Tag: M.W:100-200

SDS of cas: 57825-30-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Phenylboronic acid-catalyzed tandem construction of S-S and C-S bonds: a new method for the synthesis of benzyl disulfanylsulfone derivatives from S-benzyl thiosulfonates. Author is Jannapu Reddy, Raju; Waheed, Md.; Rama Krishna, Gamidi.

A unique phenylboronic acid-catalyzed dimerization-sulfonylation of S-benzyl thiosulfonates has been disclosed. A metal-free tandem construction of S-S and C-S bonds is an operationally simple method to access a wide range of benzyl disulfanylsulfone derivatives I (Ar1 = C6H5, 4-ClC6H5, 1-naphthyl, etc.; Ar2 = C6H5, 4-MeOC6H5, 2-thienyl, etc.) in high to excellent yields. Moreover, the robustness of this tandem transformation has been demonstrated by gram-scale reactions, and a plausible mechanism is also proposed.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The effect of vinyl esters on the enantioselectivity of the lipase-catalyzed transesterification of alcohols, published in 2001-03-19, which mentions a compound: 57825-30-6, Name is 1-(Bromomethyl)-4-ethylbenzene, Molecular C9H11Br, Application In Synthesis of 1-(Bromomethyl)-4-ethylbenzene.

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol (I) was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alc. was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, resp. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalyzed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of I was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-I and then the enantioselective hydrolysis of the resultant ester to afford (S)-I.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1127-45-3, is researched, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2Journal, Advanced Synthesis & Catalysis called Aqueous biphasic oxidation: a water-soluble polyoxometalate catalyst for selective oxidation of various functional groups with hydrogen peroxide, Author is Sloboda-Rozner, Dorit; Witte, Peter; Alsters, Paul L.; Neumann, Ronny, the main research direction is tungsten zinc polyoxometalate preparation water soluble catalyst hydrogen peroxide; alc diol pyridine amine aniline derivative aqueous oxidation catalyst; ketone carboxylic acid nitrogen oxide oxime azoxy nitro compound.COA of Formula: C9H7NO2.

A “”sandwich”” type polyoxometalate, Na12[WZn3(H2O)2][(ZnW9O34)2], was used as an oxidation catalyst in aqueous biphasic reaction media to effect oxidation of alcs., diols, pyridine derivatives, amines and aniline derivatives with hydrogen peroxide. The catalyst was shown by 183W NMR to be stable in aqueous solutions in the presence of H2O2 and showed only minimal non-productive decomposition of the oxidant. Secondary alcs. were selectively oxidized to ketones, while primary alcs. tended to be oxidized to the corresponding carboxylic acids, although secondary alcs. were selectively oxidized in the presence of primary alcs. Vicinal diols yielded carbon-carbon bond cleavage products in very high yields. Pyridine derivatives were oxidized to the resp. N-oxides, but strongly electron-withdrawing moieties inhibited the oxidation reaction. Primary amines were oxidized to the oximes, but significantly hydrolyzed in situ. Aniline derivatives were oxidized to the corresponding azoxy or nitro products depending on the substitution pattern in the aromatic ring. Catalyst recovery and recycle was demonstrated.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Buchynskyy, Andriy; Gillespie, J. Robert; Hulverson, Matthew A.; McQueen, Joshua; Creason, Sharon A.; Ranade, Ranae M.; Duster, Nicole A.; Gelb, Michael H.; Buckner, Frederick S. researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).COA of Formula: C9H11Br.They published the article 《Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors》 about this compound( cas:57825-30-6 ) in Bioorganic & Medicinal Chemistry. Keywords: aminoethyl benzyloxyphenyl benzamide derivative preparation Trypanosoma brucei; Hit-to-lead optimization; Human African Trypanosomiasis; Trypanosoma brucei inhibitor; “Sleeping Sickness”. We’ll tell you more about this compound (cas:57825-30-6).

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-Ph benzamides as a starting point for hit-to-lead medicinal chem. Eighty two analogs were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50 = 0.001 μM. The compounds displayed drug-like properties when tested in a number of in vitro assays. Compound 73 was orally bioavailable and displayed good plasma and brain exposure in mice, cured 2 out of 3 mice infected with Trypanosoma brucei in acute model when dosed orally at 50 mg/kg once per day for 4 days. Given its potent antiparasitic properties and its ease of synthesis, compound 73 represents a potential lead for the development of drug to treat Human African Trypanosomiasis.

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Product Details of 57825-30-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors. Author is Buchynskyy, Andriy; Gillespie, J. Robert; Hulverson, Matthew A.; McQueen, Joshua; Creason, Sharon A.; Ranade, Ranae M.; Duster, Nicole A.; Gelb, Michael H.; Buckner, Frederick S..

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-Ph benzamides as a starting point for hit-to-lead medicinal chem. Eighty two analogs were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50 = 0.001 μM. The compounds displayed drug-like properties when tested in a number of in vitro assays. Compound 73 was orally bioavailable and displayed good plasma and brain exposure in mice, cured 2 out of 3 mice infected with Trypanosoma brucei in acute model when dosed orally at 50 mg/kg once per day for 4 days. Given its potent antiparasitic properties and its ease of synthesis, compound 73 represents a potential lead for the development of drug to treat Human African Trypanosomiasis.

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Qi, Zaojuan; Li, Weihe; Niu, Yanning; Benassi, Enrico; Qian, Bo published the article 《A General Method for the Dibromination of Vicinal sp3 C-H Bonds Exploiting Weak Solvent-Substrate Noncovalent Interactions》. Keywords: dibromoalkyl benzene preparation; arylethane dibromination.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Recommanded Product: 57825-30-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A general procedure of 1,2-dibromination of vicinal sp3 C-H bonds of arylethanes using N-bromosuccinimide as the bromide reagent without an external initiator was established. The modulation of the strength of the intermol. noncovalent interactions between the solvent and arylethane ethanes, quant. evaluated via quantum chem. calculations, allowed to circumvent the fact that arylethane ethane cannot be dibrominated through traditional methods. The mechanism was explored by both experiments and quantum chem. calculations, revealing a radical chain with HAA process.

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Name: (4-(Pyridin-4-yl)phenyl)methanol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Regioselective Catenation of Dinuclear Palladium and Platinum Metallocycles Promoted by π···π Interactions. Author is Blanco, Victor; Abella, Dolores; Pia, Elena; Platas-Iglesias, Carlos; Peinador, Carlos; Quintela, Jose M..

Dinuclear metallocycles were assembled from an L-shaped bidentate ligand based on 4,4′-bipyridine and Pd or Pt square-planar cis complexes. The Pd (4a,b) or Pt (5a,b) square metallocycles, I6+ and II6+ (M = Pd, Pt, as NO3- (a) and PF6- (b) salts, resp.), were obtained as 1:1 regioisomeric mixtures depending on which pair of coordinative N atoms binds to the metal center. The squares display a π-deficient cavity suitable to incorporate two π-donor aromatic systems. Therefore, the reaction with macrocyclic polyethers (BPP34C10 or DN38C10) resulted in the regioselective self-assembly of the [3]catenanes 4a(BPP34C10 or DN38C10)2·6PF6 and 5a(BPP34C10 or DN38C10)2·6PF6 because only macrocycles 4a and 5a present the correct disposition of the π-deficient aromatic systems to maximize the π···π stacking interactions. Single-crystal x-ray analyses of [3]catenanes revealed that the structures are addnl. stabilized by [C-H···O], [N-H···O] bonds and [C-H···π] interactions. The 1:2 inclusion complexes of metallocycles were prepared by self-assembly of three components: the ligand 1-(4-(pyridin-4-yl)benzyl)-4,4′-bipyridin-1-ium, a square planar complex M(en)(NO3)2 (M = Pd or Pt, en = ethylenediamine), and a dioxoarom. guest in a 2:2:2 ratio. The comparative study of the formation of 1:2 inclusion complexes has allowed the authors to conclude that the π···π interactions between the host and guests are responsible for the observed regioselectivity.

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Yamamoto, Yasuo; Kawanishi, Eiji; Koga, Yuichi; Sakamaki, Shigeki; Sakamoto, Toshiaki; Ueta, Kiichiro; Matsushita, Yasuaki; Kuriyama, Chiaki; Tsuda-Tsukimoto, Minoru; Nomura, Sumihiro published the article 《N-glucosides as human sodium-dependent glucose co-transporter 2 (hSGLT2) inhibitors》. Keywords: urinary glucose amino glycoside preparation human hyperglycemia structure activity; amino glycoside preparation antidiabetic human SGLT2 inhibitor pharmacokinetic; Diabetes; Glucoside; N-glucoside; SGLT2; Sodium-dependent glucose cotransporter.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Computed Properties of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

Inhibition of renal sodium-dependent glucose co-transporter 2 (SGLT2) increases urinary glucose excretion (UGE), and thus reduces blood glucose levels in hyperglycemia. A series of N-glucosides was synthesized for biol. evaluation as human SGLT2 (hSGLT2) inhibitors. Among these compounds, N-glucoside 9d possessing an indole core structure showed good in vitro activity (IC50 = 7.1 nM against hSGLT2). Furthermore, 9d exhibited favorable in vivo potency with regard to UGE in rats based on good pharmacokinetic profiles.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Neorganicheskoi Khimii called Use of sulfur hexafluoride in the synthesis of anhydrous iron, nickel, and cobalt fluorides, Author is Opalovskii, A. A.; Labkov, E. U.; Zakhar’ev, Yu. V.; Kuchumova, L. Ya., which mentions a compound: 13940-83-5, SMILESS is [H]O[H].[H]O[H].[H]O[H].[H]O[H].[Ni+2].[F-].[F-], Molecular F2H8NiO4, Application In Synthesis of Nickel(ii)fluoridetetrahydrate.

DTA data indicate that SF6 reacts with Fe2O3, NiO, or Co2O3 at 550-600° to give FeF3, NiF2, or CoF2, resp. During the heating of FeF3.3H2O, NiF2.4H2O, and CoF2.3.7H2O in the presence of SF6 at 650°, the formation of the oxide is avoided and FeF3, NiF2, and CoF2 are obtained.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 57825-30-6, is researched, SMILESS is CCC1=CC=C(CBr)C=C1, Molecular C9H11BrJournal, Article, Research Support, Non-U.S. Gov’t, European Journal of Medicinal Chemistry called Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase, Author is Chai, Xiaoyun; Zhang, Jun; Hu, Honggang; Yu, Shichong; Sun, Qingyan; Dan, Zhigang; Jiang, Yuanying; Wu, Qiuye, the main research direction is triazole preparation cytochrome P 450 14 alpha demethylase inhibitor; mol modeling triazole cytochrome P 450 14 alpha demethylase.Electric Literature of C9H11Br.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols I (R = H, 2-F, 2,4-Cl2, 4-MeO2C, PhO2C, etc.) as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. The MIC80 values indicate that compounds I (R = H, 2-F, 4-Me, etc.) exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole, while I (R = COOR1, R1 = Me, Et, iso-Pr, COOAr, etc.; Ar = Ph, 3-O2NC6H4, 4-ClC6H4, 2-MeO2CC6H4, etc.) showed no activity or only moderate activity against all fungi tested. Noticeably, the MIC value of I (R = H, 2-F, 4-Cl) is 64 times lower than that of fluconazole against Microsporum gypseum in vitro. And I (R = H, 2-F, CO2Et) showed 128 times higher activity (with the MIC80 value of 0.0039 μg/mL) than that of fluconazole against Candida albicans and also showed higher activity than that of the other pos. controls. Computational docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. In addition, the activity of the compounds would be enhanced when the side chains were shorter.

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