Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.

91-19-0, Quinoxaline (0.65g, 5 mmol), pyruvic acid (1.32g, 15 mmol), AgNO3 (0.068g, 0.4 mmol), (NH4) 2S2O8 (1.71g, 7.5 mmol), CF3CO2H (1.7g, 15 mmol) were dissolved in a 1 : 1 mixture of DCM/H2O (50ml). The reaction mixture was stirred at 40 C. After cooling to room temperature the mixture was extracted with DCM, washed with brine and dried over Mg S04, then evaporated to give 1-quinoxalin-2-yl-ethanone (0. 89g, 100%).

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; F2G LTD; WO2005/92304; (2005); A2;,
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2213-63-0, 2,3-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,3-dichloro-quinoxaline (500 mg, 2.51 mmol) in THF (5 mL) at 0 C. was added sodium methoxide (0.57 mL of a 25% solution in methanol, 2.51 mmol) dropwise. The reaction was stirred at 0 C. for 30 min then warmed to room temperature or 1 h. The reaction mixture was diluted with dichloromethane, washed with brine, dried (MgSO4), and concentrated in vacuo to give compound 76 as a yellow solid., 2213-63-0

As the paragraph descriping shows that 2213-63-0 is playing an increasingly important role.

Reference£º
Patent; Beavers, Mary Pat; Dudash, Joseph; Zhang, Yongzheng; US2005/148586; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

General procerure: A solution of compound 14 or 3 (10 mmol) in pyridine (10 mL) was refluxed for 6 h. After cooling, it was poured on ice/water (200 mL) and acidified with diluted HCl (pH = 6) the product extracted by ethyl acetate (100 ¡Á 3). Solution of ethyl acetate dried over sodium acetate anhydrous (50 g) for 2 h, and then the solid is filtered off. A solution of ethyl acetate is evaporated under reduced pressure and crystals are collected., 34117-90-3

34117-90-3 3-Chloroquinoxalin-2-amine 817274, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Galal, Shadia A.; Abdelsamie, Ahmed S.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Elhefnawi, Mahmoud M.; Ramadan, Raghda A.; Atta, Mona H.E.; El Diwani, Hoda I.; European Journal of Medicinal Chemistry; vol. 46; 1; (2011); p. 327 – 340;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 21Preparation of Compound 59Step A – Synthesis of lnt-21AInt-19A (4.0 g, 20 mmol) was combined with NH4CI (5.4 g, 100 mmol) and 27% ammonia (32 mL) in isopropanol (40 mL). The mixture was heated in a sealed vessel for 20 h at 80 C, allowed to cool, and partitioned with CH2Cl2 and water. Washing with brine, drying (MgSO4), and concentration gave Int-21 A as a yellow solid., 2213-63-0

As the paragraph descriping shows that 2213-63-0 is playing an increasingly important role.

Reference£º
Patent; SCHERING CORPORATION; HARRIS, Joel, M.; NEUSTADT, Bernard, R.; STAMFORD, Andrew, W.; WO2011/60207; (2011); A1;,
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6925-00-4,6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0270] 5 mL of DMF was added to a solution of quinoxaline-6-carboxylic acid (60 g, 0.34 mol) in SOCl2 (300 mL). The resulting mixture was heated under reflux overnight, then cooled and concentrated to afford crude mixture of 3-chloroquinoxaline-6-carbonyl chloride and 2-chloro- quinoxaline-6-carbonyl chloride (62 g, 94 %). [0271] To a solution of O, N-dimethyl-hydroxylamine hydrochloride salt (29 g, 0.30 mol, 1.1 eq) and DIEA (182 mL, 1.08 mol, 4.0 eq) in DCM (300 mL) was added the mixture of 3-chloro- quinoxaline-6-carbonyl chloride and 2-chloro-quinoxaline-6-carbonyl chloride (52 g, 0.27 mol, 1.0 eq) at 0 C. The mixture was stirred at rt overnight, then concentrated. The resulting residue was washed with water (300 mL X 2) and extracted with EA (300 mL X 2). The combined organic layers were dried over anhydrous Na2S04, filtered and concentrated. The resulting solid was triturated with EA PE = 1/1 (300 mL) to afford 3-chloro-N-methoxy-N-methylquinoxaline-6-carboxamide (16.5 g, 24.3%).

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/40515; (2013); A1;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6298-37-9

[0171] To a solution of NaOCH3 (3.35 g, 62.07 mmol, 5.0 eq) in MeOH (60 mL), was added quinoxalin-6-amine (1.8 g, 12.41 mmol, 1.0 eq) and (HCHO)n (558.6 mg, 18.62 mmol, 1.5 eq). The mixture was heated to 50 C overnight. After cooling, NaBH4 (943.5 mg, 24.83 mmol, 2.0 eq) was added portwise, and the mixture was stirred at RT for 2 h. The resulting mixture was concentrated and the residue was dissolved in EtOAc, washed with water (3 times), dried over Na2S04 and concentrated under vacuo. The crude product was purified by chromatograph on silica gel (PE:EA = from 5: 1, to 0: 1, gradient ) to give the product (700 mg, yield: 35.5%); LC/MS: m/z (M++l) = 160.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMARESOURCES (SHANGHAI) CO., LTD.; CHEN, Ping; ZHOU, Ding; SHAO, Shaoping; CAI, Zhen-wei; WO2013/6792; (2013); A1;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, To a solution of 35C enantiomer 1 (0.0251 g, 0.078 mmol) in THF (1.205 ml) was added 4-nitrophenyl carbonochloridate (0.017 g, 0.082 mmol). The reaction was stirred at rt for 30 min. To this reaction were added quinoxalin-6-amine (0.034 g, 0.235 mmol) and triethylamine (0.033 ml, 0.235 mmol). The reaction was heated at 50 C overnight, then allowed to cool to RT. The reaction was diluted with H20 and EtOAc. The layers were separated and the aqueous phase was extracted with EtOAc (3X). The organic phases were combined, dried over Na2S04, filtered and concentrated to give 35D as a brown residue. The crude material was used without further purification.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; CHEN, Bin; CHEN, Libing; SHAN, Weifang; WO2014/150646; (2014); A1;,
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80636-30-2, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8; (7J?)-2-r(3,3-Dimethyl-2-oxo-3,4-dihydroquinoxalin-lf2H)-yl)methyl1-3′-methyl-6.8-dihvdro- 2’H,5’H-spiro[cvclopenta(g1quinoline-7,4′-imidazolidine1-2′,5′-dione; To a solution of 3,3-dimethy~3,4-dihydroquinoxalm-2(lH)-one (56 mg, 0.32 mmol) in DMF (1 mL) at ambient temperature was added sodium hydride (13 mg, 0.32 mmol, 60% dispersion in mineral oil). The resulting mixture was stirred for 20 min, then (i?)-2- (chloromethy^-S’-methyl-jS-dihydro-Z’HjS’H-spirotcyclopentafgJquinoline-T^’-imidazolidine]- 2.,5′-dione (20 mg, 0.063 mmol, described in Intermediate 18) was added and the resulting mixture was stirred at ambient temperature for 1 h. The reaction mixture was purified directly by HPLC using a reversed phase Cl 8 column and eluting with a gradient of H2theta:CH3CN:CF3Ctheta2H – 90:10:0.1 to 5:95:0.1. The pure, product-containing fractions were combined and concentrated to give the title compound as the trifluoroacetate salt. MS: m/z = 456 (M + 1). HRMS: m/z = 456.2033; calculated m/z = 456.2030 for C26H26N5O3., 80636-30-2

The synthetic route of 80636-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; STUMP, Craig, A.; QUIGLEY, Amy, G.; THEBERGE, Cory, R.; WOOD, Michael, R.; WO2010/107605; (2010); A1;,
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74003-63-7,74003-63-7, 3-Methylquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) 0.38 g of MQCA, 0.20 g of aminobutyric acid and a small amount of DMAP were added to 20 mL of dry DMF;(2) Under the condition of 0 C, 0.8 g of DCC was slowly added dropwise to the mixture of 5 mL of dry DMF. After the dropwise addition, the temperature was gradually raised to room temperature and the reaction was continued for 40 h.(3) the solvent is distilled off and purified by column chromatography to obtain the condensate of MQCA and aminobutyric acid, which is the product of formula (1).

74003-63-7 3-Methylquinoxaline-2-carboxylic acid 6484678, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Kwinbon Biotechnology Co., Ltd; He, Fangyang; Wan, Yuping; Sun, Zhen; Feng, Jing; Luo, Xiaoqin; Cui, Haifeng; Yu, Houmei; Han, Jingpeng; Duan, Yingying; (12 pag.)CN103304495; (2016); B;,
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59564-59-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59564-59-9,3,4-Dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

A solution of 3,4-dihydroquinoxalin-2-(1H)-one (2.9 g, 19.6 mmol) in methanol (20 mL) Sodium cyanoborohydride (2.5 g, 39.7 mmol) was added, Paraformaldehyde (0.9 g) and glacial acetic acid (1 mL) The reaction was stirred at 25 C for 4 hours, Sodium cyanoborohydride (1.2 g, 19.0 mmol) was added, Paraformaldehyde (0.45 g) and hydrochloric acid (0.5 mL), The reaction was heated to 50 C for 5 hours. The reaction solution was cooled to room temperature, The pH was adjusted to 8 with saturated aqueous sodium bicarbonate solution, Ethyl acetate (50 mL x 3) was added, Combine organic phase, Dried over anhydrous sodium sulfate, filter, concentrate, To give the title compound (3.0 g, yield 94.5%).

The synthetic route of 59564-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Co., Ltd.; Wu, Yongqian; (31 pag.)CN106317027; (2017); A;,
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