Tag: M.W:100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, ChemMedChem called Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design, Author is Holvey, Rhian S.; Valkov, Eugene; Neal, David; Stewart, Murray; Abell, Chris, which mentions a compound: 217192-22-8, SMILESS is OCC1=CC=C(C2=CC=NC=C2)C=C1, Molecular C12H11NO, Related Products of 217192-22-8.

Protein-protein interactions are difficult therapeutic targets, and inhibiting pathol. relevant interactions without disrupting other essential ones presents an addnl. challenge. Herein the authors report how this might be achieved for the potential anticancer target, the TPX2-importin-α interaction. Importin-α is a nuclear transport protein that regulates the spindle assembly protein TPX2. It has two binding sites-major and minor-to which partners bind. Most nuclear transport cargoes use the major site, whereas TPX2 binds principally to the minor site. Fragment-based approaches were used to identify small mols. that bind importin-α, and crystallog. studies identified a lead series that was observed to bind specifically to the minor site, representing the first ligands specific for this site. Structure-guided synthesis informed the elaboration of these fragments to explore the source of ligand selectivity between the minor and major sites. These ligands are starting points for the development of inhibitors of this protein-protein interaction.

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Safety of 8-Hydroxyquinoline 1-oxide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Synthesis of a novel hexadentate chelating agent based on 8-hydroxyquinoline. Author is Shrader, William D.; Celebuski, Joseph; Kline, Steven J.; Johnson, David.

Tris[[(hydroxyquinoline)carbonamido]ethyl]amine (I), a new hexadentate chelator, was prepared by the conversion of 8-hydroxyquinoline to succinimido hydroxyquinolinecarboxylate II and subsequent reaction with N(CH2CH2NH2)3. I is a siderophore analog with a non-naturally occurring binding unit comprising a combination of both O and N donor atoms.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Wujiyan Gongye called Preparation of high-purity nickel compound from Ni-containing waste materials, Author is Gu, Heng; Li, Xingying; Zhu, Jianchun; Zhou, Jinyun, which mentions a compound: 13940-83-5, SMILESS is [H]O[H].[H]O[H].[H]O[H].[H]O[H].[Ni+2].[F-].[F-], Molecular F2H8NiO4, COA of Formula: F2H8NiO4.

The process conditions for the preparation of high-purity Ni compounds (NiSO4.6H2O, NiF2.4H2O, Ni(Ac)2.4H2O, and NiO) from Ni-containing waste carbonate by H2SO4 leaching were studied, and a technol. process was proposed. The principle for the purification and extraction of Ni solution in the system of H2SO4 was discussed with phase diagram. The recovery of Ni was 92%, and the quality of the product met the national standard

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sen, Chiranjit; Ghosh, Subhash C. researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).HPLC of Formula: 1127-45-3.They published the article 《Transition-Metal-Free Regioselective Alkylation of Quinoline N-Oxides via Oxidative Alkyl Migration and C-C Bond Cleavage of tert-/sec-Alcohols》 about this compound( cas:1127-45-3 ) in Advanced Synthesis & Catalysis. Keywords: alkyl quinoline oxide regioselective preparation; quinoline oxide alc alkyl migration bond cleavage PIDA mediated; isoquinoline alkyl oxide regioselective preparation; alc isoquinoline oxide alkyl migration bond cleavage PIDA mediated; pyridine alkyl oxide regioselective preparation; oxide pyridine alc aalkyl migration bond cleavage PIDA mediated. We’ll tell you more about this compound (cas:1127-45-3).

An unprecedented C2-alkylation of quinoline N-oxide derivatives I [R1 = Me, Et; R2 = H, OH, HNC(O)Ph, etc.; R3 = H, 6-Me, 5-Br, etc.] via C-C bond activation of tert- and sec-alkyl alc. was described using hypervalent iodine (III) reagent PhI(OAc)2 (PIDA). This regioselective alkylation using mild hypervalent iodine reagents was more practical, operationally simple and transition metal-free. The reaction proceeded efficiently with a broad range of substrates including quinoline, isoquinoline, and pyridine N-oxides using a variety of tert-/sec- alcs. to afford compounds I, alkyl-benzo[h]quinoline-N-oxides, alkyl-pyridine-N-oxides and alkyl-isoquinoline-N-oxides. From exptl. outcome, a rationalized mechanism was proposed, mediated by PIDA.

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Computed Properties of C9H11Br. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines. Author is Zhang, Shuai; Xiao, Jun-Zhao; Li, Yan-Bo; Shi, Chang-Yun; Yin, Liang.

A Cu(I)-catalyzed asym. alkylation of HPAr1Ar2 with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr1Ar2) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some 31P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr1Ar2 does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,RP)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol.

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Name: 8-Hydroxyquinoline 1-oxide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Transition-Metal-Free Regioselective Alkylation of Quinoline N-Oxides via Oxidative Alkyl Migration and C-C Bond Cleavage of tert-/sec-Alcohols. Author is Sen, Chiranjit; Ghosh, Subhash C..

An unprecedented C2-alkylation of quinoline N-oxide derivatives I [R1 = Me, Et; R2 = H, OH, HNC(O)Ph, etc.; R3 = H, 6-Me, 5-Br, etc.] via C-C bond activation of tert- and sec-alkyl alc. was described using hypervalent iodine (III) reagent PhI(OAc)2 (PIDA). This regioselective alkylation using mild hypervalent iodine reagents was more practical, operationally simple and transition metal-free. The reaction proceeded efficiently with a broad range of substrates including quinoline, isoquinoline, and pyridine N-oxides using a variety of tert-/sec- alcs. to afford compounds I, alkyl-benzo[h]quinoline-N-oxides, alkyl-pyridine-N-oxides and alkyl-isoquinoline-N-oxides. From exptl. outcome, a rationalized mechanism was proposed, mediated by PIDA.

If you want to learn more about this compound(8-Hydroxyquinoline 1-oxide)Name: 8-Hydroxyquinoline 1-oxide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1127-45-3).

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Shrader, William D.; Celebuski, Joseph; Kline, Steven J.; Johnson, David published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).COA of Formula: C9H7NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

Tris[[(hydroxyquinoline)carbonamido]ethyl]amine (I), a new hexadentate chelator, was prepared by the conversion of 8-hydroxyquinoline to succinimido hydroxyquinolinecarboxylate II and subsequent reaction with N(CH2CH2NH2)3. I is a siderophore analog with a non-naturally occurring binding unit comprising a combination of both O and N donor atoms.

If you want to learn more about this compound(8-Hydroxyquinoline 1-oxide)COA of Formula: C9H7NO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1127-45-3).

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.Name: 8-Hydroxyquinoline 1-oxide.de la Guardia, Carolina; Stephens, David E.; Dang, Hang T.; Quijada, Mario; Larionov, Oleg V.; Lleonart, Ricardo published the article 《Antiviral activity of novel quinoline derivatives against dengue virus serotype 2》 about this compound( cas:1127-45-3 ) in Molecules. Keywords: dengue virus serotype 2 Vero cell quinoline derivative antiviral; antiviral; dengue virus; quinolines. Let’s learn more about this compound (cas:1127-45-3).

Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis and antiviral activity evaluation of two compounds based on the quinoline scaffold, which has shown potential for the development of mols. with various biol. activities. Two of the tested compounds showed dose-dependent inhibition of dengue virus serotype 2 in the low and sub micromolar range. The compounds 1 and 2 were also able to impair the accumulation of the viral envelope glycoprotein in infected cells, while showing no sign of direct virucidal activity and acting possibly through a mechanism involving the early stages of the infection. The results are congruent with previously reported data showing the potential of quinoline derivatives as a promising scaffold for the development of new antivirals against this important virus.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 19777-66-3, is researched, SMILESS is C[C@H](N)CN.[H]Cl.[H]Cl, Molecular C3H12Cl2N2Journal, Tetrahedron: Asymmetry called Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2, Author is Armstrong, Daniel W.; He, Lingfeng; Yu, Timothy; Lee, Jauh T.; Liu, Yan-song, the main research direction is enantiomeric purity chiral catalyst auxiliary synthon resolving agent.Reference of (S)-Propane-1,2-diamine dihydrochloride.

The enantiomeric purity of reagents used in asym. synthesis is of fundamental importance when evaluating the selectivity of a reaction and the product purity. In this work, 109 chiral reagents (many recently introduced) are assayed. Approx. 64% of these reagents had moderate to high levels of enantiomeric impurities (i.e. from >0.1% to <16%). The type of chiral reagents assayed and used in enantioselective synthesis include metal-ligand catalysts for allylic substitutions, catalysts for addition of Grignard reagents and other additions, epoxidations and reduction of ketones and aldehydes; Ru-complex auxiliaries for asym. cyclopropanation, as well as amine, diamine, alc., diol, amino alc., carboxylic acid and oxazolidinone auxiliaries; epoxide, lactone, furanone, pyrrolidinone, nitrile, sulfoximine and carboxylic acid synthons (including malic acid, mandelic acid, lactic acid and tartaric acid); and a variety of chiral resolving agents. Accurate, efficient assays for all compounds are given. If you want to learn more about this compound((S)-Propane-1,2-diamine dihydrochloride)Reference of (S)-Propane-1,2-diamine dihydrochloride, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(19777-66-3).

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Application of unithiol (Na 2,3-dimercaptopropanesulfonate) in analytical chemistry》. Authors are Vol’f, A. L..The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Computed Properties of C9H7NO2. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

Unithiol (I) (cf. Ptrun’kin, CA 51, 5692h) forms stable complexes with many cations and most of these are soluble in H2O. Zn and Cd were determined by titration with I in the presence of Eriochrome Black T as an indicator with the same degree of accuracy as by titration with Trilon B; alkali metals and Fe up to 5 mg./l. did not interfere. I can be used to block the interference of Zn, Pb, and Hg in the trilonometric determination of Ca and Mg. I forms complexes with the following cations: in neutral media; Pb green, Cu blue, Ni brown, and Bi yellow; in acid media; Cu dark-blue, Ag green, and Mn brown; in NH4OH; Cu blue-violet, Fe red, Ag green, Mn brown-green, Bi yellow, and Sb yellow.

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Quinoxaline – Wikipedia,
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