A new application about 2,3-Dichloroquinoxaline

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A new efficient route for the formation of quinoxaline N-oxides and N,N?-dioxides using HOF¡¤CH3CN

HOF¡¤CH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N?-dioxides in very good yields under mild conditions and short reaction times.

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More research is needed about 2-Chloroquinoxaline

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Palladium-catalyzed cross-coupling reaction of trialkylbismuthines with 2-haloazines and diazines

An efficient method for the cross-coupling reaction of primary trialkybismuth reagents with 2-haloazines and diazines is reported. The reaction functions with pyridines, pyrimidines, pyridazines and pyrazines and tolerates many functional groups. This method gives access to 2-alkylazines and diazines, a class of compounds which is important in medicinal chemistry.

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Top Picks: new discover of 6298-37-9

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TRYPTOLINE DERIVATIVES HAVING KINASE INHIBITORY ACTIVITY AND USES THEREOF

The present invention features tryptoline derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders

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Brief introduction of 2,3-Dichloroquinoxaline

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Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems

Three series of novel fused nitrogen heterocyclic systems such as 1,2,4-triazolo[1,5-a] pyridines (5-7 and 9), pyrido[1,2-b][1,2,4]triazines (10, 11, 13 and 15), and pyrido[1,2-b][1,2,4]triazepines (17, 18, 20 and 22) linked with a chromone moiety were synthesized from the key intermediate 1,6-diamino-(6-chloro-4-oxo-4H-chromen-3-yl)-2-oxo-1,2-dihydropyridine-3, 5-dicarbonitrile (4) with some electrophilic reagents. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity. Compounds 7, 9 and 15 showed the highest activities when compared with the reference drugs.

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Archives for Chemistry Experiments of 3,4-Dihydroquinoxalin-2(1H)-one

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TRICYCLIC HETEROCYCLIC COMPOUNDS AS NOTCH INHIBITORS

Disclosed are compounds of Formula (I), wherein: X is O or -NR3; R1 is -CH2CH2CH3, -CH2CF3, -CH2CH2CF3, -CH2CF2CH3, -CH2CH2CH2CF3, -CH2CH2CF2CH3, -CH2CH(CH3)CF3, -CH2CH2CH2F, or CH2(cyclopropyl); R2 is -CH2CH2CH3, -CH2CF3, -CH2CH2CF3, -CH2CF2CH3, -CH2CH2CH2CF3, -CH2CH2CH2F, -CH2CH(CH3)CF3, CH2CH2CF2CH3, -CH2(cyclopropyl), -CH(CH3)(cyclopropyl), phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, pyridinyl, formula (i), formula (ii), formula (iii), formula (iv) or formula (v); Ring A is phenyl or pyridinyl; and R3, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

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A new application about Quinoxalin-6-amine

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One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions

A series of 11-aryl-8,11-dihydrofuro[3′,4′:5,6]pyrido[3,2-f]quinoxalin-10(7H)-one derivatives were obtained via a one-pot and three-component reaction of aromatic aldehydes, 6-aminoquinoxaline and tetronic acid in EtOH. The structure of 11-(4-nitrophenyl)-8,11-dihydrofuro[3′,4′:5,6]pyrido[3,2-f]quinoxalin-10(7H)-one (4g) was confirmed by X-ray diffraction analysis. This procedure had the advantages of operation simplicity, catalyst-free and without isolating intermediates, and provided a good method for the synthesis of fused tetracyclic heterocycles containing furan, pyridine and quinoxaline moieties at the same time.

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Awesome and Easy Science Experiments about 32601-86-8

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Synthetic Route of 32601-86-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 32601-86-8, Name is 2-Chloro-3-methylquinoxaline, molecular formula is C9H7ClN2. In a Article£¬once mentioned of 32601-86-8

Synthesis of novel tricyclic heterocycles from 2[3-methyl -1,2- dihydroquinoxalin – 2 – Ylidene] malononitrile

A NUMBER of pyrrolo[1,2-a]quinoxalines (3a-f), pyrimido[l,6ajquino-xalines (5a-c, 10. 13). pyrido[l,2-a]quinoxalines (6. 7a.b. 8a.b. 14). [1.3]thiazino-[3,4-a]quinoxa[ines (9. 11) and [l.3]oxazino[3,4-a]quinoxalines (12a.b) were obtained via interaction of 2-[3-methyl-l.2-dihydrquinoxalin-2- ylidene]malono-nitrile 2 with different reagents.

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Discovery of 6-(Chloromethyl)quinoxaline

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Method for preparing heterocyclic-carboxylic acids

The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous alkaline suspension of a 5- or 6-halomethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.

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A new application about 2,3-Dichloroquinoxaline

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Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility

We report the discovery of a novel series of 2-(3-alkoxy-1-azetidinyl) quinolines as potent and selective PDE10A inhibitors. Structure-activity studies improved the solubility (pH 7.4) and maintained high PDE10A activity compared to initial lead compound 3, with select compounds demonstrating good oral bioavailability. X-ray crystallographic studies revealed two distinct binding modes to the catalytic site of the PDE10A enzyme. An ex vivo receptor occupancy assay in rats demonstrated that this series of compounds covered the target within the striatum.

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Top Picks: new discover of 2,3-Dichloroquinoxaline

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2213-63-0 is helpful to your research. Electric Literature of 2213-63-0

Electric Literature of 2213-63-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 2213-63-0, molcular formula is C8H4Cl2N2, introducing its new discovery.

Synthesis and pharmacological evaluation of some novel imidazo[2,1-b][1,3,4]thiadiazole derivatives

Synthesis of bis-1,3-{6′-arylimidazo[2,1-b][1,3,4]thiadiazol-2-yl}-1,2,2-trimethylcyclopentane (3), bis-1,3-{thiadiazolo[2′,3′:2,1]imidazo[4,5-b]quinoxalinyl}-1,2,2-trimethylcyclopentane (5) has been achieved by the reaction of bis-(5′-amino-1′,3′,4′-thiadiazolyl)-1,2,2-trimethylcyclopentane with alpha-haloketones, 2,3-dichloroquinoxaline respectively. Bromination of compound 3 furnished bis-1,3-{5′-bromo-6′-arylimidazo[2,1-b][1,3,4]thiadiazol-2-yl}-1,2,2-trimethylcyclopentane (4). The structural assignment of these compounds was supported by IR, 1H NMR and elemental analysis data. The antimicrobial, anti-inflammatory and antifungal activities of some of the compounds have also been evaluated.

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