Tag: M.W:100-200

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 13940-83-5, is researched, Molecular F2H8NiO4, about Bending modes of the water molecules and the M-O stretching modes in the series MF2.4H2O (M = iron, cobalt, nickel, zinc), the main research direction is IR metal fluoride hydrate.Formula: F2H8NiO4.

The IR spectra of MF2.4X2O (M = Fe, Co, Ni, Zn; X = H, D) are reported in the frequency ranges of the bending vibrations of the H2O mols. (ν2) at 296 and ∼100 K and the M-O lattice vibrations (νM-O) at 296 K. Four νM-O vibrations consisting of 2 doublets are identified using D substitution. The various νZn-O vibrations correlate with the metal-O distances R(Zn-O), and this correlation is further used to calculate R(M-O)’s of the remainder of the series and to refine R(Zn-O). Four ν2(H2O, HDO, D2O) vibrations, consisting of 2 sharp overlapping bands flanked by 2 broad shoulders, are identified. The number of ν2(H2O) components, the sequence of ν2 in the series and the correlation with R(M-O) suggest that the ν2 frequencies are mainly determined by R(M-O). Using this assignment the 2 types of ν2 bands are assigned to the 2 types of crystallog. distinct H2O mols. found in the MF2.4H2O structure.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Acid reaction and ionization constants of 8-hydroxyquinoline-N-oxide, published in 1969, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, Application of 1127-45-3.

The constants for the acid reactions of 8-hydroxyquinoline-N-oxide were determined at 25° and M ionic strength. The 1st ionization constant for the cation of oxine-N-oxide, H2Q+, was 0.0486 ± 0.0004. The constant for the acid reaction for the 2nd ionization of the above compound was 176 kw ± 15, where kw is the ion product of water. This constant is for the ionization of oxine-N-oxide which produces H ions and a combination of basic forms including the anion and the Na salt. The 1st ionization constant was determined by potentiometric measurements. The 2nd ionization was studied by solvent extraction methods. The reagent was synthesized by a modified K. Ramaiah and V. R. Srinivasan (1962) procedure.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Quinoline-5,8-quinones》. Authors are Petrow, Vladimir; Sturgeon, Bennett.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Quality Control of 8-Hydroxyquinoline 1-oxide. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

5-Amino-8-hydroxyquinoline sulfate (1 g.) in 10 mL. 10% H2SO4 and Na2Cr2O7 in H2O, the whole extracted with CHCl3, the CHCl3 extracts concentrated and the residue diluted with petr. ether gave 0.35 g. quinoline-5,8-quinone, light yellow needles, m. 129° (decomposition). 8-Hydroxy-5-nitrosoquinaldine (5.8 g.) in 100 mL. H2O and 6.3 g. NaOH treated with about 13 g. Na2S2O4 (I) and neutralized with AcOH gave 5-amino-8-hydroxyquinaldine (II); II as above gave 2 g. quinaldine-5,8-quinone, yellow-green prisms, m. 145° (decomposition) (from EtOH-petr. ether). Similarly 8-hydroxy-5-nitroso-7-methylquinoline gave the amine (III), yellow prisms, m. 155° (decomposition) (from C6H6), and III gave the quinone, light yellow needles, m. 181-2° (from EtOH-petr. ether). A solution of PhN2Cl (from 7 g. PhNH2.HCl and 4 g. NaNO2) added during 20 min. at 0-3° to 8.5 g. 5-amino-O-methylquinoline in 50 mL. AcOH, 200 mL. H2O, and 25 g. AcONa gave 9 g. 5-amino-6-methyl-8-phenylazoquinoline-HCl (IV), red-brown plates, m. 216° (from EtOH-petr. ether). IV (12 g.), 60 cc. concentrated HCl, 50 mL. H2O, and 150 mL. EtOH refluxed 2.5 h. gave 7 g. HCl salt, m. 212° (from EtOH), of the 5-HO analog (V), fine red needles m. 177° (from EtOH). V (1.5 g.) in EtOH, Pd-C, and H gave 0.5 g. 8-amino-5-hydroxy-6-methylquinoline (VI), pale brown plates, m. 216° (from EtOH). VI gave 6-methylquinoline-5,8-quinone, yellow needles, m. 188° (from CHCl3-petr. ether). 2,6-Dimethylquinoline (3.0 g.) in 8,5 mL. cold concentrated H2SO4, treated with 1.5 mL. concentrated HNO3 in 2.0 mL. concentrated H2SO4 2 h. on the steam bath, and the whole poured into cold dilute aqueous NH3 gave 3.8 g. 2,6-dimethyl-5-nitroquinoline (VII), pale yellow prisms, m. 106° (from pert. ether). VII (2.5 g.), 25 mL. 80% EtOH, 1 mL. concentrated HCl, and 6 g. reduced Fe gave 2.0 g. 5-amino analog (VIII), green needles, m. 190° (from C6H6-petr. ether), and VIII as above gave 60% 2,6-dimethylquinoline-5,8-quinone (IX), yellow plates, m. 150°, also obtained via 5-amino-2,6-dimethyl-8-phenylazoquinoline-HCl, red plates with green reflex, m. 210°, and 5-hydroxy-2,6-dimethyl-8-phenylazoquinoline, dark red fluffy needles, m. 168° (from EtOH), and 8-amino-5-hydroxy-2,6-dimethylquinoline (X) (X was very sensitive to air oxidation and was used directly without purification). Finely powd. 8-hydroxy-5-nitrosoquinoline (3 g.) added to 9 mL. concentrated HNO3 and 6 mL. H2O and kept 1.25 h. at 17° gave a precipitate of 8-hydroxy-5-nitroquinoline-HNO3; the whole cooled to 0° made alk. with cold KOH solution, and the red K salt decomposed with AcOH gave 2.9 g. 8-hydroxy-5-nitroquinoline, yellow needles, m. 180° (from EtOH). Similarly, 8-hydroxy-5-nitrosoquinaldine gave 8-hydroxy-5-nitroquinaldine, silky yellow needles, m. 136° (from C6H6-petr. ether) (a small amount of 8-hydroxy-5,7-dinitroquinaldine, small yellow needles, m. above 300° was a byproduct). The following compounds were prepared by this general procedure: To 1 g. nitro compound in 300 mL. H2O and 0.9 g. KOH was added 1 mol. equivalent Br or iodine dissolved in KBr or KI, resp., and the whole stirred at room temperature 2 h. and acidified, giving 60-70% yield of the halogenated product (all derivatives recrystallized from EtOCH2CH2OH): 7-bromo-8-hydroxy-5-nitroquinoline (XI), red felted needles, m. 200°; 7-bromo-8-hydroxy-5-nitroquinaldine (XII), red plates, m. 265° (decomposition); and 8-hydroxy-7-iodo-5-nitroquinaldine (XIII), bright red plates, m. 244°. As above, with I, XI gave the amino compound (XIV), light brown needles, m. 184° (decomposition) (from EtOAc-petr. ether); XII gave the amino compound (XV), golden brown needles, m. 176° (decomposition); and XIII gave the amino compound (XVI), yellow needles, m. 162° (decomposition from Et2O-petr. ether). As above, with Na2Cr2O7 were prepared the following 5,8-quinones (all recrystallized from CHCl3-petr. ether): 7-bromoquinoline (from XIV), pale yellow needles, m. 182°; 7-bromoquinaldine (from XV), orange-yellow needles, m. 178°; 7-iodoquinoline (from XVI), unstable yellow-brown needles, m. 160° (decomposition); and 7-iodoquinaldine, yellow-brown needles, m. 160° (decomposition). 4-IC6H4NH2 (XVII) (42 g.), 70 g. dry glycerol, and 33 g. As2O5 heated to 120° 20 mL. concentrated H2SO4 added dropwise with stirring, and with the temperature kept at 120° the whole refluxed 4 h., 600 mL. H2O added, the mixture filtered, the filtrate made alk. with aqueous NH3, extracted with C6H6, the C6H6 extracts extracted with 6N HCl, the base liberated from the HCl extracts with NaOH, extracted with CHCl3 and the CHCl3 extracts concentrated and distilled gave 6-iodoquinoline (XVIII), b1 120° pale yellow prisms, m. 88° (from petr. ether). XVIII (1.5 g.), 4.5 mL. concentrated H2SO4, and 0.8 mL. concentrated HNO3 in 1 mL. concentrated H2SO4 heated 1 h. at 100° gave 1.5 g. 6-iodo-5-nitroquinoline, m. 163° (from C6H6). XVII (25 g.), 20 mL. concentrated HCl, and 20 mL. paraldehyde kept overnight, the whole refluxed 2 h., H2O added, the aqueous solution decanted from the resin (XIX), the XIX extracted twice with 2N HCl, the combined HCl solutions treated as above m the preparation of XVIII gave 5.9 g. 6-iodoquinaldine (XX), prisms, m. 112° (from petr. ether). As above XX gave 90% 6-iodo-5-nitroquinaldine (XXI), pale yellow needles, m. 146 ° (from EtOH). XXI (5 g.) and 25 g. PhNH2 heated 2 h. at 180°, AcONa solution added, the excess PhNH2 steam distilled, the residue extracted with C6H6, the C6H6 extracts percolated through Al2O3, and the C6H6 evaporated gave 6-anilino-5-nitroquinaldine, felted orange needles, m. 147-8° (from EtOH). XXI (2.5 g.), 7 g. reduced Fe, 20 mL. EtOH, and 5 drops concentrated HCl refluxed 2 h., the whole filtered, and the filtrate made alk. with aqueous NH3 gave 2 g. 5-amino-6-iodoquinaldine, golden plates, m. 206° (decomposition) (from C6H6-petr. ether). 8-Hydroxyquinoline (2 g.) in CHCl3 and 2 mol ethereal peroxyphthalic acid in Et2O kept overnight, the whole evaporated to dryness, and the residue triturated with aqueous NH3 gave 8-hydroxyquinoline N-oxide (XXII), golden yellow needles, m. 138°. XXII (3.2 g. in 400 mL. 0.2% NaOH and 5.1 g. iodine in KI gave 8-hydroxy-5(?)-iodoquinoline N-oxide, yellow needles, m. 169° (from C6H6). XXII (1.6 g.) in 10 mL. AcOH and 1 mL. concentrated HNO3 kept 1 h. at 20° gave a precipitate of the nitrate which, decomposed with KOH, yielded 8-hydroxy-5(?)-nitroquinoline N-oxide (XXIII), light brown powder, m. 217-18° (decomposition) (from alc.). XXIII and I as above gave the amine, orange-red needles, m. 213° (decomposition) (from C6H6). Quinoline-5,8-quinone (0.75 g.), 1.2 g. PhNH2, and 10 mL. EtOH refluxed 1 h. and the whole poured into dilute AcOH gave 6(7)-anilinoquinoline-5,8-quinone, scarlet needles, m. 213° (decomposition) (from C6H6petr. ether). 7-Bromoquinoline-5,8-quinone (0.1 g.), 0.053 g. PhNH2.HCl, 0.05 g. AcONa, and 5 mL. alc. refluxed 2 h., and the whole poured into H2O gave 0.1 g. 6-anilino-7-bromoquinoline-5,8-quinone, dark red prisms, m. 189° (decomposition). 8-Hydroxy-5-nitroquinoline (2 g.) in 20 mL. boiling EtOH with 2 mL. 36% HCHO and 2 mL. morpholine gave 2.3 g. 8-hydroxy-7-morpholinomethyl-5-nitroquinoline, yellow prisms (which rapidly discolor), m. 112° (decomposition).

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vanadium. VII. Vanadium(IV) complexes of benzimidazoles and oxine N-oxide》. Authors are Dutta, R. L.; Lahiry, Subrata.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).COA of Formula: C9H7NO2. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

cf. CA 60, 5057b. The following complexes were prepared and their magnetic moments determined at 30-5; VO(H2O)B2+, 1.63; VO(H2O)G2+, 1.50; VOG2, 1.59; VO(BC)2.H2O 1.60; and VO(Ox)2, 1.77 Bohr magnetons, where B is benzimidazole, G is 2-guanidino benzimidazole, BC is 2-benzimidazolecarboxylate.

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Category: quinoxaline. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings. Author is Yamauchi, Satoshi; Wukirsari, Tuti; Ochi, Yoshiaki; Nishiwaki, Hisashi; Nishi, Kosuke; Sugahara, Takuya; Akiyama, Koichi; Kishida, Taro.

The new lignano-9,9′-lactones (α,β-dibenzyl-γ-butyrolactone lignans), which showed the higher cytotoxicity than arctigenin, were synthesized. The well-known cytotoxic arctigenin showed activity against HL-60 cells (EC50 = 12 μM), however, it was inactive against HeLa cells (EC50 > 100 μM). The synthesized (3,4-dichloro, 2′-butoxy)-derivative and (3,4-dichloro, 4′-butyl)-derivative bearing the lignano-9,9′-lactone structures showed the EC50 values of 10 μM and 9.4 μM against HL-60 cells, resp. Against HeLa cells, the EC50 value of the (3,4-dichloro, 4′-butyl) derivative was 27 μM. By comparing the activities with the corresponding 9,9′-epoxy structure (THF compounds), the importance of the lactone structure of (3,4-dichloro, 2′-butoxy)-derivative and (3,4-dichloro, 4′-butyl)-derivative for the higher activities was shown. The substituents on the aromatic ring of the lignano-9,9′-lactones affected the cytotoxicity level, observing more than 10-fold difference.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 13940-83-5, is researched, SMILESS is [H]O[H].[H]O[H].[H]O[H].[H]O[H].[Ni+2].[F-].[F-], Molecular F2H8NiO4Journal, Journal of Fluorine Chemistry called Effect of metal fluorides in the electrolyte on the electrolytic production of NF3, Author is Tasaka, Akimasa; Osada, Toshinori; Kawagoe, Tomoo; Kobayashi, Megumi; Takamuku, Atsushi; Ozasa, Kohtaro; Yachi, Tomonori; Ichitani, Toshiyuki; Morikawa, Katsuhiko, the main research direction is nitrogen trifluoride electrolytic production fluoride effect.Quality Control of Nickel(ii)fluoridetetrahydrate.

Electrolysis of the melts of NH4F·2HF with and without metal fluorides such as LiF, NaF, KF, CsF, MgF2, and AlF3 was conducted with a nickel anode. The mixed gas composed of NF3 and N2 with a small amount of N2F4, N2F2, N2O, and O2 was liberated at the anode by electrolysis at 25 mA/cm2 and at 120°. The addition of LiF into the melt was most effective for increasing the NF3 current efficiency and for minimizing the consumption of nickel anode. In contrast, KF in the melt decreased the current efficiency for NF3 and other constituents in the anode gas as well as hydrogen generated at the cathode. It also stimulated the consumption of Ni anode. The concentration of nickel ion in the molten KF-NH4F-HF system was low compared with that in the melts of NH4F·2HF with and without alkali metal fluorides such as LiF and CsF because KNiF3 was deposited on the cathode and the cell bottom. The SEM observation and the XPS and XRD analyses revealed that the oxidized layer formed on nickel in molten NH4F·2HF with and without LiF, CsF, and 0.3 mol% NaF was composed of NiF2 with a small amount of Ni oxides of divalent and trivalent states and highly oxidized nickel fluorides. The surface layer formed on nickel in molten NH4F·2HF with 6.7 mol% NaF was mainly composed of NiF2 and NaNiF3. On the other hand, the oxidized layer in the melt containing KF was composed of only KNiF3, and was very brittle. Therefore, it is concluded that KF is detrimental to the nickel anode, depending on the composition of molten fluoride.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Heterocyclic N-oxides. III. 8-Hydroxyquinoline N-oxide》. Authors are Ramaiah, K.; Srinivasan, V. R..The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Related Products of 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

