Tag: M.W:100-200

Application of 18514-76-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.18514-76-6, Name is 5-Nitroquinoxaline, molecular formula is C8H5N3O2. In a Article£¬once mentioned of 18514-76-6

ATP-citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R*,5S*)-omega-substituted-3-carboxy-3,5- dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo

A series of (3R*,5S*)-omega-substituted-3-carboxy-3,5-dihydroxyalkanoic acids have been synthesized and evaluated as inhibitors of the recombinant human form of ATP-citrate lyase. The best of these have K(i)’s in the 200- 1000 nM range. As the corresponding thermodynamically favored gamma-lactone prodrugs, a number of compounds are able to inhibit cholesterol and fatty acid synthesis in HepG2 cells and reduce plasma triglyceride levels in vivo. The best of these, compound 77, is able to induce clear hypocholesterolemic and hypotriglyceridaemic responses when administered orally to rat and dog. These results provide evidence to support the hypothesis that compounds which inhibit ATP-citrate lyase have the potential to be a novel class of hypolipidemic agent, which possess combined hypocholesterolemic and hypotriglyceridemic activities.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 18514-76-6

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N852 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 2-Chloro-7-methylquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 90272-84-7

The unexpected and facile molybdenum mediated formation of tri- and tetracyclic pentathiepins from pyrazine-alkynes and sulfur

The synthesis of a novel family of pentathiepino-pyrrolo[1,2-a]pyrazine derivatives is reported. These compounds are formed by the reaction of alkynyl-substituted heterocyclic precursors with elemental sulfur in the presence of molybdenum oxo bis-tetrasulfide under very mild conditions.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1059 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C8H5N3O2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 6639-87-8

Investigation on the photoreactions of nitrate and nitrite ions with selected azaarenes in water

The photoreactions of selected azaarenes with nitrate and nitrite ions were investigated under irradiation at lambda = 313 nm. The excitation of both anions leads to several photochemical reactions forming mainly hydroxyl radicals and nitrogen oxides. The purification capability of natural waters i.e. the oxidation of inorganic and organic substances results from the formation of hydroxyl radicals. Nitrated isomers of azaarenes were found among the main products of the investigated photoreactions. The nitrogen oxides were responsible for the production of nitrated derivatives which possess a high toxic potential. Their formation was explained by the parallel occurance of two mechanism, a molecular and a radical one. The molecular mechanism became more important with increasing ionisation potentials of the azaarenes. The spectrum of oxidized products corresponded to the one got in the photoreactions of azaarenes with hydrogen peroxide. The formation of several oxidation and nitration products of the pyridine ring with its low electron density was explained by the reaction of excited states of azaarenes. The photoreactions with nitrite ions only led to the formation of oxidized and nitrated products. Nitroso products were not formed. The reactivity of nitrogen monoxide is too low for its reaction with the azaarenes.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N942 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 59564-59-9, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 59564-59-9

Structure-activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: Reality behind anticancer drug discovery

The pan-histone deacetylase (HDAC) inhibitors comprise a fish-like structural orientation where hydrophobic aryl- and zinc-binding groups act as head and tail, respectively of a fish. The linker moiety correlates the body of the fish linking head and tail groups. Despite these pan-HDAC inhibitors, selective HDAC-8 inhibitors are still in demand as a safe remedy. HDAC-8 is involved in invasion and metastasis in cancer. This review deals with the rationale behind HDAC-8 inhibitory activity and selectivity along with detailed structure-activity relationships of diverse hydroxamate-based HDAC-8 inhibitors. HDAC-8 inhibitory potency may be increased by modifying the fish-like pharmacophoric features of such type of pan-HDAC inhibitors. This review may provide a preliminary basis to design and optimize new lead molecules with higher HDAC-8 inhibitory activity. This work may surely enlighten in providing useful information in the field of target-specific anticancer therapy.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N151 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 2-Chloroquinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2

Oxidative magnesiation of halogenopyridines: Introduction of electrophilic substituents to the pyridine moiety under the Barbier condition

Oxidative magnesiation of halogenopyridines was carried out using active magnesium prepared by the reduction of magnesium chloride, to give pyridinylmagnesium halides, which were treated with electrophiles to afford the corresponding pyridine derivatives.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N699 | ChemSpider

Electric Literature of 2213-63-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 2213-63-0, Name is 2,3-Dichloroquinoxaline,introducing its new discovery.

Discovery of novel morpholino-quinoxalines as PI3Kalpha inhibitors by pharmacophore-based screening

A pharmacophore model of PI3Kalpha inhibitors was built using the DiscoveryStudio 2.0 package. Pharmacophore-based screening (PBS) retrieved a series of novel morpholino-quinoxalines as PI3Kalpha inhibitors, as exemplified by 1a (PI3Kalpha IC50: 0.44 muM). All target compounds showed good in vitro cytotoxicity against tested human cell lines. A pharmacophore mapping analysis and docking study indicated that both the morpholino group and the sulfonyl group contributed significantly to the potent PI3Kalpha inhibitory activity and cytotoxicity of the compounds.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1599 | ChemSpider

Application of 15804-19-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a Article£¬once mentioned of 15804-19-0

A new facile, efficient synthesis and structure peculiarity of quinoxaline derivatives with two benzimidazole fragments

A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 15804-19-0. In my other articles, you can also check out more blogs about 15804-19-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N358 | ChemSpider

Related Products of 59564-59-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 59564-59-9, molcular formula is C8H8N2O, introducing its new discovery.

FUSED TETRACYCLIC PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]ONDOLE DERIVATIVES AND METHODS OF USE

This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4- b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N143 | ChemSpider

Application of 80636-30-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.80636-30-2, Name is 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one, molecular formula is C10H12N2O. In a Article£¬once mentioned of 80636-30-2

Novel potassium channel openers. Part 4: Transformation of the 1,4- benzoxazine skeleton into 1,4-benzothiazine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroquinoxaline, indoline, and 1,5-benzoxazepine

As part of a search for a new potassium channel opener, the 1,4- benzoxazine skeleton derived from the benzopyran skeleton of cromakalim, was transformed into other fused rings such as 1,4-benzothiazine, 1,2,3,4- tetrahydroquinoline, 1,2,3,4-tetrahydroquinoxaline, indoline, and 1,5- benzoxazepine. The 1,4-benzothiazine derivative displayed approximately 20 times more potent vasorelaxant activity than cromakalim. (C) 2000 Elsevier Science Ltd.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N986 | ChemSpider

Synthetic Route of 2213-63-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article£¬once mentioned of 2213-63-0

Thermochemical study of chlotopyrazines and chloroquinoxalines

The standard (po = 0.1 MPa) molar enthalpies of formation for liquid 2-chloropyrazine and crystalline 2,6-dichloropyrazine, 2,3-dichloroquinoxaline and 2,3,6,7-tetrachloroquinoxaline were derived from the standard molar enthalpies of combustion, in oxygen, to yield CO2(g), N2(g), and HCl * 600H2O(l), at the temperature T = 298.15 K, measured by rotating-bomb combustion calorimetry. The standard molar enthalpies of vaporization or of sublimation, at T = 298.15 K, were measured by Calvet microcalorimetry.

Density functional theory with the B3LYP functional and two different basis sets, 6-31G* and 6-311G**, was used to optimize the geometries of all chloro-substituted pyrazines and some chloro-substituted quinoxalines. The calculation of the energy of isodesmic reactions allowed the estimation of the standard molar enthalpies of formation in the gas phase for all compounds including some not studied experimentally.

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Quinoxaline | C8H6N1471 | ChemSpider

February 2026

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