Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (301 mg, 1.00 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (228 mg, 1.20 mmol) to afford the desired title compound (255 mg, yield 54%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.82 (1H, brs), 9.48 (1H, brs), 7.86 (1H, t, J=7.2 Hz), 7.78 (2H, d, J=7.2 Hz), 7.64 (1H, t, J=5.6 Hz), 7.38 (2H, m), 7.18 (2H, m), 4.90 (1H, dd, J=12.4 Hz, 6.0 Hz), 4.84 (1H, m), 4.02-3.90 (2H, m), 3.57-3.20 (2H, m), 2.05 (4H, m), 1.55 (1H, m), 0.95 (6H, d, J=4.8 Hz). LCMS (ESI, m/z): 474 (M+H)+., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of freshly prepared saturated aqueous ammonia (20mL) and 2-quinoxalinecarboxylate (115mg, 0.612 mmol) was stirred at room temperature for 18 hours. The solution was then evaporated under reduced pressure to yield the product as an off-white solid in quantitative yield. Elemental analysis calcd (percent) for C9H7N3O (173.06): Calc. C 62.40 H 4.07 N 24.26; found: C 62.40 H 4.11 N 23.94. 1H NMR (400 MHz, d6-DMSO): δ (ppm) 9.439 (s, 1H, H5), 8.237 (dd, J1-2 = 8 Hz, J1-3 = 2 Hz, 1H, H1), 8.194 (dd, J4-3 = 8 Hz, J4-2 = 0.8 Hz, 1H, H4), 7.997 (q-br, J2/3-3/2/1/4 = 10 Hz, 2H, H2/3)., 1865-11-8

As the paragraph descriping shows that 1865-11-8 is playing an increasingly important role.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

6924-66-9, PyBOP (164 mg, 315 muiotaetaomicronIota) was added to a mixture of 8-amino-2-(2-chloro-4,6-difluorophenyl)- 2-azaspiro[4.5]decan-1 -one (isomer 1 , intermediate I56) (150 mg, 55 % purity, 262 muiotaetaomicronIota), quinoxaline-5-carboxylic acid (57.1 mg, 328 muiotaetaomicronIota) and N,N-diisopropylethylamine (230 muIota, 1 .3 mmol) in DMF (2.9 ml) and the mixture was stirred over night at room temperature. For workup, the reaction mixture was concentrated and the residue was purified by preparative HPLC to give the title compound 61 .3 mg (49 % yield). LC-MS (Method 1): Rt= 1.17 min; MS (ESIpos): m/z = 471 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.485 (0.75), 1.498 (0.85), 1.515 (2.19), 1.527 (2.38), 1.546 (2.66), 1.557 (2.60), 1.576 (1.35), 1.588 (1.22), 1.700 (5.70), 1.709 (5.70), 2.028 (2.94), 2.036 (3.07), 2.060 (2.85), 2.067 (2.63), 2.187 (3.41), 2.204 (6.95), 2.221 (4.07), 2.327 (1.88), 2.523 (4.79), 2.665 (1.41), 2.669 (1.91), 2.673 (1.41), 3.511 (1.03), 3.530 (2.32), 3.535 (2.00), 3.552 (2.88), 3.570 (1.41), 3.621 (1.47), 3.637 (2.60), 3.655 (1.91), 3.661 (2.16), 3.679 (0.97), 3.896 (1.16), 3.906 (1.44), 3.916 (1.19), 3.925 (1.41), 3.935 (1.13), 7.507 (1.47), 7.514 (2.07), 7.530 (2.22), 7.538 (4.04), 7.545 (3.19), 7.549 (3.01), 7.556 (2.54), 7.561 (3.13), 7.567 (3.23), 7.578 (1.78), 7.961 (3.57), 7.981 (5.01), 8.000 (4.26), 8.255 (4.76), 8.258 (4.85), 8.275 (4.23), 8.279 (4.07), 8.428 (4.60), 8.431 (4.54), 8.446 (4.32), 8.449 (3.98), 9.078 (16.00), 9.079 (15.72), 9.763 (3.66), 9.782 (3.60)

