Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3476-89-9,1,2,3,4-Tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.

Example 4: Synthesis of 2- (3, 4-DIHYDRO-2H-QUINOXALIN-1-YLMETHYL)-1, 1, 1-TRIFLUORO-4- (5- fluoro-2-methoxyphenyl)-4-methylpentan-2-ol A solution of 2-[2-(5-FLUORO-2-METHOXYPHENYL)-2-METHYLPROPYL]-2-TRIFLUOROMETHYLOXIRANE (see Example 1) (54.4 mg) and tetrahydroquinoxaline (124. 8 mg) in DMF (0.6 mL) was heated at 100C for 6 hours. The resulting mixture was diluted with diethyl ether, washed with water and brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by preparative TLC (eluted with 25% diethyl ether-benzene) to give the title compound as a clear oil (31.2 mg)., 3476-89-9

The synthetic route of 3476-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2004/63163; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

HATU (0.631 g, 1.66 mmol) was added to a mixture of Intermediate 125 (0.50 g, 1.5 mmol) and quinoxalin-6-amine (0.219 g, 1.51 mmol) in DMF (10 mL) and DIPEA (0.53 mL, 3 mmol) and the reaction mixture was stirred at rt for 16 h. The reaction mixture was partitioned between aq NaHCC -NaCl (30 mL) and EtOAc (2 x 50 mL) and the combined organic components were dried, filtered concentrated and then purified by flash silica chromatography: (40g SiC , eluted with solv A = Hexane / solv B = EtOAc, gradient from 0 – 70%B, hold at 70%B) to yield the title compound (790 mg) as light yellow solid. LC-MS retention time = 1.15 min; m/z = 459.1 [M+H]+. (Column: Waters Aquit BEH C18 2.1 X 50 mm 1.7U. Solvent A = 100% Water: 0.05% TFA. Solvent B = 100% Acetonitrile: 0.05% TFA. Flow Rate = 0.8 mL/min. Gradient: 2-98% B. Gradient Time = 1.5 min. Wavelength = 220)., 6298-37-9

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VIIV HEALTHCARE (No.5) LIMITED; BENDER, John A.; LOPEZ, Omar D.; NGUYEN, Van N.; YANG, Zhong; WANG, Alan Xiangdong; WANG, Gan; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; THANGATHIRUPATHY, Srinivasan; (350 pag.)WO2016/172425; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80636-30-2,3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.,80636-30-2

3,4-Dihydro-1,3,3-trimethylquinoxalin-2(1H)-one. In a 200-mL r.b. flask, a solution of 3,4-dihydro-3,3-dimethylquinoxalin-2(1H)-one (1.00 g, 5.66 mmol) in dry THF was treated with NaH (0.28 g, 7.09 mmol, 1.25 equiv). The reaction mixture was stirred at room temperature for 30 minutes before iodomethane (0.39 mL, 6.24 mmol, 1.1 equiv) was added to the reaction flask. The reaction was then stirred at room temperature overnight then partitioned between EtOAc (100 mL) and H2O (20 mL). The aqueous layer was extracted with EtOAc (2*30 mL). The combined organic layers were then washed with brine (20 mL), dried (MgSO4), filtered, and concentrated to a thick oil. Purification by flash chromatography (25% EtOAc/hexane) afforded 830 mg (78%) of 3,4-dihydro-1,3,3-trimethylquinoxalin-2(1H)-one as a white solid. Data for 3,4-dihydro-1,3,3-trimethylquinoxalin-2(1H)-one: 1H NMR (400 MHz, CDCl3) delta 6.90 (m, 3H), 6.67 (d, J=7.7, 1H), 3.69 (bs, 1H), 3.36 (s, 3H), 1.37 (s, 6H).

80636-30-2 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one 595203, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Ligand Pharmaceuticals, Inc.; US6462038; (2002); B1;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[1499] to a solution of quinoxaline-2-carboxylic acid (6 g, 34.45 mmol) in MeOH (80 ml) was added con. H2SO4 (675.8 mg, 6.89 mmol) dropwise, then the mixture was stirred at 65 ¡ãC for 10 hours. After cooling to room temperature, the mixture was neutralized with a sat. NaHCO3 and extracted with DCM (60 ml x 3). The organic phases were combined, dried with anhydrous Na2SO4, and evaporated to afford compound 356a (5.80 g, yield: 89.47percent) as a brown solid. The crude product was used directly in the next step without further purification. 1H NMR (CDCl3, 400 mhz) delta 9.56 (s, 1h), 8.31 (d, j = 7.6 hz, 1h), 8.20 (d, j = 8.0 hz, 1h), 7.97 – 7.84 (m, 2h), 4.13 (s, 3h).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The tail group containing monomer, dimer ortrimer (0.266 mmol) was dissolved in methanol (25 mL), to which Pd/C-10% (60mg) was added at 0oC under nitrogen with stirring. The reactionmixture was hydrogenated at room temperature and atmospheric pressure for 4 h.The catalyst was removed over Kieselguhr and the solvent was removed underreduced pressure to give the amine, which was dissolved in DMF (1 mL, dry). Theappropriate head group carboxylic acid (0.266 mmol) was dissolved in DMF (1 mL,dry) to which HBTU (260 mg, 0.685 mmol) and triethylamine (50 muL) were added tothe reaction mixture at room temperature with stirring and the reaction mixturewas left standing at room temperature overnight. The product was purified byHPLC (no work up required). Fractions containing the product were collected andfreeze dried to give the required product., 879-65-2

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Article; Scott, Fraser J.; Puig-Sellart, Mireia; Khalaf, Abedawn I.; Henderson, Catherine J.; Westrop, Gareth; Watson, David G.; Carter, Katharine; Grant, M. Helen; Suckling, Colin J.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3478 – 3486;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-chloro-3-methylquinoxaline L [45] (500mg, 2.8mmol) and 3-trifluoromethylaniline (2,5mL, 20mmol) in anhydrous DMF (10mL) was heated at 140C in a sealed vial under microwave irradiation. After completion of the reaction (45min), CH2Cl2 was added, and the organic phase was washed successively with 1M HCl and brine. The organic layer was then dried with Na2SO4, filtered and evaporated. The resulting solid was purified by silica gel column chromatography (eluent: CH2Cl2) to afford 3-Methyl-N-(3-(trifluoromethyl)phenyl)quinoxalin-2-amine. Yield 69%. Amber powder. mp 98C. 1H NMR (250MHz, CDCl3) delta=8.24 (s, 1H), 7.93 (d, J=8.1 Hz, 1H), 7.87 (dd, J=8.1, 1.1 Hz, 1H), 7.78 (dd, J=8.2, 1.0 Hz, 1H), 7.64-7.53 (m, 1H), 7.52-7.39 (m, 2H), 7.37-7.27 (m, 1H), 6.77 (bs, 1H, NH), 2.65 (s, 3H). 13C NMR (63MHz, CDCl3) delta=147.7, 144.6, 140.3 (d, J=3.2 Hz), 137.9, 131.5 (q, J=33.1 Hz), 129.4 (d, J=6.0 Hz), 128.2, 126.9, 126.1, 124.3 (q, J=272.9 Hz), 122.8, 119.6 (d, J=3.8 Hz), 116.6 (d, J=3.4 Hz), 21.03. LC-MS (ESI, 35 eV): tR=4.75min, m/z 304 [M+H]+., 32601-86-8

