Tag: M.W:100-200

17056-99-4, Quinoxalin-5-ol is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. Diethylthiocarbamic acid O-quinoxalin-5-yl ester. ; A mixture of 5-hydroxyquinoxaline (2.13 g, 14.6 mmol), finely ground K2CO3 (4.0 g, 29 mmol), and DMF (50 mL) was stirred at 23 C. for 1 h. Solid diethylthiocarbamoyl chloride (2.439 g, 16.1 mmol) was then added. The resulting mixture was stirred for 2 h, then was diluted with water (150 mL) and extracted with Et2O (2¡Á100 mL). The combined organic extracts were washed with water (100 mL) and brine (100 mL), then dried and concentrated to a viscous orange oil, which was used without purification (3.63 g, 95%). MS (ESI+): mass calcd. for C13H15N3OS, 261.1; m/z found, 262 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.85-8.65 (m, 2H), 7.96 (dd, J=8.5, 1.1, 1H), 7.71 (t, J=7.9, 1H), 7.46 (dd, J=7.6, 1.2, 1H), 3.87 (q, J=7.1, 2H), 3.78 (q, J=7.1, 2H), 1.38 (t, J=7.1, 3H), 1.28 (t, J=7.1, 3H). 13C NMR (125 MHz, CDCl3): 186.6, 149.4, 144.9, 144.5, 143.4, 137.0, 128.9, 127.0, 123.1, 48.2, 44.5, 13.1, 11.5.

17056-99-4, The synthetic route of 17056-99-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allison, Brett; Phuong, Victor K.; Pippel, Marna C.W.; Rabinowitz, Michael H.; Venkatesan, Hariharan; US2006/69286; (2006); A1;,
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6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl (4-nitrophenyl) butane-1,4-diyldicarbamate (3) (550 mg,1.55 mmol), quinoxalin-6-amine (339 mg,2.33 mmol), DMF (6.6 mL), and Et3N (0.43 mL, 3.11 mmol) in a 20 mL microwave vial washeated in a Biotage microwave at normal absorption for 2.75 h at 80 C. Solvent was removed invacuo. The crude product was purified on a silica cartridge (40 g) with a CombiflashCompanion, eluting at 35 mL/min with a gradient running from 100% DCM to 100 % EtOAcover 55 min to afford the free base tert-butyl (4-(3-(quinoxalin-6-yl)ureido)butyl)carbamate (334mg, 0.890 mmol, 60 % yield) LCMS (ES)+ [M+H]+ = 360.2 (0.78 min).

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Boehm, Jeffrey; Davis, Roderick; Murar, Claudia E.; Li, Tindy; McCleland, Brent; Dong, Shuping; Yan, Hongxing; Kerns, Jeffrey; Moody, Christopher J.; Wilson, Anthony J.; Graves, Alan P.; Mentzer, Mary; Qi, Hongwei; Yonchuk, John; Kou, Jen-Pyng; Foley, Joseph; Sanchez, Yolanda; Podolin, Patricia L.; Bolognese, Brian; Booth-Genthe, Catherine; Galop, Marc; Wolfe, Lawrence; Carr, Robin; Callahan, James F.; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 579 – 588;,
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67074-63-9, 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

24c. 1,2,3,4-tetrahydroquinoxaline To a solution of 24b (300 mg, 1.85 mmol) in THF (2 mL) was added 1N LiAlH4 (10 mL, 10 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was quenched with H2O (1 mL) at 0 C., 15% NaOH (1 mL), followed by H2O (1 mL). The reaction mixture was extracted with EtOAc. The EtOAc was then washed with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24c (260 mg, 95%) as white powder. LC-MS ESI m/z 149 [M+H]+., 67074-63-9

As the paragraph descriping shows that 67074-63-9 is playing an increasingly important role.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6344-72-5,6-Methylquinoxaline,as a common compound, the synthetic route is as follows.

6344-72-5, Example 10 Synthesis of 6-n-butylaminomethyl-quinoxaline In a 50 ml flask, 6-methyl-quinoxaline (1.25 g, 8.68 mmol) was dissolved together with N-bromosuccinimide (2.32 g, 13.0 mmol) and benzoyl-peroxide (0.15 g, 0.62 mmol) in 31 g of chlorobenzene. The solution was stirred with heating at 85 C for 2.0 hours to yield a reddish solution. The solution was cooled down to room temperature and one volume of pentane was added to facilitate the removal of succinimides. The precipitate was washed with pentane and the extracts were combined with the chlorobenzene solution. The yellow solution was vacuum dried to give a yellow residue mainly composed of 6-bromomethyl-quinoxaline. The yellow solid was dissolved in 19.0 g of n-butylamine to give a yellow solution that was stirred at room temperature for ~5 minutes. Analysis of a sample showed that the 6-bromomethyl-quinoxaline was consumed to give exclusively 6-n-butylaminomethyl-quinoxaline as a deep yellow oil (1.71 g, 92% over all yield). MS (70 ev): 215 M+, 172 (M+-CH3-CH2-CH2), 143 (M+-CH3-CH2-CH2-CH2).

6344-72-5 6-Methylquinoxaline 242567, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Air Products and Chemicals, Inc.; US6548670; (2003); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: The aniline (10 mmol) was combined with the aldehyde (10 mmol) in 20 mL of absolute ethanol. To this solution was added glacial acetic acid (ca. 0.1 mL) and the mixture is stirred at room temperature for 12 h. The solvent was then removed and the crude product was dried under high vacuum for overnight to give pure imine product with quantitative yield.

1593-08-4, The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vuong, Hien; Klumpp, Douglas A.; Synthetic Communications; vol. 49; 2; (2019); p. 316 – 323;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of quinoline-6-carboxylic acid (3.48 g; 20 mmol) and thionylchloride (10 ml; 137 mmol) was stirred at 60 C. for 4 hours. The mixture was allowed to cool to room temperature. The solid quinoline-6-carboxylic acid chloride was washed with diethyl ether., 6925-00-4

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Peters, Dan; Christensen, Jeppe Kejser; Harps¡ãe, Kasper; Liljefors, Tommy; US2009/286797; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

Step B – Synthesis of Int-21BInt-21 A (1.20 g, 6.7 mmol) was combined with 1-phenyl-3-bromopropane-1,2-dione (1.67 g, 7.4 mmol, prepared as a yellow oil by bromination in CHCl3 at 50 C, followed by chromatography) in THF (10 mL) and ether (15 mL). The mixture was stirred 18 h, concentrated, treated with ethanol (40 mL), heated at 90 C for 72 h, and allowed to cool.Concentration, addition of methanol (10 mL), and filtration gave Int-21B as a brown solid., 34117-90-3

As the paragraph descriping shows that 34117-90-3 is playing an increasingly important role.

Reference£º
Patent; SCHERING CORPORATION; HARRIS, Joel, M.; NEUSTADT, Bernard, R.; STAMFORD, Andrew, W.; WO2011/60207; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 8-amino-2-(2-chlorophenyl)-2-azaspiro[4.5]decan-1-one (isomer 1 Intermediate I35), (80.0 mg, 287 muetaiotaomicronIota) in DMF (2.6 ml) was added PyBOP (149 mg, 287 muiotaetaomicronIota), N,N-diisopropylethylamine (180 muIota, 1.0 mmol) quinoxaline-5-carboxylic acid (45.4 mg, 261 muiotaetaomicronIota) and the reaction was stirred for 6 h at room temperature. For work-up, water (45 ml) and methanol (2 ml) were added and the mixture was stirred for 1 h. The resulting precipitate was collected by filtration, washed with water/methanol (4:1) and dried to give the title compound 88.0 mg.LC-MS (Method 1 ): Rt = 1.11 min; MS (ESIpos): m/z = 435 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.511 (1.32), 1.535 (1.90), 1.553 (1.86), 1.566 (1.15), 1.583 (0.94), 1.701 (6.81), 1.710 (7.70), 1.718 (4.21), 1.727 (4.89), 2.031 (2.37), 2.040 (2.45), 2.062 (2.30), 2.072 (2.09), 2.151 (3.91), 2.167 (7.46), 2.185 (4.20), 2.327 (0.71), 2.523 (2.11), 2.669 (0.74), 3.639 (4.24), 3.657 (7.45), 3.674 (4.09), 3.893 (0.95), 3.902 (1.18), 3.912 (0.99), 3.921 (1.16), 3.931 (0.92), 7.366 (0.91), 7.378 (2.34), 7.384 (0.94), 7.389 (2.78), 7.395 (1.80) 7.397 (1.97), 7.408 (5.72), 7.414 (9.89), 7.417 (11.90), 7.426 (4.60), 7.431 (1.87), 7.563 (2.52) 7.567 (4.20), 7.570 (2.67), 7.582 (2.11), 7.585 (3.42), 7.588 (2.18), 7.962 (3.09), 7.980 (3.80) 7.983 (4.01), 8.001 (3.67), 8.255 (4.10), 8.259 (4.31), 8.276 (3.62), 8.279 (3.59), 8.432 (3.87) 8.436 (3.99), 8.451 (3.77), 8.454 (3.48), 9.074 (3.30), 9.079 (16.00), 9.086 (3.50), 9.774 (2.94) 9.793 (2.89), 6924-66-9

As the paragraph descriping shows that 6924-66-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

2-Amino-3-chloroquinoxaline (2a). The compound was synthesized by a slightly modified version of the procedure of Saikachi and Tagami [1] using a reaction temperature of only 80 C. Compound 1 (8.0 g, 40.2 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (60 mL) and heated to 80 ?C. Then, ammonia gas was bubbled through the hot solution for 3 h while the reaction was monitored by TLC. The crude product was poured into water (100 mL). The precipitate was collected by filtration, dried over CaCl2 and crystallized from chloroform to give 4.8 g (63%) pale yellow crystals, mp. 137-139 C. The NMR data are in accordance with a semihydrate. 1H-NMR (CDCl3): delta 1.85 (br, 1 H, 0.5 H2O), 5.53 (br s, 2 H, NH2), 7.47 (td, 3J = 8.3, 6.8, 4J = 1.7 Hz, 1 H, H-6), 7.63 (td, 3J = 8.3, 6.8, 4J = 1.4 Hz, 1 H, H-7), 7.69 (ddd, 3J = 8.3, 4J = 1.5, 5J = 0.5 Hz, 1 H, H-8), 7.86 ppm (ddd, 3J = 8.2, 4J = 1.3, 5J = 0.5 Hz, 1 H, H-5). 13C-NMR (CDCl3): delta 125.4 (CH-6), 126.1 (CH-8), 128.1 (CH-5), 130.6 (CH-7), 137.1, 137.3 (Cq-4a, Cq-3), 140.3 (Cq-8a), 148.7 ppm (Cq-2). MS (EI 70 eV, 165 ?C): m/z (%) = 181 (30) [M+(37Cl)], 179 (100) [M+(35Cl)], 144 (84), 117 (23), 102 (8), 90 (26), 44 (81). Water was separated by azeotropic distillation with toluene at normal pressure. Residual toluene was removed in vacuum. Anal. Calcd for C8H6ClN3 (179.61 gmol-1): C, 53.50; H, 3.37; N 23.40. Found: C, 53.59; H, 3.40; N 22.96.

2213-63-0, The synthetic route of 2213-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adam, Mohamed Shaker S.; Mohamad, Ahmad Desoky; Jones, Peter G.; Kindermann, Markus K.; Heinicke, Joachim W.; Polyhedron; vol. 50; 1; (2013); p. 101 – 111;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, EXAMPLE 8 Preparation of 5-chloro-7-[2-(pyridin-2-yl)ethyl]-2-(quinoxalin-2-yl)-benzoxazole This is prepared from 2-amino-4-chloro-6-[2-(pyridin-2-yl)ethyl]phenol and 2-quinoxaline carboxylic acid using method B to give the intermediate amide (32%). This is cyclised with methanesulphonic acid in toluene with azeotropic removal of water with a Dean-Stark trap to give the title compound as a white crystalline solid (9%), m.p 182-183 C. TLC (SiO2, EtOAc:hexanes 1:1, Rf=0.27). Mass spectrum CI (methane) m/z=387 [M+H]+.

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Euro-Celtique, S.A.; US6166041; (2000); A;,
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