Tag: M.W:100-200

91192-32-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91192-32-4,6-Methoxyquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

Step 2: Preparation of 2-chloro-6-methoxyquinoxaline and 3-chloro-6-methoxyquinoxaline A solution of 6-methoxyquinoxalin-2(1H)-one & 7-methoxyquinoxalin-2(1H)-one (3 g, 18.28 mmol) in POCl3 (20 ml) was refluxed for 3 h. The solvent was evaporated under reduced pressure and the residue was diluted with cold water. The aqueous solution was basified by solid sodium carbonate and extracted with ethyl acetate. The combine organic layer was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography (20% ethyl acetate in pet ether) to afford mixture of regioisomers (3.7 g). 2 g of the above mixture was separated by SFC purification to afford 2-chloro-7-methoxyquinoxaline (0.7 g, 34.7%) and 2-chloro-7-methoxyquinoxaline (0.9 g, 44.6%) as off white solid. 2-chloro-6-methoxyquinoxaline: 1H NMR (400 MHz, DMSO-d6): delta ppm 1H NMR (400 MHz, CDCl3): delta ppm 8.71 (s, 1H), 7.91-7.89 (d, J=8 Hz, 1H), 7.46-7.38 (m, 2H), 3.97 (s, 3H); MS: MS m/z 194.9(M++1).

91192-32-4 6-Methoxyquinoxalin-2(1H)-one 13437707, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael; US2013/115190; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, General procedure: A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

A mixture of 2-chloro-3-methylquinoxaline (100 mg, 0.56 mmol), 2-chlorophenol (144 mg, 1.12 mmol) and potassium carbonate (929 mg, 6.72 mmol) in DMSO (5.6 mL) was heated at 120C in a sealed tube for 18 h. The reaction mixture was partitioned between EtOAc (60 mL) and water (60 mL). The organic layer was separated and the aqueous layer was back-extracted with 10% propan-2-ol in chloroform (2 x 60 mL). The combined organic layers were dried (Na2S04) and concentrated in vacuo. The residue was purified by flash column chromatography (Si02, 0-100% EtO Ac/heptane, followed by 1-100%) MeOH/EtOAc), then repurified by preparative HPLC, yielding the title compound (37.5 mg, 24%) as an off-white solid. deltaEta (500 MHz, DMSO-d6) 8.03-7.99 (m, IH), 7.73-7.58 (m, 4H), 7.56-7.45 (m, 2H), 7.44-7.35 (m, IH), 2.80 (s, 3H). LCMS (ES+) 271.0/273.0 (M+H)+, RT 1.69 minutes., 32601-86-8

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; FOULKES, Gregory; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; KROEPLIEN, Boris; REUBERSON, James Thomas; ROOK, Sarah Margaret; ZHU, Zhaoning; WO2015/86523; (2015); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

25594-62-1, 2-Acetylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 22-bromo-1 -(quinoxalin-2-yl)ethanone (JS111 )Pyridinium tribromide (2.935 g, 9.18 mmol) was added to a stirred solution of JS1 10 (580 mg, 3.67 mmol) in 1 :1 CHCI3/EtOH (60 ml) and the mixture was heated at 50 C for 16 h. Removal of the solvent in vacuo was followed by addition of H20 and extraction with EtOAc (3x). The combined organic extracts were further washed with H20 and brine, dried (MgS04), filtered and concentrated in vacuo. Flash chromatography (CH2CI2 isocractic) afforded the title compound as a brown solid (656 mg, 2.61 mmol, 71 .2%). Mpt: Decomposed before melting [Lit. (Pharmazie 1983, 38(12), 829-32) 1 12-1 14 C]; Rf = 0.26 (CH2CI2); IR (vmax/crrf1, thin film): 1708 (CO stretch), 1392, 762 (C-Br Stretch); 1 H NMR (600 MHz, CDCI3): deltaEta = 4.96 (s, 2H, 12-H), 7.88-7.90 (m, 1 H, 8-H), 7.93-7.96 (m, 1 H, 7-H), 8.20-8.21 (m, 2H, 6,9-H), 9.53 (s, 1 H, 3-H); 13C NMR (150 MHz, CDCI3): 5C = 31.3 (C-12), 129.7 (C-6), 130.6 (C-9), 131 .3 (C- 8), 133.0 (C-7), 141.0 (C-10), 143.4 (C-3), 144.3 (C-5), 144.7 (C-2), 192.4 (C-11 ); LRMS m/z (El+): 252 [M(81Br)]+, 250 [M(79Br)]+, 142, 1 15 [(81Br)], 1 13 [(79Br)]; HRMS m/z (Epsilon ): Found 249.97396; Ci0H7BrN2O requires 249.97363; Anal. Calcd. for Ci0H7BrN2O: C, 47.84; H, 2.81 ; N, 1 1 .16. Found C, 47.70; H, 2.68; N, 10.86%., 25594-62-1

25594-62-1 2-Acetylquinoxaline 11105814, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin; WO2012/168733; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution of Zn(ClO4)2¡¤6H2O (18.7 mg, 0.05 mmol) in H2O (2 mL) was added 1 equiv. of 4,4′-bpy (7.8 mg, 0.05 mmol) in CH3OH (5 mL). This was stirred for 5 min, and then a 5 mL CH3OH solution of Hqc (9.5 mg, 0.05 mmol) was added to the reaction mixture and then filtered to give an orange solution. Slow evaporation of the solvent at room temperature gave rise to colorless block single crystals suitable for X-ray single-crystal analysis after 2 weeks (Yield 42%). Anal. Calc. for C28H18N6O6Zn: C, 56.06; H, 3.02; N, 14.01. Found: C, 55.93; H, 3.09; N, 14.12%. IR (KBr)/cm-1: 3066(w), 1654(s), 1503(m), 1449(s), 1349(m), 1283(w), 1227(w), 1010(w), 820(w), 553(m), 442(w).

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Xiao, Bo; Xiao, Hai-Yang; Yang, Li-Jun; Inorganica Chimica Acta; vol. 407; (2013); p. 274 – 280;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6298-37-9,6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluorophenyl)propanoic acid (500 mg, 1.66 mmol) and quinoxalin-6-amine (219 mg, 1.5 mmol) in DMF (7 mL), DIPEA (0.80 mL, 4.5 mmol) was added, followed by HATU (631 mg, 1.66 mmol) and then the reaction mixture was stirred at rt for 16 h. The reaction mixture was partitioned between aq. NaHCCb-NaCl (10 mL) and EtOAc (3 x 25 mL), and the combined organic components were dried (Na2S04), filtered, concentrated and then purified by flash silica chromatography (24 g Silica, eluted with solv A = Hexane / solv B = EtOAc, gradient from 0 – 50%B, hold at 50%B) to afford the title compound (515 mg). LC-MS retention time = 1.15 min; m/z = 429.0 [M+H]+. (Column: Waters Aquity BEH C18 2.1 x 50 mm 1.7U. Solvent A = 100% Water: 0.05% TFA. Solvent B = 100% Acetonitrile: 0.05% TFA. Flow Rate = 0.8 mL/min. Gradient: 2-98% B. Gradient Time = 1.5 min. Wavelength = 220). NMR (400 MHZ, chloroform-d) delta 8.96 – 8.65 (m, 3H), 8.31 (d, J=2.3 Hz, IH), 8.01 (d, J=9.0 Hz, IH), 7.81 (dd, J=9.0, 2.3 Hz, IH), 6.83 (d, J=6.0 Hz, 2H), 6.77 – 6.66 (m, IH), 5.19 (d, J=6.8 Hz, IH), 4.58 (d, J=6.3 Hz, IH), 3.30 (dd, J=14.1, 6.5 Hz, IH), 3.20 – 3.05 (m, IH), 1.46 (s, 9H).

