Tag: M.W:100-200

Chai, Xiaoyun; Zhang, Jun; Yu, Shichong; Hu, Honggang; Zou, Yan; Zhao, Qingjie; Dan, Zhigang; Zhang, Dazhi; Wu, Qiuye published the article 《Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols》. Keywords: triazolyl difluorophenyl aralkylamino propanol preparation antifungal activity computational chem.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Computed Properties of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, e.g., I, as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

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Reference:
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Zhang, Qiao; Wang, Simin; Zhang, Qian; Xiong, Tao published the article 《Radical Addition-Triggered Remote Migratory Isomerization of Unactivated Alkenes to Difluoromethylene-Containing Alkenes Enabled by Bimetallic Catalysis》. Keywords: difluoromethyl alkene preparation diastereoselective; alkene radical addition isomerization.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Quality Control of 1-(Bromomethyl)-4-ethylbenzene. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A fascinating alkene remote migratory isomerization engendered by carbon radical addition to C=C bond in alkenes Ar(CH2)nCH=CH2 (Ar = C6H5, 4-FC6H4, 2-pyridyl, etc.; n = 2, 4, 5, 6, 7) via bimetallic catalysis has been disclosed. A diverse array of alkenes bearing distantly incorporated the difluoromethylene ArCH=CH(CH2)mCF2C(O)R (m = 1, 4, 5, 6, 9; R = OMe, OEt, morpholin-4-yl, etc.) functionality have been expediently obtained. The retainment of C=C bonds in products could serve as an useful synthetic platform furnishing otherwise difficult to access value-added densely functionalized difluoromethylene containing mols. In addition, some exptl. studies have been implemented to shed light on the probable mechanism.

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Oh, Sangmi; Kim, Sungbum; Kong, Sunju; Yang, Gyongseon; Lee, Nakyung; Han, Dawoon; Goo, Junghyun; Siqueira-Neto, Jair L.; Freitas-Junior, Lucio H.; Song, Rita published the article 《Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi》. Keywords: dihydroimidazobenzimidazole derivative preparation antileishmanial antitrypanosomal; 2,3-Dihydroimidazo[1,2-a]benzimidazole; Anti-parasitic activity; Chagas disease; Leishmaniasis.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Electric Literature of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A high-throughput (HTS) and high-content screening (HCS) campaign of a com. library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogs as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which were known as the causative parasites for visceral leishmaniasis and Chagas disease, resp. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds I and II showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, resp.) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, resp.) without serious cytotoxicity toward THP-1 and U2OS cell lines.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Effects of substituents on the intramolecular hydrogen bond in 8-quinolinol-N-oxides, published in 1980-10-31, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, SDS of cas: 1127-45-3.

IR spectral and deuteration studies on 8-quinolinol-N-oxides and its 5-nitro-, 5-nitroso-, 5-amino-, 5-phenylazo-, 5,7-dibromo- and 5,7-diiodo-derivatives in solid and in solution state confirm the presence of a strong intramol. unsym. H bond involving the hydroxyl hydrogen atom and the N-oxide oxygen atom. The structure of the complex absorption pattern in the region 2850 cm-1-1800 cm-1 is explained in terms of Fermi resonance interaction between the νOH of O-H…O and the overtone and combination bands of (δOH + νC-O) and other fundamental vibrations of the mol. The absence of any significant absorptions in the νOH region in the spectra of 5,7-dichloro- and 5,7-dinitro-derivatives coupled with strong and broad absorption in 1500 cm-1-600 cm-1 region is perhaps due to the presence of very short hydrogen bonds in these compounds

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sigler, K.; Gaskova, D.; Chladkova, K.; Knebl, R.; Wimmer, T.; Vacata, V.; Gebel, J. researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Quality Control of 8-Hydroxyquinoline 1-oxide.They published the article 《Standardized system for quantifying residual dirt on medical appliances cleansed in hospital washers-disinfectors: Dirt detection by different methods》 about this compound( cas:1127-45-3 ) in Folia Microbiologica (Prague, Czech Republic). Keywords: quantification residual dirt medical appliance hospital; disinfection surgical appliance residual dirt quantification; cleansing surgical appliance residual dirt quantification. We’ll tell you more about this compound (cas:1127-45-3).

An easy-to construct, easy-to-operate standardized system was developed for determining the residual biol. contamination of surgical instruments, endoscopes and other medical appliances subjected to hospital cleansing and/or disinfection. It consists of standard-sized pieces of glass, metal or endoscope plastic – dirt carriers – either bare or enclosed in truncated Eppendorf caps to simulate hard-to-access conditions. The surface of the carriers is covered with model dirt simulating biol. contamination and the carriers are then affixed to sturdy metal holders. Conventional model dirts were found to peel or flake off the carrier surface, lowering the precision of residual soil determination A newly developed model dirt consisting of liver mash, lactose and sunflower oil and exhibiting low tendency to peel off surfaces was therefore used. The whole setup was subjected to chem. or enzymic cleansing programs at elevated temperature in hospital washer-disinfectors of two types, and the residual dirt after cleansing was determined by three methods. The method using toxicant-doped dirt that quenches the luminescence of an indicator bacterium Photobacterium phosphoreum gave satisfactory data under laboratory conditions but with hospital-washed samples it exhibited excessive fluctuations caused by bacterium-dirt interactions and by phys. influences. Both other methods gave better results but displayed some process sensitivity. The luciferin-luciferase-based ATP bioluminescence assay sometimes gave low or even neg. dirt level values and showed a low effect of reduced dirt accessibility on cleansing of metal carriers. The Bradford protein assay showed about equal cleansing efficiency for both easily and poorly accessible carriers after enzymic cleansing. Our system can be used for determining low levels of residual contamination of medical appliances after cleansing/disinfection and assessing the efficiency of com. washer-disinfectors; its efficiency can be further increased by using a cleansing process-insensitive method for soil detection and quantification.

