Tag: 879-65-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution quinoxaline-2-carboxylic acid 5 (0.2 g, 1.14 mmol) in dichloromethane was added triethylamine (0.18 ml, 1.2 equiv) and ethylchloroformate (0.14 ml, 1.2 equiv) at 0 C and stirred for 30 min. Then, the above reaction mixture was transferred to a dropping funnel and added to a cooled solution of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin 3 (0.1 g, 0.158 mmol) in dichloromethane and triethylamine at 0 C. The contents were stirred at the same temperature for 1h and gradually allowed to warm at room temperature and stirring continued for another 1h. After completion, water (5 mL) was added into reaction mixture and basified to pH ~ 8 with sodium carbonate and extracted with chloroform (3 ¡Á 25 mL). The solvent was evaporated and purified on column chromatography with silica gel (100-200) with 90% chloroform/hexane to furnish compound 6 in good yield (0.111 g, 89%). 1H NMR (400 MHz, CDCl3) delta: 10.17 (s, 1H), 9.83 (s, 1H), 8.85-8.78 (m, 8H), 8.24-8.21 (m, 5H), 8.19-8.14 (m, 6H), 7.88-7.85 (m, 2H), 7.70-7.64 (m, 9H), -2.85 (s, 2H). ESIMS m/z: calcd for C53H36N7O: 786.3(M+H), found: 786.3 (M+H).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kumar, Dalip; Chandra Shekar; Mishra, Bhupendra; Kurihara, Ryohsuke; Ogura, Maiko; Ito, Takeo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3221 – 3224;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To the resin 13 (560 mg) in DMF (2.5 mL) were added a solutionof the appropriate Fmoc-protected amino acid (see Tables 1-3)(0.3 M), PyBOP (0.3 M) and HOBt (0.3 M) in dry DMF (4.2 mL). Thesuspensions were stirred for 3 min and then DIPEA (0.6 M) wasadded. The suspensions were stirred for 3 h under an argon atmosphereat rt. The resins were washed successively with DCM(150 mL), MeOH (120 mL), DCM (75 mL) and dried overnight undervacuum to give resins 14, each bearing an appropriate Fmoc-protectedamino acid. To the resins 14 (161 mg, 0.13 mmol) wereadded a solution of piperidine (20%, v/v) in DCM (2.1 mL) and themixtures were stirred for 1 h at rt. After filtration, the resins werewashed successively with DCM (50 mL), MeOH (45 mL), DCM(25 mL) and dried under vacuum to give resins 15. Portions(65 mg) of resins 15 were placed in reactor wells (12 mL) of anautomated synthesizer reaction block (40-well format) (AdvancedChemTech). To each well was added a solution of appropriate carboxylicacid (see Tables 1-3) (0.3 M), PyBOP (0.3 M) and HOBt 6-Cl(0.3 M) and DIPEA (0.6 M) in dry DMF (2 mL). The suspensionswere vortexed at 300 rpm over a period of 5 h under an argonatmosphere. The wells were then filtered to remove the reactivesolution from the resins 16 and washed successively with THF,DCM, MeOH and DCM.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Talbot, Amelie; Maltais, Rene; Kenmogne, Lucie Carolle; Roy, Jenny; Poirier, Donald; Steroids; vol. 107; (2016); p. 55 – 64;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1.22: f4-(3-Chloro-phenvlethynvl)-4-hydroxv-piperidin-1-vll-quinoxalin-2-vl- methanone; MS (LC/MS): 392 [M+H]TLC Rf: 0.24 (EtOAc/cyclohex 1 :1)

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/89700; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

Thionyl chloride (1 mL) was added to a solution of 2-quinoxalinecarboxylic acid (125 mg, 0.718 mmol) in methanol (20 mL). The resulting solution was stirred for 3 hours and evaporated to dryness under reduced pressure. The resulting off-white solid was collected (115 mg, 85%). 1H NMR (400 MHz, CDCl3): delta (ppm) 9.567 (s, 1H, H5), 8.342 (dd, J1-2 = 8 Hz, J1-3 2 Hz, 1H, H1), 8.284 (dd, J4-3 = 8Hz, J4-2 = 0.8 Hz, 1H, H4), 7.938 (q-br, J2/3-3/2/1/4 = 8.4 Hz 2H, H2/3).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider