A new application about 2,3-Dichloroquinoxaline

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The condensation of 3-n-butyl-4-amino-5-mercapto-s-triazole 1 with chloroacetic acid, alpha-haloketones, benzoin, 2,3-dichloro-quinoxaline, carbon disulphide, aromatic carboxylic acids and aromatic carboxaldehydes furnished in one step, the cyclic products, 3-n-butyl 7H-s-triazolo [3,4-b] [1,3,4] thiadiazin-6 (5H)-one 2,6-aryl-3-n-butyl-7H-s-triazolo [3,4-b] [1,3,4] thiadiazines 3,3-n-butyl-6,7-diphenyl-5H-s-triazolo [3,4-b] [1,3,4] thiadiazine 4, 3-n-butyl-5H-s-triazolo [3′,4′:2,3] [1,3,4] thiadiazino [5,6-b] quinoxaline 5,3-n-butyl-s-triazolo [3,4-b] [1,3,4] thiadiazole-6 (5H)-thione 6, 3-n-butyl-6-aryl-s-triazolo [3,4-b] [1,3,4]-thiadiazoles 7 and 6-aryl-5,6-dihydro-3-n-butyl-s-triazolo [3,4-b] [1,3,4] thiadiazoles 8 respectively. The compounds have been characterized on the basis of elemental analysis and spectral data. The antibacterial and antifungal activity of some of the compounds have also been evaluated.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1464 | ChemSpider

 

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Reference of 477776-17-3, New research progress on 477776-17-3 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.477776-17-3, Name is 6-(Chloromethyl)quinoxaline, molecular formula is C9H7ClN2. In a article,once mentioned of 477776-17-3

The invention concerns the preparation of compounds of formula STR1 and acid addition and quaternary ammoniun salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula STR2 in which Q is O, S, –CR7 =CR8 –, –N=CR8 — and –N=N–; R4, R5 and R6, and R7 and R8 when present, each represent hydrogen or a substituent selected from lower alkyl, lower alkenyl, lower alkoxy, NO2, NH2, haloloweralkyl, hydroxyloweralkyl, aminoloweralkyl, substituted amino, halogen, loweralkoxycarbonyl, cyano, CONH2 and hydroxy; and additionally either R4 and R5 when adjacent or R6 and R8 when adjacent, together with the carbon atoms to which they are attached also represent a fused five or six membered carbocylic or heterocyclic ring optionally carrying one or more substituents as defined above; R is an optionally substituted aryl or heteroaryl radical or a cycloalkyl radical containing 5 to 7 carbon atoms; R1, R2, R3 and R9 are each hydrogen or a lower alkyl group; n is 0 or 1; X is =O, =S or =NH; Y is –O– or a direct bond and Z is — CO– or –CH2 –, with the proviso that when Ar is unsubstituted phenyl and R9 is hydrogen then Y is –O–. The compounds of formula I exhibit psychotropic activity and are useful as antidepressants.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1062 | ChemSpider

 

Properties and Exciting Facts About 1448-87-9

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Synthetic Route of 1448-87-9, New Advances in Chemical Research in 2021. Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a article,once mentioned of 1448-87-9

6-nitro-, 2-methyl-6-nitro- and 2,3-dimethyl-6-nitroquinoxaline have been transformed into their N-oxides by MCPBA in chloroform; the nitro group orients the oxygen atom preferentially to nitrogen atom N1, but the N4:N1 selectivity is diminished in the methylated derivatives.Under the action of POCl3 (the Meisenheimer reaction), the N-oxides of the unmethylated compounds are transformed into chloro-nitroquinoxalines having lost the N-oxide oxygen atom.The orientation of the entering chloride ion is discussed on the basis of electronic effects induced by the N-oxide and nitro groups, and it is suggested that the last step, the elimination of “HPO2Cl2” is a concerted process.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N646 | ChemSpider

 

New explortion of 15804-19-0

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 15804-19-0, and how the biochemistry of the body works.Electric Literature of 15804-19-0

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. Electric Literature of 15804-19-0, In a article, mentioned the application of 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2

The reaction of 1,4-dihydro-2,3-quinoxalinedione (H2L?) with CuCl2 in the presence of LiOH in DMF has led to the 3D coordination polymer [Cu3L2Cl2(DMF)4]n (1) with an (82 · 10)-a, lig (LiGe), topology, where L2- is 2,3-dioxyquinoxalinate(-2). This compound is the first coordination polymer of any transition metal featuring L2- and contains the ligand in a novel 3.1111 (Harris notation) coordination mode. IR data are discussed in terms of the chemical composition of the polymer and the coordination mode of L2-. Variable-temperature (2-300 K) magnetic susceptibility and variable-field (0-5 T) magnetization studies reveal that L2- propagates weak antiferromagnetic exchange interactions through its “quinoxaline” moiety.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N339 | ChemSpider

 

