Tag: M.W:100-200

6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6924-66-9, PyBOP (156 mg, 300 muiotaetaomicronIota) was added to a mixture of quinoxaline-5-carboxylic acid (50.0 mg, 95 % purity, 273 muiotaetaomicronIota), 9-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro[5.5]undecan-1 -one (isomer 1 , Intermediate I62) (1 17 mg, 80 % purity, 300 muiotaetaomicronIota) and N,N-diisopropylethylamine (190 muIota, 1 .1 mmol) in DMF (2.8 ml) and the mixture was stirred for 5 h at room temperature. For work-up, the reaction mixture was concentrated and the residue was purified by flash chromatography (dichloromethane/methanol gradient, 0% -> 10% methanol) to give after trituration with methanol the title compound (45 mg).LC-MS (Method 1 ): Rt = 1 .19 min; MS (ESIpos): m/z = 467 [M+H]+1H-NMR (400 MHz, CHLOROFORM-d) delta [ppm] : 0.000 (6.00), 1.500 (16.00), 1.522 (1 16)1.532 (1.31), 1.540 (1.24), 1.550 (1.78), 1 560 (1 39), 1 568 (1 31) 1.578 (1 28), 1 592 (0 63)1.600 (0.57), 1.609 (0.49), 1.683 (1.07), 1 690 (1 09), 1 718 (1 20) 1.724 (1 26), 1 802 (1 09)1.809 (1.01), 1.837 (1.28), 1.843 (1.21), 1 892 (0 52), 1 904 (0 71) 1.920 (1 15), 1 927 (1 38)1.939 (1.65), 1.950 (2.10), 1.973 (3.19), 1 980 (1 79), 1 997 (1 21) 2.010 (1 63), 2 018 (2 38)2.044 (1.85), 2.055 (1.64), 2.068 (1.62), 2 078 (1 23), 2 089 (2 00) 2.099 (2 12), 2 117 (1 87)2.149 (1.86), 2.159 (1.59), 2.166 (1.37), 2 176 (1 05), 2 182 (1 06) 2.199 (1 86), 2 209 (1 45)2.233 (0.84), 2.242 (0.64), 3.417 (0.91), 3 431 (1 72), 3 447 (2 02) 3.462 (2 13), 3 475 (2 12)3.491 (1.41), 3.505 (0.65), 4.068 (0.47), 4 077 (0 49), 4 085 (0 89) 4.096 (1 13), 4 105 (0 89)4.114 (1.12), 4.124 (0.86), 4.142 (0.45), 6 931 (1 58), 6 938 (1 71) 6.951 (1 97), 6 953 (2 21)6.958 (2.18), 6.960 (2.43), 6.973 (1.84), 6 980 (1 97), 7 129 (3 74) 7.134 (3 68), 7 141 (4 30)7.143 (4.53), 7.151 (3.42), 7.154 (3.87), 7 161 (3 63), 7 165 (3 30) 7.180 (0 47), 7 840 (3 12)7.859 (3.92), 7.860 (4.21), 7.879 (3.46), 8 186 (3 53), 8 190 (3 76) 8.207 (3 23), 8 211 (3 17)8.813 (6.84), 8.817 (7.40), 8.840 (3.59), 8 844 (3 65), 8 859 (3 43) 8.863 (3 30), 8 902 (7 05)8.907 (6.43), 10.321 (1.64), 10.340 (1.64)

As the paragraph descriping shows that 6924-66-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

Weighing 2.2mmol (0.348g) quinoxaline-2- formaldehyde in 100 ml flask in three adding proper amount of anhydrous ethanol, heating to reflux, using a 100 ml beaker weighing 1mmol (0.227g) N-ethyl -3,6-diamino-carbazole, adding an amount of ethanol and heating, the in-by-drop in the flask, will soon have the yellow flocculent solid precipitated, the drop finishes, continue to reflux reaction 5h. After the reaction, to take advantage of heat filtering, product a plurality of times with hot ethanol washing, drying, obtain raphide 0.43 g. In accordance with the aforesaid containing structural unit and diphenylenimine quinozaline the molecular structure of the target derivative., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou University of Science and Technology; Qian, Yong; Chen, Wenjing; (5 pag.)CN105348269; (2016); A;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-05-3,2,5-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 2 Preparation of 4-N’,N’-dimethylamino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide A suspension of sodium hydride (60%, 114 mg, 2.85 mmol) in N,N-dimethylformamide (10 ml) under nitrogen at room temperature was treated with p-dimethylaminobenzenesulfonamide (214 mg, 1.07 mmol), and after stirring one hour, solid 2,5-dichloroquinoxaline (231 mg, 1.16 mmol) was added. After stirring overnight, the reaction mixture was poured into water (100 ml) and the pH adjusted to 3-4 by the addition of 1N hydrochloric acid solution. The resulting precipitate was collected, dried and purified by silica gel flash chromatography (EtOAc/hexanes/THF) to yield the title product (56 mg, 14%) as a solid. Analysis of the title compound gave the following results: 1 H NMR (300 MHz, d6 -DMSO)delta2.92(s, 6H, CH3), 6.72 (d, 2H, J=7.8 Hz, Ar-H), 7.68-7.84 (overlapping multiplets, 3H, Ar-H), 7.85 (d, 2H, J=8.0 Hz, Ar-H), 8.61 (s, 1H, Ar-H), 11.78(s, 1H, exchanges with D2 O, NH); IR(KBr) 1600, 1582, 3.448, 1148 and 1089 cm-1; FDMS(DMSO) m/e=362, 364 (M+). Analysis of C16 H15 ClN4 O2 S: Theory: C, 52.96; H, 4.17; N, 15.44. Found: C, 53.17; H, 4.30; N, 15.30., 55687-05-3

55687-05-3 2,5-Dichloroquinoxaline 10679487, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Eli Lilly and Company; US5529999; (1996); A;,
Quinoxaline – Wikipedia
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6344-72-5,6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Methylquinaxoline (100 g, 0.69 mol) was heated in a sealed tube to 160 0C and was then added selenium dioxide (100 g, 0.90 mol). The sealed tube was then stirred at 160 0C for 3 days, then allowed to cool to room temperature. The contents solidified and were dissolved in dichloromethane. Solids were filtered through a celite/silica gel cake. The cake was washed with dichloromethane and washes were combined and concentrated to give a pinkish solid, which was washed with hexane and then dried under vacuum to give quinoxaline-6- carbaldehyde as a white solid (50.5 g, contained ca. 10% of 6-methylquinaxoline).

6344-72-5 6-Methylquinoxaline 242567, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-23-5,6-Fluoroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

55687-23-5, A solution of 6-fluoroquinoxalin-2(1H)-one & 7-fluoroquinoxalin-2(1H)-one (3 g, 18.28 mmol) in POCl3 (20 ml) was refluxed for 3 h. The solvent was evaporated under reduced pressure and the residue was diluted with cold water. The aqueous solution was basified by solid sodium carbonate and extracted with ethyl acetate. The combine organic layer was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography (20% ethyl acetate in pet ether) to afford regioisomers as a mixture. The above mixture was separated by SFC purification to afford 2-chloro-6-fluoroquinoxaline (0.75 g, 44%) and 2-chloro-7-fluoroquinoxaline (0.65 g, 38%) as white solid. 2-chloro-6-fluoroquinoxaline: 1H NMR (400 MHz, DMSO-d6): delta ppm 8.75 (s, 1H), 8.14-8.11 (d, J=12 Hz, 1H), 7.67-7.64 (d, J=12 Hz, 1H), 7.59-7.54 (m, 1H); 19F NMR: delta ppm -107.15 (1F).

As the paragraph descriping shows that 55687-23-5 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael; US2013/115190; (2013); A1;,
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6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-methylquinoxaline (2.0 g, 13.9 mmol), N-bromosuccinimide (3.0 g, 16.9 mmol), and benzoyl peroxide (411 mg, 1.7 mmol) in anhydrous carbon tetrachloride (50 mL) was stirred at reflux for 2 days. Dichloromethane (50 mL) was added after cooling to room temperature. The mixture was extracted with 1 N NaOH (1 x 100 mL) and brine (1 x 100 mL). The organic extract was recovered, dried over MgSO4, filtered, evaporated, and dried in vacuo. The crude product was purified by flash chromatography (0-30% EtOAc/hexanes), affording 6- (bromomethyl)quinoxaline (1.10 g, 35% yield)., 6344-72-5

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
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55687-23-5, 6-Fluoroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-23-5, Intermediate 141: tert-Butyl ?-r2-f7-fluoro-2-oxoquinoxalin-lC2H)- vDethyllpiperidin-4-yl)carbamate andIntermediate 142: tert-Butyl {l-[2-C6-fluoro-2-oxoquinoxalin-lf2H)- yl)ethyl]piperidin-4-yllcarbamateA suspension of a 1:1 mixture of 7-fluoroquinoxalin-2(lH)-one (Intermediate 143) and 6-fluoroquinoxalin-2(lH)-one (Intermediate 144) (1.5 g total, 9.1 mmol) was treated with sodium hydride (60% in oil, 0.44 g, 11.0 mmol) at O0C. The reaction was allowed to stir at room temperature for 2 hours. The reaction mixture was cooled to 0 C and 2-{4-[(tert- butoxycarbonyl)amino]piperidin-l-yl} ethyl methanesulfonate (Intermediate 6, 1.33 mmol/mL, 11.0 mmol), dissolved in dry DMF (5 mL) was added and it was stirred at room temperature overnight. The reaction mixture was diluted with water and with diethyl ether (5x 50 mL). The combined organic phases were dried over sodium sulfate and concentrated to dryness under reduced pressure. Chromatography with hexanes/ acetone (5:1 to 3:1). The higher Rf material was isolated as a mixture of Intermediate 141 with an O-alkylated isomer, which was rechromatographed on silica gel with hexanes/ ethyl acetate (1:3) to give pure Intermediate 141 as a colorless solid, 0.24 g, 14%. Isolation of the lower Rf material from the first column gave 0.38 g (21%) of pure Intermediate 142 as a colorless solid. Intermediate 141:MS QBS): 391 (MH+) for C20H27FN4O31H NMR omegaMSO-D6) delta 1.25-1.38 (m, HH); 1.56-1.68 (m, 2H); 2.01 (t, 2H); 2.50- 2.56 (m, 2H); 2.82-2.93 (m, 2H); 3.16 (s, IH); 4.27 (t, 2H); 6.72 (d, IH); 7.23 (t, IH); 7.50 (d, IH); 7.83-7.91 (m, IH); 8.17 (s, IH). Intermediate 142:MS (ESV 391 (MH+) for C20H27FN4O31H NMR (DMSO-DO’) delta 1.24-1.38 (m, HH); 1.65 (d, 2H); 2.03 (t, 2H); 2.51-2.58 (m, 2H); 2.88 (d, 2H); 3.11-3.26 (m, IH); 4.31 (t, 2H); 6.75 (d, IH); 7.57 (td, IH); 7.63-7.71 (m, 2H); 8.29 (s, IH).

55687-23-5 6-Fluoroquinoxalin-2(1H)-one 12686386, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/134378; (2006); A1;,
Quinoxaline – Wikipedia
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (38.0 mg, 0.200 mmol) to afford the desired title compound (44.6 mg, yield 51%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.82 (1H, brs), 9.56 (1H, brs), 7.85 (1H, t, J=8.0 Hz), 7.63 (1H, dt, J=8.0 Hz, 1.6 Hz), 7.37 (2H, m), 7.04-6.93 (3H, m), 4.90 (1H, t, J=7.6 Hz), 4.61 (1H, m), 3.90-3.40 (4H, m), 3.41 (2H, t, J=5.2 Hz), 2.67 (2H, q, J=8.0 Hz), 2.10 (1H, m), 2.00-1.55 (4H, m), 1.70 (2H, q, J=8.0 Hz), 0.97 (3H, d, J=6.4 Hz), 0.94 (3H, d, J=6.4 Hz). LCMS (ESI, m/z): 525 (M+H)+., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (150 mg, 0.780 mmol), was added to a methylene chloride solution (5.2 ml) of (2S)-1-{4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}-3-methyl-1-oxobutan-2-amine dihydrochloride (200 mg, 0.520 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (102 mg, 0.520 mmol), 1-hydroxybenzotriazole monohydrate (84.3 mg, 0.620 mmol) and N-methylmorpholine (0.343 ml, 3.12 mmol), at room temperature, and stirring was carried out at room temperature for 3 days. Water was added to the reaction solution, followed by extraction with methylene chloride and subsequent sequential washing with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the residue resulting from concentration was suspended in a mixed solvent of ethanol-diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (190 mg, yield 76%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.44 (1H, brs), 10.15 (1H, brs), 8.08 (1H, dd, J=6.3 Hz, 2.7 Hz), 8.02-8.00 (1H, m), 7.61-7.37 (4H, m), 6.70 (1H, t, J=9.2 Hz), 5.32-5.27 (1H, m), 5.09 (1H, t, J=7.4 Hz), 4.06-3.59 (4H, m), 2.34-1.82 (5H, m), 1.14-1.10 (6H, m). IR (KBr) cm-1: 2965, 1690, 1630, 1525, 1465. MS (ESI, m/z): 484 (M+H)+. HRMS (ESI, m/z): 484.1765 (Calcd for C24H27ClN5O4: 484.1752). Anal. Calcd for C24H26ClN5O4: C, 59.56; H, 5.42; N, 14.47; Cl, 7.33. Found: C, 59.48; H, 5.50; N, 14.49; Cl, 7.16.

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of benzhydrazide (1) (0.172 g, 1.27 mmol) in ethanol(15 mL) was added to a solution of quinoxaline2carbaldehyde(2c) (0.2 g, 1.27 mmol) in ethanol (25 mL). The reaction mixture was refluxed for 10 h, then the solvent was distilled off to 1/4volume, and the formed precipitate was filtered off. The yieldwas 0.31 g (89%), m.p. 224-226 . 1 NMR, : 7.55 (m, 2 );7.61 (m, 1 ); 7.84 (m, 2 ); 7.98 (m, 2 ); 8.10 (m, 2 ); 8.66(s, 1 , (3)); 9.55 (s, 1 , CH=N); 12.2 (br.s, 1 , NH).Found (%): , 69.61; , 4.44; N, 20.22. C16H12N4O. Calculated (%): C, 69.55; H, 4.38; N, 20.28., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nosova; Chupakhin; Lipunova; Slepukhin; Valova; Charushin; Russian Chemical Bulletin; vol. 63; 6; (2014); p. 1344 – 1349; Izv. Akad. Nauk, Ser. Khim.; vol. 63; 6; (2014); p. 1344 – 1349,6;,
Quinoxaline – Wikipedia
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