Tag: M.W:100-200

91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, General procedure: A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, c. N-(Quinoxalin-6-yl)acetamide A solution of quinoxalin-6-amine (14.0 g, 0.97 mol) in acetic anhydride (120 mL) was stirred at 100 C. for 1 h. Excess acetic anhydride was removed under reduced pressure. To the residue was added 150 mL of saturated aqueous sodium bicarbonate solution. The mixture was extracted with DCM (3*150 mL), and the combined organic layers were dried over sodium sulfate and concentrated under reduce pressure to give N-(quinoxalin-6-yl)acetamide as a yellow solid (8.4 g, yield 47%). ESI MS: m/z 188.1 [M+H]+.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sunovion Pharmaceuticals Inc.; US2012/178748; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Hydroxy-2-quinoxalinecarboxylic acid (3.00 g, 15.8 mmol) was dissolved in DMF (50 mL), followed by addition of 4-dimethylaminopyridine (2.12 g, 17.4 mmol). The reaction mixture was stirred at rt until the 4-dimethylaminopyridine dissolved, at which point N,N?-disuccinimidyl carbonate (4.45 g, 17.4 mmol) was added. The reaction mixture was stirred at rt for 30 min (Check HPLC to confirm reaction completion. If the reaction was not complete, additional 0.1 eq portions of DSC were added until HPLC showed complete conversion). A soln. of N-Boc-ethylenediamine (3.04 g, 19.0 mmol) and triethylamine (2.40 g, 3.30 mL, 23.7 mmol) in DMF (10 mL) was then added, and the reaction was stirred at rt for 1 h (check HPLC for reaction completion). The reaction mixture was then poured onto a vigorously stirring soln. of 1M HCl (250 mL). The resulting precipitate was collected by vacuum filtration, washed several times with water, and dried under high-vacuum, giving compound 5 as a yellow solid (5.10 g, 97% yield)., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ventana Medical Systems, Inc.; Belosludtsev, Yuri; DeGeer, Traci D.; French, Wendy J.; Hao, Junshan; Kelly, Brian D.; Murillo, Adrian E.; Polaske, Nathan W.; (55 pag.)US2018/186821; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6924-66-9,6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: N-Q-chlorophenvDquinoxalme-S-carboxamideA solution (0.1 M) of quinoxaline-5-carboxylic acid in CH2Ck was treated with DIPEA (2.2 eq.), 3- chloroaniline (1.1 eq.) and HATU (1.1 eq.). The reaction mixture was stirred at RT overnight. The solution was diluted with EtOAc and the organic phase was washed with aqueous NaHC?3 (saturated solution) and dried. Evaporation of the solvent gave a crude that was washed with MeCN and filtered off affording (93%) the title compound as a solid; MS (ES+) m/z 284, 286 (M+H)+.

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/28789; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, 1H-indole-6-amine (116.3 mg, 0.88 mmol), final product 03 (94.5 mg, 0.29 mmol) and triethylamine (95.4 mg, 0.94 mmol) were added to a round bottom flask, and 2 mL of DMF was dissolved.Heat to 50 C and stir overnight.At the end of the reaction, 2 mL of water was added, acidified with trifluoroacetic acid, and purified by HPLC to obtain 87.4 mg of a yellow oil

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (113 mg, 0.350 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol) to afford the desired title compound (107 mg, yield 66%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.85 (1H, brs), 9.56 (1H, m), 7.87 (1H, dd, J=8.2 Hz, 7.8 Hz), 7.78 (2H, d, J=9.0 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.40 (1H, d, J=7.4 Hz), 7.38 (1H, d, J=8.2 Hz), 7.19 (2H, dd, J=9.0 Hz, 4.2 Hz), 5.00 (1H, m), 4.83 (1H, m), 4.07-3.81 (2H, m), 3.61-3.16 (2H, m), 2.14-1.46 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2965, 2220, 1685, 1630, 1505, 1250. MS (ESI, m/z): 460 (M+H)+. HRMS (ESI, m/z): 460.1973 (Calcd for C25H26N5O4: 460.1984).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

91-19-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.

Step 11 -(quinoxalin-2-yl)ethanone (JS110)Quinoxaline (1 .1864 g, 9.1 1 mmol), Pyruvic acid (1.90 ml, 27.3 mmol), AgN03 (0.124 g, 0.73 mmol), N2H8S208 (3.12 g, 13.67 mmol) and H2S04 (0.49 ml, 9.1 1 mmol) were stirred in 1 :1 CH2CI2/H20 (150 ml) at 40 C for 2 ? h. The solution was then basified via the addition of NaOH and the organics extracted (3x) and washed brine, dried (MgS04), filtered and solvent removed. Flash chromatography (Pet Ether; 3:1 Pet Ether/EtOAc) afforded the title compound as a yellow solid (617.5 mg, 3.91 mmol, 42.9%). Mpt: 70-74 C [Lit.( J. Org. Chem., 1991 , 56, 2866-2869) 76-97 C]; Rf = 0.24 (3:1 Pet Ether/EtOAc); IR (vmax/cm”1, thin film): 1689 (CO stretch), 1357; 1H NMR (500 MHz, CDCI3): deltaEta = 2.84 (s, 3H, 12-H), 7.82-7.90 (m, 2H, 7,8-H), 8.14-8.21 (m, 2H, 6,9-H), 9.47 (s, 1 H, 3-H); 13C NMR (125 MHz, CDCI3): 5C = 25.6 (C-12), 129.5 (C-6), 130.5 (C-8), 130.8 (C-9), 132.3 (C-7), 141 .1 (C-10), 143.1 (C-3), 143.9 (C-5), 146.6 (C- 2), 199.8 (C-11 ); LRMS m/z (El+): 172 [M]+, 130 [M-Ac]+, 86; HRMS m/z (El+): Found 172.06372; Ci0H8N2O requires 172.0631 1 ; Anal. Calcd. for Ci0H8N2O: C, 69.76; H, 4.68; N, 16.27. Found C, 69.28; H, 4.56; N, 16.00%.

The synthetic route of 91-19-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin; WO2012/168733; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6924-66-9,6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PyBOP (100 mg, 193 muiotaetaomicronIota) was added to a mixture of 8-amino-2-(3,5-difluorophenyl)-2- azaspiro[4.5]decan-1-one (isomer 1; Intermediate I28) (50.0 mg, 161 muiotaetaomicronIota), quinoxaline-5- carboxylic acid (30.8 mg, 177 muiotaetaomicronIota) and N,N-diisopropylethylamine (140 muIota, 800 muiotaetaomicronIota) in DMF (1.8 ml) and the mixture was stirred over night at room temperature. For work-up, the reaction mixture was concentrated and the residue was stirred with methanol. The precipitate was collected by filtration, washed with water and methanol and then dried to give the title compound 53.5 mg (76 % yield).LC-MS (Method 1): Rt= 1.23 min; MS (ESIpos): m/z = 437 [M+H]+1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 9.78 (d, 1H), 9.10-9.05 (m, 2H), 8.44 (dd, 1H), 8.27 (dd, 1H), 7.98 (dd, 1H), 7.56-7.48 (m, 2H), 7.02 (tt, 1H), 3.96-3.78 (m, 3H), 2.14-2.00 (m, 4H), 1.75-1.62 (m, 4H),

6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

13708-12-8, 5-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Methylquinoxaline (0.180 mL, 1.387 mmol, commercially available from, for example, Sigma-Aldrich), NBS (289 mg, 1.624 mmol), benzoyl peroxide (37 mg, 0.153 mmol) and 1,2- dichloroethane (4 mL) was stirred at 110 C for 2 h. Further portions of NBS (260 mg, 1.461 mmol)and benzoyl peroxide (31 mg, 0.128 mmol) were added and the reaction refluxed for a further 2 h. The solution was concentrated to give 1.1 g of a brown solid which was purified by chromatography on 5i02 (Biotage SNAP 50 g cartridge, eluting with O-100% diethylether/cyclohexane). The desired fractions were concentrated to give 5-(bromomethyl)quinoxaline (310 mg, 0.882 mmol, 63.6 % yield) as a yellow oil.LCMS (2 mm Formic): Rt=0.91 mi [MH] = 223, 225.

13708-12-8, 13708-12-8 5-Methylquinoxaline 61670, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.

91-19-0, A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider