Tag: M.W:100-200

Related Products of 57825-30-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).

Inhibitors based on a benzo-fused spirocyclic oxazepine scaffold were discovered for stearoyl-CoA (CoA) desaturase 1 (SCD1) and subsequently optimized to potent compounds with favorable pharmacokinetic profiles and in vivo efficacy in reducing the desaturation index in a mouse model. Initial optimization revealed potency preferences for the oxazepine core and benzylic positions, while substituents on the piperidine portions were more tolerant and allowed for tuning of potency and PK properties. After preparation and testing of a range of functional groups on the piperidine nitrogen, three classes of analogs were identified with single digit nanomolar potency: glycine amides, heterocycle-linked amides, and thiazoles. Responding to concerns about target localization and potential mechanism-based side effects, an initial effort was also made to improve liver concentration in an available rat PK model. An advanced compound 17m with a 5-carboxy-2-thiazole substructure appended to the spirocyclic piperidine scaffold was developed which satisfied the in vitro and in vivo requirements for more detailed studies.

As far as I know, this compound(57825-30-6)Related Products of 57825-30-6 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(ii)fluoridetetrahydrate( cas:13940-83-5 ) is researched.Name: Nickel(ii)fluoridetetrahydrate.Ishikawa, Yuki; Miyamoto, Keiko; Horn, Ernst published the article 《Crystal structure of μ3-fluoro-tri-μ2-fluoro-tris(tetramethylethylene-diamine nickel(II)) fluoride trihydrate, [Ni3(tmen)3F5]+·F-·3H2O, C18H54F6N6Ni3O3》 about this compound( cas:13940-83-5 ) in Zeitschrift fuer Kristallographie – New Crystal Structures. Keywords: crystal structure nickel tetramethylethylenediamine fluoro bridged complex fluoride trihydrate; mol structure nickel tetramethylethylenediamine fluoro bridged complex fluoride trihydrate. Let’s learn more about this compound (cas:13940-83-5).

The crystal structure of the title compound is herein given. The title compound was synthesized by a reaction of nickel difluoride tetrahydrate and N,N,N’,N’-tetramethylethylenediamine. The title compound is a fluoride bridged trinuclear complex. Crystallog. data are given.

This literature about this compound(13940-83-5)Name: Nickel(ii)fluoridetetrahydratehas given us a lot of inspiration, and I hope that the research on this compound(Nickel(ii)fluoridetetrahydrate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Electric Literature of C3H12Cl2N2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about The effect of π-π stacking interaction of the indole ring with the coordinated phenoxyl radical in a nickel(II)-salen type complex. Comparison with the corresponding Cu(II) complex. Author is Oshita, Hiromi; Suzuki, Takashi; Kawashima, Kyohei; Abe, Hitoshi; Tani, Fumito; Mori, Seiji; Yajima, Tatsuo; Shimazaki, Yuichi.

To gain new insights into the effect of the π-π stacking interaction of the indole ring with the phenoxyl radical moiety as seen in the active form of galactose oxidase, the authors prepared Ni(II) complexes of a methoxy substituted salen-type ligand containing a pendent indole ring on the dinitrogen chelate backbone and characterized their 1-electron oxidized forms. The x-ray crystal structure anal. and the other physicochem. experiments of the Ni(II) complex revealed no significant intramol. interaction of the indole ring with the coordination plane. However, the x-ray crystal structures of the oxidized Ni(II) complex exhibited the π-π stacking interaction of the indole ring mainly with one of the two phenolate moieties. While the phenoxyl radical electron was delocalized on the two phenolate moieties in the Ni(II)-salen coordination plane, the phenolate moiety in close contact with the indole moiety was considered to be the initial oxidation locus, indicating that the indole ring interacted with the phenoxyl radical by π-π stacking. The UV-visible-NIR spectrum of the oxidized Ni(II) complex with the pendent indole ring was different from that of the complex without the side chain indole ring, but the differences were rather small in comparison with the oxidized Cu(II)-salen complexes with the π-π stacking interaction of the indole ring. Such differences are due to the electronic structure difference, the localized radical electron on one of the phenolate moieties in the oxidized Cu(II) complexes being more favorable for the π-π stacking interaction.

This literature about this compound(19777-66-3)Electric Literature of C3H12Cl2N2has given us a lot of inspiration, and I hope that the research on this compound((S)-Propane-1,2-diamine dihydrochloride) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Inorganica Chimica Acta called Cationic cyclopalladated ferrocenylpyrimidine complex as an efficient catalyst for the synthesis of substituted biarylmethanol by the Suzuki reaction in water, Author is Li, Hong-Mei; Xu, Chen; Hao, Xin-Qi; Li, Zhen; Wang, Zhi-Qiang; Fu, Wei-Jun; Song, Mao-Ping, which mentions a compound: 217192-22-8, SMILESS is OCC1=CC=C(C2=CC=NC=C2)C=C1, Molecular C12H11NO, Synthetic Route of C12H11NO.

A new cationic cyclopalladated ferrocenylpyrimidine 2 has been synthesized and characterized by elemental anal., IR, 1H and C13 NMR. Addnl., its detailed structure has been determined by single-crystal x-ray diffraction and intermol. C-H···O hydrogen bonds were found in the its crystal. 2 Was successfully used in Suzuki reaction of aryl bromides or chlorides excluding water-soluble group with 4-(hydroxymethyl)phenylboronic acid for the synthesis of substituted biarylmethanol in water. Complex 2 was very efficient for these reactions. Typically, using 0.5-1 mol% of catalyst in the presence of 3 equivalent of K3PO4·3H2O as base in water at 100° provided coupling products in good yields.

This literature about this compound(217192-22-8)Synthetic Route of C12H11NOhas given us a lot of inspiration, and I hope that the research on this compound((4-(Pyridin-4-yl)phenyl)methanol) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

SDS of cas: 57825-30-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Construction of polyaromatics via photocyclization of 2-(fur-3-yl)ethenylarenes, using a 3-furyl group as an isopropenyl equivalent synthon. Author is Chen, Ying-Zhe; Ni, Ching-Wen; Teng, Fu-Lin; Ding, Yi-Shun; Lee, Tunng-Hsien; Ho, Jinn-Hsuan.

The construction of different types of substituted arenes was demonstrated through the photocyclization of 2-(fur-3-yl)ethenylarenes using a 3-furyl group as an isopropenyl equivalent synthon in the photocyclization reaction. The furan portion of the photocyclization intermediate could be fragmented via a base-induced elimination reaction to yield a series of substituted polyaromatics, including naphthalene, benzofuran, benzothiophene, phenanthrene, phenalene, acenaphthene, and triphenylene. Using different reagents, this method made it possible to introduce Me or 2-hydroxyethyl groups as substituents at specific positions in these arenes.

This literature about this compound(57825-30-6)SDS of cas: 57825-30-6has given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-4-ethylbenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Dyes and Pigments called Effect of composition on the properties of novel optically active methacrylic copolymers containing side-chain zinc-porphyrin chromophores suitable to chiral recognition, Author is Benelli, T.; Angiolini, L.; Caretti, D.; Lanzi, M.; Mazzocchetti, L.; Salatelli, E.; Giorgini, L., which mentions a compound: 19777-66-3, SMILESS is C[C@H](N)CN.[H]Cl.[H]Cl, Molecular C3H12Cl2N2, Recommanded Product: 19777-66-3.

New chiral methacrylic copolymers, bearing in the side chain one or two L-lactic acid residues linked to a porphyrin moiety, with variable molar content of Me methacrylate co-units, have been prepared by radical copolymerization of the corresponding monomers. The resulting macromols. have been fully characterized both in solution and in the solid state with particular attention to their thermal, UV-Vis and chiroptical properties by comparison with those of the related porphyrin containing homopolymers and monomeric models. The zinc-porphyrin coordination complexes of the above functional derivatives have been studied as macromol. hosts for the chiral recognition of optically active diamine on the basis of the amine/zinc coordination complex exhibiting CD spectra related to the absolute configuration of the diamine guest. The results are discussed in terms of diamine complexation ability by the zinc-porphyrin complex which is related to copolymer composition and, consequently, to backbone flexibility and chromophore mobility.