Extracurricular laboratory:new discovery of 2213-63-0

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New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Product Details of 2213-63-0, In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Treatment of 6-aminothiouracil (1) with 2,3-dichloroquinoxaline (2) in ethanol/TEA afforded 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one (3), which was refluxed in DMF to give 2-aminopyrimido[2?,1?:2,3]thiazolo[4,5-b]quinoxaline-4-one (4). Compound 4 was utilized as a key intermediate for the synthesis of a new pyrimido[2?,1?:2,3]thiazolo[4,5-b]quinoxaline derivatives 5-14 via the reaction with 2-chlorobenzaldehyde, 2-chlorocyclohex-1-enecarbaldehyde, 2-chlorobenzoic acid, 2,4-dichlorobenzoic acid, 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde, 2-chloro-4,6-dimethylnicotinonitrile, alpha,beta-unsaturated ketones and isonicotinaldehyde, respectively. The chemical structures of the newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. These compounds were also screened for their analgesic and anti-inflammatory activities. Some of these compounds (3, 4, 9, 10 and 12-14) exhibited promising activities.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1234 | ChemSpider

 

Properties and Exciting Facts About Quinoxaline-2,3(1H,4H)-dione

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C8H6N2O2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 15804-19-0, in my other articles.

Computed Properties of C8H6N2O2, New Advances in Chemical Research in 2021. Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a article,once mentioned of 15804-19-0

Ytterbium triflate are found to catalyze efficiently the Phillips-type heterocyclization reactions of 1,2-phenylenediamine and alkyl oxalate under solvent-free and mild conditions to afford the corresponding quinoxaline-2,3-dione derivatives in high yields. The catalyst could be recovered almost quantitatively from the aqueous layer after the reaction was completed and it could be reused in subsequent reaction without decrease in activity.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N411 | ChemSpider

 

What I Wish Everyone Knew About 2,3-Dichloroquinoxaline

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 2213-63-0. In my other articles, you can also check out more blogs about 2213-63-0

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Literature survey indicates that 2-substituted quinoxaline derivatives possess different pharmacological and biological activities, of which most potent activities are anti-bacterial, anti-fungal, anti-inflammatory, and analgesic activity. In view of above literature, we planned to synthesize novel 2-Substituted quinoxaline derivatives. The final synthesised were characterized by physical (M.P, TLC) and spectral analysis (1HNMR, IR). The 2-substituted quinoxaline nucleus was constructed by condensation of o-phenylene diamine and diethy loxalate in equimolar quantities which upon heating yielded quinoxaline-2, 3-diol moiety. The quinoxaline-2,3-diol was treated with POCl3 to furnish 2,3-di chloro quinoxaline (2). Further the 2-chloro-3-hydrazinoquinoxaline (3) was synthesized by the reaction of 2,3-dichloroquinoxaline (2) and hydrazine hydrate in methanolic medium upon refluxing for 60 min. different Schiff’s bases of 2-chloro-3-hydrazine quinoxaline were obtained by refluxing the appropriate substituted benzaldehyde and 2-chloro-3-hydrazinoquinoxaline (3) in acetic medium for 3 h. All the synthesized compounds were screened for their antibacterial and antifungal activities by using cup plate method against Bacillus subtilis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus Niger and Candida albicans at 100, 50 ig/mL concentration using ciprofloxacin and clotrimazole as reference standard drugs respectively. Compounds 4e and 4f showed significant activity against Pseudomonas aeruginosa, 4a and 4d showed significant activity against Bacillus subtilis, the compound 4c showed good activity against the organism Bacillus pumilus, whereas the compound 4a shown moderate antifungal activity against Candida albicans. The rest of the compounds showed weak activity when compared to the standard ciprofloxacin and clotrimazole.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1379 | ChemSpider

 

You Should Know Something about 2,3-Dichloroquinoxaline

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Imidazo[1,2-a]quinoxaline compounds for the treatment of cancers as well as pharmaceutical compositions that include these compounds and their uses in therapy. The compound of general formula (I):

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Now Is The Time For You To Know The Truth About 2213-63-0

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New Advances in Chemical Research, May 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing theoretical assessments of solvent structures and their interactions with reaction intermediates. Application of 2213-63-0, We’ll be discussing some of the latest developments in chemical about CAS: 2213-63-0, name is 2,3-Dichloroquinoxaline. In an article,Which mentioned a new discovery about 2213-63-0

Catch it if you can! Redox-active resorcin[4]arene cavitands with quinone walls can be reversibly reduced to the hydroquinone form, influencing their host-guest complexation strength. Specifically, a top-covered triptycenequinone cavitand forms kinetically stable complexes with cycloalkanes; this complexation is weaker in the reduced hydroquinone form.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1502 | ChemSpider

 

Extracurricular laboratory:new discovery of 2213-63-0

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New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Application In Synthesis of 2,3-Dichloroquinoxaline, In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Sulfanyl-glycosides have been synthesized by reaction of 2,3-dimercaptoquinoxaline (1) with acetohalo sugars in presence of base to give the thioglycosides-derived quinoxalines 5-7 and 9. Similarly, the acyclic analogs 23-26 were prepared by coupling of 1 with different acyclo-alkylating agents. The preparation of 3-morpholinyl-quinoxalines 10 and 11 allowed the synthesis of 3-glycosylsulfanyl-2-morpholinyl-quinoxalines 12-14 and 17 as well as the acyclic analogs 27-29. Microwave irradiation of the reactants turned out to be preferred over the conventional method for achieving the synthetic goals. This study made an available venue to the synthesis of diverse quinoxaline derivatives.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1269 | ChemSpider