Tag: M.W:100-200

13708-12-8, 5-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1 A mixture of 10 parts of 5-methylquinoxaline, 10 parts of 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione, 1.7 parts of benzenecarboperoxoic acid and 318 parts of tetrachloromethane was stirred for 16 hours at reflux temperature under 2 lamps of 250 Watt. The reaction mixture was cooled and the organic layer was decanted. The product was filtered off and dried, yielding 15.5 parts (100%) of 5-(bromomethyl)quinoxaline (interm. 1)., 13708-12-8

As the paragraph descriping shows that 13708-12-8 is playing an increasingly important role.

Reference£º
Patent; Janssen Pharmaceutica N.V.; US5028606; (1991); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: The following compounds were prepared following a reductive amination procedure like the one described for the preparation of product 11 starting from the corresponding amine and methylketone intermediates using triethyl amine, sodium cyanoborohydride and titanium tetraisopropoxide in DCM. Changes of solvent, reductant are mentioned inTable B below., 83570-42-7

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
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59564-59-9, 3,4-Dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59564-59-9, 24b. 4-methyl-3,4-dihydroquinoxalin-2(1H)-one To a solution of 24a (500 mg, 3.378 mmol) in MeOH (3 mL) was added NaBH3CN (425 mg, 6.76 mmol), paraformaldehyde (102 mg), followed by HOAc (30 muL). The reaction mixture was stirred at rt for 4 h. Another portion of NaBH4CN (212 mg, 3.37 mmol) and parafornaldehyde (51 mg) were added to the reaction mixture along with conc. HCl (10 muL). The reaction mixture was stirred at 50 C. for 5 h and cooled to rt. The pH was adjusted to 8 and the solvent was evaporated under reduced pressure. The desired product was extracted into EtOAc and washed it with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24b (537 mg, 98%) as beige powder. LC-MS ESI m/z 163 [M+H]+.

As the paragraph descriping shows that 59564-59-9 is playing an increasingly important role.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

The compound [IILA2-3] is formed by coupling 5- [1-amino-2- (3-fluorophenyl)- ethyl]-3- (3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt, (IVa2-2) and quinoxaline-2-carboxylic acid or quinoxaline-2-carbonylchloride as shown in step 3 of Scheme 1. This coupling reaction is generally conducted at a temperature from [ABOUT-30C] to about [80C,] preferably from about [0C] to about [25C.] The coupling reaction may occur with a coupling reagent that activates the acid functionality. Exemplary coupling reagents include dicyclohexylcarbodiimide/hydroxybenzotriazole (DCC/HBT), N-3-dimethylaminopropyl-N’-ethylcarbodiimide (EDC/HBT), [2-ETHYOXY-1-] ethoxycarbonyl-1, 2-dihydroquinoline (EEDQ), carbonyl diimidazole (CDI)/dimethylaminopyridine (DMAP), and diethylphosphorylcyanide. The coupling is conducted in an inert solvent, preferably an aprotic solvent, such as [ACETONITRILE,] [DICHLOROMETHANE,] chloroform, or N, N-dimethylformamide. One preferred solvent is methylene chloride. In one embodiment, quinoxaline acid is combined with methylene chloride, oxalyl chloride and a catalytic amount of N, N-dimethylformamide to form an acid chloride complex. The compound IVa2-2 is added to the acid chloride complex followed by triethylamine at a temperature from about [0C] to about [25C] to form the compound [ILLA2-3.]

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2004/14875; (2004); A1;,
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67074-63-9, 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67074-63-9

24c. 1,2,3,4-tetrahydroquinoxaline To a solution of 24b (300 mg, 1.85 mmol) in THF (2 mL) was added 1N LiAlH4 (10 mL, 10 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was quenched with H2O (1 mL) at 0 C., 15% NaOH (1 mL), followed by H2O (1 mL). The reaction mixture was extracted with EtOAc. The EtOAc was then washed with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24c (260 mg, 95%) as white powder. LC-MS ESI m/z 149 [M+H]+.

67074-63-9 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one 12938663, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A sealable reaction tube equipped with a magnetic stirrer bar was charged with azaarenes (1.0 mmol), sodium benzenesulfinate (2 equiv), TBAI (0.2 equiv), tert-butyl peroxybenzoate (TBPB, 1 equiv), and water (1 ml). The reaction was carried out at 100 C. After completion, the result was diluted with diethyl ether, washed with water and brine, and dried with Mg2SO4. After solvent removal under reduced pressure, the residue was purified by column chromatography on silica gel to afford the corresponding product., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Dong, Dao-Qing; Gao, Xing; Li, Li-Xia; Hao, Shuang-Hong; Wang, Zu-Li; Research on Chemical Intermediates; vol. 44; 12; (2018); p. 7557 – 7567;,
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6925-00-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

PyAOP 308 mg, 0.59 mml , 1.2 eq) was added to a suspension of quinoxaline-6-carboxylic acid (94 mg, 0.54 mmol, 1.1 eq) in DCM (2.0 mL).6-(4-isopropyl-4H-1,2,4- triazol-3-yl)pyridin-2-amine (100 mg, 0.49 mmol, 1.0 eq) and Et3N (0.16 mL, 1.13 mmol, 2.3 eq) were added and the reaction was stirred overnight. The reaction was partitioned between EtOAc and H2O. The layers were separated and the organic layer was washed with sat. NaHCO3, 10% citric acid, and brine. The organic layer was dried (MgSO4), filtered, and concentrated under reduced pressure. The resultant orange gum was purified by column chromatography eluting with DCM/MeOH (0% MeOH , 8% MeOH) to afford Example 1 (23.7 mg, 0.07 mmol, 13%) as a colorless amorphous solid: LCMS (ESI) m/z 360.15 (M+1).

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; WANG, Guoqiang; GRANGER, Brett; SHEN, Ruichao; HE, Yong; XING, Xuechao; MA, Jun; LONG, Jiang; HE, Jing; WANG, Bin; OR, Yat, Sun; (131 pag.)WO2018/218042; (2018); A1;,
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6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6344-72-5, Example 292 Synthesis of 6-(bromomethyl)quinoxaline. To a solution of 6-methylquinoxaline (5 g, 34.7 mmol) in DCE (100 mL) was added NBS (7.12 g, 40 mmol) and benzoyl peroxide (840 mg, 3.47 mmol). The reaction mixture was stirred at 85 C. for 16 h under nitrogen. H2O (100 mL) was added, and the mixture was extracted with DCM (150 mL*3). The combine organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo to give the crude product which was purified by silica gel chromatography (PE/EtOAc=1/1) to give 6-(bromomethyl)quinoxaline as a yellow solid. (5.5 g, 71%). ESI-MS [M+H]+: 224.1.

As the paragraph descriping shows that 6344-72-5 is playing an increasingly important role.

Reference£º
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
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1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The requisite aldehyde (0.560 mmol) was dissolved in EtOH (3 mL) before sequential addition of piperidine (0.056 mmol) and rhodanine (0.560 mmol). The flask was sealed, heated to 70 C for 16 h and cooled to room temperature. Water (10 mL) was added and the resulting precipitate filtered, washing with water, ice-cooled EtOH and Et2O. The remaining solid was collected and dried under vacuum.

1593-08-4, The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bataille, Carole J.R.; Brennan, Meabh B.; Byrne, Simon; Davies, Stephen G.; Durbin, Matthew; Fedorov, Oleg; Huber, Kilian V.M.; Jones, Alan M.; Knapp, Stefan; Liu, Gu; Nadali, Anna; Quevedo, Camilo E.; Russell, Angela J.; Walker, Roderick G.; Westwood, Robert; Wynne, Graham M.; Bioorganic and Medicinal Chemistry; vol. 25; 9; (2017); p. 2657 – 2665;,
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