Tag: M.W:100-200

2213-63-0, 2,3-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of sodium (1 mmol) and an alcohol (3 mL) was stirred for 15 min at room temperature. Then 2,3-dichloroquinoxaline (1 mmol) was added to the mixture until the complete consumption of the starting materials (monitored by TLC). After evaporation of the solvent, the resulting precipitate was washed with H2O; it did not require any further purification., 2213-63-0

The synthetic route of 2213-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Keivanloo, Ali; Soozani, Atena; Bakherad, Mohammad; Mirzaee, Mahdi; Rudbari, Hadi Amiri; Bruno, Giuseppe; Tetrahedron; vol. 73; 12; (2017); p. 1633 – 1639;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130345-50-5,Quinoxaline-6-carbaldehyde,as a common compound, the synthetic route is as follows.

To a solution of quinoxaline-6-carbaldehyde (0.96 g, 6.1 mol; see Example 4(a) above) in a mixed solvent of THF (40 mL) and iPrOH (10 mL), was added (phenylamino-(2- trifluoromethyl-pyrimidin-4-yl)-methyl)-phosphonic acid diphenyl ester (3.0 g, 6.1 mmol; see Example 3(b) above) and Cs2CO3 (2.64 g, 8 mmol). It was stirred at room temperature overnight and then treated with 3N HCl (10 mL) for 1 hour. The reaction mixture was then diluted with methyl t-butyl ether and extracted with IN HCl twice. The combined aqueous layers were neutralized with 30% aqueous KOH to pH of ca. 8, then extracted with ethyl acetate (3x). Organic layers were dried over MgSO4 and concentrated to yield a dark orange oil, which was purified on silica gel column with EtOAc/hexane (4:1) to give 2-quinoxalin-6-yl-l-(2- trifluoromethyl-pyrimidin-4-yl)-ethanone (1.67 g) as a yellow solid. LC-MS/ES+: M+l: 319.39. 1H NMR (300 MHz, CDCl3), delta 9.08 (d, IH), 8.75 (m, 2H), 8.03-7.96 (m, 3H), 7.67 (dd, IH), 4.71 (s, 2H)., 130345-50-5

130345-50-5 Quinoxaline-6-carbaldehyde 763958, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: To the flask containing a mixture of substituted benzaldehyde (1mmole) and 2-aminophenol (1mmole) was added silica chloride(1 eq) and was heated on a sand bath at 120 C, TLC was taken afterevery 1 h. After 4 h, TLC showed appearance of new spot. The productwas isolated by first separating out the catalyst by filtration using organicsolvent; the organic layer was dried using anhydrous sodiumsulfate and evaporated under vacuum. The solid thus obtained was recrystallized using petroleum ether and its % yield and melting pointswere determined. The results are tabulated in Table 1 and Table 2.

1593-08-4, 1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desai, Sulaksha; Desai, Vidya; Shingade, Sunil; Bioorganic Chemistry; vol. 94; (2020);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8

To a 80 mL microwave tube was added 2-methylquinoxaline (0.576 g, 4 mmol), Fe (NO3)3¡¤ 9H2O (0.808 g, 2 mmol) and DMSO (50 mL) were heated to 135 C for 3 min at 150 W in a CEM Discover microwave reactor.After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was poured into saturated NaHCO3Aqueous solution, ethyl acetate (3 x 30 mL), and the combined organic layers were washed with anhydrous Na2SO4After drying, it was concentrated under reduced pressure and recrystallized from n-hexane (35 mL) to give 0.506 g of a yellow target product in 80% yield.

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Patent; ZHEJIANG UNIVERSITY OF TECHNOLOGY; XIE, YUANYUAN; XIE, TINGHUI; HUANG, YINGYI; GAN, BING; YAN, YIYAN; LI, PINGPING; (10 pag.)CN106083713; (2016); A;,
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6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PyBOP (149 mg, 287 muiotaetaomicronIota) was added to a mixture of quinoxaline-5-carboxylic acid (45.4 mg, 261 muiotaetaomicronIota), 8-amino-2-(3-chlorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 1 , Intermediate I50) (80.0 mg, 287 muiotaetaomicronIota) and N,N-diisopropylethylamine (180 muIota, 1 .0 mmol) in DMF (2.6 ml) and the mixture was stirred over night at room temperature. For work-up, water (45 ml) and methanol (2 ml) were added and the mixture was stirred for 4 h. The precipitate was collected by filtration, washed with a mixture of water and methanol (4:1 ) and dried to give the title compound 109 mg (93 % yield).LC-MS (Method 1 ): Rt= 1 .22 min; MS (ESIpos): m/z = 435 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .494 (2.45), 1 .506 (2.64), 1 .524 (2.94), 1 .535 (2.88) 1 .555 (1 .60), 1 .566 (1.50), 1 .650 (1 .19), 1.660 (1 .47), 1.683 (10.64), 1.706 (3.13), 1 .714 (3.63) 2.012 (3.13), 2.023 (3.32), 2.046 (3.09), 2.055 (2.76), 2.081 (5.42), 2.099 (9.45), 2.116 (5.61 )2.327 (0.87), 2.518 (2.62) 2.523 (1.85), 2.669 (0.91 ), 2.729 (0.63), 2.888 (0.76), 3.804 (5.72) 3.813 (1 .63), 3.822 (9.67) 3.829 (1.66), 3.839 (5.52), 3.888 (1.32), 3.898 (1 .62), 3.907 (1 .29) 3.917 (1 .57), 3.927 (1 .22) 7.189 (3.31 ), 7.191 (3.67), 7.194 (3.70), 7.196 (3.56), 7.209 (3.89) 7.21 1 (4.22), 7.214 (4.32) 7.216 (4.10), 7.394 (5.26), 7.415 (9.49), 7.435 (5.33), 7.589 (3.61 ) 7.591 (3.98), 7.594 (3.89) 7.596 (3.88), 7.610 (3.00), 7.61 1 (3.01 ), 7.615 (3.35), 7.617 (2.95) 7.910 (5.41 ), 7.916 (10.28), 7.921 (5.48), 7.960 (5.22), 7.977 (5.64), 7.981 (6.35), 7.999 (5.99) 8.253 (6.1 1 ), 8.257 (6.58), 8.274 (5.36), 8.278 (5.38), 8.430 (6.23), 8.433 (6.27), 8.448 (5.77) 8.452 (5.22), 9.069 (7.93), 9.074 (16.00), 9.080 (15.91 ), 9.084 (7.60), 9.770 (4.17), 9.788 (4.13), 6924-66-9

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation X. Preparation of 2-quinoxalyl isocyanate Diphenylphosphoryl azide (1.23 mL) was added to a solution of triethylamine (800 ul) and 2-quinoxaline carboxylic acid 1 g (5.74 mmol) stirring in 10 mL of dry dimethylformamide in an icewater cooling bath (2). The reaction was stirred for 2.33 h during which time the reaction was allowed to warm to 25. The reaction was poured into ice water and extracted three times with diethyl ether. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and then concentrated in vacuo. The crude azide was dissolved in 15 mL of benzene and heated at reflux for 1.5 h. The solvent was removed in vacuo to provide the desired solid isocyanate. FT IR indicated a strong isocyanate absorption.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; US5198560; (1993); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, Example 44 {(S)-3-[3-(4-Fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-quinoxalin-6-yl- methanone The compound was prepared following the procedure described in the Example 36, using 6-quinoxalinecarboxylic acid as the acid of choice and S-3- [3- (4-fluoro-phenyl)- [1, 2,4] oxadiazol-5-yl]-piperidine hydrochloride (prepared as described in the Example 12). {(S)-3-[3-(4-Fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-quinoxalin-6- yl-methanone was obtained pure after purification through a silica gel cartridge (eluent: DCM/MeOH/NH40H 98/2/0. 2). Yield: 83% (white solid); [a] o= +120 (c=1.0, CHC13) ; LCMS (Tr): 7.0 min (method A); MS (ES+) gave m/z : 404.0. 1H-NMR (CDC13, 330 K, 300 MHz), 8 (ppm): 8. 88 (s, 2H); 8. 18 (dd, 2H); 8. 06 (m, 2H); 7.82 (dd, 1H) ; 7.15 (dd, 2H); 4.47 (mbr, 1H); 4.02 (mbr, 1H) ; 3.65 (dd, 1H); 3.44-3. 23 (m, 2H) ; 2.36 (m, 1H) ; 2.14-1. 88 (m, 2H); 1.74 (m, 1H).

As the paragraph descriping shows that 6925-00-4 is playing an increasingly important role.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2

Method III N,N’-Carbonyldiimidazole (13.95 g) and 2-quinoxalinecarboxylic acid (15 g) in tetrahydrofuran (600 ml) were heated under reflux for 2 hours. 5-Amino-1H-tetrazole (7.32 g) in tetrahydrofuran (36 ml) and dimethylformamide (24 ml) was added and the mixture was heated under reflux for 50 minutes. The solvent was distilled off under reduced pressure and the residue was dissolved in water (300 ml). The solution was acidified to pH2 with dilute hydrochloric acid and the solid was collected and crystallized from dimethylformamide. It had m.p. 284-285 (d) (70%).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Allen & Hanburys Limited; US3997535; (1976); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Step 4: Starting material 8-4 (0.15 g, 0.45 mmol) was dissolved in DCM (0.5 mL) and TFA (0.5 mL). The resulting mixture was stirred at room temperature for 2 h. Solvent was removed to give desired compound 8-5. Compound 8-5,3-oxo-3,4-dihydroquinoxaline-2-carboxylic acid (100 mg, 0.52 mmol), HATU (250 mg, 0.66 mmol) and iPr2NEt (0.4 mL, 2.29 mmol) were mixed in DMF (2 mL). The resulting mixture was heated at 85 C. overnight. The mixture was cooled to room temperature and the solvent was removed. The residue was purified by column chromatograph (silica gel, gradient elution with 7 N NH3-methanol/DCM, 1:60, v/v to 7N NH3-methanol/DCM, 1:10, v/v) to give desired product 8-6 (M+1: 402.2).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHENG, CLIFFORD; SHIPPS, JR., GERALD W.; HUANG, XIAOHUA; HUANG, YING; SHAO, NING; RAO, ASHWIN; PALANI, ANANDAN; ORTH, PETER; VOIGT, JOHANNES H.; HERR, ROBERT J.; ROSSITER, LANA MICHELE; ZENG, QI; SUN, XIANFENG; US2012/122837; (2012); A1;,
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1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
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