Tag: M.W:100-200

Formula: C9H11Br. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists. Author is Widler, Leo; Altmann, Eva; Beerli, Rene; Breitenstein, Werner; Bouhelal, Rochdi; Buhl, Thomas; Gamse, Rainer; Gerspacher, Marc; Halleux, Christine; John, Markus R.; Lehmann, Hansjoerg; Kalb, Oskar; Kneissel, Michaela; Missbach, Martin; Muller, Irene R.; Reidemeister, Sibylle; Renaud, Johanne; Taillardat, Agnes; Tommasi, Ruben; Weiler, Sven; Wolf, Romain M.; Seuwen, Klaus.

Parathyroid hormone (PTH) is an effective bone anabolic agent. However, only when administered by daily s.c. injections exposure of short duration is achieved, a prerequisite for an anabolic response. Instead of applying exogenous PTH, mobilization of endogenous stores of the hormone can be envisaged. The secretion of PTH stored in the parathyroid glands is mediated by a calcium sensing receptor (CaSR) a GPCR localized at the cell surface. Antagonists of CaSR (calcilytics) mimic a state of hypocalcemia and stimulate PTH release to the bloodstream. Screening of the internal compound collection for inhibition of CaSR signaling function afforded 2a (I). In vitro potency could be improved > 1000 fold by optimization of its chem. structure. The binding mode of our compounds was predicted based on mol. modeling and confirmed by testing with mutated receptors. While the compounds readily induced PTH release after iv application a special formulation was needed for oral activity. The required profile was achieved by using microemulsions. Excellent PK/PD correlation was found in rats and dogs. High levels of PTH were reached in plasma within minutes which reverted to baseline in about 1-2 h in both species.

Compound(57825-30-6)Formula: C9H11Br received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bromomethyl)-4-ethylbenzene), if you are interested, you can check out my other related articles.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Identification of the Aromatic Tertiary N-Oxide Functionality in Protonated Analytes via Ion/Molecule Reactions in Mass Spectrometers, Author is Duan, Penggao; Gillespie, Todd A.; Winger, Brian E.; Kenttamaa, Hilkka I., which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Computed Properties of C9H7NO2.

A mass spectrometric method is presented for the rapid identification of compounds that contain the aromatic N-oxide functional group. This method utilizes a gas-phase ion/mol. reaction with 2-methoxypropene that yields a stable adduct for protonated aromatic tertiary N-oxides (and with one protonated nitrone) in different mass spectrometers. A variety of protonated analytes with O- or N-containing functional groups were examined to probe the selectivity of the reaction. Besides protonated aromatic tertiary N-oxides and one nitrone, only three protonated amines were found to form a stable adduct but very slowly. All the other protonated analytes, including aliphatic tertiary N-oxides, primary N-oxides, and secondary N-oxides, are unreactive toward or react predominantly by proton transfer with 2-methoxypropene.

Compound(1127-45-3)Computed Properties of C9H7NO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(8-Hydroxyquinoline 1-oxide), if you are interested, you can check out my other related articles.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.SDS of cas: 57825-30-6.Yamauchi, Satoshi; Nishimoto, Asuka; Nishiwaki, Hisashi; Nishi, Kosuke; Sugahara, Takuya published the article 《Discovery of stereospecific cytotoxicity of (8R,8’R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring》 about this compound( cas:57825-30-6 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: lignan arctigenin insect cells 28S rRNA structure activity relationship; 28S rRNA; Arctigenin; Insect cells; Lignan; Structure-activity relationship. Let’s learn more about this compound (cas:57825-30-6).

One of the arctigenin stereoisomers, (8R,8’R)-trans-form 1, showed stereospecific cytotoxicity against insect cells, Sf9 and NIAS-AeAl-2 cells. By the comparison with other stereoisomers, the most importance of the 8’R stereochem. for the higher activities was clarified. On the other hand, the wider range of activity level among stereoisomers against cancer cells, HL-60, was not observed The structure-activity relationship research using derivatives bearing (8R,8’R)-trans-form was performed to show the same level of activities of 3-iodo, 4-iodo, and 3,4-methylenedioxy derivatives 28, 29, and 36 as (8R,8’R)-trans-arctigenin 1. In the examination of thiono derivatives, 4-iodo thiono and 3,4-methylenedioxy thiono derivatives 66, 67 showed similar level of activities to that of (8R,8’R)-trans-arctigenin 1. The expression of ribosomal 28S rRNA gene of Sf9 cells was increased by (8R,8’R)-trans-arctigenin 1, whereas a degradation of DNA was not observed

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Computed Properties of C9H7NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Solvent effect on the intramolecular hydrogen bond in 8-quinolinol N-oxide. Author is Dziembowska, T.; Malarski, Z.; Szczodrowska, B..

Solvent effect on intramol. hydrogen bond in 8-quinolinol N-oxide has been studied by IR, UV, 1H NMR and 13C NMR spectroscopy, dipole moment measurements and quantum-mech. calculations The solute-solvent interactions are of local character and they vary considerably over the range of solvent under study. The results suggest that formation complexes with solvent mols. weaken the intramol. hydrogen bond in 8-quinolinol N-oxide.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Binder properties of the metal fluoride-hydrogen fluoride-water system, published in 1973, which mentions a compound: 13940-83-5, Name is Nickel(ii)fluoridetetrahydrate, Molecular F2H8NiO4, Recommanded Product: 13940-83-5.

The binding properties of the MFm-HF-H2O system were investigated, where M is Na, K, Mg, Co, Ni, or Zr and m an integer. The systems KF-HF-H2O and ZrF4-HF-H2O had the highest yield strength, showing promising tech. utilization.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Proton polarizability of intramolecular hydrogen bonds with molecules nonconjugated and conjugated between donor and acceptor groups, published in 1980-11-01, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, Computed Properties of C9H7NO2.

IR and NMR spectroscopy was used to study proton polarizability in compounds [o-RC6H4CO2H, R = Me2NCH2 or Me2N; I, R1 = CH2OH or OH; and II] with intramol. H bonds. When the H-bond donor and acceptor groups are not electronically conjugated, IR continua indicate a large proton polarizability. When they are conjugated the continua are very weak. Thus, not only the proton potential but also the dependence of the dipole moment on the vibrational coordinate is decisive for occurrence of the continua.

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Kim, Heung Jae; Kwak, Woo Young; Min, Jong Pil; Lee, Jae Young; Yoon, Tae Hyun; Kim, Ha Dong; Shin, Chang Yell; Kim, Mi Kyung; Choi, Song Hyen; Kim, Hae Sun; Yang, Eun Kyoung; Cheong, Ye Hwang; Chae, Yu Na; Park, Kyung Jin; Jang, Ji Myun; Choi, Soo Jung; Son, Moon Ho; Kim, Soon Hoe; Yoo, Moohi; Lee, Bong Jin published an article about the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1 ).Recommanded Product: 57825-30-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:57825-30-6) through the article.

A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229, I) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clin. development.

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Formula: F2H8NiO4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Crystal structure of μ3-fluoro-tri-μ2-fluoro-tris(tetramethylethylene-diamine nickel(II)) fluoride trihydrate, [Ni3(tmen)3F5]+·F-·3H2O, C18H54F6N6Ni3O3. Author is Ishikawa, Yuki; Miyamoto, Keiko; Horn, Ernst.

The crystal structure of the title compound is herein given. The title compound was synthesized by a reaction of nickel difluoride tetrahydrate and N,N,N’,N’-tetramethylethylenediamine. The title compound is a fluoride bridged trinuclear complex. Crystallog. data are given.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.Category: quinoxaline.Liu, Qifa; Wei, Wei; Lu, Ming; Sun, Feng; Li, Jiang; Zhang, Yuchao published the article 《Chloromethylation of Aromatic Compounds Catalyzed by Surfactant Micelles in Oil-Water Biphasic System》 about this compound( cas:57825-30-6 ) in Catalysis Letters. Keywords: micelle catalyzed chloromethylation aromatic compound oil water biphasic system. Let’s learn more about this compound (cas:57825-30-6).

In this work, the chloromethylation reaction of aromatic compounds was performed successfully by micellar catalysis in oil/water biphasic system at high reactant loadings that exceeded the solubilization capacity of micellar solutions The effects of cationic, nonionic and anionic surfactants on the reaction were compared. The mechanism of chloromethylation reaction and the mechanism of micellar catalysis were investigated. The results show that the micellar catalysis is an effective way to realize the chloromethylation. The chloromethylation reaction consists of electrophilic substitution reaction and nucleophilic substitution reaction. Cationic surfactants, especially those containing longer hydrophobic carbon chain, are more effective. Selectivity for mono-chloromethylation was remarkably improved and regioselectivity was found to be dependent on the nature of the surfactant. Under the optimal reaction conditions, chloromethylation of isopropylbenzene could obtain 97.5% selectivity in mono-chloromethylation and 8.28 para/ortho selectivity ratio at 89.8% conversion. Good conversion and high selectivity in mono-chloromethylation were obtained.

Compound(57825-30-6)Category: quinoxaline received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bromomethyl)-4-ethylbenzene), if you are interested, you can check out my other related articles.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Optically active complexes of Schiff bases. I. Syntheses and properties of optically active tetradentate Schiff bases, published in 1972, which mentions a compound: 19777-66-3, Name is (S)-Propane-1,2-diamine dihydrochloride, Molecular C3H12Cl2N2, Recommanded Product: (S)-Propane-1,2-diamine dihydrochloride.

Reproducible syntheses and resolutions of 1,2-diamines were reported. Isomeric Schiff bases were prepared by condensation of 1 mole of (+),(-), or meso-1,2-diamine with 2 moles MeCOCH2COMe, salicylaldehyde or (+)-hydroxymethylenecamphor and identified by NMR and ir spectra. Configurational studies of the Schiff bases were made on the basis of ORD and CD spectra.

Compound(19777-66-3)Recommanded Product: (S)-Propane-1,2-diamine dihydrochloride received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Propane-1,2-diamine dihydrochloride), if you are interested, you can check out my other related articles.

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