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Synthesis and characterization of electron-accepting nonsubstituted tetraazaacene derivatives

Oligoacenes are of interest as organic p-type semiconductors for use in electronic devices, but their use as n-type semiconductors is limited. N-Heteroacenes have been investigated as oligoacene-based n-type semiconductors due to their enhanced electron affinity. Herein, we report the synthesis, X-ray crystal structures, electrochemical, and field-effect transistor properties of TANC and BTANC.

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AN UNEXPECTED RING-OPENING IN THE REISSERT REACTION ON 2,3-DIPHENYLQUINOXALINE-N-OXIDE.

When quinoxaline-N-oxide 1 is reacted with KCN and benzoyl chloride in water (the Reissert reaction) or methanol, the products are 2-, 5- and 6- chloroquinoxaline (the latter being the major product: 42+/-6percent) and small amounts of 2-cyanoquinoxaline.Using three equivalents of trimethylsilyl cyanide instead of KCN, and dichloromethane as the solvent, leads to a 72percent yield of 2-cyanoquinoxaline.The reaction of trimethylsilyl cyanide and benzoyl chloride with 2,3-diphenylquinoxaline-N-oxide 2 leads to an unexpected ring-opening product 13; its structure is based on spectroscopic data and on an X-ray crystallographic analysis.

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Electric Literature of 1448-87-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1448-87-9, molcular formula is C8H5ClN2, introducing its new discovery.

Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination

A rapid construction of enantioenriched benzo-fused quinolizidines, indolizidines, and their analogues by ruthenium-catalyzed asymmetric cascade hydrogenation/reductive amination of quinolinyl- and quinoxalinyl-containing ketones has been developed. This reaction proceeds under mild reaction conditions, affording chiral benzo-fused aliphatic N-heterocyclic compounds with structural diversity in good yields (up to 95 %) with excellent diastereoselectivity (up to >20:1 dr) and enantioselectivity (up to >99 % ee). Furthermore, this catalytic protocol is applicable to the formal synthesis of (+)-gephyrotoxin.

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Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent

Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogues.

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More research is needed about 3,4-Dihydroquinoxalin-2(1H)-one

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New synthesis of diazepino[3,2,1-ij]quinoline and pyrido[1,2,3-de] quinoxalines via addition-elimination followed by cycloacylation

This paper describes a convenient and efficient synthesis of new fused tricyclic diazepino[3,2,1-ij]quinolines and substituted pyrido[1,2,3-de] quinoxalines. o-Phenylenediamines are transformed in the tricycle nucleus in only a few-step synthetic sequence to produce ethyl 2,8-dioxo-1,2,3,4- tetrahydro-8H [1,4]diazepino[3,2,1-ij]quinoline-7-carboxylate, ethyl 8-oxo-1,2,3,4-tetrahydro-8H-[1,4]diazepino[3,2,1-ij]quinoline-7-carboxylate and ethyl 2,7-dioxo-2,3-dihydro-1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxylate. The method is economical and simple to perform.

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Discovery of 2,3-Dichloroquinoxaline

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ORGANIC COMPOUND, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE

A novel organic compound is provided. That is, a novel organic compound that is effective in improving the element characteristics and reliability is provided. The organic compound has a benzofuroquinoxaline skeleton or a benzothienoquinoxaline skeleton. The organic compound is represented by General Formula (G1). In the formula, Q represents O or S, and each of R1 to R8 independently represents any of hydrogen, a halogeno group, a substituted or unsubstituted alkyl group having 1 to 6 carbon atoms, a substituted or unsubstituted aryl group having 6 to 12 carbon atoms, and a substituted or unsubstituted heteroaryl group having 3 to 12 carbon atoms. At least one of R1 to R8 includes a substituted or unsubstituted condensed aromatic or heteroaromatic ring having 3 to 24 carbon atoms.

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Archives for Chemistry Experiments of 1448-87-9

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With anti-tumor activity double-aryl […] quinoxaline derivative and its synthesis method (by machine translation)

The invention discloses a double-aryl having anti-tumor activity […] quinoxaline derivative and its synthesis method, in order to quinoxaline as parent appropriate structural modification of the derivatives, from O-phenylenediamine starting after four-step reaction to replace the previously atom and double-urea smooth synthesis with an anti-tumor activity double-aryl […] quinoxaline derivatives, the derivatives are important heterocyclic compound, has good biological activity, derivatives of the general structure is as follows: The synthetic method is easy and simple, there are few reaction steps, the output is high, application prospect is good. (by machine translation)

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More research is needed about Methyl quinoxaline-2-carboxylate

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Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents

The quinoxaline moiety in antitumor quinoxaline antibiotics cleaved double stranded DNA at the 5? side guanine of the 5?-GG-3? site upon irradiation with UV light with a long wavelength and without any additive. The quinoxaline-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the quinoxaline-carbohydrate hybrids exhibited strong and selective cytotoxicity against cancer cells with photoirradiation.

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Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and bioactivity of 2,3-dihydro-4H-<1,3>thiazino<3',2':2,3>-as-triazino<5,6-b>indole and quinoxalino<2',3':4,5>thiazolo<3,2-b>indolo<2,3-e>-as-triazine and their isomeric systems

2,3-Dihydro-7-methyl-5H-as-triazino<5,6-b>indole-3-thione 2 on condensation with 1,3-dibromopropane and 2,3-dichloroquinoxaline gives the cyclized products, 2,3-dihydro-9-methyl-4H-<1,3>thiazino<3',2':2,3>-as-triazino<5,6>indole 4 and 10-methylquinoxalino<2',3':4',5'>thiazolo<3,2-b>indolo<2,3-e>-as-triazine 6 respectively and not the angular isomers, 2,3-dihydro-9-methyl-1H-<1,3>thiazino<2',3':3,4>-as-triazino<5,6-b>indole 3 and 2-methylquinoxalino<2',3':4,5>thiazolo<2,3-c>indolo<2,3-e>-as-triazine 5.The uniquivocal synthesis of the latter 3 and 5 have been accomplished by reaction of 6-methylisatin-3-thiosemicarbazone 1 with 1,3-dibromopropane and 2,3-dichloroquinoxalines, respectively.The antibacterial and antifungal activity of the synthesized compounds have also been evaluated.

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Simple exploration of Quinoxalin-6-amine

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NOVEL ULK1 INHIBITORS AND METHODS USING SAME

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.

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