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Desroches, Justine; Kieffer, Charline; Primas, Nicolas; Hutter, Sebastien; Gellis, Armand; El-Kashef, Hussein; Rathelot, Pascal; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 68 – 86;,
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1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 25 mL pressure vial was charged with 2-methylquinoline (1a) (71.5 mg, 0.50 mmol, 1.0 equiv.), I2 (317.3 mg, 1.25 mmol, 2.5 equiv.) and DMSO (3.0 mL). The vial was sealed and the resulting mixture was stirred at 110 C for 4-6 h under an air atmosphere, after disappearance of the reactant (monitored by TLC), then added benzohydrazide (2a) (81.6 mg, 0.6 mmol, 1.2 equiv.) , K2CO3 (414.0 mg, 3.0 mmol, 6.0 equiv.) at 110 C for another 4-6 h. After the reaction completed, and added 50 mL water to the mixture, then extracted with EtOAc 3 times (3 ¡Á 50 mL). The extract was washed with 10% Na2S2O3 solution (w/w), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was puried by flash column chromatography on silica gel to yield the corresponding product 3aa as a yellow solid (72% yield)., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Shang, Zhi-Hao; Sun, Ji-Na; Guo, Jiang-Shan; Sun, Yuan-Yuan; Weng, Wei-Zhao; Zhang, Zhen-Xiao; Li, Zeng-Jing; Zhu, Yan-Ping; Tetrahedron; vol. 76; 6; (2020);,
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13708-12-8, 5-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-methylquinoxaline (9.50 g, 66.0 mmol) in acetonitrile (80 mL) was added 1-bromopyrrolidine-2,5-dione (27.0 g, 151.7 mmol) at room temperature. The resulting solution was stirred for 16 h at 60 C. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate (500 mL). The insoluble solids in the mixture were filtered out and the filtrate was washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to yield 5-bromo-8-methylquinoxaline as brown solid (6.00 g, 41%). MS: m/z=222.9 [M+H]+.

13708-12-8, As the paragraph descriping shows that 13708-12-8 is playing an increasingly important role.

Reference£º
Patent; Merck Patent GmbH; SHERER, Brian A.; BRUGGER, Nadia; LAN, Ruoxi; CHEN, Xiaoling; (60 pag.)US2019/23687; (2019); A1;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, To a solution of compound D or E (1 mmol) in dichloromethane (10 ml) at 0 C. under atmosphere of nitrogen are added triethylamine (0.55 ml, 2 mmol) and slowly the acid chloride in solution in dichloromethane (5 ml). The reaction mixture is stirred at room temperature for 2 h. The reaction is hydrolyzed with water and then extracted with dichloromethane. The organic phase is dried on anhydrous MgSO4 and then concentrated under vacuum. The products are purified on a silica column in a mixture of cyclohexane and ethyl acetate in a proportion of 8:2.Yield: 70%1H NMR (300 MHz, CDCl3) delta ppm: 0.88 (t, J=6.9 Hz, 3H); 1.25 (m, 18H); 1.68 (m, 6H); 2.45 (t, J=7.5 Hz, 2H); 7.58 (s, 1H); 8.04 (m, 2H); 8.27 (s, 1H); 8.74 (d, J=1.5 Hz, 1H); 8.79 (d, J=1.5 Hz, 1H).13C NMR (50 MHz, CDCl3) delta ppm: 14.1, 22.7, 25.5, 29.4, 29.5, 29.6, 31.9, 37.9, 116.8, 124.0, 130.1, 139.5, 140.2, 143.7, 145.4, 171.9.ESI-MS m/z: 370 ([M+H]+, 100).IR cm-1: 732, 786, 832, 957, 1026, 1217, 1355, 1498, 1542, 1583, 1619, 1671, 1749, 2851, 2921, 3054, 3304

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); US2011/118270; (2011); A1;,
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83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, After dissolving 6-(quinoxalin-6-yl)ethan-1-one (4.6 g, 27.0 mmol) synthesized in Step 1 and diethyl oxalate (7.3 mL, 53.9 mmol) in ethanol (9 mL), a 2 M ethoxysodium solution (26.9 mL, 53.9 mmol) was slowly added dropwise thereto at 50C, and the result was refluxed for 2 hours. After cooling the result to room temperature, the solvent was vacuum concentrated, and the result was acidified by adding 2 M HCl dropwise thereto. Dichloromethane was introduced thereto for extraction, and the organic layer was dried using anhydrous magnesium sulfate and then filtered. The filtrate was concentrated and purified using column chromatography to obtain a target compound (6.7 g). 1H NMR spectrum (300 MHz, CDCl3) delta 8.96(s, 2H), 8.78(s, 1H), 8.35(dd, 1H), 8.24(d, 1H), 7.27(s, 1H), 4.44(q, 2H), 1.45(t, 3H).

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; Hanmi Pharmaceutical Co., Ltd.; LEE, Kyung Ik; JUNG, Young Hee; SONG, Ji Young; JUN, Seung Ah; (89 pag.)EP3480193; (2019); A1;,
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