Tag: M.W:100-200

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (100 mg, 0.290 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (60.0 mg, 0.290 mmol) to afford N-[(1S)-1-{[4-(4-fluorophenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]-3-hydroxy-N-methylquinoxaline-2-carboxamide (88.0 mg, yield 63%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.74 (1H, brs), 7.81 (1H, d, J=7.8 Hz), 7.67 (1H, d, J=7.3 Hz), 7.61 (1H, d, J=11.2 Hz, 7.3 Hz), 7.38-7.32 (1H, m), 7.15 -7.10 (2H, m), 7.05-7.02 (2H, m), 5.08 (1H, d, J=11.5 Hz), 4.65-4.55 (1H, m), 4.12-4.06 (2H, m), 3.96-3.79 (2H, m), 2.77 and 2.76 (3H, s), 2.07-1.24 (5H, m), 0.97 (3H, dd, J=6.4 Hz, 2.4 Hz), 0.92 (3H, dd, J=6.4 Hz, 3.2 Hz). IR (ATR) cm-1, 3460, 2960, 1685, 1640, 1505, 1455, 1205, 1055. MS (ESI, m/z): 503 (M+Na)+. Anal. Calcd for C26H29FN4O4: C, 64.99; H, 6.08; F, 3.95; N, 11.66. Found: C, 64.69; H, 6.16; F, 4.14; N, 11.38.

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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91-19-0,91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Bromine was added dropwise to a magnetically stirred refluxing solution of quinoxaline (1) or tetrahydroquinoxaline 15 or 19 in the relevant solvent. The resulting reaction mixture was heated at reflux temperature. The reaction was monitored by TLC or 1H NMR spectroscopy. After the desired time, the resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. The crude was purified appropriate method described in below.

The synthetic route of 91-19-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

Reference Example 20 To a suspension of 2,3-dichloroquinoxaline (300 mg, 1.51 mmol) in methanol (15 mL) and N,N-dimethylformamide (1.0 mL) was added sodium methoxide (28% in methanol, 309 mg, 1.66 mmol) dropwise at 0 0C. After being stirred for 2 hour at room temperature, the reaction mixture was concentrated in vacuo. The residue was diluted with chloroform and water. The organic layer was separated with phase separator and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane to hexane: ethyl acetate = 19: 1) to give 2-chloro-3-methoxyquinoxaline (the compound of Reference Example 20 listed in Table of Reference Example as described hereinafter) as a colorless powder (251 mg,%)., 2213-63-0

The synthetic route of 2213-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; MORIMOTO, Hiroshi; SAKAMOTO, Toshiaki; HIMIYAMA, Toshiyuki; KAWANISHI, Eiji; MATSUMURA, Takehiko; WO2010/30027; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

b) Without Pd-catalyst and base – detection of 2-aminoquinoxaline and 3a: Compound 2a (120 mg, 0.65 mmol) was heated with Ph2PH (0.11 mL, 0.64 mmol) for 1.5h at 130 C. Then the resulting blue viscous substance was extracted with diethyl ether to give an olive-green powder (186 mg). The filtrate displayed 31P NMR signals of Ph2PH, Ph4P2 and 3a, signal intensities 31:61:5. An aliquot (90 mg) of the powder was treated with Et2O / aqueous NaOH. Phase separation and drying over CaCl2 gave ca. 50 mg of a viscous yellow mixture of 3a and 2-aminoquinoxaline (13CH signal intensities 1:1), contaminated by small amounts of unconverted Ph2PH and unidentified side products. The 13C NMR data of 3a are in good agreement with those of the pure product. – 2-Aminoquinoxaline: The 1H NMR data are in good agreement with reported values [5]. 13C NMR (CDCl3): d 151.97 (Cq-2), 140.89 (Cq-8a), 137.78 (CH-3), 137.43 (Cq-4a), 130.29 (CH-7), 128.83 (CH-5), 125.88 (CH-8), 125.05 (CH-6); HRMS (ESI in MeOH): Calcd. for 2-aminoquinoxaline (C8H7N3) [M+H+] 146.0713; found: 146.0713; calcd. for 3a (C20H16N3P) [M+H+] 330.1155; found: 330.1158.

34117-90-3, As the paragraph descriping shows that 34117-90-3 is playing an increasingly important role.

Reference£º
Article; Adam, Mohamed Shaker S.; Mohamad, Ahmad Desoky; Jones, Peter G.; Kindermann, Markus K.; Heinicke, Joachim W.; Polyhedron; vol. 50; 1; (2013); p. 101 – 111;,
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32998-25-7, 2-Chloro-3-methoxyquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE: 4-Chloro-l -(2-chloro-phenyl)-[l ,2,4]triazolo[4,3-a]quinoxaline (IIx). A mixture of 2-chloro-3-methoxyquinoxaline (455 mg) and 2-chlorobenzhydrazide (439 mg) in acetonitrile (10 mL) was heated at 150 C for 15 min under MW conditions. The reaction mixture was cooled in an ice/water bath and the precipitated solid was collected by filtration. This material was suspended in acetonitrile (10 mL) and phosphoryl chloride (1.09 mL) was added. The mixture was heated at 150 C for lh under MW conditions, before another 0.5 mL of phosphoryl chloride was added and the mixture was heated for an additional lh at 150 C under MW conditions. The reaction mixture was poured onto ice and diluted with ice/water to a final volume of 50 mL. It was neutralized with solid NaHC03 and the resulting yellow precipitate was collected by filtration, water and dried to afford IIx (409 mg).

32998-25-7, 32998-25-7 2-Chloro-3-methoxyquinoxaline 20227409, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; H. LUNDBECK A/S; J?RGENSEN, Morten; BRUUN, Anne, Techau; RASMUSSEN, Lars, Kyhn; LARSEN, Mogens; WO2013/34755; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Methanol solution (70 cm3) of [RuHCl(CO)(PPh3)3] (0.2 g, 2¡Á10-4 mol)and 3-hydroxy-2-quinoxalinecarboxylic acid (0.05 g, ~2¡Á10-4 mol) wasrefluxed for 3 h. The crystals suitable for X-ray analysis were obtained byslow evaporation of the reaction mixture. Yield 82%. IR (KBr, n/cm-1):1945 (s, nRu-H), 1926 (s, nRu-CO), 1708 (s, nCOO/OH), 1641 (s, nC=N, nC=C). UV-VIS (solid state, l/nm): 475, 400, 350, 250. UV-VIS [methanol, l/nm(log e)]: 466.4 (2.52), 388.8 (3.14), 322.0 (3.70), 276.0 (4.03), 251.2(4.33), 207.2 (4.85). 1H NMR (400 MHz, CDCl3) d: 14.45 (s, OH), 13.89(s, OH), 8.68 (d, hqxc, J 8.7 Hz), 8.17 (d, hqxc, J 8.6 Hz), 7.69 (dd, 17 H,J 16.4 and 5.7 Hz), 7.64-7.10 (m, PPh3/hqxc), 6.93 (s, 4 H), -10.51 (t,HRu, J 19.1 Hz). 13C NMR (101 MHz, CDCl3) d: 173.12 (s), 158.68 (s),143.00 (s), 138.04 (s), 134.29 (s), 133.41 (dt, J 8.7 and 6.1 Hz), 132.16 (s),131.80 (dd, J 22.8 and 6.1 Hz), 131.44 (s), 128.09 (q, J 4.9 Hz), 127.76 (s),127.27 (s), 126.87 (s), 126.34 (s). 31P NMR (202 MHz, CDCl3) d: 43.69(s). Found (%): C, 65.25; H, 4.52; N, 3.27. Calc. for C46H36N2O4P2Ru (%):C, 65.48; H, 4.30; N, 3.32., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma?ecki, Jan G.; MaronI, Anna; Kusz, Joachim; Mendeleev Communications; vol. 25; 2; (2015); p. 103 – 105;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, Example 305: Preparation of N4-cyclopropyl-N2-(quinoxalin-6-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine2-Chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine (0.060 g, 0.253 mmol) and quinoxalin-6-amine (0.037 g, 0.253 mmol) were mixed in acetic acid (1 ml). The mixture was microwaved at 120 C for 20 min and then concentrated. 17 mg of product was recovered after automated reverse phase chromatography (water-MeCN). MS calcd for [Ci6Hi3F3N6+H]+:347.13, found 347.10.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; YALE UNIVERSITY; SHAW, Reuben J.; EGAN, Daniel F.; COSFORD, Nicholas; TURK, Benjamin; VAMOS, Mitchell; PANICKAR, Dhanya Raveendra; CHUN, Matthew; SHEFFLER, Doug; (315 pag.)WO2016/33100; (2016); A1;,
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1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of commercially available quinoxaline-2-carbaldehyde (0.500 g, 3.16 mmol) in DCM (14.0 mL) were added 2-methylpropane-2-sulfinamide (0.383 g, 3.16 mmol) and Ti(OEt)4 (3.31 mL, 15.8 mmol). The reaction mixture was refluxed for 17 h, cooled to room temperature and quenched with water. The solids were filtered through a CELITE pad and washed with DCM. The organic phase was separated and washed with water, brine, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, hexanes:EtOAc, 100:0 to 50:50) to yield Int-16A (0.690 g, 84%) as a tan solid. NMR (500MHz, DMSO-c) delta 9.54 (s, 1H), 8.68 (s, 1H), 8.29 – 8.17 (m, 2H), 8.06 – 7.92 (m, 2H), 1.27 (s, 9H). HPLC retention time (Method 2): 2.132 mia; LCMS (ES): m/z 262.2 [M+H]+., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Guohua; MIGNONE, James; (95 pag.)WO2019/94319; (2019); A1;,
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6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of an a-halogenoketone, an amine and a base (DIPEA or triethylamine) in a solvent (e.g. DMF, ethanol, acetonitrile, dioxane or THF) was irradiated in a microwave oven at 100C to 200C (more in particular at 120 to 200 C) for 5 to 180 min. (more in particular for 15 to 120 min). The reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Amino-5-bromoquinoxaline hydrobromide 6-Aminoquinoxaline (2.08 g, 14.4 mmol) was dissolved in 11.5 ml glacial acetic acid. The solution was cooled in water-while a solution of bromine (0.74 ml, 2.3 g, 14.4 mmol) in 1.5 ml glacial acetic acid was added slowly over 15 min. After stirring for an additional 30 min, the orange red solid formed was filtered off and washed thoroughly with dry ether. The solid was dried in vacuo overnight to yield 4.44 g crude product (a yield of 100%). The compound, 6-amino-5-bromoquinoxaline hydrobromide, had no definite melting point. A phase change (from fine powder to red crystals) was noticed at about 220 C. Decomposition was observed at about 245 C. It was used directly for the next step., 6298-37-9

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Allergan, Inc.; US5373010; (1994); A;,
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