Tag: M.W:100-200

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

From the resulting compound (144 mg, 0.500 mmol), through condensation with 3-hydroxyquinoxaline-2-carboxylic acid (95.1 mg, 0.500 mmol), a mixture containing the desired title compound was afforded. Repurification by preparative TLC afforded the desired title compound (28.5 mg, yield 13%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.85 (1H, brs), 9.79 (1H, brs), 7.88 (1H, d, J=8.2 Hz), 7.68-7.55 (1H, m), 7.41-7.30 (2H, m), 7.17-7.08 (2H, m), 7.07-6.98 (2H, m), 4.59 (1H, m), 4.28 (2H, d, J=4.6 Hz), 4.00-3.20 (4H, m), 2.04-1.85 (2H, m), 1.71-1.48 (2H, m). IR (KBr) cm-1: 2950, 1695, 1650, 1620, 1505, 1210. MS (ESI, m/z): 425 (M+H)+. HRMS (ESI, m/z): 425.1626 (Calcd for C22H22FN4O4: 425.1625).

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, To a stirred solution of 1-(quinoxalin-6-yl)ethan-1-one (0.8 g,4.65 mmol) in dry methanol (20 mL) at 0 C, NaBH4 (0.36 g, 9.30 mmol) was added portion wise and the resulting mixture was stirred for 1 h. After completion of the reaction (monitored by TLC), the mixture was quenched with ice cold water and the aqueous layer was extracted with DCM (2 x 40 mL). The combined organic layer was washed with water (20 mL), dried over anhydrous Na2S04 and concentrated under vacuum. The resulting crude material was forwarded to the next step without any further purification. Yield: 75% (600 mg, dark brown liquid). 1H NMR (400 MHz, DMSO-cfe): delta 8.91-8.89 (m, 2H), 8.03 (t, J = 1 1.6 Hz, 2H), 7.87-7.86 (m, 1 H), 5.49 (d, J = 5.9 Hz, 1 H), 4.98-4.97 (m, 1 H), 1.42 (d, J = 8.6 Hz, 3H). LCMS: (Method A) 175.0 (M+H), Rt. 1.89 min, 95.0% (Max).

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S.A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (134 pag.)WO2019/37860; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80636-30-2,3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

80636-30-2, A solution of the compound obtained in the above step (1) (300 mg) in concentrated sulfuric acid (12 mL) was cooled to -15 C, and thereto was added dropwise a solution of nitric acid (44 muL) in concentrated sulfuric acid (0.6 mL). The mixture was stirred at the same temperature for 3 hours. To the reaction mixture was added sodium hydroxide (5.4 g) and ice, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and brine, dried over sodium sulfate and concentrated in vacuo. The resultant residue was suspended in ethyl acetate- diethylether, and the precipitates were collected by filtration. The resultant solid was purified by column chromatography on NH-silica gel (Chromatorex NH-silica gel, solvent; n-hexane/ethyl acetate = 4/1 ? 1/4) to give 3,3-dimethyl-6-nitro-3,4- dihydro- quinoxalin-2(lH)-one (26 mg) as a yellow powder. MS(APCI) m/z: 222 [M+H]+

As the paragraph descriping shows that 80636-30-2 is playing an increasingly important role.

Reference£º
Patent; TANABE SEIYAKU CO., LTD.; WO2007/89034; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

INTERMEDIATE: (3-Methyl-quinoxalin-2-yl)-hydrazine (Ha). 2-Oxo-propanoic acid methyl ester (9.0 mL) was added to a solution of 1,2-benzenediamine (10.8 g) in methanol (80 mL). The resulting suspension was refluxed for 10 min before it was cooled to ambient temperature. The precipitated solid was filtered off and dried to afford 3-methyl-lH-quinoxalin-2-one (15.3 g) sufficiently pure for the next step. 1.60 g of this material was dissolved in phosphoryl chloride (10 mL) and heated under MW conditions at 130 C for 0.5h. The volatiles were removed in vacuo, and the residue was treated with ice/water to quench excess phosphoryl chloride. Diethyl ether and brine were added and the organic layer was dried over Na2SO i, filtered, and concentrated in vacuo to afford 2-chloro-3- methyl-quinoxaline (1.7 g) sufficiently pure for the next step. This material was dissolved in ethanol (150 mL) and hydrazine hydrate (2.43 mL) was added. The mixture was refluxed for 1.5h. The volatiles were removed in vacuo, and the residual solid was washed with water, filtered off and dried Ila (1.2 g) sufficiently pure for the next step., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; H. LUNDBECK A/S; J?RGENSEN, Morten; BRUUN, Anne, Techau; RASMUSSEN, Lars, Kyhn; LARSEN, Mogens; WO2013/34755; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6639-87-8,6-Nitroquinoxaline,as a common compound, the synthetic route is as follows.

6639-87-8, [0170] To a solution of 6-nitroquinoxaline (2.2 g, 12.57 mmol, 1.0 eq) in MeOH, was added dropwise Ranney-Ni (0.7 mL) and hydrazine hydrate (5 mL) was added at 0 C. The mixture was stirred for 2 h at RT. The mixture was filtered and washed with MeOH. The solid was dried under vacuo to give the product (1.8 g, yield: 98.75%>). LC/MS: m/z (M++l) = 146. 42C. Preparation of N-methylquinoxalin-6-amine

As the paragraph descriping shows that 6639-87-8 is playing an increasingly important role.

Reference£º
Patent; PHARMARESOURCES (SHANGHAI) CO., LTD.; CHEN, Ping; ZHOU, Ding; SHAO, Shaoping; CAI, Zhen-wei; WO2013/6792; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, To a solution of 8-methyl-2-phenylquinoline-3-carboxaldehyde (80 mg, 0.32 mmol) in THF (5 mL) was added di-w-butyltin dichloride (10 mg, 0.032 mmol), phenylsilane (70 mg, 0.64 mmol) and 6-aminoquinoxaline (46 mg, 0.32 mmol). The mixture was heated in a microwave at 1000C for 3 h. Purification by preparative HPLC {Method 2) gave the title compound as an off-white solid (45 mg, 37%). deltaH (CDCl3) 8.61 (d, J2.1 Hz, IH), 8.51 (d, J 1.9 Hz, IH), 8.24 (s, IH), 7.84 (d, J9.0 Hz, IH), 7.71-7.76 (m, IH), 7.61-7.66 (m, IH), 7.40-7.58 (m, 6H), 7.10 (dd, J9.2, 2.6 Hz, IH), 6.88 (d, J2.6 Hz, IH), 4.64-4.69 (m, 2H), 4.52-4.60 (m, IH), 2.82 (s, 3H). LCMS (ES+) 377.2 (M+H)+, RT 4.23 minutes {Method 4).

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; WO2009/81105; (2009); A2;,
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34117-90-3, 3-Chloroquinoxalin-2-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthetic procedure for the preparation of (0): In a 5mL round bottom flask, aminopyrazine (250 mg, 1.3 mmol, 1 eq.), diazo compound (968 mg, 3.48 mmol, 2.5 eq.), Rh2(OAc)4 (61.52 mg, 0.139 mmol 10 mol %), and 3 mL of chlorobenzene were placed. The reaction mixture was heated at 100C for 24 hours. The progress of the reaction was monitored by LCMS. After 24 hours, the reaction reached 100% conversion. The mixture was adsorbed on celite and purified on silica column using 40% EtOAc in Heptane as eluent. Yield, 469 mg, 78.4%

34117-90-3, The synthetic route of 34117-90-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROMEGA CORPORATION; HALL, Mary; KIRLAND, Thomas; MACHLEIDT, Thomas; SHAKHMIN, Anton; WALKER, Joel, R.; (141 pag.)WO2018/22865; (2018); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

In a 250 mL round bottom flask,Add 2.1078g (2.0 mmol) of bis[tris(2-methyl-2-phenylpropyl)]tin oxide, 0.6975g (4.0 mmol) of quinoxaline-2-carboxylic acid, and 60 mL of toluene in order. Put on a Dean-Stark trap, heat and reflux at 112-120 for 12 h. After the reaction was completed, filter while hot, and the filtrate was removed with a rotary evaporator to obtain a white solid, which was recrystallized from ethanol, which was tri(2-methyl-2-phenylpropyl)tinquinoxaline-2-carboxylic acid Ester complex. Yield: 79%,

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Hengyang Normal University; Zhu Xiaoming; Yu Jiangxi; Jiang Wujiu; Feng Yonglan; Kuang Daizhi; Ou Yaping; Zhang Fuxing; (14 pag.)CN111116637; (2020); A;,
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55687-23-5, 6-Fluoroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55687-23-5

Lithium hydride (57 mg, 7.3 mmol) was added to a solution of 6-fluoroquinoxalin-2(1 H)one (1 g, 6.0 mmol) in N,N-dimethylformamide (6 ml) under cooling on ice and the mixture was stirred at room temperature for 30 minutes. The mixture was cooled on ice again and a solution of 2-(2-bromoethyl)-1,3-dioxolane (0.88 ml, 7.3 mmol) in N,N-dimethylformamide (2 ml) was gradually added thereto and the mixture was stirred for 4 hours. Water was added thereto, the mixture was then extracted with ethyl acetate, and the extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to yield 0.5 g (32%) of the title compound. 1H-NMR(400MHz,DMSO-d6)delta:1.93-1.99(2H,m),3.76-3.80(2H,m),3.89-3.92(2H,m),4.23-4.27(2H,m),4.96-4.99(1H,m),7.17-7.28(1H,m),7.45-7.48(1H,m),7.88-7.90(1 H,m),8.18(1 H,s). MS(ESI)m/z:265(M+H)+.

The synthetic route of 55687-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; INAGAKI, Hiroaki; FUJISAWA, Tetsunori; ITOH, Masao; YOKOMIZO, Aki; TSUDA, Toshifumi; HIGUCHI, Saito; DAS, Biswajit; KATOCH, Rita; UPADHYAY, Dilip, J.; EP2674430; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59564-59-9,3,4-Dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

59564-59-9, 24b. 4-methyl-3,4-dihydroquinoxalin-2(1H)-one To a solution of 24a (500 mg, 3.378 mmol) in MeOH (3 mL) was added NaBH3CN (425 mg, 6.76 mmol), paraformaldehyde (102 mg), followed by HOAc (30 muL). The reaction mixture was stirred at rt for 4 h. Another portion of NaBH4CN (212 mg, 3.37 mmol) and parafornaldehyde (51 mg) were added to the reaction mixture along with conc. HCl (10 muL). The reaction mixture was stirred at 50 C. for 5 h and cooled to rt. The pH was adjusted to 8 and the solvent was evaporated under reduced pressure. The desired product was extracted into EtOAc and washed it with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24b (537 mg, 98%) as beige powder. LC-MS ESI m/z 163 [M+H]+.

The synthetic route of 59564-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
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