Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

Under the protection of nitrogen,Add 3-methyl-2-chloro-quinoxaline (1.78 g, 10 mmol) to a solution of 2-benzylaminoethoxyethanol (9.76 g, 50 mmol) in N-methylpyrrolidone (100 mL).Heated to 190 C reflux for 15 h,The reaction was monitored by LC-MS, and the reaction was completed. The reaction mixture was cooled, and ice water was added to the reaction mixture, which was extracted with ethyl acetate (50 mL*3), and the organic mixed phase was washed with water (100 mL) and saturated brine (100 mL*2) Dry over anhydrous sodium sulfate, filter, decompress the solvent under reduced pressure, and then purified by chromatography on silica gel column.Drying in vacuo gave 2.58 g of white solid compound VIII-2.Yield: 76.8%,, 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Patent; Chengdu Yuandong Bio-pharmaceutical Co., Ltd.; Zhang Tao; Zeng Yanqun; Yan Shengyong; Wang Ying; (22 pag.)CN108774183; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.473932-16-0,2-(Quinoxalin-6-yl)acetic acid,as a common compound, the synthetic route is as follows.

Trimethylsilyldiazomethane [2.0M in hexanes] (0.08?xL) was added dropwise to a solution of quinoxalin-6-yl-acetic acid (0.030g, 0.159mmol) in toluene/methanol [8/1] (0.5mL) and stirred until the bubbling stopped. The reaction was then evaporated and the crude product was purified via silica gel column chromatography in hexane: ethyl acetate (1:1) to give 0.013g of quinoxaJin-6-yl-acetic acid methyl ester. This was added to a solution of hydrazine (O.lOinL) in methanol and stirred at room temperature overnight. The reaction mixture was evaporated in vacuo to give 0.019g of quinoxalin-6-yl-acetic acid hydrazide. 1H NMR (400 MHz, DMSO-d6) 8 9.77 (bs, IH), 9.35 (m, 2H), 8.46 (d, IH, J=8.8Hz), 8.39 (m, IH), 8.19 (dd, IH, J=2.0, 8.8Hz), 4.68 (bs, 2H), 4.07 (s, 2H).

473932-16-0, The synthetic route of 473932-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/75567; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, Step 4A: Quinoxaline-6-carboxylic acid N-methyl-hydrazide HOBT (0.5432 g, 4.020 mmole) and EDC.HCl (0.7732 g, 4.033 mmle) were added to a slurry of 6-quinoxaline carboxylic acid (0.5894 g, 3.384 mmole) in 1:1:2 acetonitrile/THF/DMF (12 mL) at room temperature. The solid slowly dissolved. After 3 hours the solution of activated ester was slowly cannulated into a solution of methylhydrazine (0.370 mL, 6.79 mmole) in acetonitrile (6 mL) at 0 C. After 2 hours the solution was concentrated in vacuo and purified via flash column chromatography (methylene chloride/methanol+1% ammonium hydroxide) to give 0.4258 g of a yellow solid identified as quinoxaline-6-carboxylic acid N-methyl-hydrazide. MS (ESP+) 203.04 (M+1)

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biogen Idec MA Inc.; US2010/56505; (2010); A1;,
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6639-87-8, 6-Nitroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 3-chloro-2-methvl-N-auinoxalin-6-vl-benzenesulfonamide, STX 957:; 6-aminoquinoxaline (KRB01083) :; To a solution of 6-nitroquinoxaline [24] (500 mg, 2.86 mmol) in methanol (20 mL) was added 10% palladium on carbon (50 mg) and the mixture was stirred under 1 atm H2 for 4 h. The mixture was filtered through celite and the filtrate evaporated. The residue was passed through a silica plug and evaporated to afford 6-aminoquinoxaline as a yellow solid (342 mg, 82%), single spot at Rf 0.32 (ethyl acetate).’H NMR (CDCI3) : 8 8.65 (1H, d, J= 1.7 Hz), 8.55 (1H, d, J=1.7 Hz), 7.87 (1H, d, J=8. 9 Hz), 7.18 (1H, dd, J=8.9, 2.5 Hz), 7.13 (1H, d, J=2.5 Hz), 4.20 (2H, br. s,-NH2) [25]., 6639-87-8