6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: The following compounds were prepared following a reductive amination procedure like the one described for the preparation of product 11 starting from the corresponding amine and methylketone intermediates using triethyl amine, sodium cyanoborohydride and titanium tetraisopropoxide in DCM. Changes of solvent, reductant are mentioned inTable B below., 83570-42-7

The synthetic route of 83570-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
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6344-72-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6344-72-5,6-Methylquinoxaline,as a common compound, the synthetic route is as follows.

A suspension of 3,4-diaminotoluene (50.0 g; 0.409 mol.) and glyoxal (40% aq. soln.; 52.0 mL; 0.450 mol.) in water (150 mL) and CH3CN (20.0 mL) was heated to 60 0C for 1 h. Heating was then discontinued and brine (100 mL) was added. The solution was extracted with EtOAc (3 x 150 mL) and the combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo. Purification via distillation under reduced pressure (1200C, 10 torr) provided 6-methylquinoxaline (48.0 g, 81 %) as a clear, colorless oil. 1 H NMR (400 MHz, CDCl3) delta ppm 2.61 (s, 3 H) 7.61 (dd, J=8.59, 1.77 Hz, 1 H) 7.88 (s, 1 H) 8.00 (d, J=8.59 Hz, 1 H) 8.79 (dd, J=9.85, 1.77 Hz, 2 H) MS(ES+) m/e 145 [M+H]+. A suspension of 6-methylquinoxaline (8.O g; 0.055 mol.) and selenium dioxide (6.77 g; 0.061 mol.) in 1 ,4-dioxane (5.0 mL) was irradiated at 2000C for 30 min. in a Biotage Initiator microwave synthesizer. The above procedure was repeated five further times and the combined, cooled reaction mixtures were dissolved in CH2CI2, filtered through a plug of celite, and concentrated in vacuo. Purification via flash column chromatography (silica gel,20-50% ethyl acetate in hexanes) followed by crystallization from CH2CI2 provided quinoxaline-6-carbaldehyde (40.0 g, 91%) as a white solid. 1H NMR EPO (400 MHz, CDCI3) delta ppm 10.25 (s, 1 H) 8.95 (s, 2 H) 8.57 (d, J=1.3 Hz, 1 H) 8.24 (dd, J=8.6, 1.5 Hz, 1 H) 8.20 (d, J=8.6 Hz, 1 H). MS(ES+) m/e 159 [M+H]+.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/127458; (2006); A2;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0201] H3C CH3 H3C CH3 boronic acid, 1.68 g of potassium carbonate, 0.049 g of tri(otolyl)phosphine, 20 mL of toluene, 5 mL of ethanol, and 6 mL of water were put in a three-neck flask equipped with a reflux pipe, and the air in the flask was replaced with nitrogen. The inside of the flask was degassed under reduced pressure, 0.018 g of palladium acetate was added thereto, and the mixture was heated at 80 C for 19 hours. Then, water was added to this solution, and the organic layer was extracted with toluene. The obtained organic layer was washed with water and saturated saline, and was dried with magnesium sulfate. The solution obtained by the drying was filtered. The solvent of this solution was distilled off, and then the obtained residue was purified by flash column chromatography using hexane and ethyl acetate in a volume ratio of 5: 1 as a developing solvent to give a target quinoxaline derivative as pale pink powder in a yield of 67 %). Synthesis Scheme (c-1) of Step 1 is shown below.

32601-86-8, As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Patent; SEMICONDUCTOR ENERGY LABORATORY CO., LTD.; INOUE, Hideko; YAMAGUCHI, Tomoya; SEO, Hiromi; TAKAHASHI, Tatsuyoshi; SEO, Satoshi; WO2014/199842; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13311-79-0,6-Methoxy-1,2,3,4-tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Dichloroacetyl chloride (2.4 mL, 24 mmol) was added dropwise to a suspension of 2 (10 mmol) and Na2CO3 (2.55g, 24 mmol) in benzene (30 ml) at room temp with stirring. The mixture was stirred continuously for 1 hr and then it was taken up in a mixture of water and EtOAc. The organic phase was washed with saturated NaCl aq, dried over anhyNa2SO4 and vacuum distillation gave the residue. Recrystallization of the residue with ethanol gave pure products 4a-f., 13311-79-0

13311-79-0 6-Methoxy-1,2,3,4-tetrahydroquinoxaline 12549514, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ye, Fei; Liu, Xin-Ying; Qu, Li-Hua; Fu, Ying; Zhao, Li-Xia; Qu, Hai-Hao; Indian Journal of Heterocyclic Chemistry; vol. 24; 2; (2014); p. 167 – 174;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13708-12-8,5-Methylquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 5-methylquinoxaline (9.50 g, 65.97 mmol) in CH3CN (80 mL) was added 1-bromopyrrolidine-2,5-dione (27.00 g, 151.74 mmol) at room temperature. The resulting solution was stirred for 16 h at 60 C. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate (500 mL). The insoluble solids in the mixture were filtered out and the filtrate was washed with brine and dried over Na2504. The solvent was removed under reduced pressure to yield 5-bromo-8-methylquinoxaline as brown solid (6.00 g, 4 1%). MS: m/z = 222.9 [M+Hj .

13708-12-8, 13708-12-8 5-Methylquinoxaline 61670, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; SHERER, Brian A.; CHEN, Xiaoling; CLEARY, Esther; BRUGGER, Nadia; (198 pag.)WO2018/31434; (2018); A1;,
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80636-30-2, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80636-30-2

EXAMPLE 296 3,3-Dimethyl-4-[(1-methyl)ethyl]oxycarbonyl-1,2,3,4-tetrahydroquinoxalin-2-one (IV) To 2.28 g of 4-chlorocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one (prepared by the method of Example 32 but using 3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one rather than 6-fluoro-3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one) in 25 ml of 2-propanol (the starting material is not all in solution) are added 0.694 g of lithium isopropoxide. After about 1.5 hr the reaction mixture became homogeneous and then again heterogeneous as the product precipitated out. After a total of 2 hr the solvent is removed under reduced pressure and the residue is partitioned between dichloromethane aid saline. The organic layers are dried over sodium sulfate and the filtrate is concentrated. Ether is added and the resulting solid is collected to give the title compound. NMR (CDCl3) 1.28, 1.63, 5.01, 6.80, 6.98-7.11, 7.27, 7.96 delta.

80636-30-2 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one 595203, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; The Upjohn Company; US5541324; (1996); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59564-59-9,3,4-Dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

59564-59-9, EXAMPLE 294 4-Methoxycarbonyl-1,2,3,4-tetrahydroquinoxalin-2-one (IV) To 2.99 g of 1,2,3,4-tetrahydroquinoxalin-2-one (IV) in 30 ml of methyl tert-butyl ether are added 2.18 ml of methyl chloroformate. After stirring for 1 hr, 4.9 ml of diisopropylethylamine are added. The reaction is stirred an additional 30 min and then concentrated under reduced pressure. The residue is partitioned between dichloromethane and aq. sodium bicarbonate and the organic layers dried over sodium sulfate and concentrated. The crude product is crystallized from dichloromethane/hexane/ethyl ether to give the title compound, NMR (CDCl3) 3.84, 4.45, 6.87, 7.11, 7.65, 8.27 delta.

As the paragraph descriping shows that 59564-59-9 is playing an increasingly important role.

Reference£º
Patent; The Upjohn Company; US5541324; (1996); A;,
Quinoxaline – Wikipedia
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