This literature about this compound(19777-66-3)Recommanded Product: 19777-66-3has given us a lot of inspiration, and I hope that the research on this compound((S)-Propane-1,2-diamine dihydrochloride) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

HPLC of Formula: 57825-30-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about An efficient synthesis of benzyl bromides from aromatic aldehydes using polymethylhydrosiloxane and (bromodimethyl)sulfonium bromide or N-bromosuccinimide. Author is Das, Biswanath; Srinivas, Yallamalla; Holla, Harish; Laxminarayana, Keetha; Narender, Ravirala.

Polymethylhydrosiloxane (PMHS) in combination with (bromodimethyl)sulfonium bromide or NBS was utilized for the first time for reductive bromination of aromatic aldehydes at room temperature to afford the corresponding benzyl bromides in excellent yields.

This literature about this compound(57825-30-6)HPLC of Formula: 57825-30-6has given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-4-ethylbenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Palladium-Catalyzed Alkenylation of Quinoline-N-oxides via C-H Activation under External-Oxidant-Free Conditions, the main research direction is palladium catalyst stereoselective regioselective alkenylation quinoline oxide.Quality Control of 8-Hydroxyquinoline 1-oxide.

The direct cross-coupling of quinoline-N-oxides with olefin derivatives has been realized using palladium acetate as the catalyst in the absence of external ligand and oxidant to give the corresponding 2-alkenylated quinolines and 1-alkenylated isoquinolines chemo- and regioselectively in 27-95% yield. The catalytic process is proposed to proceed via direct C-H bond activation of the quinoline-N-oxide with Pd(OAc)2 followed by Heck coupling with the olefin. The resultant N-oxide of the alkenylated quinoline can oxidize the reduced Pd(0) to regenerate the Pd(II) active species and simultaneously release the 2-alkenylated quinoline without using any external oxidants and reductants.

This literature about this compound(1127-45-3)Quality Control of 8-Hydroxyquinoline 1-oxidehas given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Application of 57825-30-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Synthesis and biological studies of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives. Author is Suresh, M.; Lavanya, P.; Naga Raju, K.; Jonnalagadda, Sreekanth B.; Venkata Rao, C..

A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, 1H-NMR, 13C NMR, LCMS mass spectra and elemental anal.

This literature about this compound(57825-30-6)Application of 57825-30-6has given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-4-ethylbenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Bromomethylation of aromatic compounds》. Authors are Nazarov, I. N.; Semenovskii, A. V..The article about the compound:1-(Bromomethyl)-4-ethylbenzenecas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1).Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene. Through the article, more information about this compound (cas:57825-30-6) is conveyed.

Passage of HBr into 150 ml. MePh, 15 g. paraformaldehyde, 8.5 g. ZnCl2, and a little P 1 hr. at 50° gave after washing with NaHCO3 and H2O, 58% mixed MeC6H4CH2Br isomers (I), b10 82-90°, and some diaryl derivatives b13 145-50°. Passage of HBr into 150 ml. CCl4, 15 g. paraformaldehyde, and 10 g. ZnCl2 with a little P for 35 min. and dropwise addition of 53 g. EtPh at 50° in a continuous stream of HBr over 1.3 hrs. similarly gave 48.3% mixed EtC6H4CH2Br (II), b7.5 96-100°. Passage of HBr 6 hrs. into 90 ml. concentrated HBr, 70 g. MePh, 30 g. paraformaldehyde, and a little P, followed by 19 hrs. at 50° gave, after washing, 71.3% mixed MeC6H4CH2Br, b23 112-20°; similarly, EtPh gave 85% mixed EtC6H4CH2Br, b10 101-4°, while iso-PrPh gave 78% mixed iso-PrC6H4CH2Br (III), b20 126-30°. Hydrolysis of I gave mixed o- and p-MeC6H4CH2OH, b12 106-10°; II gave the corresponding Et analogs, b12 120-4° and III gave mixed iso-Pr analogs, b12 121-5°. The hydrolyses were run with chalk in hot H2O 24 hrs. Oxidation of the alcs. with CrO3 gave mixtures of o- and p-C6H4(CO2H)2; oxidation with 10% HNO3 in an autoclave at 200° gave the same products, in which the p-isomers predominated.

This literature about this compound(57825-30-6)Recommanded Product: 1-(Bromomethyl)-4-ethylbenzenehas given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-4-ethylbenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider