Tag: M.W:100-200

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enzyme-Linked Immunosorbent Assay Detection of Pyrrolizidine Alkaloids: Immunogens Based on Quaternary Pyrrolizidinium Salts, published in 1996-04-30, which mentions a compound: 57825-30-6, Name is 1-(Bromomethyl)-4-ethylbenzene, Molecular C9H11Br, Quality Control of 1-(Bromomethyl)-4-ethylbenzene.

Polyclonal antibody-based enzyme-linked immunosorbent assays (ELISAs) were developed for the detection of retrorsine (1, 351 g/mol), monocrotaline (2, 325 g/mol), and retronecine (3, 155 g/mol) in the ppb range. A set of three bifunctional linking arms was synthesized. By N-alkylation of pyrrolizidine alkaloids (PAs) retrorsine, monocrotaline, and retronecine acetonide, six haptens were synthesized and used to generate rabbit antisera. The resulting anti-retrorsine antiserum gave a 50% inhibition (I50) value of 0.9 ppb for retrorsine with detection limits of 0.5-10 ppb. The same ELISA system also detected isatidine (retrorsine N-oxide) dihydrate (403 g/mol) with an I50 of 1 ppb and senecionine (352 g/mol) with an I50 of 100 ppb. A second monocrotaline-based ELISA detected monocrotaline with an I50 of 36 ppb 2 with detection limits of 5-500 ppb and shows no cross-reactivity with 1 or senecionine; this ELISA demonstrates the potential for the substrate-specific detection method. A third retronecine-based ELISA detects 3 with an I50 of 3000 ppb (3 ppm) and detection limits of 600-10,000 ppb. None of these ELISAs cross-react with the structurally similar swainsonine or lupinine alkaloids. PAs were detected in extracts of Senecio vulgaris and Crotalaria retusa, but not in Lupinus spp., as a demonstration of the ELISA’s usefulness.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.COA of Formula: C9H7NO2.Kacens, J.; Cebure, A.; Neilands, O. published the article 《8-Hydroxyquinophthalone derivatives》 about this compound( cas:1127-45-3 ) in Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija. Keywords: hydroxyquinonaphthalone; quinophthalone hydroxy. Let’s learn more about this compound (cas:1127-45-3).

8-Acetoxyquinophthalone (I, R = Ac, X = H) (II) was prepared in 62% yield by reaction of 8-quinolinol oxide with 1,3-indandione in Ac2O. Analogously prepared was I (R = Ac, X = Cl) in 62% yield. Hydrolysis of the acetate gave the corresponding alcs. (I, R = H, (Cl). Treatment of II with SO2Cl2 gave indandione (III, X = H). Analogously III (X = C) was obtained.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Propane-1,2-diamine dihydrochloride(SMILESS: C[C@H](N)CN.[H]Cl.[H]Cl,cas:19777-66-3) is researched.COA of Formula: C9H7NO2. The article 《Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2》 in relation to this compound, is published in Tetrahedron: Asymmetry. Let’s take a look at the latest research on this compound (cas:19777-66-3).

The enantiomeric purity of reagents used in asym. synthesis is of fundamental importance when evaluating the selectivity of a reaction and the product purity. In this work, 109 chiral reagents (many recently introduced) are assayed. Approx. 64% of these reagents had moderate to high levels of enantiomeric impurities (i.e. from >0.1% to <16%). The type of chiral reagents assayed and used in enantioselective synthesis include metal-ligand catalysts for allylic substitutions, catalysts for addition of Grignard reagents and other additions, epoxidations and reduction of ketones and aldehydes; Ru-complex auxiliaries for asym. cyclopropanation, as well as amine, diamine, alc., diol, amino alc., carboxylic acid and oxazolidinone auxiliaries; epoxide, lactone, furanone, pyrrolidinone, nitrile, sulfoximine and carboxylic acid synthons (including malic acid, mandelic acid, lactic acid and tartaric acid); and a variety of chiral resolving agents. Accurate, efficient assays for all compounds are given. This literature about this compound(19777-66-3)Category: quinoxalinehas given us a lot of inspiration, and I hope that the research on this compound((S)-Propane-1,2-diamine dihydrochloride) can be further advanced. Maybe we can get more compounds in a similar way.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Propane-1,2-diamine dihydrochloride(SMILESS: C[C@H](N)CN.[H]Cl.[H]Cl,cas:19777-66-3) is researched.COA of Formula: C38H34N2O4P2. The article 《Metal Complexes with Cis α Topology from Stereoselective Quadridentate Ligands with Amine, Pyridine, and Quinoline Donor Groups》 in relation to this compound, is published in Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:19777-66-3).

Though the principles governing quadridentate topol. and metal stereochem. were known for some time, the cis α topol. was little exploited in designing catalysts for asym. reactions. Study of the inorganic chem. of labile metal cis α complexes was undertaken as a prelude to exploring their potential to serve as catalysts for a variety of different reactions. The synthesis of 1st row transition metal complexes of quadridentate ligands with ethylenediamine (en) and S-propylenediamine (S-pn) backbones that were alkylated at N with either pyridine (py) or quinoline (qn) donor groups as well as with noncoordinating benzyl (Bn) or pentafluorobenzyl (F5Bn) groups was undertaken. The steric and electronic properties vary throughout the ligand series, en(Bn)py, 1, en(F5Bn)py, 2, S-pn(F5Bn)py, 3, and S-pn(F5Bn)qn, 4. These ligands were reacted with MCln salts (n = 2, M = Mn, Fe, Co, Ni, Cu, Zn; n = 3, M = Fe) to generate, in most cases, octahedral complexes with the targeted cis α topol. UV/visible, NMR, IR, cyclic voltammetry (CV), and conductivity anal. are described for the metal compounds x-ray structural anal. of [Cu{en(F5Bn)py}Cl]Cl reveals a five coordinate square pyramidal geometry. Single or major diastereomers were obtained for all diamagnetic Zn(II) complexes as well as for Co(III) analogs that were prepared by oxidation of Co(II) species using Br2 as the oxidant. Electronic differences among ligands are reflected in the oxidation potentials of the resp. metal complexes as determined by CV, with fluorinated systems showing greater resistance to oxidation, as expected.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Obshchei Khimii called Synthesis and study of N-oxides of heterocyclic compounds. I. N-Oxides of derivatives of morphine, tetra-hydroisoquinoline, and quinoline, Author is Khaletskii, A. M.; Pesin, V. G.; Tsin, Chshou, which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Quality Control of 8-Hydroxyquinoline 1-oxide.

cf. Ochiai, C.A. 48, 3359i. Heating 8.4 g. codeine with 45 ml. 3% H2O2 at 50-60° gave after evaporation 8 g. codeine N-oxide, m. 206-8° (H2O); HCl salt, m. 214-17° (EtOH). To 5 g. dihydrohydroxycodeinone-HCl was added 10 ml. 10% NaOH yielding 93% dihydrohydroxycodeinone, m. 213-16°, which with 3% H2O2 as above gave 46.2% dihydrohydroxycodeinone N-oxide, decompose 152-3°, which gives a red color with Ac2O; picrate, m. 190-2°; HCl salt, m. 167-8°. The oxide treated with SO2 in warm EtOH gave 62.5% C18H23O8NS, decompose 169-70°, which was evidently an isomer of dihydrohydroxycodeinone sulfate; with BaCl2 solution it readily gave BaSO4; hydrolysis with 10% NaOH gave the original dihydrohydroxycodeinone, m. 207-9° (sulfate, m. 138-9°). Salsolidine (3 g.) in 20 ml. Me2CO and 30 ml. H2O treated with 2.5 ml. 30% H2O2 after several days at room temperature gave 15.48% N-hydroxysalsolidine, m. 100-1° (aqueous EtOH), which reduced Fehling and Tollens reagents. Similarly, N-methylsalsolidine gave N-methylsalsolidine N-oxide picrate, m. 133-4° (aqueous EtOH); HCl salt analog, decompose 162-3°. Oxidation of salsoline with 3% H2O2 in AcOH or with BzO2H in CHCl3 either gave no reaction or failed to yield any definite products. N-Methylsalsoline with aqueous H2O2 at room temperature in 3 days gave N-methylsalsoline N-oxide, m. 183° (EtOH); HCl salt, m. 186°. Oxidation of 8-hydroxyquinoline in CHCl3 with BzO2H with cooling gave yellow 8-hydroxyquinoline N-oxide, m. 137-8° (H2O); the same formed on oxidation with 30% H2O2 in AcOH-Ac2O at 40-5° in 3 hrs., but with 30% H2O2-AcOH in 2 hrs. only the starting material was recovered. 8-Hydroxyquinoline N-oxide treated with alc. KOH and Etl at reflux gave 8-ethoxyquinoline N-oxide, isolated as picrate, m. 135-8°; the same formed on treatment of 8-ethoxyquinoline with AcOH-Ac2O-30% H2O2 at 45-50°; HCl salt, m. 158°; free oxide, m. 61-2°. Similarly 2-phenylquinoline-4-carboxylic acid and AcOH-H2O2 gave 76% N-oxide, m. 244°, and 15% benzoylanthranilic acid, m. 170-2°. Oxidation of 2-phenylquinoline-4-carboxylic acid with BzO2H in CHCl3 in 2 days gave no evident reaction, the same being true of oxidation with 25% H2O2 in EtOH-Me2CO at 50°. Reduction of 2-phenylquinoline-4-carboxylic acid N-oxide with Na hydrosulfite in aqueous EtOH gave the original 2-phenylquinoline-4-carboxylic acid, m. 205-7°.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Parameters of dosimetric interest of some vanadium and nickel compounds.Category: quinoxaline.

Mass attenuation coefficients (μm), effective at. numbers (Zeff) and electron densities (Nel) of some V compounds V2O3, VO2, VF3, VF4, NH4VO3 and Ni compounds NiF2, NiCl2, NiCl2.6H2O, Ni(ClO4)2.6H2O, NiF2.4H2O have been computed over a wide energy region from 10 keV to 100 GeV. In all the parameters, a similar trend is observed All the parameters initially possesses maximum values, which decreases very rapidly upto 100 keV, then becomes almost constant upto 3 MeV and with the further increase in the incident photon energy beyond 3 MeV, values of all the parameters also increase which may be due to dominance of different partial photon interaction process in different energy regions.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Syntheses of 8-hydroxyquinoline N-oxide and its metallic complex salts》. Authors are Murase, Ichiro.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).SDS of cas: 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

8-Hydroxyquinoline N-oxide (IH) was obtained by the direct oxidation of 8-hydroxyquinoline with AcOH + 30% H2O2 or phthalic monoperacid as yellow crystals m. 138°. Greenish yellow CuI2.H2O, greenish black (MnI)2O.H2O and brownish black FeI3 were obtained. Fe(II), Ni, Co, and Zn do not form complexes.

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Application In Synthesis of 1-(Bromomethyl)-4-ethylbenzene. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1). Author is Deng, Yongqi; Yang, Zhiwei; Shipps, Gerald W.; Lo, Sie-Mun; West, Robert; Hwa, Joyce; Zheng, Shuqin; Farley, Constance; Lachowicz, Jean; van Heek, Margaret; Bass, Alan S.; Sinha, Dinesh P.; Mahon, Craig R.; Cartwright, Mark E..

Inhibitors based on a benzo-fused spirocyclic oxazepine scaffold were discovered for stearoyl-CoA (CoA) desaturase 1 (SCD1) and subsequently optimized to potent compounds with favorable pharmacokinetic profiles and in vivo efficacy in reducing the desaturation index in a mouse model. Initial optimization revealed potency preferences for the oxazepine core and benzylic positions, while substituents on the piperidine portions were more tolerant and allowed for tuning of potency and PK properties. After preparation and testing of a range of functional groups on the piperidine nitrogen, three classes of analogs were identified with single digit nanomolar potency: glycine amides, heterocycle-linked amides, and thiazoles. Responding to concerns about target localization and potential mechanism-based side effects, an initial effort was also made to improve liver concentration in an available rat PK model. An advanced compound 17m with a 5-carboxy-2-thiazole substructure appended to the spirocyclic piperidine scaffold was developed which satisfied the in vitro and in vivo requirements for more detailed studies.

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Quality Control of 8-Hydroxyquinoline 1-oxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Chemiluminescent system of 8-hydroxyquinoline N-oxide-cobalt(II)-hydrogen peroxide. Author is Wang, Lun; Zhu, Changqing; Wu, Jialiang; Tong, Hongwu; Rao, Congshu; Zhang, Sujun.

8-Hydroxyquinoline N-oxide, synthesized in authors’ laboratory, is used as an energy receptor in Co(II)-H2O2 system and high intensity chemiluminescence of the system is observed A method for the measurement of trace Co is proposed. The detection limit and the relative standard deviation are 8.0 × 10-6 mg/mL and 3.2%, resp. Trace Co in copper ore, pig-liver, and shrimps is determined with satisfactory results. The possible mechanism of the chemiluminescence system is discussed.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Thermal decomposition of hydrated salts of copper and nickel. VII. Fluoride, chloride, and iodide of nickel》. Authors are My, Le Van; Perinet, Guy; Bianco, Pierre.The article about the compound:Nickel(ii)fluoridetetrahydratecas:13940-83-5,SMILESS:[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Ni+2].[F-].[F-]).HPLC of Formula: 13940-83-5. Through the article, more information about this compound (cas:13940-83-5) is conveyed.

cf. preceding abstract The F-, Cl-, and I- of Ni were heated from ambient temperature to 750° at 5°/hr. Pyrolysis in air led to the formation of oxides. The dehydration of I- gave an anhydrous salt directly, but the removal of the last mol. of H2O was difficult in all cases.

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