Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, General procedure: To a solution of S7 (502.3 mg, 1.4 mmol) in THF (10 mL) containing 10 muL DMF was added oxalylchloride (360.0 muL, 0.3 mmol) at room temperature. The solution was stirred for 2 h andconcentrated. The resulting acid chloride S8 (37.0 mg, 0.1 mmol) was reacted with thecorresponding amine (0.2 mmol) and N,N-Diisopropylethylamine (52.3 muL, 0.3 mmol) overnight.The solution was extracted with ethyl acetate (3 mL), washed with citric acid solution, saturatedNaHCO3, and concentrated. The residue was then purified by preparative TLC.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Lee, Hsin-Yu; Suciu, Radu M.; Horning, Benjamin D.; Vinogradova, Ekaterina V.; Ulanovskaya, Olesya A.; Cravatt, Benjamin F.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 16; (2018); p. 2682 – 2687;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 10 ml solution of 3-hydroxy-2-quinoxalinecarboxylic acid in methanol at a concentration of 0. lmol ¡¤ I / 1 was added dropwise to a solution of 5 ml of Co (Cl0) at a concentration of 0.05 mol / 4) 2.6H20 aqueous solution, shake to get a red clear solution, standing at room temperature8 days for self-assembly reaction, to obtain red lumpy crystals, and then followed by anhydrous ethanol, ether washing, drying, that is,A cobalt complex of the formula [Co (qc) 2 (H20) 2] ¡¤ 2H20, wherein qc represents a 3-hydroxy-2-quinoxaline carboxylate represented by the formula(I), yield 54%. The cobalt complex prepared in this example was a mononuclear complex with X-single crystal diffractometer analysis. elementAnalysis: According to the theoretical structure of C18H18CoN4iiq, the calculated value

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing university of information science and technology; Xiao, bo; Chen, MinDong; Liu, qi; (9 pag.)CN103709204; (2016); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

879-65-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (32 mg, 0.101 mmol) obtained in Example 1, (3), quinoxaline-2-carboxylic acid (35 mg, 0.202 mmol), and O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (42 mg, 0.111 mmol) were dissolved in DMF (2.0 mL), then the solution was added with triethylamine (20 mg, 0.202 mmol), and the mixture was stirred over night. The reaction mixture was treated in a conventional manner to obtain the title compound (10 mg, yield 21%) as yellow crystals. 1H NMR (CDCl3, 400MHz) delta: 3.63 (2H, s), 7.07 (1H, d, J=9Hz), 7.33 (2H, d, J=9Hz), 7.62 (2H, d, J=8Hz), 7.71 (1H, t, J=8Hz), 7.8-8.0 (5H, m), 8.09 (1H, d, J=8Hz), 8.1-8.3 (2H, m), 8.50 (1H, s), 9.75 (1H, s), 9.91 (1H, s)

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Nippon Chemiphar Co., Ltd.; USHIODA, Masatoshi; KOBAYASHI, Kunio; SAITO, Daisuke; SAKUMA, Shogo; IMAI, Toshiyasu; INOUE, Kazuhide; EP2803662; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 5 N,N’-Dibutylcarbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride 2-Chloro-3-methylquinoxaline (3.572 g., 0.02 mole) was dissolved in 50 ml. of methanol, treated with Norit and filtered. The filtrate was added to 3.767 g. (0.02 mole) of 1,3-dibutylthiourea dissolved in 25 ml. of methanol. The resulting solution was stirred at room temperature for 1 hour and evaporated on a rotary evaporator. The residual oil was triturated successively with several portions of ether, 2:1 pentane-ether and acetone, and was filtered and washed with pentane, to give 2.60 g. (38.6%) of product as a tan solid, m.p. 97-99. Analysis for: C18 H27 ClN4 S Calculated: C, 58.92; H, 7.41; N, 15.27; Cl, 9.66; S, 8.74. Found: C, 58.93; H, 7.50; N, 15.31; Cl, 9.71; S, 9.01.

32601-86-8, 32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of freshly prepared saturated aqueous ammonia (20mL) and 2-quinoxalinecarboxylate (115mg, 0.612 mmol) was stirred at room temperature for 18 hours. The solution was then evaporated under reduced pressure to yield the product as an off-white solid in quantitative yield. Elemental analysis calcd (%) for C9H7N3O (173.06): Calc. C 62.40 H 4.07 N 24.26; found: C 62.40 H 4.11 N 23.94. 1H NMR (400 MHz, d6-DMSO): delta (ppm) 9.439 (s, 1H, H5), 8.237 (dd, J1-2 = 8 Hz, J1-3 = 2 Hz, 1H, H1), 8.194 (dd, J4-3 = 8 Hz, J4-2 = 0.8 Hz, 1H, H4), 7.997 (q-br, J2/3-3/2/1/4 = 10 Hz, 2H, H2/3).

1865-11-8, The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

59564-59-9, 3,4-Dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 80 5-Methyl-4-(1,2,3,4-tetrahydro-3-oxo-1-quinoxalinyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid Methyl Ester Example 27 (23 mg, 0.1 mmol) was stirred with 1,2,3,4-tetrahydroquinoxalin-2-one (44.4 mg, 0.3 mmol) in DMF (0.5 mL) for 1 hr at 50 C. Water was added and the resulting solid material was collected, washed with water and dried. The material was triturated with methanol, filtered, and dried again to provide 20 mg (59%) of a white solid. 1H NMR (d-DMSO): delta 8.30-8.25 (m, 2H), 7.12-7.03 (m, 2H), 6.83 (br s, 2H), 4.38 (s, 2H), 3.73 (s, 3H), 2.49 (s, 3H), 1.72 (s, 3H)., 59564-59-9

59564-59-9 3,4-Dihydroquinoxalin-2(1H)-one 185949, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol Myers Squibb Company; US6982265; (2006); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0181] To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) were added HATU (13.3 g, 35 mmol. 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and Omicron,Nu- Dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at rt overnight, then the solvent was concentrated. The residue was purified via flash column (PE/EA = 2/1, v/v) t

6925-00-4, As the paragraph descriping shows that 6925-00-4 is playing an increasingly important role.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/49701; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, The first organolithium R3Li (2.5 mmol) is added slowly to a solution of compound D (1 mmol) in anhydrous THF at -78 C. under inert atmosphere of nitrogen. The solution becomes reddish-black. The mixture is stirred at -78 C. for 2.5 h. The mixture is placed at 0 C. and the second organolithium R4Li (2 mmol) is immediately added slowly. The mixture is stirred at 0 C. for 2 h. The reaction is hydrolyzed by a saturated aqueous NH4Cl solution and extracted with ethyl acetate. The organic phase is washed with water saturated with NaCl, dried on anhydrous MgSO4 and concentrated under reduced pressure. The residue obtained is dissolved in CHCl3 (20 ml) and then MnO2 (5 mmol, 430 mg) is added and the mixture carried at reflux for 4 h. The reaction is hydrolyzed and then filtered on celite. The organic phase is dried on anhydrous MgSO4 and concentrated under vacuum. The products are purified on a silica column in a mixture of cyclohexane and ethyl acetate in a proportion of 5:5.Yield: 30%1H NMR (300 MHz, CDCl3) delta ppm: 0.96 (m, 6H); 1.31-1.32 (m, 8H); 1.40-1.52 (m, 2H); 1.68-1.79 (m, 2H); 2.9 (m, 4H); 4.10 (s, 2H); 7.05 (m, 2H); 7.74 (d, J=9.6 Hz, 1H).13C NMR (75 MHz, CDCl3) delta ppm: 13.9, 14.0, 22.5, 29.1, 29.2, 29.3, 29.4, 31.6, 35.1, 35.4, 108.0, 120.5, 129.3, 135.8, 142.5, 146.9, 152.6, 156.6.ESI-MS m/z: 286 ([M+H]+, 40).IR cm-1: 725, 830, 855, 930, 960, 1080, 1135, 1235, 1340, 1465, 1500, 1620, 2925, 2855, 2955, 3215, 3335.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); US2011/118270; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8 N,N’-Bis(2-propenyl)carbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride 2-Chloro-3-methylquinoxaline (3.56 g., 0.02 mole) was dissolved in 50 ml. of methanol, treated with Norit and filtered. The filtrate was added to 3.125 g. (0.02 mole) of 1,3-diallylthiourea in 50 ml. of methanol. The mixture was stirred at room temperature for 31/2 hours, then freed of solvent. Acetone was added to the residue and the solution again freed of solvent. The residue was triturated with ether and with acetone, filtered, washed and dried to give 4.12 g. (61.5% yield), m.p. 90-93 C. Analysis for: C16 H19 ClN4 S Calculated: C, 57.39; H, 5.72; N, 16.73; Cl, 10.59. Found: C, 56.99; H, 5.66; N, 16.58; Cl, 10.77.

32601-86-8, The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-chloro-3-methylquinoxaline (350 mg, 1.96 mmol), 2-amino-1-(piperidin-1-yl)ethanone hydrochloride (445 mg, 2.49 mmol) and DIPEA (1.027 mL, 5.88 mmol) in acetonitrile (4.0 mL) was heated to 100 C for 40 h. The reaction mixture was concentrated and dissolved in ethyl acetate (15 mL) and water (20 mL). The organic layer was separated. The aqueous layer was washed with ethyl acetate (5 x 15 mL). The organic layers were combined, dried through a hydrophobic frit and concentrated in vacuo. The crude material was purified using silica chromatography with a gradient of 0-70 % (3:1 ethylacetate:ethanol + 1 % triethylamine)/cyclohexane. The relevant fractions were combined and concentratedin vacuo to yield 2-((3-methylquinoxalin-2-yl)amino)-1-(piperidin-1-yl)ethanone (182 mg, 0.640 mmol, 32 % yield) as a brown powder. LCMS (High pH, ES+): tR = 0.96 min, [M+H]+ 285.19. 1H NMR (400 MHz, CDCl3) delta 1.59-1.75 (m, 6H), 2.64 (s, 3H), 3.47-3.53 (m, 2H), 3.63-3.69 (m, 2H), 4.33 (d, J = 3.79 Hz, 2H), 6.26 (br. s., 1H), 7.36 (ddd, J = 8.15, 7.01, 1.26 Hz, 1H), 7.51 (ddd, J = 8.27, 7.01,1.39 Hz, 1H), 7.69 (dd, J = 8.34, 1.01 Hz, 1H), 7.83 (dd, J = 8.08, 1.26 Hz, 1H) 13C NMR (101 MHz, CDCl3) delta 20.9, 24.4, 25.5, 26.3, 42.8, 43.3, 45.5, 124.2, 125.7, 128.1, 128.8, 136.9, 141.3, 145.4, 150.2, 166.8 HRMS: (C16H20N4O) [M+H]+ requires 285.1710, found [M+H]+ 285.1702 numax (neat): 3392, 1639, 1582, 1508, 1439, 1253, 1013, 769 cm-1., 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Article; Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A.; Synthesis; vol. 49; 16; (2017); p. 3775 – 3793;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider