Tag: M.W:100-200

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

EXAMPLE 183 N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo [4,5-c]quinolin-1-yl]butyl}quinoxaline-2-carboxamide Using the general method of Example 181 1-(4-aminobutyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.5 g, 4.78 mmol) was reacted with 2-quinoxalinecarboxylic acid (1.0 g, 5.74 mmol) to provide 270 mg of N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}quinoxaline-2-carboxamide as a yellow crystalline solid, m.p. 85-87 C. Analysis: Calculated for C26H27N7O2: %C, 66.51; %H, 5.80; %N, 20.88; Found: %C, 66.12; %H, 5.70; %N, 20.62.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Coleman, Patrick L.; Crooks, Stephen L.; Griesgraber, George W.; Lindstrom, Kyle J.; Merrill, Bryon A.; Rice, Michael J.; US2003/144283; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (137 mg, 0.717 mmol) was added to a methylene chloride solution (4.8 ml) of (2S)-3-methyl-1-oxo-1-(4-{[6-(trifluoromethyl)pyridin-3-yl]oxy}piperidin-1-yl)butan-2-amine dihydrochloride (200 mg, 0.478 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (93.7 mg, 0.478 mmol), 1-hydroxybenzotriazole monohydrate (77.5 mg, 0. 574 mmol) and N-methylmorpholine (0.263 ml, 2.39 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and then the solid substance was collected by filtration to afford the desired title compound (145 mg, yield 59%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.08 (1H, brs), 10.15 (1H, brs), 8.41 (1H, dd, J=10.6 Hz, 2.7 Hz), 8.02 (1H, brs), 7.66-7.30 (5H, m), 5.09-5.04 (1H, m), 4.78-4.70 (1H, m), 4.10-3.64 (4H, m), 2.35-1.95 (5H, m), 1.14-1.09 (6H, m). IR (KBr) cm-1: 2965, 1685, 1640, 1530, 1340. MS (ESI, m/z): 518 (M+H)+. HRMS (ESI, m/z): 518.2016 (Calcd for C25H27F3N5O4: 518.2015). Anal. Calcd for C25H26F3N5O4¡¤0.5H2O: C, 57.03; H, 5.17; N, 13.30; F, 10.83. Found: C, 56.82; H, 4.98; N, 13.03; F, 10.89., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, Example 12-(1,2-Dimethyl-3-oxo-5-quinoxalin-6-yl-2,3-dihydro-1H-pyrazol-4-yl)-benzonitrileStep 1A: Quinoxaline-6-carboxylic acid methoxy-methyl-amideA 2000 mL round bottomed flask was charged with 21.0 g (121 mmoles) of quinoxaline-6-carboxylic acid, 32.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (169 mmoles), 22.8 g of 1-hydroxybenzotriazole (169 mmoles), and 24.7 g of N,O-dimethylhydroxylamine hydrochloride (253 mmoles) under a nitrogen atmosphere. To this, 315 mL of tetrahydrofuran and 210 mL of dichloromethane were added. Next, 127 mL of triethylamine (729 mmoles) was charged, and the reaction was allowed to stir for 12 hours. After the reaction was complete, the contents of the flask were concentrated to 1/3 volume under vacuum, and 440 mL of water was added. The mixture was extracted with ethyl acetate (3¡Á200 mL); the subsequent organic fractions were then washed with saturated sodium bicarbonate (1¡Á200 mL) and dried over sodium sulfate. The final product (26.1 g; 99% yield) was obtained after removing the solvent under vacuum. The product was used without further purification.1H NMR 300 MHz (CDCl3) delta 3.35 (s, 3H), 3.49 (s, 3H), 7.97 (d, J=8.7 Hz, 1H), 8.05 (d, J=8.7 Hz, 1H), 8.36 (s, 1H), 8.81 (s, 1H).M/Z Theoretical: 217.09; M/Z+1 217.77.

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Biogen Idec MA Inc.; US2010/56505; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

6924-66-9, Example 25To a 50 mL flask containing 20 mL of DMF was added 1 mL of oxalyi chloride slowly and stirred for 10 min at RT. 100 mg of quinoxaline-5-carboxyltc acid was dissolved in 2 mL of the above solution and stirred for 5 min at RT. Then 50 mg of E was dissolved in 1 mL pyridine and added to the above solution. The reaction was completed in 5 min at RT and quenched with 1 mL NH4OH. The solvent was then evaporated under vacuum and the residue dissolved in CH3CN and water and purified with prep HPLC (0% to 95% water/ Acetonitriie) to afford 25 (26.7 mg, 54%). 1H-NMR (DMSO, 300 MHz): delta 9.04-9.02 (m, 2H), 8.49 (d, J = 3.9 Hz, 1 H), 8.31 (d, J = 6.0 Hz, 1 H), 8.24 (d, J = 8.4 Hz, 1 H), 7.94 (t, J – 7.2 Hz, 1 H), 7.73 (d, J = 6.9 Hz, 1 H), 7.62-7.57 (m, 2H), 7.22 (t, J = 8.4 Hz, 1 H), 7.06 (t, J = 6.6 Hz, 1 H)1 6.98 (d, J = 7.8 Hz, 2H), 6.80 (d, J = 7.5 Hz, 1 H), 4.83 (me, 1 H), 3.18-3.06 (m, 3H), 2.77-2.75 (m, 1 H), 0.65 (m, 2H), 0.51 (m, 2H).LCMS m/z [M+Hj+ C32H25N5O3S requires: 560.64. Found 560.08 HPLC Tr (min), purity %: 3.36, 98%

6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; GILEAD SCIENCES, INC.; MACKMAN, Richard, L.; SPERANDIO, David; YANG, Hai; WO2011/5842; (2011); A1;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6925-00-4

In a [11 3] neck flask was placed Quinoxaline-6-carboxylic acid (20.2 g) in 500 ml of THF. To this solution was slowly added [THIONYLCHLOLIDE] [(42ML,] [5EQ.).] The reaction mechanically stirred was warmed up to reflux and followed by HPLC quenching the sample with NH40H. After 3h at reflux no more starting material was present, the solvent was removed under reduced pressure and [SOC12] was chased with toluene 3 times. The solid was suspended in 100 ml EtOAc and filtered to obtain 23.47g of a beige solid. HPLC : 1. [114MIN. IHNMR] (DMSO-d6) [69.] 01-7.40 (m, [5H).]

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2004/7491; (2004); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3476-89-9,1,2,3,4-Tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.

24d. 1-Methyl-4-(2-nitro-phenyl)-1,2,3,4-tetrahydro-quinoxaline To a solution of 1,2,3,4-tetrahydroquinoxaline (60 mg, 0.403 mmol) in DMSO (2 mL) was add potassium tert-butoxide (91 mg, 0.81 mmol), followed by 2-fluoro-nitrobenzene (57 mg, 0.403 mmol). The reaction mixture was stirred at 80 C. for 16 h. The desired product was isolated via silica gel chromatography using 0% to 50% EtOAc in hexane as eluding solvent to afford 24d (49 mg, 45%) as radish foam. LC-MS ESI m/z 270 [M+H]+., 3476-89-9

As the paragraph descriping shows that 3476-89-9 is playing an increasingly important role.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
Quinoxaline – Wikipedia
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6925-00-4, (2S)-3-Phenyl-2-[(1-quinoxalin-6-ylmethanoyl)amino]propionic acid, t-butyl ester: Quinoxaline-6-carboxylic acid (2b, 2.57 g, 14.8 mmol) is dissolved in anhydrous dichloromethane (75 mL) and N,N-diethyl-isopropylamine (2.83 mL, 16.2 mmol) under argon in a flask equipped with stir bar and septum. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.11 g, 16.2 mmol) is added and allowed to stir 10 minutes before 1-hydroxybenzotriazole hydrate (2.19 g, 16.2 mmol) is added. After another 5 minutes, L-phenylalanine t-butyl ester hydrochloride (3.80 g, 14.8 mmol) is added and the mixture is allowed to stir at room temperature overnight. The reaction mixture is diluted with dichloromethane (100 mL) and washed with saturated sodium bicarbonate solution (1*100 mL), water (1*100 mL), and brine (1*100 mL). The organic layer is dried over MgSO4 and concentrated to a brown foam which is applied to a column of silica gel in dichloromethane and eluted with 2% methanol/dichloromethane. Concentration of the appropriate fractions gives 4.4 g (79%) of the desired product as a very thick oil.

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Procter & Gamble Company; US2004/6104; (2004); A1;,
Quinoxaline – Wikipedia
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution OF 4- [ (4-BROMOPHENYL) (ethoxyimino) methyl]-1- (4-methyl-4- piperidinyl) piperidine (100 mg, 0.24 MMOL), 3-hydroxy-2-quinoxalinecarboxylic acid (56 mg, 0.29 MMOL) and ET3N (87 mg, 0.86 MMOL) in DMF (6 mL), HATU (119 mg, 0.31 MMOL) was added at room temperature and the reaction was stirred for 24h. The reaction mixture was poured into ice water and the first crop of solid was collected by filtration. The water layer was extracted with ethyl acetate and the organic layer was washed with NAHC03, dried and concentrated to give the second crop of solid. The two crops of crude were combined and purified by flash chromatography (2% to 10%, MEOH/CH2CI2) to afford the title compound as an orange solid. MS 579 (M+).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/113323; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6639-87-8,6-Nitroquinoxaline,as a common compound, the synthetic route is as follows.

2. 1,2,3,4-tetrahydro-5-amino-6-nitroquinoxaline 5-Amino-6-nitroquinoxaline was synthesised by reaction of 6-nitroquinoxaline with hydroxylamine in an alkaline medium in accordance with J. Chem. Soc., Perkin I, 1975, 1229. The product was reacted With sodium borohydride as in Example 1). The 1,2,3,4-tetrahydro-5-amino-6-nitroquinoxaline obtained in the form of brown crystals in a yield of 11.5% of the theoretical had a melting point of 213 C., 6639-87-8

6639-87-8 6-Nitroquinoxaline 96029, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Henkel Kommanditgesellschaft auf Aktien; US5089025; (1992); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
Quinoxaline – Wikipedia
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