Tag: M.W:100-200

7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7251-61-8, Selenium dioxide (7.69 g, 69.35mmol) was added to a mixture of 1,4-dioxane (60 mL) and H2O (2.5 mL) and heated to reflux. 2-Methylquinoxaline (5 g, 34.67 mmol) was dissolved in 1,4-dioxane (10 mL) and added dropwise to the heated solution. A colour change to red-brown was observed. After heating for 4 h the hot mixture was filtered through Celite and washed with 1,4-dioxane (2 ¡Á 25 mL). The filtrate was allowed to cool and remove the solvent by evaporation. Chromatography of the residue (EtOAc-cyclohexane, 1:5) gave 6 as yellow needles (4.34 g, 79%); Rf = 0.42 (EtOAc-cyclohexane 1:5); mp 98-100 C; 1H-NMR (400MHz, CDCl3) d = 10.29 (s, 1H, CHO), 9.43(s, 1H), 8.20-8.27 (m, 2H), 7.90-7.95 (m, 2H); 13C-NMR (100MHz, CDCl3) delta192.7 (CHO), 145.9, 144.9 (each C), 142.5 (CH), 141.9 (C), 132.9, 131.1, 130.5, 129.6 (each CH); LRMS (ESI): Found 159.0 [M+H]+, C9H7N2O requires 159.1.

The synthetic route of 7251-61-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jarikote, Dilip V.; Li, Wei; Jiang, Tao; Eriksson, Leif A.; Murphy, Paul V.; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 826 – 835;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (150 mg, 0.430 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (81.0 mg, 0.430 mmol) to afford the desired title compound (71.0 mg, yield 43%) as a white solid. 1H-NMR (CDCl3 400 MHz) delta: 12.77 and 10.14 (1H, brs), 8.14 (1H, t, J=4.9 Hz), 7.98 (1H, d, J=8.1 Hz), 7.66-7.50 (3H, m), 7.37 (1H, brs), 6.86 (1H, dd, J=11.7 Hz, 4.9 Hz), 6.73 (1H, t, J=8.8 Hz), 5.40-5.32 (1H, m), 5.09 (1H, t, J=7.1 Hz), 4.10-3.91 (2H, m), 3.82-3.62 (2H, m), 2.39-2.17 (1H, m), 2.12-1.98 (2H, m), 1.95-1.83 (2H, m), 1.11 (6H, d, J=6.6 Hz). IR (ATR) cm-1: 1685, 1630, 1525, 1470, 1430, 1270, 1250, 1215. MS (ESI, m/z): 450 (M+H)+. Anal. Calcd for C24H27N5O3¡¤0.75H2O: C, 62.26; H, 6.20, N, 15.13. Found: C, 61.95; H, 5.86; N, 15.15.

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3- hydroxyquinoxaline-2-carboxylic acid (11.55 mmol, 1.0 eq.) in 10 mL of dry DMF was added EDAC (17.33 mmol, 1.5 eq.) and N-hydroxysuccinimide (17.33 mmol, 1.5 eq.) and the reaction stirred 16 hours under dry nitrogen. The reaction was filtered through a sintered glass funnel and the yellow precipitate washed 2 times with 2 mL DMF then dried under vacuum to give 3.25 g (11.3 mmol, 98%) of the active ester 1 as a yellow solid

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; VENTANA MEDICAL SYSTEMS, INC.; MURILLO, Adrian, E.; KOSMEDER, Jerome, W.; MAY, Eric; DAY, William; LEFEVER, Mark; PEDATA, Anne, M.; BIENIARZ, Christopher; MILLER, Phillip; WO2012/3476; (2012); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6344-72-5,6-Methylquinoxaline,as a common compound, the synthetic route is as follows.

6344-72-5, Example 9 6-Bromomethylquinoxaline: A mixture of 6-methylquinoxaline (1.5 g, 10.4 mmol), N-bromosuccinimide (2.2 g, 12.5 mmol) and benzoylperoxide (0.30 g, 1.25 mmol) in benzene (35 mL) was stirred rapidly and heated to reflux for 5 h. Upon cooling the mixture was diluted with ethyl acetate (25 mL), washed with 1N sodium hydroxide solution (50 mL) and saturated sodium chloride solution (50 mL). The organic layer was dried (MgSO4) and evaporated to a crystalline solid (2.5 g, 77% desired product, 23% alpha,alpha-dibrominated product as determined by 1H NMR). The mixture was used in subsequent reactions.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2006/264631; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of quinoxaline-2-carboxylic acid (23.51 mg, 0.135 mmol) and 2-(3H- [l ,2,3]triazolo[4,5-]pyridin-3-yl)-l , l ,3,3-tetramethylisouronium hexafluorophosphate(V) (HATU, 51.3 mg, 0.135 mmol) and N-(3-aminobicyclo[l . l . l]pentan-l-yl)-2-(3,4- dichlorophenoxy)acetamide hydrochloride (45.6 mg, 0.135 mmol, Example 2B) was added N- ethyl-N-isopropylpropan-2-amine (69.8 mg, 0.540 mmol) in N,N-dimethylformamide (1 mL). The mixture was stirred at room temperature for 20 minutes, and then water (0.02 mL) was added. The mixture was purified by preparative HPLC (Phenomenex Luna CI 8(2) 5 mupiiota 100 A AXIA column 250 mm x 21.2 mm, flow rate 25 mL/minute, 5-95% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid in water)) to give the titled compound (45 mg, 0.098 mmol, 73%). JH NMR (400 MHz, DMSO-<) delta ppm 9.62 (s, 1H), 9.44 (s, 1H), 8.78 (s, 1H), 8.20 (m, 2H), 8.00 (m, 2H), 7.56 (d, J = 9 Hz, 1H), 7.29 (d, J = 3 Hz, 1H), 7.02 (dd, J = 9, 3 Hz, 1H), 4.53 (s, 2H), 2.43 (s, 6H). MS (ESI+) m/z 457 (M+H)+., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; PLIUSHCHEV, Marina, A.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; SWEIS, Ramzi, Farah; DART, Michael, J.; RANDOLPH, John, T.; MURAUSKI, Kathleen; (674 pag.)WO2019/90076; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

91192-32-4, 6-Methoxyquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91192-32-4, Intermediate 149: 2-Chloro-7-methoxyquinoxalineA solution of 4-methoxybenzene-l,2-diamine (16.8 g, 0.12 mmol) in ethanol (250 mL) was treated with a solution of ethyl oxoacetate (50 wt % in toluene, 50 mL, 0.23 mmol) dropwise with cooling in an ice bath. The reaction was allowed to warm to room temperature and after 2 hours, a precipitate was collected by filtration giving 15 g of a brown solid as a 2:1 mixture of 6-methoxyquinoxalin-2(lH)-one to 7-methoxyquinoxalin-2(lH)-one. These EPO isomers were inseparable by TLC. The mixture was suspended in phosphorus oxychloride (150 niL) and heated to reflux for 1 hour. The reaction was cooled to room temperature and was quenched on ice. The pH of the mixture was adjusted to pH 8 with solid sodium carbonate, it was extracted with ethyl acetate, washed with brine, dried over sodium sulfate, filtered, and concentrated to dryness to give 10.4 g of a crude mixture of 2-chloro-6- methoxyquinoxaline and the desired 2-chloro-7-methoxyquinoxaline. Chromatography on silica gel with 5% ethyl acetate in hexanes afforded 0.77 g of the product as a colorless solid. MS (ESt: 195 (MH+) for C9H7ClN2O1H NMR (CDCht delta 3.96 (s, 3H); 7.29 (d, IH); 7.41 (dd, IH); 7.97 (d, IH); 8.63 (s, IH).

As the paragraph descriping shows that 91192-32-4 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/134378; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6344-72-5,6-Methylquinoxaline,as a common compound, the synthetic route is as follows.

6-Bromomethylquinoxaline (1) (De Selms, R. C.; Greaves, R. J., Scheigh, W. R. J. Het. Chem. 1974, 11, 595); Bromomethylquinoxaline is unstable and decomposes when stored for long time. It should be used up within a day or two of its preparation. To a clear solution of 6-methylquinoxaline (60 g, 0.416 mol) in 550 mL of CCl4 was added in one portion solid NBS (Aldrich, 81.5 g, 0.458 mol, 1.1 eq) and AlBN (Aldrich, 1.6 g, 9.7 mmol, 2.3 mol %). The resulting mixture was heated at reflux for 2 hr and cooled to rt. The precipitate of succinimide was removed by filtration. The filtrate was evaporated on rotary evaporator until solid begins to crystallize out of the solution. Remaining mixture was left at rt for 2 hr, then the crystallized product was filtered off, washed with small amount of hexanes-CCl4 mixture (ca. 20:1) and dried in vacuum. The isolated solid contained just traces of the di-bromo side-product and was used in the following step without further purification. Yield 33.3 g (36%) as colorless crystals., 6344-72-5

As the paragraph descriping shows that 6344-72-5 is playing an increasingly important role.

Reference£º
Patent; Wyeth; US2005/282820; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

25652-34-0, 6-Nitroquinoxalin-2-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 26-3 2-Chloro-6-nitroquinoxaline At room temperature, phosphorus pentoxide (15.2 g) was added to a phosphorus oxychloride solution (70 mL) of the compound (7.1 g) obtained in Production Example 26-2. The reaction liquid was stirred with heating under reflux for 8 hours, then cooled to room temperature, and poured into water with ice. The formed precipitate was collected by filtration and washed with water. This was dried under reduced pressure to obtain the entitled compound (2.4 g)., 25652-34-0

The synthetic route of 25652-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sakuraba, Shunji; Kameda, Minoru; Kishino, Hiroyuki; Haga, Yuji; Otake, Norikazu; Moriya, Minoru; US2009/264426; (2009); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under the protection of nitrogen,Add 3-methyl-2-chloro-quinoxaline (1.78 g, 10 mmol) to a solution of 2-isopropylaminoethoxyethanol (5.88 g, 40 mmol) in N-methylpyrrolidone (100 mL).Heated to 190 C reflux for 15 h,The reaction was monitored by LC-MS, and the reaction mixture was completed. The reaction was cooled and ice water (100 mL) was added to the reaction mixture, which was extracted with ethyl acetate (50 mL*3), and the organic phase was mixed with water (100 mL) and saturated brine (100 mL*2) After washing,Dry over anhydrous sodium sulfate, filter, decompress the solvent under reduced pressure, and then purified by chromatography on silica gel column.Drying in vacuo gave 2.27 g of white solid compound VIII-1.Yield: 78.5%,

32601-86-8, The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chengdu Yuandong Bio-pharmaceutical Co., Ltd.; Zhang Tao; Zeng Yanqun; Yan Shengyong; Wang Ying; (22 pag.)CN108774183; (2018); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6344-72-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6344-72-5,6-Methylquinoxaline,as a common compound, the synthetic route is as follows.

Example 9 6-Bromomethylquinoxaline: A mixture of 6-methylquinoxaline (1.5 g, 10.4 mmol), N-bromosuccinimide (2.2 g, 12.5 mmol) and benzoylperoxide (0.30 g, 1.25 mmol) in benzene (35 mL) was stirred rapidly and heated to reflux for 5 h. Upon cooling the mixture was diluted with ethyl acetate (25 mL), washed with 1N sodium hydroxide solution (50 mL) and saturated sodium chloride solution (50 mL). The organic layer was dried (MgSO4) and evaporated to a crystalline solid (2.5 g, 77% desired product, 23% alpha,alpha-dibrominated product as determined by 1H NMR). The mixture was used in subsequent reactions.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2006/264631; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider