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New heterocyclic compactly condensed systems benzimidazo [2,3d] thiazole (45-b)quimoxaline dyes

The paper presents experimental data regarding a number of seven new benzimidazo[2,3-d]thiazolo[4,5-b] quinoxaline dyes have been synthesized by condensation of 2,3-dichloroquinoxaline with different 1,3-dihydro-2H- benzimidazole-2-thione derivatives. Reaction products were purified and characterized by means of elemental analysis, UV-VIS, IR, 1H and 13C-NMR, mass spectra and thermal analysis. Structure-property relationships in the dyes are discussed with respect to the nature of the substituents in the benzimidazole moieties.

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A pharmacological expedition of tetrazole compounds towards medical field – an overview

Tetrazole moiety exhibits a wide and increasing number of applications. The nitrogen-rich ring system is used extensively in pharmaceuticals. This paper is focused on biological activities of tetrazoles that have been reported earlier by various authors. They find a significant place in medical field as it has ring systems patented for the treatment of central nervous system disorders, sexual dysfunction, asthma, obesity, diabetes and various diseases.

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13C Nuclear Magnetic Resonance Spectra of Quinoxaline Derivatives

The 13C n.m.r. spectra of a series of 5-, 6-, and 2-substituted quinoxalines have been analysed by consideration of their 1H coupled spectra.Typical values of the coupling constants are: C(2,3), 1JCH 181.9, 2JCH 11.4, C(5,8), 1JCH 162.6, 3JCH 6.5, C(6.7), 1JCH 159.4, 3JCH 9.1; C(9), 3JCH(2) = 3JCH(7) = 10.0, 3JCH(5) 5.4; C(10), 3JCH(3) = 3JCH(6) = 10.0, 3JCH(8) 5.4 Hz.The magnitudes of the coupling constants in the benzenoid ring are similar to these for the corresponding positions in naphthalene, but application of naphthalene chemical shift substitutions effects leads in some cases to the wrong peak sequence in the related quinoxalines.Within the quinoxaline series itself, however, acceptable additivity of substituent effects is found (+/- 0.8 p.p.m.), provided that the reference compounds are carefully chosen.Analysis of mixtures of quinoxalines from substituted o-phenylenediamines and alpha-oxo-aldehydes is possible by consideration of the multiplicity of the ring-junction quaternary carbon signals in the fully coupled spectra.

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Organic electroluminescent compound, preparation method thereof and electroluminescent device (by machine translation)

The structural general formula of the organic electroluminescent compound, is. The preparation method of the organic electroluminescent compound comprises: steps 1: adding a base and a palladium catalyst A with B under the inert gas protection THF and fully reacting the intermediate, with the catalyst, at, under an inert gas protection 90 C -100 C to obtain the intermediate, step C; of the organic electroluminescent compound in 2: by fully reacting C with the starting D of deionized water. DMSO. After fully reacting, of the organic electroluminescent compound in an inert gas protection method, the method comprises DMAP, steps of adding a, second base, and a first metal second 90 C -100 C under the protection of an inert gas to obtain, an intermediate . The organic electroluminescent device; further discloses an organic electroluminescent device containing the organic electroluminescent compound, in an inert gas protection mode under the action of inert gas, at a temperature ranging from: 1st. (by machine translation)

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Quinoxaline – Wikipedia,
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Application of 1448-87-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1448-87-9, molcular formula is C8H5ClN2, introducing its new discovery.

Cobalt-catalyzed C-N bond-forming reaction between N-aromatic 2-chlorides and secondary amines

Secondary amines react with N-aromatic 2-chlorides in the presence of a catalytic amount of cobalt chloride. When DPPP was added as ligand, the yield was further improved, The N-aromatic-containing tertiary amines formed are interesting due to their potential biological activity. This work represents the first cobalt-catalyzed approach to C-N bond formation involving N-aromatic 2-chlorides and secondary amines having a certain amount of versatility and functional group tolerance. Wiley-VCH Verlag GmbH & Co. KGaA.

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Ionic liquids for the synthesis of five-membered N,N-, N,N,N-and N,N,N,N-heterocycles

Due to special properties of ILs (Ionic Liquids) like their wide liquid range, good solvating ability, negligible vapour pressure, non-inflammability, environment friendly medium, high thermal stability, easy recycling and rate promoters etc. they are used in organic synthesis. The investigation for the replacement of organic solvents in organic synthesis is a growing area of interest due to increasing environmental issues. Therefore, ionic liquids have attracted the attention of chemists and act as a catalyst and reaction medium in organic reaction with high activity. There is no doubt that ionic liquids have become a major subject of study for modern chemistry. In comparison to traditional processes the use of ionic liquids resulted in improved, complimentary or alternative se-lectivities in organic synthesis. The present manuscript reported the synthesis of multiple nitrogen containing five-membered heterocyclic compounds using ionic liquids. This review covered interesting discoveries in the past few years.

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INDOLYL PYRAZINONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS

This invention relates to a compound of Formula I (I)and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.

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About 3d-Metal-Complexes of 2-Hydrazinoquinoxalines

Some complexes of 3d-metals and 2-hydrazinoquinoxalines were synthesized and characterized spectrometrically.These compounds probably exist in solution as tetragonal distorted octahedrons.The organic ligands are to be found at the quadratic base, and anions or solvent-molecules, respectively, at the tops of the octahedron.The existence of chelates can be concluded from i.r. spectra.Together with u.v./vis-spectra back donation can be assumed.An assignment of the u.v./vis-bands is suggested and the ligand-field parameters Dq are estimated.

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Synthesis and antidiabetic activity of 3,6,7-trisubstituted-2-(1H-imidazol- 2-ylsulfanyl)quinoxalines and quinoxalin-2-yl isothioureas

Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)- quinoxalines 2a-1 and 2-(quinoxalin-2-yl)-isothioureas 3a-1 were prepared. All the test compounds 2a-1 and 3a-1 were screened in vitro, in a RIN5F cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-1 and the insulinotropic activity of compound 21 was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4- thiadiazo-2-ylsulfanyl)-quinoxaline (1)).

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Organoselenium compounds from purines: Synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect

We describe here a simple method for the synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities, and memory improvement effect. This class of compounds was synthesized in good yields by a reaction of 6-chloropurine with diaryl diselenides using NaBH4 as reducing agent and PEG-400 as solvent. Furthermore, the synthesized compounds were evaluated for their in vitro antioxidant and acetylcholinesterase (AChE) inhibitor activities. The best AChE inhibitor was assessed on the in vivo memory improvement. Our results demonstrated that the 6-((4-chlorophenyl)selanyl)-9H-purine and 6-(p-tolylselanyl)-9H-purine presented in vitro antioxidant effect. In addition, 6-((4-fluorophenyl)selanyl)-9H-purine inhibited the AChE activity and improved memory, being a promising therapeutic agent for the treatment of Alzheimer’s disease.

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