Tag: M.W:100-200

New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. Recommanded Product: 1448-87-9, We’ll be discussing some of the latest developments in chemical about CAS: 1448-87-9, name is 2-Chloroquinoxaline. In an article，Which mentioned a new discovery about 1448-87-9

The 13C n.m.r. spectra of a series of 5-, 6-, and 2-substituted quinoxalines have been analysed by consideration of their 1H coupled spectra.Typical values of the coupling constants are: C(2,3), 1JCH 181.9, 2JCH 11.4, C(5,8), 1JCH 162.6, 3JCH 6.5, C(6.7), 1JCH 159.4, 3JCH 9.1; C(9), 3JCH(2) = 3JCH(7) = 10.0, 3JCH(5) 5.4; C(10), 3JCH(3) = 3JCH(6) = 10.0, 3JCH(8) 5.4 Hz.The magnitudes of the coupling constants in the benzenoid ring are similar to these for the corresponding positions in naphthalene, but application of naphthalene chemical shift substitutions effects leads in some cases to the wrong peak sequence in the related quinoxalines.Within the quinoxaline series itself, however, acceptable additivity of substituent effects is found (+/- 0.8 p.p.m.), provided that the reference compounds are carefully chosen.Analysis of mixtures of quinoxalines from substituted o-phenylenediamines and alpha-oxo-aldehydes is possible by consideration of the multiplicity of the ring-junction quaternary carbon signals in the fully coupled spectra.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N631 | ChemSpider

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. Reference of 6925-00-4, In a article, mentioned the application of 6925-00-4, Name is Quinoxaline-6-carboxylic acid, molecular formula is C9H6N2O2

The invention provides novel compounds selected from the group consisting of: 1The compounds of the present invention are useful for the treatment and prevention of a variety of diseases and conditions associated with undesirable or abnormal inflammatory responses, such as ischemia-reperfusion injury. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment or prevention for the above disorders using theses compounds or the compositions containing them.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N802 | ChemSpider

Application of 1448-87-9, New Advances in Chemical Research in 2021. Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a article，once mentioned of 1448-87-9

A technically simple procedure for direct C?H difluoromethylation of heteroaromatic compounds using off-the-shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono-difluoromethylation versus bis-difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late-stage C?H mono- and bis-difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 1448-87-9. In my other articles, you can also check out more blogs about 1448-87-9

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N708 | ChemSpider

Reference of 1448-87-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1448-87-9, Name is 2-Chloroquinoxaline,introducing its new discovery.

Reaction of 2-chloroquinoxaline (1) with O-potassio-3,3-dimethyl-2-butanone (2) in liquid NH3 affords 1-(quinoxalin-2-yl)-3,3-dimethyl-2-butanone (3) via a thermal SRN1 mechanism and 2-tert-butylfuro<2,3-b>quinoxaline (4) via a competing ionic, addition-substitution process.When the SRN1 component of this … scheme is inhibited by di-tert-butyl nitroxide, only furoquinoxaline 4 is produced.O-Potassio-2,4-dimethyl-3-pentanone (5) reacts in a similar fashion with 1 to give SRN1 products, 2-(quinoxalin-2-yl)-2,4-dimethyl-3-pentanone (6) and 2-isopropylquinoxaline (8), along with quinoxalino<3,4-b>-2,2,5,5-tetramethylcyclopentanone (7), which results from addition-substitution.Reaction of 1 with O-potassio-3-methyl-2,4-pentanedione (9) affords low yields of 2-(quinoxalin-2-yl)butanone (10) by a sluggish SRN1 pathway.Reactions of 4-chloroquinazoline (11a) and 4-chloro-2-phenylquinazoline (11b) with enolate 2 provide excellent yields of the respective 4-quinazolinyl ketones 12a,b via an apparent SNAr mechanism.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N542 | ChemSpider

Electric Literature of 59564-59-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.59564-59-9, Name is 3,4-Dihydroquinoxalin-2(1H)-one, molecular formula is C8H8N2O. In a Article，once mentioned of 59564-59-9

In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs. The observed selectivity and potency (IC50 values 10-200 nM against HDAC6) is markedly dependent on the absolute configuration of the chiral moiety, and suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N188 | ChemSpider

Reference of 6640-47-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 6640-47-7, Name is Quinoxaline-2,3-diamine,introducing its new discovery.

Three new alpha,alpha?-diimine ligands were synthesized based on condensation of 1,10-phenanthroline-5,6-dione with 1,2-phenylenediamine derivatives using different approaches. All compounds were fully characterized by IR, 1H and 13C NMR, UV-visible, and MS spectroscopies. We report the first example of a dipyrido[3,2-f:2?,3?-h]quinoxalino[2,3-b]quinoxaline, which exhibits a strong absorption at 430 nm and an interesting electrochemical behavior. These new molecules may have biological potential and are of synthetic and technological importance.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N254 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C8H6N2O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2

New series of [1,2,4]triazolo [4,3-a]quinoxaline and bis([1,2,4]triazolo)[4,3-a:3?,4?-c]quinoxaline derivatives have been designed, synthesized and biologically evaluated for their cytotoxic activities against three tumor cell lines (HePG-2, Hep-2 and Caco-2). Compounds 16e, 21, 25a and 25b exhibited the highest activities against the examined cell lines with IC50 values ranging from 0.29 to 0.90 muM comparable to that of doxorubicin (IC50 ranging from 0.51 to 0.73 muM). The most active members were further evaluated for their topoisomerase II (Topo II) inhibitory activities and DNA intercalating affinities as potential mechanisms for their anti-proliferative activities. Interestingly, the results of Topo II inhibition and DNA binding assays were consistent with that of the cytotoxicity data, where the most potent anti-proliferative derivatives exhibited good Topo II inhibitory activities and DNA binding affinities, comparable to that of doxorubicin. Moreover, the most active compound 25a caused cell cycle arrest at G2/M phase and induced apoptosis in Caco-2 cells. In addition, Furthermore, molecular docking studies were performed for the novel compounds against DNA-Topo II complex to investigate their binding patterns. Based on these studies, it was concluded that DNA binding and/or Topo II inhibition may contribute to the observed cytotoxicity of the synthesized compounds.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N332 | ChemSpider

6344-72-5, Name is 6-Methylquinoxaline, belongs to quinoxaline compound, is a common compound. Formula: C9H8N2In an article, once mentioned the new application about 6344-72-5.

Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trimethyl orthoformate, a common laboratory solvent, serves as a methyl source. This method permits methylation of (hetero)aryl chlorides and acyl chlorides at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that trimethyl orthoformate serves as a source of methyl radical via beta-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N21 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 2,3-Dichloroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 2213-63-0

2,3-Dichloroquinoxaline has been cyclo-condensed with 2-aminopyridine, 2-aminothiazoles, 2-aminothiadiazoles, 2-aminobenzimidazole and 2-mercaptobenzimidazole to give the corresponding novel heterocyclic systems.The reaction of 2,3-dichloroquinoxaline with thioacetamide has also been studied.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1321 | ChemSpider

1448-87-9, Name is 2-Chloroquinoxaline, belongs to quinoxaline compound, is a common compound. COA of Formula: C8H5ClN2In an article, once mentioned the new application about 1448-87-9.

The oxidation reaction of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described.Neutral oxidation of 2-chloro- and 2,3-dichlorodioxalines 2-4 afforded the corresponding chloro- and dichloropyrazinedicarboxilic acids 13 and 14 in good yield.On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alkaline medium gave different products, with the quinoxalin-2(1H)-one (5) forming 1,4-dihydroquinoxaline-2,3-dione (9), while various substituted quinoxalin-2,3-dione derivatives (see 9-11) gave a new type of dimeric products.The structural assignments for the new compounds were based on spectroscopic data.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N649 | ChemSpider