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Quinoxaline – Wikipedia,
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Name: 8-Hydroxyquinoline 1-oxide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Hypervalent Iodine(III)-Mediated Regioselective Cyanation of Quinoline N-Oxides with Trimethylsilyl Cyanide. Author is Xu, Feng; Li, Yuqin; Huang, Xin; Fang, Xinjie; Li, Zhuofei; Jiang, Hongshuo; Qiao, Jingyi; Chu, Wenyi; Sun, Zhizhong.

A regioselective cyanation of quinoline N-oxides with trimethylsilyl cyanide was developed by using (Diacetoxyiodo) benzene (PIDA) as mediated hypervalent iodine(III) reagent under metal-free and base-free reaction conditions to obtain 2-cyanoquinolines. The efficient PIDA reagent could play the role of an activator of the substrates and an accelerator of N-O bond cleavage. The reaction system featured a wide range of substrate suitability and high yields. The procedure was enlarged gram-scale to synthesize the tuberculosis (TB) inhibitor. Finally, according to some exptl. results, a plausible mechanism for the cyanation reaction is proposed.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Biochemical studies on quinoline derivatives. VII. Metabolic products of 8-quinolinol N-oxide》. Authors are Ito, Ryoji; Otaka, Hajime; Usui, Shigeru; Hashimoto, Yukichi.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Synthetic Route of C9H7NO2. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

cf. CA 56, 13486h. Main metabolic products of 8-quinolinol N-oxide (I) found in the urine of injected rabbits were 8-hydroxy-2-quinolone (II) and 7,8-dihydroxy-2-quinolone. 8,x-dihydroxy-2-quinolone, a product of further metabolism of 8-hydroxy-4-quinolone, an alkylated derivative of quinoline, and a compound of unknown structure were also found: 8-Quinolinol (III), 7,8-dihydroxyquinoline (IV), IV N-oxide, 8-quinolylsulfuric acid (V), V N-oxide, and I were not present. All other metabolic products, except a part of II, occurred in urine as glucuronides or ethereal sulfates. Metabolic products were in accord with those of II, but very different from those of III. In vitro oxidation of I by quinoline dehydrogenase was very difficult, and oxidation products were not detected.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhou, Bingcheng; Li, Xun; Li, Yan; Xu, Yaochun; Zhang, Zhengxi; Zhou, Mi; Zhang, Xinglong; Liu, Zhen; Zhou, Jiahai; Cao, Chunyang; Yu, Biao; Wang, Renxiao researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene.They published the article 《Discovery and Development of Thiazolo[3,2-a]pyrimidinone Derivatives as General Inhibitors of Bcl-2 Family Proteins》 about this compound( cas:57825-30-6 ) in ChemMedChem. Keywords: thiazolo pyrimidinone preparation Bcl2 protein inhibitor SAR. We’ll tell you more about this compound (cas:57825-30-6).

A class of compounds with a common thiazolo[3,2-a]pyrimidinone motif has been developed as general inhibitors of Bcl-2 family proteins. The lead compound was originally identified in a random screening of a small compound library using a fluorescence polarization-based competitive binding assay. Its binding to the Bcl-xL protein was further confirmed by 15N-HSQC NMR experiments Structural modifications on the lead compound were guided by the outcomes of mol. modeling studies. Among the 42 compounds obtained, a number of them exhibited much improved binding affinities to Bcl-2 family proteins as compared to the lead compound The most potent compound, BCL-LZH-40 (I), inhibited the binding of BH3 peptides to Bcl-xL, Bcl-2, and Mcl-1 with inhibition constants (Ki) of 17, 534, and 200 nM, resp.

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Quinoxaline | C8H6N2 | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Chemical shifts observed in Lα X-ray emission lines of elements in the range of 26 ≤ Z ≤ 30 in their halogen compounds.SDS of cas: 13940-83-5.

The chem. shifts and full widths at half maximum intensity of Lα x-ray emission lines of elements in the range 26 ≤ Z ≤ 30 were studied in their halogen compounds using a wavelength-dispersive X-ray fluorescence spectrometry. The chem. shifts for F based compounds are higher than that of Cl and Br based compounds

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Safety of 8-Hydroxyquinoline 1-oxide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Iodine-Catalyzed Direct C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes. Author is Zhang, Zhenhao; Pi, Chao; Tong, Heng; Cui, Xiuling; Wu, Yangjie.

An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes catalyzed by iodine under metal- and external oxidant-free reaction conditions has been developed. A variety of (E)-2-styrylazaheterocycles have been produced in moderate to excellent yields. The mechanistic exploration indicated that the N-oxide group played dual roles as both the directing group and an internal oxidant in this catalytic cycle.

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Quinoxaline – Wikipedia,
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