cf. CA 57, 6761f. Unlike 8-hydroxyquinoline (I), the title compound (II) shows no OH stretching at 3400 or 3660 cm.-1, Badger and Moritz (CA 53, 11382g). The broad medium-intensity band of II at 2857-2440 cm.-1 is independent of concentration and is interpreted as evidence of strong intramol. H bonding involving the O-H and N-O groups. Preliminary study by the method of Irving, et al. (CA 43, 8941i) with 23 cations indicates that II chelates more selectively than I. The results at pH 5.2, 8.4, and 12.4 are tabulated. II is conveniently prepared in fair yield by heating (water bath, 65-75°) 14.5 g. I in 30 ml. glacial HOAc with 10 ml. 30% H2O2. At intervals of 1 hr. a total of 30 ml. more of H2O2 was added in 3 equal increments. The mixture was concentrated in vacuo, made alk. with saturated aqueous Na2CO3, and left overnight after addition of 60 ml. CHCl3. Unreacted I was removed by steam distillation of the mixture after filtration, drying and removal of CHCl3 by distillation Hot filtration of the aqueous residue gave on cooling 5.96 g. yellow needles of II, m. 139°.

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Icelli, Orhan; Erzeneoglu, Salih published the article 《Effective atomic numbers of some vanadium and nickel compounds for total photon interactions using transmission experiments》. Keywords: effective atomic number vanadium nickel compound total photon interaction; x ray transmission vanadium nickel compound effective atomic number.They researched the compound: Nickel(ii)fluoridetetrahydrate( cas:13940-83-5 ).HPLC of Formula: 13940-83-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:13940-83-5) here.

Effective at. numbers of V2O3, VO2, VF3, NH4VO3, VF4, NiF2, NiCl2, NiF2·4H2O, NiCl2·6H2O, and Ni(ClO4)2·6H2O were measured in the x-ray energy range of 15.746-40.930 keV using an Si(Li) detector. The measured values are compared with the theor. ones calculated using WinXcom.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Linking [2]rotaxane wheels to create a new type of metal organic rotaxane framework.Application In Synthesis of (4-(Pyridin-4-yl)phenyl)methanol.

Three new [2]rotaxanes with aromatic nitrogen donors appended to the crown ether wheel were synthesized by the combination of tetraarom. nitrogen group substituted dibenzo-24-crown-8 ether wheel (tetraarom. nitrogen group = 8-hydroxyquinoline, 3-pyridyl, 4-pyridyl) and a dicationic 1,2-bis(pyridinium)ethane axle and used as ligands to coordinate Cd(II) ions. One of these yields a new type of 2-periodic, metal organic rotaxane framework in which the wheel rather than the axle was used to link the metal nodes. The cadmium complexes and reactant precursor were characterized via x-ray determination

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HPLC of Formula: 1127-45-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about First Safe and Practical Synthesis of 2-Amino-8-hydroxyquinoline. Author is Storz, Thomas; Marti, Roger; Meier, Roland; Nury, Patrice; Roeder, Michael; Zhang, Kesheng.

The first safe and efficient synthesis of the important building block 2-amino-8-hydroxyquinoline (1) is described. Starting from the readily available N-oxide of the cheap bulk chem. 8-hydroxyquinoline (2), the target compound is obtained in a two-step one-pot procedure in good overall yield (53-66%) and purity (>98%) on a kilogram scale without chromatog.

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