature for another 1 h. After completion of the reaction, water (5 mL) was added into the reaction mixture and basified to pH ~ 8 with sodium carbonate and extracted with chloroform (3 ¡Á 25 mL). The solvent was evaporated and purified on a silica gel (100-200) column chromatography by using 5% methanol/chloroform to produce porphyrin 8 in good yield. (0.095 g, 76%). 1H NMR (400 MHz, DMSO-d6) delta: 10.20 (s, 1H), 9.85 (s, 1H), 9.00-8.90 (m, 8H), 8.79-8.78 (m, 5H), 8.32-8.21 (m, 5H), 8.13-8.07 (m, 6H), 7.99-7.77 (m, 3H), -2.93 (s, 2H). ESIMS m/z: calcd for C50H33N10O: 788 (M+), found: 789 (M+H).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Kumar, Dalip; Chandra Shekar; Mishra, Bhupendra; Kurihara, Ryohsuke; Ogura, Maiko; Ito, Takeo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3221 – 3224;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: The tail group containing monomer, dimer ortrimer (0.266 mmol) was dissolved in methanol (25 mL), to which Pd/C-10% (60mg) was added at 0oC under nitrogen with stirring. The reactionmixture was hydrogenated at room temperature and atmospheric pressure for 4 h.The catalyst was removed over Kieselguhr and the solvent was removed underreduced pressure to give the amine, which was dissolved in DMF (1 mL, dry). Theappropriate head group carboxylic acid (0.266 mmol) was dissolved in DMF (1 mL,dry) to which HBTU (260 mg, 0.685 mmol) and triethylamine (50 muL) were added tothe reaction mixture at room temperature with stirring and the reaction mixturewas left standing at room temperature overnight. The product was purified byHPLC (no work up required). Fractions containing the product were collected andfreeze dried to give the required product.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Scott, Fraser J.; Puig-Sellart, Mireia; Khalaf, Abedawn I.; Henderson, Catherine J.; Westrop, Gareth; Watson, David G.; Carter, Katharine; Grant, M. Helen; Suckling, Colin J.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3478 – 3486;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2

Example 99N-((ls,4s)-4-(2-(4′-(2-((3S,5R)-3,5-dimethylpiperazin-l-yl)ethyl)biphenyl-3-yloxy)-5- fluoronicotinamido)cyclohexyl)quinoxaline-2-carboxamide Step (a) N-((l s,4s)-4-(5-fluor o-2-(3-iodophenoxy)nicotinamido)cyclohexyl)quinoxaline-2- carboxamideTo a suspension of N-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(3-iodophenoxy Nicotinamide (2.56 g, 5.21 mmol) in acetonitrile (100 niL) was added quinoxaline-2-carboxylic acid (0.907 g, 5.21 mmol) and triethylamine (7.26 mL, 52.06 mmol). On addition of triethylamine the reaction mixture became a homogeneous solution. 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (3.48 mL, 5.47 mmol) was then added and the mixture stirred at RT for 2 h. The mixture was evaporated to dryness and the residue dissolved in DCM (150 mL) and washed with saturated NaHCCh (aq), brine, dried (MgSO4) and evaporated to give the sub-title compound as a light brown foam. Yield: 3.08 g 1H NMR (400 MHz, CDCl3) delta 9.67 (s, IH), 8.37 (dd, J= 8.1, 3.2 Hz, IH), 8.22 – 8.18 (m, IH), 8.11 – 8.07 (m, 2H), 7.95 (d, J= 6.9 Hz, IH), 7.91 – 7.85 (m, 3H), 7.64 – 7.59 (m, IH), 7.59 – 7.56 (m, IH), 7.20 – 7.14 (m, 2H), 4.33 – 4.24 (m, IH), 4.24 – 4.13 (m, IH), 2.07 – 1.82 (m, 6H), 1.80 – 1.67 (m, 2H). MS: [M+H]+ = 612 (MultiMode+).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

Example 108; 4-(4-Fluoro-benzyl)-1-(quinoxaline-2-carbonyl)-piperidine-4-carbonitrile To a stirred solution of Quinoxaline-2-carboxylic acid (100 mg, 0.57 mmol) in DMF was added DIPEA (0.3 ml, 0.72 mmol), EDCI (220 mg, 1.15 mmol), and HOBT (116 mg, 0.86 mmol) at 0 C. The reaction mixture was stirred for half an hour atroom temperature and was added 4-(4-Fluoro-benzyl)-piperidine-4-carbonitrile (125 mg, 0.57 mmol). The reaction mixture was stirred overnight atroom temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated under reduced pressure. Thus obtained crude was purified with column chromatography (Si-gel, 0.5% MeOH-DCM) to afford 110 mg (51.4%) of 4-(4-Fluoro-benzyl)-1-(quinoxaline-2-carbonyl)-piperidine-4-carbonitrile. LC/MS [M+H]+: 375.4. 11H-NMR (400 MHz, DMSO-d6) delta (ppm): 9.1 (s, 1H), 8.17-7.94 (m, 4H), 7.36 (t, 2H), 7.17 (t, 2H), 4.64 (d, 1H), 4.0 (d, 1H), 3.27 (m, 1H), 2.99 (m, 3H), 1.93 (m, 1H), 1.79 (m, 3H). HPLC: 97.1%

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

3. Take a 50 mL round bottom flask.To which quinoxaline-2-carboxylic acid (175 mg, 1 mmol) andEDCI (230mg, 1.2mmol) andHOBT (176mg, 1.3mmol)Soluble in 20mL DMF solution,The ratio of the amounts of the three raw materials is 1:1.2:1.3.Compound D (308 mg, 1.2 mmol) was added after half an hour.Stir at room temperature and monitor with TLC.After the reaction was completed, the reaction solution was washed with water, 5% HCl, 5% Na?The organic phase was dried over anhydrous Na 2 SO 4 and evaporated under reduced pressure.The crude product was separated and purified by thin layer chromatography (PE: EA = 2:1) to afford objective compound 1.Product 1 was a pale yellow solid with a yield of 40%.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

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Patent; Hefei University of Technology; Li Qingshan; Shen Bangnian; Li Yao; Ruan Banfeng; (19 pag.)CN109912574; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2

2-Quinoxalinecarboxylic acid (0801-134) (1.0 g, 5.7 mmol, 1.0 eq.)Dissolved in 20 ml of methanol,Add thionyl chloride (1.25 mL, 17.2 mmol, 3.0 equivalents),Heat reflux for 3 hours.Cooled to room temperature, concentrated to dryness under reduced pressure, extracted with ethyl acetate, washed with water, liquid-separated, dried over anhydrous sodium sulfate, filtered concentrated, and concentrated under reduced pressure.After silica gel column chromatography (eluent: eluent: petroleum ether: ethyl acetate = 5:1),The product was obtained as a pale yellow solid, methyl 2-quinoxalinecarboxylate (1.01 g, yield: 93.5%).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

In one embodiment, quinoxaline acid is combined with [GDI] in anhydrous tetrahydrofuran and heated to provide the acyl imidazole.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2004/14875; (2004); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

Aniline 6 (3.70 g, 22.4 mmol) was added to a 250 mL round bottom flask with stir bar followed by quinoxaline-2-carboxylic acid (4.88 g, 28.0 mmol), EDC HCl (5.58 g, 29.1 mmol),and DMF (75 mL). DIPEA (11.5 mL) was added and the reaction was stirred for 16 h. A sample aliquot was taken from the reaction, dissolved in 1 mL HPLC grade MeCN, and analyzed with LC-MS to confirm the completion of the reaction.The reaction was diluted with DCM (500 mL) water (500 mL) and sat. aq. sodium bicarbonate (250 mL). The layers wereseparated and the aqueous was extracted with DCM (3 x 150 mL). The combined organic layers were washed with 0.1 NHCl (1 x 75 mL), then brine, dried over sodium sulfate, and condensed to give amide 7 as a tan solid (7.12 g, 99%).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Porter, Jacob D.; Lindeman, Sergey V.; Dockendorff, Chris; Tetrahedron Letters; vol. 61; 12; (2020);,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of the product of Example 4A (25 mg, 0.088 mmol) in N,N- dimethylformamide (0.5 mL) was added quinoxaline-2-carboxylic acid (16.8 mg, 0.097 mmol), 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (36.7 mg, 0.097 mmol, HATU), and N,N-diisopropylethylamine (0.046 mL, 0.26 mmol) at ambient temperature. The reaction mixture was stirred for 3 hours and then was purified by preparative HPLC [Waters XBridge C185 mum OBD column, 30 ¡Á 100 mm, flow rate 40 mL/minute, 5-100% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid)] to give the title compound (30 mg, 0.068 mmol, 77% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 9.57 (s, 1H), 9.40 (s, 1H), 8.74 (s, 1H), 8.21 – 8.10 (m, 2H), 7.96 (ddd, J = 5.5, 4.6, 3.2 Hz, 2H), 7.47 (t, J = 8.9 Hz, 1H), 7.05 (dd, J = 11.4, 2.8 Hz, 1H), 6.84 (ddd, J = 8.9, 2.9, 1.2 Hz, 1H), 4.47 (s, 2H), 2.38 (s, 6H); MS (ESI+) m/z 440 (M+H)+.

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; CALICO LIFE SCIENCES; ABBVIE, INC.; SIDRAUSKI, Carmela; PLIUSCHEV, Marina; FROST, Jennifer, M.; BLACK, Lawrence, A.; XU, Xiangdong; SWEIS, Ramzi, Farah; SHI, Lei; ZHANG, Qinwei, I.; TONG, Yunsong; HUTCHINS, Charles, W.; CHUNG, Seungwon; DART, Michael, J.; (661 pag.)WO2017/193063; (2017); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the product of Example 4A (25 mg, 0.088 mmol) in N,N- dimethylformamide (0.5 mL) was added quinoxaline-2-carboxylic acid (16.8 mg, 0.097 mmol), 1 – [bis(dimethylamino)methylene] – 1H- 1 ,2,3-triazolo[4,5-]pyridinium 3-oxid hexafluorophosphate (36.7 mg, 0.097 mmol, HATU), and N,N-diisopropylethylamine (0.046 mL, 0.26 mmol) at ambient temperature. The reaction mixture was stirred for 3 hours and then was purified by preparative HPLC [Waters XBridge C18 5 mupiiota OBD column, 30 x 100 mm, flow rate 40 mL/minute, 5-100% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid)] to give the title compound (30 mg, 0.068 mmol, 77% yield). JH NMR (400 MHz, DMSO-<) delta ppm 9.57 (s, 1H), 9.40 (s, 1H), 8.74 (s, 1H), 8.21 - 8.10 (m, 2H), 7.96 (ddd, J = 5.5, 4.6, 3.2 Hz, 2H), 7.47 (t, J = 8.9 Hz, 1H), 7.05 (dd, J = 11.4, 2.8 Hz, 1H), 6.84 (ddd, J = 8.9, 2.9, 1.2 Hz, 1H), 4.47 (s, 2H), 2.38 (s, 6H); MS (ESI+) m/z 440 (M+H)+. As the paragraph descriping shows that 879-65-2 is playing an increasingly important role. Reference£º
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; PLIUSHCHEV, Marina, A.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; SWEIS, Ramzi, Farah; DART, Michael, J.; RANDOLPH, John, T.; MURAUSKI, Kathleen; (674 pag.)WO2019/90076; (2019); A1;,
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