Tag: M.W:100-200

Jorge, Ana Rita; Chernobryva, Mariya; Rigby, Stephen E. J.; Watkinson, Michael; Resmini, Marina published an article about the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1 ).Formula: C9H11Br. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:57825-30-6) through the article.

Recent advances in nanomaterials have identified nanogels as an excellent matrix for novel biomimetic catalysts using the mol. imprinting approach. Polymerisable Co-cyclen complexes with phosphonate and carbonate templates were prepared, fully characterized and used to obtain nanogels that show high activity and turnover with low catalytic load, compared to the free complex, in the hydrolysis of 4-nitrophenyl phosphate, a nerve agent simulant. The chem. structure of the template has an impact on the coordination geometry and oxidation state of the metal center in the polymerisable complex resulting in very significant changes in the catalytic properties of the polymeric matrix. Both pseudo-octahedral Co(III) and trigonal-bipyramidal Co(II) structures were used for the synthesis of imprinted nanogels, and the catalytic data demonstrate that: (i) the imprinted nanogels can be used in 15% load and show turnover; (ii) the structural differences in the polymeric matrixes resulting from the imprinting approach with different templates are responsible for the mol. recognition capabilities and the catalytic activity. Nanogel P1, imprinted with the carbonate template, shows > 50% higher catalytic activity than P2 imprinted with the phosphonate.

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Application of 57825-30-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design. Author is Tian, Yulin; Jin, Jing; Wang, Xiaojian; Hu, Jinping; Xiao, Qiong; Zhou, Wanqi; Chen, Xiaoguang; Yin, Dali.

We have discovered a series of triazole/oxazole-containing 2-substituted 2-aminopropane-1,3-diol derivatives as potent and selective S1P1 agonists (prodrugs) based on pharmacophore-guided rational design. Most compounds showed high affinity and selectivity for S1P1 receptor. Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate. These three compounds were also identified to have favorable pharmacokinetic properties.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and Biological Activity of Ethyl 2-(substituted benzylthio)-4-(3′-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate Derivatives, published in 2012, which mentions a compound: 57825-30-6, mainly applied to hydropyrimidine benzylthio biphenyl derivative bactericide fungicide, Electric Literature of C9H11Br.

In the present study, a new series of Et 2-(substituted benzylthio)-4-[3′-(ethoxycarbonyl)biphenyl-4-yl]-6-methyl-1,4-dihydropyrimidine-5-carboxylate derivatives (I) was synthesized. The newly synthesized compounds were characterized by 1H-NMR, mass and C, H, N analyses. All newly synthesized compounds were screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes and Klebsiella pneumoniae) and antifungal (Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Penicillium marneffei and Trichophyton mentagrophytes) activity. The results revealed that all synthesized compounds have a significant biol. activity against the tested microorganisms. Compounds I (R = H, Br, Et, OMe, NMe2, t-Bu, NO2) exhibited good antimicrobial activity.

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Synthetic Route of C9H11Br. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi. Author is Oh, Sangmi; Kim, Sungbum; Kong, Sunju; Yang, Gyongseon; Lee, Nakyung; Han, Dawoon; Goo, Junghyun; Siqueira-Neto, Jair L.; Freitas-Junior, Lucio H.; Song, Rita.

A high-throughput (HTS) and high-content screening (HCS) campaign of a com. library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogs as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which were known as the causative parasites for visceral leishmaniasis and Chagas disease, resp. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds I and II showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, resp.) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, resp.) without serious cytotoxicity toward THP-1 and U2OS cell lines.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Light-induced changes in the fluorescence yield of chlorophyll α in Anacystis nidulans II. Fast changes and the effect of photosynthetic inhibitors on both the fast and slow fluorescence induction, published in 1973, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, Safety of 8-Hydroxyquinoline 1-oxide.

The intensity dependence and spectral variations during the fast transient of chlorophyll a fluorescence were analyzed in a blue-green alga, A. nidulans. A prolonged dark adaptation and relatively high intensity of exciting illumination were required to evoke DPS (dip-peak-quasi steady state) type fluorescence yield fluctuations in Anacystis. At low to moderate intensities of exciting light, the time for the development of P depended on light intensities, but for M (maximum level), this remained constant at these intensities. Fluorescence emission was heterogeneous during the induction period. The P and M levels were relatively enriched in short-wave length system II chlorophyll a emission compared to D and S levels. The fast DPS transient was affected by an electron transport cofactor (methyl viologen) and inhibitors (e.g., DCMU [3-(3,4-dichlorophenyl)-1,1-dimethylurea], NH2OH) in a manner suggesting that these changes are mostly related to the oxidation-reduction level of intermediates between the 2 photosystems. The slow SM changes in fluorescence yield paralleled O evolution and were resistant to various electron transport inhibitors (o-phenanthroline, 8-hydroxyquinoline 1-oxide, salicylaldoxime, DCMU, NH2OH, and antimycin a). It appears that in Anacystis a net electron transport-supported oxidation-reduction state of the quencher regulates only partially the development of the DPS transient of the fluorescence yield but the development of the slow fluorescence yield changes may not be regulated by these reactions. The slow rise in the yield may be induced by a structural modification of the thylakoid membrane.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Propane-1,2-diamine dihydrochloride(SMILESS: C[C@H](N)CN.[H]Cl.[H]Cl,cas:19777-66-3) is researched.Application of 1194-22-5. The article 《A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids》 in relation to this compound, is published in Tetrahedron Letters. Let’s take a look at the latest research on this compound (cas:19777-66-3).

The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Odingo, Joshua O.; Early, Julie V.; Smith, Jake; Johnson, James; Bailey, Mai A.; Files, Megan; Guzman, Junitta; Ollinger, Juliane; Korkegian, Aaron; Kumar, Anuradha; Ovechkina, Yulia; Parish, Tanya researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Product Details of 1127-45-3.They published the article 《8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis》 about this compound( cas:1127-45-3 ) in Drug Development Research. Keywords: hydroxyquinoline antibacterial anticancer agent Mycobacterium tuberculosis liver cancer; Mycobacterium tuberculosis; tuberculosis; antibacterial; hydroxyquinoline; structure-activity relationship. We’ll tell you more about this compound (cas:1127-45-3).

There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8-hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities. We conducted a structure-activity relationship study of the series regarding its antitubercular activity using 26 analogs. The 8-hydroxyquinolines showed good activity against M. tuberculosis, with min. inhibitory concentrations (MIC90) of <5μM for some analogs. Small substitutions at C5 resulted in the most potent activity. Substitutions at C2 generally decreased potency, although a sub-family of 2-styryl-substituted analogs retained activity. Representative compounds demonstrated bactericidal activity against replicating M. tuberculosis with >4 log kill at 10× MIC over 14 days. The majority of the compounds demonstrated cytotoxicity (IC50 of <100μM). Further development of this series as antitubercular agents should address the cytotoxicity liability. However, the 8-hydroxyquinoline series represents a useful tool for chem. genomics to identify novel targets in M. tuberculosis. From this literature《8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis》,we know some information about this compound(1127-45-3)Product Details of 1127-45-3, but this is not all information, there are many literatures related to this compound(1127-45-3).

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors.Reference of (4-(Pyridin-4-yl)phenyl)methanol.

The structure-based design, synthesis, and biol. activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 57825-30-6, is researched, Molecular C9H11Br, about Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design, the main research direction is S1P1 agonist oxazole triazole preparation pharmacophore modeling structure activity; Immunomodulator; Lymphocyte; Pharmacophore; Prodrug; S1P(1) agonist.SDS of cas: 57825-30-6.

We have discovered a series of triazole/oxazole-containing 2-substituted 2-aminopropane-1,3-diol derivatives as potent and selective S1P1 agonists (prodrugs) based on pharmacophore-guided rational design. Most compounds showed high affinity and selectivity for S1P1 receptor. Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate. These three compounds were also identified to have favorable pharmacokinetic properties.

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Reference of (S)-Propane-1,2-diamine dihydrochloride. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Optically active complexes of Schiff bases. I. Syntheses and properties of optically active tetradentate Schiff bases. Author is Gullotti, Michele; Pasini, Alessandro; Fantucci, Piercarlo; Ugo, Renato; Gillard, Robert D..

Reproducible syntheses and resolutions of 1,2-diamines were reported. Isomeric Schiff bases were prepared by condensation of 1 mole of (+),(-), or meso-1,2-diamine with 2 moles MeCOCH2COMe, salicylaldehyde or (+)-hydroxymethylenecamphor and identified by NMR and ir spectra. Configurational studies of the Schiff bases were made on the basis of ORD and CD spectra.

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