Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

6.4 g of methyl p-hydroxybenzoate and 5.3 g of potassium carbonate were dissolved in 250 ml of N,N-dimethylformamide and reacted at 85 C for 12 h.Then, 7 g of 2-chloro-3-methylquinoxaline obtained in the step (2) was added thereto, and after continuing the reaction for 12 hours, 250 ml of water was added to the reaction solution.The aqueous phase was extracted twice with ethyl acetate.The crude product was purified by silica gel column chromatography (eluent: petroleum ether: ethyl acetate = 50:1, v: v)., 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Patent; Shandong University; Li Xun; Li Zhiyu; Liu Yuantao; Yuan Mingxia; Zhou Huaiyu; Zhou Jianfeng; Han Xuemei; (21 pag.)CN104529915; (2018); B;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120258-69-7,2,8-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

2,8-Dichloroquinoxaline (Pharmabridge Inc., Doylestown, PA; 2.00 g, 10.05 mmol) and 2-methylallylamine (Matrix, Columbia, SC; 4.29 ml, 60.3 mmol) were combined in a tube, sealed, and heated to 80 C in an oil bath. After 4 h, the reaction was cooled and the reaction was partitioned between saturated aqueous NaHC03 and DCM. The aqueous layer was extracted with DCM 3 times, and the combined organics were dried over anhydrous Na2S04, filtered, and concentrated in vacuo to give 8-chloro-N-(2- methylallyl)quinoxalin-2 -amine (2.40 g, 10.27 mmol, quantitative yield) as an orange semi-solid: FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, CDCl3) delta ppm 8.28 (1 H, s), 7.77 – 7.85 (1 H, m), 7.69 (1 H, d, J=7.7 Hz), 7.29 – 7.34 (1 H, m), 5.04 (1 H, s), 4.96 (1 H, s), 4.20 (2 H, d, J=5.9 Hz), 1.87 (3 H, s). m/z (ESI, +ve) 234.1 (M+H)+.

120258-69-7, As the paragraph descriping shows that 120258-69-7 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; CEE, Victor J.; BROWN, James; CHAVEZ JR., Frank; CHEN, Jian J.; HERBERICH, Bradley J.; HARRINGTON, Essa Hu; LANMAN, Brian Alan; LEE, Matthew; PETTUS, Liping H.; REED, Anthony B.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan; WO2014/22752; (2014); A1;,
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91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, At room temperature, will be 52 mg (0.4 mmol) quinoxaline, 414 mg (2.8 mmol) 2, 2 – ethoxy acetic acid, 182 mg (0.8 mmol) of the ammonium persulfate and 260 mg (0.8 mmol) Cs2CO3Dissolved in 6 ml in dimethyl sulfoxide, mix, nitrogen 30 min after the blue LEDs arranged under the lamp illumination reaction 20 h, adding 7.2 concentration is 3 M hydrochloric acid catalytic hydrolysis 20 h, using sodium bicarbonate adjusting pH to neutral, extraction, the combined organic phase, by the rotary concentrate by the Rotavapor after turns on lathe does, then to the volume ratio of 15:1 petroleum ether: ethyl acetate mixed solution of eluant, performing silica gel column chromatography purification and separation, to obtain the corresponding formylation heterocyclic derivatives, its reaction is Product purity is 99%, and the yield is 63%.

As the paragraph descriping shows that 91-19-0 is playing an increasingly important role.

Reference£º
Patent; Harbin Institute of Technology; Yang Chao; Jia Wei; Gou Baoquan; (9 pag.)CN108640807; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2

Preparation of Quinoxaline-2-carboxylic acid {(S)-1-[3-oxo-1-(propane-1-sulfonyl)-azepan-4-ylcarbamoyl]-3-methyl-1-butyl}-amide Following the general procedure of Examples 280h-j except substituting quinoxaline-2-carboxylic acid for benzofuran-2-carboxylic acid and 1-propanesulfonyl chloride for 3-flurobenzenesulfonyl chloride provided the title compound as a mixture of diastereomers. Separation of the diastereomers by HPLC provided diastereomer 1: MS(ES) 503.4 (M+H)+and diastereomer 2 MS(ES) 503.4 (M+H)+.

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; SmithKline Beecham Corporation; US2002/147188; (2002); A1;; ; Patent; SmithKline Beecham Corporation; US2003/144175; (2003); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (2.00 g, 6.84 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (1.48 g, 7.80 mmol) under nitrogen stream to afford the desired title compound (2.71 g, yield 85%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.88 (1H, s), 9.62 (1H, d, J=6.0 Hz), 7.87 (1H, dd, J=7.6 Hz, 2.0 Hz), 7.65 (1H, dt, J=7.6 Hz, 2.0 Hz), 7.40 (1H, dt, J=7.6 Hz, 2.0 Hz), 7.37 (1H, d, J=7.6 Hz), 7.12 (2H, m), 7.02 (2H, m), 4.76 (1H, q, J=8.4 Hz), 4.61 (1H, m), 4.12-3.80 (2H, m), 3.60-3.20 (2H, m), 2.08-1.88 (2H, m), 1.75-1.45 (2H, m), 1.23 (1H, dd, J=6.4 Hz), 0.53-0.38 (4H, m). MS (ESI, m/z): 465 (M+H)+. Anal. Calcd for C25H25FN4O4: C, 64.64; H, 5.42; N, 12.06. Found: C, 64.27; H, 5.30; N, 12.01.

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1204-75-7, The resulting compound (317 mg, 1.00 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (190 mg, 1.00 mmol) to afford the desired title compound (358 mg, yield 79%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.86 (1H, brs), 9.56 (1H, m), 7.88 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.8 Hz), 7.14 (2H, m), 7.03 (2H, m), 5.00 (1H, m), 4.60 (1H, m), 4.03-3.79 (2H, m), 3.57-3.20 (2H, m), 2.07-1.44 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2965, 1690, 1630, 1505, 1205. MS (ESI, m/z): 453 (M+H)+. HRMS (ESI, m/z): 453.1950 (Calcd for C24H26FN4O4: 453.1938) Anal. Calcd for C24H25FN4O4: C, 63.71; H, 5.57; N, 12.38; F, 4.20. Found: C, 63.67; H, 5.46; N, 12.42; F, 4.09.

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6924-66-9, PyBOP (153 mg, 295 mumol) was added to a mixture of 8-amino-2-(4-fluorophenyl)-2- azaspiro[4.5]decan-1 -one (isomer 1 , Intermediate 118) (64.4 mg, 246 muiotaetaomicronIota), quinoxaline-5- carboxylic acid (56.3 mg, 307 muiotaetaomicronl) and N,N-diisopropylethylamine (210 mul, 1 .2 mmol) in DMF (1 .0 ml) and the mixture was stirred over night at room temperature. For work-up, water was added and the mixture was extracted with dichloromethane. The organic phase was washed with water, filtered through a silicone filter and concentrated to give the title compound 93.0 mg (89 % yield).LC-MS (Method 1 ): Rt= 1 .12 min; MS (ESIneg): m/z = 417 [M-H]-1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 9.77 (d, 1 H), 9.09-9.05 (m, 2H), 8.43 (dd, 1 H), 8.26 (dd, 1 H), 7.97 (dd, 1 H), 7.75-7.68 (m, 2H), 7.26-7.19 (m, 2H), 3.96-3.84 (m, 1 H), 3.79 (t, 2H), 2.12-1 .99 (m, 4H), 1.75-1 .60 (m, 4H), 1 .59-1 .45 (m, 2H)

As the paragraph descriping shows that 6924-66-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, Preparation 6-amino-5-bromoquinoxaline Hydrobromide 6-Aminoquinoxaline (2.08 g, 14.4 mmol) was dissolved in 11.5 ml glacial acetic acid. The solution was cooled in water while a solution of bromine (0.74 ml, 2.3 g, 14.4 mmol) in 1.5 ml glacial acetic acid was added slowly over 15 minutes. After stirring for an additional 30 minutes, the orange red solid formed was filtered off and washed thoroughly with dry ether. The solid was dried in vacuo overnight to yield 4.44 g crude product (a yield of 100%). The compound, 6-amino-5-bromoquinoxaline hydrobromide, had no definite melting point. A phase change from fine powder to red crystals was observed at about 2200 C. Decomposition was observed at about 2450 C. The material was used directly for preparation of 6-amino-5-bromoquinoxaline as follows.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gil, Daniel W.; Whitcup, Scott; Brin, Mitchell F.; Donello, John E.; US2004/266776; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

Int-16A. (i?)-2-Methyl-N-(quinoxalin-2-ylmethylene)propane-2-sulfinamide. To a solution of commercially available quinoxaline-2-carbaldehyde (0.500 g, 3.16 mmol) in DCM (14.0 mL) were added 2-methylpropane-2-sulfinamide (0.383 g, 3.16 mmol) and Ti(OEt)4 (3.31 mL, 15.8 mmol). The reaction mixture was refluxed for 17 h at which point it was cooled to room temperature and quenched with water. After filtration of the reaction mixture through a CELITE pad and subsequent washing of the cake with DCM, the organic phase of the filtrate was separated and washed with water, sat. brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by flash chromatography (silica gel, hexanes:EtOAc, 100:0 to 50:50) to yield Int-16A (0.690 g, 84%) as a tan solid. NMR (500 MHz, OMSO-de) delta 9.54 (s, 1H), 8.68 (s, 1H), 8.29 – 8.17 (m, 2H), 8.06 – 7.92 (m, 2H), 1.27 (s, 9H). HPLC retention time (Method 2): 2.132 mia; LCMS (ES): m/z 262.2 [M+H]+

1593-08-4, As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Guohua; MIGNONE, James; (117 pag.)WO2018/89360; (2018); A1;,
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