Tag: M.W:100-200

23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of quinoxaline-6-carboxylic acid methyl ester (2084mg, 11.07mmol) in ethanol (25mL) was added an aqueous solution of 1 N sodium hydroxide (25mL), and the solution was stirred for 4 hours under reflux. 1 N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, then, the precipitated solid was collected by filtration, washed with water and isopropanol, then dried to obtain the title compound (1477mg, 8.479mmol, 76.6%) as a solid. 1H-NMR Spectrum (DMSO-d6) delta(ppm) : 8.18 (1H, d, J=8.4Hz), 8.29 (1H, dd, J=8.4, 1.2Hz), 8.61 (1 H, d, J=1.2Hz), 9.00-9.07 (2H, m).

23088-23-5, As the paragraph descriping shows that 23088-23-5 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: To the resin 13 (560 mg) in DMF (2.5 mL) were added a solutionof the appropriate Fmoc-protected amino acid (see Tables 1-3)(0.3 M), PyBOP (0.3 M) and HOBt (0.3 M) in dry DMF (4.2 mL). Thesuspensions were stirred for 3 min and then DIPEA (0.6 M) wasadded. The suspensions were stirred for 3 h under an argon atmosphereat rt. The resins were washed successively with DCM(150 mL), MeOH (120 mL), DCM (75 mL) and dried overnight undervacuum to give resins 14, each bearing an appropriate Fmoc-protectedamino acid. To the resins 14 (161 mg, 0.13 mmol) wereadded a solution of piperidine (20%, v/v) in DCM (2.1 mL) and themixtures were stirred for 1 h at rt. After filtration, the resins werewashed successively with DCM (50 mL), MeOH (45 mL), DCM(25 mL) and dried under vacuum to give resins 15. Portions(65 mg) of resins 15 were placed in reactor wells (12 mL) of anautomated synthesizer reaction block (40-well format) (AdvancedChemTech). To each well was added a solution of appropriate carboxylicacid (see Tables 1-3) (0.3 M), PyBOP (0.3 M) and HOBt 6-Cl(0.3 M) and DIPEA (0.6 M) in dry DMF (2 mL). The suspensionswere vortexed at 300 rpm over a period of 5 h under an argonatmosphere. The wells were then filtered to remove the reactivesolution from the resins 16 and washed successively with THF,DCM, MeOH and DCM.

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Talbot, Amelie; Maltais, Rene; Kenmogne, Lucie Carolle; Roy, Jenny; Poirier, Donald; Steroids; vol. 107; (2016); p. 55 – 64;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1865-11-8,Methyl quinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: In a round bottom flask, the previously prepared methyl ester 2 (2 g, 10.6 mmol) was stirred in ethanol (50 mL) in the presence of cesium carbonate (0.3 g, 0.92 mmol) at ambient temperature. The progress of the reaction was followed by GC chromatography. At the end of the transesterification, the reaction mixture was evaporated to dryness and the product was extracted with dichloromethane (425 mL). The combined organic layers were then dried over MgSO4 and, after filtration, evaporated to dryness. The ethyl ester 3 was obtained as beige powder. Yield: 67percent., 1865-11-8

As the paragraph descriping shows that 1865-11-8 is playing an increasingly important role.

Reference£º
Article; Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine; Tetrahedron; vol. 72; 10; (2016); p. 1375 – 1380;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (69.6 mg, 0.360 mmol) and 1-hydroxybenzotriazole monohydrate (55.6 mg, 0.360 mmol) were added to a methylene chloride solution (3.0 ml) of the resulting compound (100 mg, 0.300 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (57.5 mg, 0.300 mmol), at room temperature, under nitrogen stream, followed by further addition of N-methylmorpholine (0.170 ml, 1.50 mmol), and stirring was carried out at room temperature overnight. The reaction solution was poured into a 2N aqueous hydrochloric acid solution, followed by extraction with ethyl acetate and sequential washing with water, a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Biotage, Inc., 25+M), the residue resulting from concentration was suspended in a mixed solvent of methylene chloride-diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (59.1 mg, yield 44%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.9 (1H, brs), 9.70 (1H, brs), 7.88 (1H, dd, J=7.8 Hz, 4.6 Hz), 7.65 (1H, dt, J=7.8 Hz, 1.0 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38(1H, d, J=7.8 Hz), 7.13 (2H, m), 7.03 (2H, m), 5.02 (1H, m), 4.60 (1H, m), 4.02-3.19 (4H, m), 2.06-1.85 (2H, m), 1.72-1.44 (2H, m), 1.31 (3H, d, J=6.6 Hz). IR (KBr) cm-1: 2935, 1685, 1640, 1505, 1205. MS (ESI, m/z): 439 (M+H)+. HRMS (ESI, m/z): 439.1791 (Calcd for C23H24FN4O4: 439.1782)., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (118 mg, 0.610 mmol) was added to a methylene chloride solution (5.0 ml) of 1-[(2S)-2-amino-3-methylbutanoyl]-N-(4-fluorophenyl)piperidin-4-amine dihydrochloride (150 mg, 0.410 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (80.3 mg, 0.410 mmol), 1-hydroxybenzotriazole monohydrate (66.4 mg, 0.490 mmol) and N-methylmorpholine (0.225 ml, 2.05 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride and subsequent sequential washing with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and the resulting organic layer was dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the residue resulting from concentration was suspended in a mixed solvent of ethanol-diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (121 mg, yield 64%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.19 (1H, brs), 10.11 (1H, brs), 8.00 (1H, m), 7.62 (1H, m), 7.44-7.26 (2H, m), 6.90 (2H, q, J=7.2 Hz), 6.59-6.54 (2H, m), 5.08-5.05 (1H, m), 4.67-4.51 (1H, m), 4.24 (1H, brs), 3.51-3.30 (3H, m), 3.07-2.90 (1H, m), 2.32-2.12 (3H, m), 1.48-1.35 (2H, m), 1.13-1.09 (6H, m). IR (KBr) cm-1: 2960, 1685, 1630, 1510, 1215. MS (FAB, m/z): 466 (M+H)+. HRMS (FAB, m/z): 466.2242 (Calcd for C25H29FN5O3: 466.2255). Anal. Calcd for C25H28FN5O3: C, 64.50; H, 6.06; N, 15.04; F, 4.08. Found: C, 64.18; H, 5.77; N, 14.93; F, 4.02., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, EXAMPLE 3 Preparation of quinoxaline-2-carboxylic acid {2-(3-fluoro-phenyl)-1-[4-(3-hydroxy-3-methyl-butyl)-5-oxo-tetrahydro-furan-2-yl]-ethyl}-amide (IIa1-3) 2-Quinoxaline acid (3.05 g, 1.2 eq) and carbonyl diimidazole (2.72 g, 1.15 eq) were heated in anhydrous THF (30 ml) under nitrogen for 2 h.An aliquot was taken and derivatized quickly with pyrrolidine in acetonitrile (HPLC assay should show complete anhydride formation, on scale, 2-quinoxaline acid will be refluxed in THF first, and atmospherically strip off some THF to ensure complete dryness).The mixture was then cooled, and added via a cannula to the amine (IIIa1-2) (4.5 g, crude oil from example 2) solution [note: no exotherm observed].The reaction was stirred for 1 h at room temperature, and assay showed no starting material left.The reaction was quenched with water (50 ml).The layers were separated, and the organic phase was washed with 10% NaHCO3 (50 ml) once, and concentrated to give an oil under vacuum. The oil was water wet, but directly used in the next step. 9.58 (s, 1H), 8.05-8.18 (m, 3H), 7.85-7.88 (m, 2H), 7.81-7.27 (m, 3H), 4.58-4.65 (m, 1H), 3.02-3.20 (m, 1H), 2.44-2.61 (m, 1H), 2.34-2.38 (m, 1H), 1.95-2.08 (m, 1H), 1.76-1.98 (m, 1H), 1.38-1.61 (m, 6H), 1.15 (s, 6H).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US2004/19217; (2004); A1;,
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34117-90-3, 3-Chloroquinoxalin-2-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 : N2-(pentan-3-yl)quinoxaline-2,3-diamine. A thick-walled microwave bottle equipped with a stirbar was charged with 3-chloroquinoxalin-2-amine (1.0 equiv) and 20 volume equivalents of 3-aminopentane. The bottle was fitted with a septum and cap and heated to 120 0C in a microwave for 30 min. The resulting solution was concentrated in vacuo. Flash chromatography (20% – 60% EtOAc/Hexanes) provided the title compound (78%) as a yellow solid. LCMS m/z (APCI) = 231.1 (M+H).

34117-90-3, As the paragraph descriping shows that 34117-90-3 is playing an increasingly important role.

Reference£º
Patent; CYTOKINETICS, INCORPORATED; WO2008/16669; (2008); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (220 mg, 0.580 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (110 mg, 0.580 mmol) to afford the desired title compound (132 mg, yield 45%) as a white solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.57 and 10.15 (1H, brs), 7.98 (1H, d, J=4.6 Hz), 7.65-7.53 (4H, m), 7.37 (1H, brs), 6.99 (2H, d, J=8.6 Hz), 5.07 (1H, t, J=7.3 Hz), 4.72-4.65 (1H, m), 4.03-3.62 (5H, m), 2.36-2.10 (2H, m), 2.02-1.80 (3H, m), 1.12 (3H, d, J=6.8 Hz), 1.11 (3H, d, J=6.8 Hz). IR (ATR) cm-1: 1685, 1630, 1610, 1515, 1445, 1320, 1250. MS (ESI, m/z): 517 (M+H)+. Anal. Calcd for C26H27F3N4O4: C, 60.46; H, 5.27; N, 10.85. Found: C, 60.23; H, 5.23; N, 10.82., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

H2S04 (0673 ml, 1263 mmol) was added to a solution of quinoxaline-2-carhoxylic acid (1.1 g, 6.32 mmol) in Methanol (20 nil) at 0 O( The reaction mixture was refluxed for 3h. After completion of reaction, methanol was evaporated under reduced pressure and the residue was diluted withdichlorornethane. The organic portion was washed with saturated sodium bicarbonate solution, brine and evaporated under reduced pressure to give methyl quinoxaline-2-carboxylate (1.1 g, 5.85 rnmol,93%)

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PI INDUSTRIES LTD.; SAXENA, Rohit; PANMAND, Deepak Shankar; JENA, Lalit Kumar; SRIVASTAVA, Khushboo; RAJU, Jella Rama; MANJUNATHA, Sulur G; SAMANTA, Jatin; GARG, Ruchi; AUTKAR, Santosh Shridhar; VENKATESHA, Hagalavadi M; GADAKH, Ramdas Balu; KLAUSENER, Alexander G. M.; POSCHARNY, Konstantin; (219 pag.)WO2018/116072; (2018); A1;,
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2427-71-6, 6-Chloro-2(1H)-quinoxalinone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloroquinoxalin-2(1H)-one (1.0 g, 5.5 mmol) and phosphorus tribromide (PBr3; 3.5 mL, 36.1 mmol) was heated at 120 C. for 4 h. The reaction mass was cooled to RT, diluted with cold H2O and extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, filtered and concentrated under vacuum to get crude product. The crude compound was purified by silica gel column chromatography (eluting with EtOAc/hexane) to afford 2-bromo-6-chloroquinoxaline (550 mg, 2.26 mmol, 42%) as a solid. 1H NMR (200 MHz, CDCl3): delta 8.86 (s, 1H), 8.11 (s, 1H), 7.99 (d, J=8.8 Hz, 1H), 7.75 (dd, J=9.0, 2.4 Hz, H). MS (ESI): m/z 243 [M+]., 2427-71-6

2427-71-6 6-Chloro-2(1H)-quinoxalinone 75507, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; US2012/329802; (2012); A1;,
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