The synthetic route of 6639-87-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; STERIX LIMITED; WO2005/42513; (2005); A1;,
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23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation Example I-1. Quinoxaline-6-carboxylic acid To a solution of quinoxaline-6-carboxylic acid methyl ester (2084mg, 11.07mmol) in ethanol (25mL) was added an aqueous solution of 1 N sodium hydroxide (25mL), and the solution was stirred for 4 hours under reflux. 1 N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, then, the precipitated solid was collected by filtration, washed with water and isopropanol, then dried to obtain the title compound (1477mg, 8.479mmol, 76.6%) as a solid. 1H-NMR Spectrum (DMSO-d6) delta (ppm): 8.18 (1 H, d, J=8.4Hz), 8.29 (1H, dd, J=8.4, 1.2Hz), 8.61 (1 H, d, J=1.2Hz), 9.00-9.07 (2H, m)., 23088-23-5

As the paragraph descriping shows that 23088-23-5 is playing an increasingly important role.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; EP1782811; (2007); A1;,
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41959-35-7, 6-Nitro-1,2,3,4-tetrahydroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,41959-35-7

A mixture of 1 ,2,3,4-tetrahydro-6-nitro- quinoxaline (22.324 mmol), di-tert-butyl dicarbonate (22.324 mmol), triethylamine (44.648 mmol) and 4-dimethylaminopyridine (4.465 mmol) in DCM (40 ml) was stirred at room temperature for 2 hours. The reaction mixture was poured onto water and extracted with DCM. The organic layer was decanted, dried over MgSO4, filtered and evaporated to dryness. The residue (7.7g) was purified by HPLC (9Og SiO2 15/40 mum – eluent: DCM 100 to DCM/MeOH 99/1 ). The pure fractions were collected and evaporated to dryness, yielding 3.55g (57%) of intermediate 33.

The synthetic route of 41959-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; WO2009/37343; (2009); A1;,
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83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, General procedure: The following compounds were prepared following a reductive amination procedure like the one described for the preparation of product 11 starting from the corresponding amine and methylketone intermediates using triethyl amine, sodium cyanoborohydride and titanium tetraisopropoxide in DCM. Changes of solvent, reductant are mentioned inTable B below.

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7467-91-6,Quinoxalin-6-ol,as a common compound, the synthetic route is as follows.,7467-91-6

TMAD (0.55 g, 3.20 mmol) was added to a stirred mixture of 2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-pyrazinyloxy]ethanol (1.00 g, 3.08 mmol), 6-hydroxyquinoxaline* (0.45 g, 3.08 mmol) and triphenylphosphine (0.85 g, 3.24 mmol) in THF (10 mL) at room temperature. After 20 h, the reaction mixture was concentrated and put through a silica column using toluene/EtOAc (1 : 1) as eluent. The chromatographic procedure was repeated once. Solvents were removed in vacuo and the resulting N-t-BOC derivative was treated with dichloromethane/TFA/H2O (50: 45: 5; 20 mL) for 30 min with stirring. The reaction mixture was concentrated, dissolved in 0.1 M aqueous HCl and washed with toluene. The aqueous phase was frozen and lyophilized, dissolved in EtOH and concentrated to give 0.843 g (70percent) of the title compound. HRMS m/z calcd for C18H20N6O2 (M) + 352.1648, found 352.1642. *Prepared as described in J. Org. Chem. 1951,16, 438-442.

As the paragraph descriping shows that 7467-91-6 is playing an increasingly important role.

Reference£º
Patent; BIOVITRUM AB; WO2004/9586; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

1593-08-4, This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10.

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1204-75-7, Step E (Compound 5) [00138] 3-Hydroxy-2-quinoxalinecarboxylic acid (2.86 g. /15.0 mmol. ) was suspended in ethanol (75 ml. ). Added (slowly.) was concentrated sulfuric acid (5.0 ml. ) and the reaction mixture was allowed to stir at room temperature overnight. The precipitated product was filtered off and dried under reduced pressure. No further purification, material used as is. Yield: 2.15 g. LC/MS data-Retention time: 1.89 min. in 10-90 gradient. MS+: 219.2.

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/56547; (2005); A2;,
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Quinoxaline | C8H6N2 | ChemSpider