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VIIV HEALTHCARE (No.5) LIMITED; BENDER, John A.; LOPEZ, Omar D.; NGUYEN, Van N.; YANG, Zhong; WANG, Alan Xiangdong; WANG, Gan; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; THANGATHIRUPATHY, Srinivasan; (350 pag.)WO2016/172425; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67074-63-9,4-Methyl-3,4-dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

A solution of 4-methyl-3,4-dihydroquinoxalin-2-(1H) -one (3.0 g, 18.5 mmol) in tetrahydrofuran (50 mL) Cooled to 0 C, lithium aluminum hydride (2.1 g, 55.3 mmol) was added in portions, The reaction was continued slowly to 25 C for 1 hour. The reaction solution was quenched with water (50 mL) ethyl acetate (30 mL x 3) was added, Combine organic phase, Dried over anhydrous sodium sulfate, filter, concentrate, The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 5: 1) To give the title compound (2.5 g, yield 91.3%)., 67074-63-9

As the paragraph descriping shows that 67074-63-9 is playing an increasingly important role.

Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Co., Ltd.; Wu, Yongqian; (31 pag.)CN106317027; (2017); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6309-61-1,6-Methylquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

6309-61-1, b. 1,4,6-trimethyl-1,4-dihydro-quinoxaline-2,3-dione. To a solution of 6-methyl-1,4-dihydro-quinoxaline-2,3-dione (5.3 g, 30 mmol) in THF (150 mL) was added, at 0 C. under argon, sodium hydride (3.68 g, 80% in mineral oil, 120 mmol) followed by methyl iodide (7.5 mL, 120 mmol). The solution was stirred at 0 C. for 3 hrs and at room temperature overnight. The reaction mixture was cooled to 0 C. and acidified with 1N HCl. The solution was extracted with dichloromethane washed with brine, dried (Mg2SO4), filtered and evaporated. The residue was chromatographed on silica gel (10 to 25% acetonitrile in dichloromethane) to give 1.1 g of 1,4,6-trimethyl-1,4-dihydro-quinoxaline-2,3-dione (18%). 1H NMR (300 MHz; CDCl3): 2.44 (s, 3 H), 3.66 (s, 6 H), 7.06-7.15 (m, 3 H).

6309-61-1 6-Methylquinoxaline-2,3(1H,4H)-dione 73225, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Pfahl, Magnus; Tachdjian, Catherine; Spruce, Lyle W.; Al-Shamma, Hussien A.; Boudjelal, Mohamed; Fanjul, Andrea N.; Wiemann, Torsten R.; Pleynet, David P.M.; US2003/144329; (2003); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.,6298-37-9

To a solution of 6-aminoquinoxaline (290 mg, 2 mmol) and hydroxypentadecanoic acid (518 mg, 2 mmol) in dichloromethane (40 ml) are added triethylamine (0.83 ml, 6 mmol), EDC (768 mg, 4 mmol) and HOBt (405 mg, 3 mmol). The mixture is stirred overnight at room temperature under inert atmosphere of nitrogen. The reaction is hydrolyzed, extracted with dichloromethane and then washed with a concentrated NH4Cl solution. The organic phase is dried on anhydrous MgSO4 and concentrated under reduced pressure. The residue obtained is then dissolved in DMF (10 ml), and then imidazole (136 mg, 2 mmol) and TBDMS-Cl (332 mg, 2.2 mmol) are added. The mixture is stirred overnight at room temperature under inert atmosphere of nitrogen. The reaction is hydrolyzed and then extracted with ethyl acetate, dried on anhydrous MgSO4 and concentrated under vacuum. The silylated product is purified on a silica column in a mixture of cyclohexane and ethyl acetate in a proportion of 8:2. The product is then dissolved in THF (10 ml) and TBAF (3 ml, 1 M in THF) is added. After 5 minutes the reaction is hydrolyzed and extracted with ethyl acetate. The organic phase is dried on anhydrous MgSO4 and concentrated under vacuum. The product is obtained with a total yield of 38% on three steps.

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); US2011/118270; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider