Tag: M.W:100-200

2213-63-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article, authors is Sangilipandi£¬once mentioned of 2213-63-0

Synthesis, structure, antibacterial studies and DFT calculations of arene ruthenium, Cp?Rh, Cp?Ir and tricarbonylrhenium metal complexes containing 2-chloro-3-(3-(2-pyridyl)pyrazolyl)quinoxaline ligand

The ligand [2-chloro-3-(3-(2-pyridyl)pyrazolyl)quinoxaline] (L) have been prepared from 2,3-dichloroquinoxaline and 3-(2-pyridyl)-1H-pyrazole. The reaction of N,N?-bidentate chelating ligand (L) and the corresponding metal precursors [(arene)Ru(mu-Cl)Cl]2 {arene = p-cymene, benzene, hexamethylbenzene (HMB)}, [Cp?M(mu-Cl)Cl]2 {Cp? = pentamethylcyclopentadiene; M = Rh, Ir}, [CpRuCl(PPh3)2] {Cp = cyclopentadiene; PPh3 = triphenylphosphine} and [Re(CO)5Br] leads to the formation of mononuclear metal complexes having the general formula [(arene)Ru(L)Cl]+ where, arene = p-cymene (1), C6H6 (2), C6Me6 (3), [Cp?M(L)Cl]+ where, M = Rh (4), Ir (5), [CpRu(L)PPh3]+ (6) and [Re(L)(CO)3Br] (7). All these platinum group metal complexes were synthesized and isolated with PF6 counter anions except complex (6) whereas the complex (7) was isolated as a neutral complex. All these metal complexes were fully characterized by FT-IR, 1H NMR, UV-Vis and mass spectroscopic and analytical techniques. Moreover, the complexes (1-7) were determined by the single-crystal X-ray diffraction analysis. Single crystal X-ray data confirms that the coordination occurs to the N-atoms of the pyridyl and pyrazolyl moieties of the ligand. Agar well diffusion method reveals that complexes (1, 2, 4 and 5) are having good antibacterial activity against the three different bacteria, pathogenic test organisms Staphylococcus aureus subsp. aureus, Staphylococcus epidermidis and Escherichia coli. The electronic transitions and absorption band of the complexes calculated by using time-dependent DFT method are in good agreement with the experimental results.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2213-63-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1529 | ChemSpider

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 32601-86-8, molcular formula is C9H7ClN2, introducing its new discovery. 32601-86-8

AMINO-SUBSTITUTED ISOTHIAZOLES

The present invention relates to isothiazoles of general formula (I) which inhibit the mitotic checkpoint : in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 32601-86-8, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 32601-86-8

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N995 | ChemSpider

2213-63-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article, authors is Soliman, Ahmed M.M.£¬once mentioned of 2213-63-0

Synthesis of some novel imidazopyrazole and pyrazolopyrimidine derivatives

Figure Persented 5-Amino-3-anilino-1H-pyrazole-4-carbonitrile 1 was alkylated with various halo reagents under phase transfer conditions to give the corresponding imidazopyrazole derivatives 2a-2c -6. Pyrazolo[1,5-a] pyrimidine derivatives 11, 12, 13, 14 were prepared by treating compound 1 with different dicarbonyl reagents, namely, diethymalonate, ethyl 3-oxo-3-phenylpropanoate, pentane-2,4-dione or ethyl 3-oxobutanoate.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.2213-63-0. In my other articles, you can also check out more blogs about 2213-63-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1550 | ChemSpider

32601-86-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.32601-86-8, Name is 2-Chloro-3-methylquinoxaline, molecular formula is C9H7ClN2. In a Article, authors is Sekhar, Kondapalli Venkata Gowri Chandra£¬once mentioned of 32601-86-8

Synthesis of triazoloquinoxalines as antitubercular agents

1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1- aryl-4-methyl-1,2,4-triazolo[4, 3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, 1H NMR, 13C NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 32601-86-8

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1043 | ChemSpider

1448-87-9, In an article, published in an article,authors is Borzenko, Andrey, once mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline,molecular formula is C8H5ClN2, is a conventional compound. this article was the specific content is as follows.

Nickel-catalyzed monoarylation of ammonia

Structurally diverse (hetero)aryl chloride, bromide, and tosylate electrophiles were employed in the Ni-catalyzed monoarylation of ammonia, including chemoselective transformations. The employed JosiPhos/[Ni(cod)2] catalyst system enables the use of commercially available stock solutions of ammonia, or the use of ammonia gas in these reactions, thereby demonstrating the versatility and potential scalability of the reported protocol. Proof-of-principle experiments established that air-stable [(JosiPhos)NiCl2] precatalysts can be employed successfully in such transformations. Lighten Up: The substrate scope of the title reaction includes (hetero)aryl chloride, bromide, and tosylate electrophiles. The versatility and potential scalability of the reported method is demonstrated by the use of either commercially available stock solutions of ammonia or ammonia gas.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N533 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

[0175] To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) was added HATU (13.3 g, 35 mmol. 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and Omicron,Nu- Dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at r.t. overnight, then the solvent was evaporated. The residue was purified via flash column (PE/EA = 2/1, v/v) to afford N-meth (5.1 g, 80 %).

6925-00-4, 6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/43935; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (184 mg, 0.530 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (104 mg, 0.530 mmol) to afford the desired title compound (134 mg, yield 49%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.84 (1H, brs), 9.56 (1H, m), 7.87 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.8 Hz), 7.30 (2H, d, J=8.6 Hz), 7.11 (2H, dd, J=8.6 Hz, 5.0 Hz), 5.00 (1H, m), 4.69 (1H, m), 4.08-3.79 (2H, m), 3.58-3.20 (2H, m), 2.10-1.46 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2945, 1685, 1640, 1505, 1240. MS (ESI, m/z): 519 (M+H)+. HRMS (ESI, m/z): 519.1850 (Calcd for C25H26F3N4O5: 519.1855).

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 36 iV-Methyl-iV-tetrahvdro-lH-pyran^-ylquinoxaline–carboxamide To a suspension of quinoxaline-6-carboxylic acid (0.7g, 4 mmol) and N-methyltetrahydro- 2H-pyran-4-amine (0.7 g, mmol), in DMF (6 ml) and dichloromethane (6 ml), were added DMAP (0.49 g, 4 mmol), etaOBT (0.54 g, 4 mmol), NEt3 (1.6 ml) and EDCI (1.26g). The reaction mixture was stirred at room temperature for 4h and then concentrated under vacuum. The crude product was purified on a silica gel column eluting with chloroform/methanol/ triethylamine (95:5:0.5) to give an oil (1.5g) which formed a beige solid upon trituration with dichloromethane/diethyl ether. Mp = 130-131C, LC-MS, MH+ = 272; 1H NMR (300 MHz, CDCl3) delta 8.91 (s, 2H); 8.18 (d, J = 8.4 Hz, IH); 8.11 (s, IH); 7.79 (d, J = 8.4 Hz, IH); 4.95- 3.50 (m, 5H); 3.07 and 2.91 (s + s, 3H); 2.02-1.65 ppm (m, 4H)., 6925-00-4

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/143963; (2008); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Quinoxalinecarboxylic acid (0801-134) (1.0 g, 5.7 mmol, 1.0 eq.)Dissolved in 20 ml of methanol,Add thionyl chloride (1.25 mL, 17.2 mmol, 3.0 equivalents),Heat reflux for 3 hours.Cooled to room temperature, concentrated to dryness under reduced pressure, extracted with ethyl acetate, washed with water, liquid-separated, dried over anhydrous sodium sulfate, filtered concentrated, and concentrated under reduced pressure.After silica gel column chromatography (eluent: eluent: petroleum ether: ethyl acetate = 5:1),The product was obtained as a pale yellow solid, methyl 2-quinoxalinecarboxylate (1.01 g, yield: 93.5percent)., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (270 mg, 1.41 mmol), 1-hydroxybenzotriazole monohydrate (150 mg, 1.13 mmol) and N-methylmorpholine (0.410 ml, 3.77 mmol) were added to a methylene chloride solution (10 ml) of the resulting compound (340 mg, 0.940 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (180 mg, 0.940 mmol), at room temperature, under nitrogen stream, and stirring was carried out at room temperature overnight. The reaction solution was washed sequentially with water, a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated, the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Yamazen Corporation, W-Prep 2XY), the residue resulting from concentration was suspended in diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (459 mg, yield 98%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.86 (1H, brs), 9.55 (1H, brs), 7.89 (1H, d, J=8.3 Hz), 7.66 (1H, t, J=7.2 Hz), 7.43-7.37 (2H, m), 7.11-7.06 (1H, m), 6.98-6.93 (1H, m), 6.78-6.73 (1H, m), 4.93 (1H, q, J=7.8 Hz), 4.51-4.43 (1H, m), 3.99-3.87 (2H, m), 3.81 (3H, d, J=6.8 Hz), 3.58-3.45 (2H, m), 2.11-1.84 (3H, m), 1.75-1.49 (2H, m), 0.98 (3H, d, J=6.8 Hz), 0.97 (3H, d, J=6.8 Hz). IR (KBr) cm-1: 2960, 1685, 1640, 1500, 1450, 1215, 1190, 1150, 1030. MS (ESI, m/z): 497 (M+H)+. Anal. Calcd for C26H29FN4O5¡¤1/4H2O: C, 62.33; H, 5.93; N, 11.18; F, 3.79. Found: C, 62.07; H, 6.02; N, 11.04; F, 3.68., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider