Tag: M.W:100-200

Recommanded Product: 6-Methylquinoxaline, New research progress on 6344-72-5 in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.6344-72-5, Name is 6-Methylquinoxaline, molecular formula is C9H8N2. In a article，once mentioned of 6344-72-5

Ruthenium arene complexes, [(eta6-p-cymene)2Ru2(L)Cl2](PF6)2 [3b, L = 2, 7-bis(di-2-pyridinyl)-1,8-naphthyridine] and [(eta6-p-cymene)Ru(L?)Cl](PF6) [4, L? = tri(2-pyridinyl)amine], were synthesized and characterized by spectroscopic and analytical techniques. The molecular structure of [(eta6-p-cymene)2Ru2(L)Cl2]Cl2 (3a) was further determined by single-crystal X-ray analysis. The use of these ruthenium complexes as pre-catalysts for oxidative coupling of 1,2-diols/1,2-aminoalcohol with o-phenylenediamines leading to quinoxalines was investigated. Complex 3b appeared to be a good catalyst for this transformation.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N39 | ChemSpider

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.Recommanded Product: 2,3-Dichloroquinoxaline, In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Velcrands are a specific class of cavitands whose complementary surfaces induce self-dimerization. The insertion of a velcrand as physical cross-linking unit into a polymer is reported. To this purpose, the velcrand was functionalized at the lower rim with an isocyanate group. The functional velcrand was reacted with poly (ethylene-co-(2-hydroxethylmethacrylate)) (PE-HEMA), a polymer equipped with free hydroxyl groups suitable for reaction with the isocyanate group. The obtained functionalized polymer was characterized by nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), proving the introduction of velcraplexes in the polymer. Films with varying amounts of velcrands were obtained by solution casting and slow evaporation, testifying the processability of the functionalized polymers. The obtained films were used to measure the oxygen barrier properties of the functionalized material.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1575 | ChemSpider

Electric Literature of 130345-50-5, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 130345-50-5, Name is Quinoxaline-6-carbaldehyde, molecular formula is C9H6N2O. In a article，once mentioned of 130345-50-5

By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N234 | ChemSpider

New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 15804-19-0, name is Quinoxaline-2,3(1H,4H)-dione, introducing its new discovery. name: Quinoxaline-2,3(1H,4H)-dione

A novel series of quinoxalinediones possessing imidazolyl and related heteroaromatic substituents was synthesized and evaluated for their activity to inhibit [3H]AMPA binding from rat whole brain. From the structure- activity relationships, it was found that the 1H-imidazol-1-yl moiety could function as a bioisostere for the cyano and nitro groups, and that 6-(1H- imidazol-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (11) showed the most potent activity for the AMPA receptor. Compound 11 was evaluated for selectivity versus other excitatory amino acid receptors, and its action against AMPA at its receptor in the rat striatum was characterized. These data showed that compound 11 was a selective antagonist for the AMPA receptor with a K(i) value of 0.084 muM, being approximately equipotent with 2,3-dihydro-6-nitro- 7-sulfamoylbenzo(f)quinoxaline (3) (NBQX; K(i) = 0.060 muM). Compound 11 was also found to give protection against sound-induced seizure on DBA/2 mice at the minimum effective dose of 3 mg/kg ip (3; 10 mg/kg ip).

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N372 | ChemSpider

New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2213-63-0, name is 2,3-Dichloroquinoxaline, introducing its new discovery. Product Details of 2213-63-0

A new series of 1-N-thiocarboxamide-3-phenyl-2-pyrazolines 1-6 was synthesized by cyclization of different Mannich bases with unsubstituted thiosemicarbazide. The reaction of cyclized pyrazoline derivatives 1-6 with 2,3-dichloroquinoxaline afforded the title compounds 7-12. The structures of the new compounds were confirmed by elemental analyses as well as 1H, 13C NMR, IR and electronic spectral data. The HM1:IMSS strain of Entamoeba histolytica parasite was cultured in vitro and the sensitivity of the parasite to the synthesized compounds was evaluated using the microdilution method. Among all the pyrazoline derivatives 1-6, none was found to be a better inhibitor as compared to the reference drug, metronidazole. The quinoxaline derivatives, 9, 11 and 12 were found to be potent inhibitors of E. histolytica.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1231 | ChemSpider

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.25594-62-1, In a article, mentioned the application of 25594-62-1, Name is 2-Acetylquinoxaline, molecular formula is C10H8N2O

The efficient selective oxidation and functionalization of C-H bonds with molecular oxygen and a copper catalyst to prepare the corresponding ketones was achieved with ethyl chloroacetate as a promoter. In this transformation, various substituted N-heterocyclic compounds were well tolerated. Preliminary mechanistic investigations indicated that organic radical species were involved in the overall process. The N-heterocyclic compounds and ethyl chloroacetate work synergistically to activate C-H bonds in the methylene group, which results in the easy generation of free radical intermediates, thus leading to the corresponding ketones in good yields.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N755 | ChemSpider

Application of 1448-87-9, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a article，once mentioned of 1448-87-9

A series of pyrrolidine based inhibitors of dipeptidyl peptidase IV were developed from a high throughput screening hit for the treatment of type 2 diabetes. Potency, selectivity, and pharmacokinetic properties were optimized resulting in the identification of a pre-clinical candidate for further profiling.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N720 | ChemSpider

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 2-Chloroquinoxaline, We’ll be discussing some of the latest developments in chemical about CAS: 1448-87-9, name is 2-Chloroquinoxaline. In an article，Which mentioned a new discovery about 1448-87-9

The SNAr-type reaction of the piperidine amide of cyanoacetic acid with a series of heteroaryl halides followed by in situ oxidation of the resultant anion with peracetic acid provided a convenient, one-pot protocol for preparative access to heteroaryl alpha-keto amides. In this procedure, the amide of cyanoacetic acid functions as an Umpolung-type synthon of the alpha-keto amide moiety.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N741 | ChemSpider

Computed Properties of C8H8N4, New research progress on 6640-47-7 in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 6640-47-7, Name is Quinoxaline-2,3-diamine, molecular formula is C8H8N4. In a Article，once mentioned of 6640-47-7

Benzofuroxan (1) reacts with phosphorus ylide 2 to give benzimidazole derivatives 8 and 10, whereas reaction of 1 with ylide 12 furnishes quinoxaline 17 via an initial Wittig-type reaction.Similarly the reaction between the furoxano<3,4-b>quinoxalines 19a or 19b and the ylide 2 yielded compounds 22a and 22b, respectively.In these reactions as well as in the reactions of the above furoxans with other phosphorus ylides, a significant deoxygenation of the furoxans to furazans with subsequent oxidation of the ylides is generally observed.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N251 | ChemSpider

Product Details of 6925-00-4, New research progress on 6925-00-4 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 6925-00-4, Name is Quinoxaline-6-carboxylic acid, molecular formula is C9H6N2O2. In a Patent，once mentioned of 6925-00-4

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N797 | ChemSpider