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Application In Synthesis of 8-Hydroxyquinoline 1-oxide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Hypervalent Iodine(III)-Mediated Regioselective Cyanation of Quinoline N-Oxides with Trimethylsilyl Cyanide. Author is Xu, Feng; Li, Yuqin; Huang, Xin; Fang, Xinjie; Li, Zhuofei; Jiang, Hongshuo; Qiao, Jingyi; Chu, Wenyi; Sun, Zhizhong.

A regioselective cyanation of quinoline N-oxides with trimethylsilyl cyanide was developed by using (Diacetoxyiodo) benzene (PIDA) as mediated hypervalent iodine(III) reagent under metal-free and base-free reaction conditions to obtain 2-cyanoquinolines. The efficient PIDA reagent could play the role of an activator of the substrates and an accelerator of N-O bond cleavage. The reaction system featured a wide range of substrate suitability and high yields. The procedure was enlarged gram-scale to synthesize the tuberculosis (TB) inhibitor. Finally, according to some exptl. results, a plausible mechanism for the cyanation reaction is proposed.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Structure called Low-dimensional compounds containing bioactive ligands. Part XVI: Halogenated derivatives of 8-quinolinol N-oxides and their copper(II) complexes, Author is Lukoova, Andrea; Baran, Peter; Volarevic, Vladislav; Ilic, Aleksandar; Vilkova, Maria; Litecka, Miroslava; Harmosova, Michaela; Potocnak, Ivan, which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Application of 1127-45-3.

Four N-oxides, 8-quinolinol N-oxide (8-HQNO), 5,7-dichloro-8-quinolinol N-oxide (HdClQNO), 5,7-dibromo-8-quinolinol N-oxide (HdBrQNO) and 7-iodo-8-quinolinol N-oxide (HIQNO) as well as their six copper complexes, CuCl2(8-HQNO)2(H2O) (1), CuCl2(HdClQNO)2(H2O)2 (2), Cu(dClQNO)2(CHCl3) (3), Cu(dClQNO)2(H2O) (4), {[Cu(dBrQNO)2]•2H2O}n (5) and CuCl2(HIQNO)2(H2O)4 (6) were synthesized as possible anticancer agents. Crystal structures of N-oxides contain planar mols. held together via hydrogen bonds involving oxygen atoms of N-oxide groups as acceptors. Crystal structure of 5 represents the first structure of a copper(II) complex with an N-oxide ligand derived from 8-HQNO and is formed by infinite chains. In the chain, the Cu(II) atom coordinates to six oxygen atoms from two bidentate chelating dBrQNO ligands occupying apexes of elongated tetragonal bipyramid with bridging oxygen atoms of N-oxide groups in axial positions. Antiproliferative activity of prepared N-oxides as well as their complexes was studied using in vitro MTT assay against the MDA-MB-231, HCT-116 and A549 cancer cell lines and their selectivity was verified on MSCs cells. Among the tested cancer cell lines, A549 and MDA-MB-231 cells were the most sensitive to the tested complexes. Complex 1 showed the highest cytotoxicity against both tumor cell lines. At concentration, which could be tested in animal models, 1 induced cell death in >50% of cancer cells and in 20% of MSCs indicating its selectivity.

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SDS of cas: 13940-83-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Binder properties of the metal fluoride-hydrogen fluoride-water system. Author is Sychev, M. M.; Sviderskaya, O. I.; Borisova, V. B.; Lazareva, N. V..

The binding properties of the MFm-HF-H2O system were investigated, where M is Na, K, Mg, Co, Ni, or Zr and m an integer. The systems KF-HF-H2O and ZrF4-HF-H2O had the highest yield strength, showing promising tech. utilization.

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Category: quinoxaline. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about First Safe and Practical Synthesis of 2-Amino-8-hydroxyquinoline. Author is Storz, Thomas; Marti, Roger; Meier, Roland; Nury, Patrice; Roeder, Michael; Zhang, Kesheng.

The first safe and efficient synthesis of the important building block 2-amino-8-hydroxyquinoline (1) is described. Starting from the readily available N-oxide of the cheap bulk chem. 8-hydroxyquinoline (2), the target compound is obtained in a two-step one-pot procedure in good overall yield (53-66%) and purity (>98%) on a kilogram scale without chromatog.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 57825-30-6, is researched, Molecular C9H11Br, about Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity, the main research direction is quinazolinedione inhibitor respiration syncytial virus RNA polymerase.Name: 1-(Bromomethyl)-4-ethylbenzene.

A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability (selectivity index, SI ∼ 24). Scaffold optimization delivered analogs with improved potency and selectivity profiles. Most notable were compounds 15 and 19 (EC50 = 300-500 nM, CC50 > 50 μM, SI > 100), which significantly reduced viral titer (>400,000-fold), and several analogs were shown to block the activity of the RNA-dependent RNA-polymerase complex of RSV.

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Electric Literature of C9H11Br. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action. Author is Windisch, Marc Peter; Jo, Suyeon; Kim, Hee-Young; Kim, Soo-Hyun; Kim, Keumhyun; Kong, Sunju; Jeong, Hyangsuk; Ahn, Sujin; No, Zaesung; Hwang, Jong Yeon.

In this report we describe 2-iminobenzimidazole (IBI) analogs, identified during the course of a phenotypic high-throughput screening campaign, as novel hepatitis C virus (HCV) inhibitors. A series of IBI derivatives was synthesized and evaluated for their inhibitory activity against infectious HCV. Among the IBIs derivatives studied in this work, we identified promising compounds, e.g. I, with high antiviral efficacy, high selectivity index, and good microsomal stability. Noteworthy, the IBI series exhibited inhibitory activity on early and late steps of the viral cycle, but not in the HCV replicon system demonstrating a mechanism of action distinct from clin.-stage and approved anti-HCV drugs. Overall, our results suggest that IBIs are predestinated for further exploration as lead compounds for novel HCV interventions.

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Electric Literature of F2H8NiO4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Structural stud of divalent-metal fluoride hydrates, MF2.4H2O of the nickel, cobalt, iron, manganese, zinc series.

The lattice parameters, a, b, and c, resp., for the orthorhombic MF2.4H2O crystals are: M = Zn (space group Pca21, exptl. d. = 2.34, Z = 4, calculated d. = 2.35), 12.602, 5.279, 7.524 Å; Mn, 12.851, 5.395, 7.705 Å; Fe 12.880, 5.350, 7.530 Å; Co, 12.638, 5.276, 7.534 Å; Ni, 12.447, 5.265, 7.487 Å. A 2nd form of orthorhombic ZnF2.4H2O was observed with a = 9.810, b = 5,203, c = 9.451 Å, exptl. d. = 2.45, Z = 4, calculated d. = 2.42, space group Pna21. In both forms, the Zn is in a deformed octahedral site comprised of 2 F atoms and 4 H2O mols.

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Recommanded Product: 19777-66-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Structure and magnetic properties of a chiral two-dimensional ferrimagnet with TC of 38 K.

The construction of mol.-based magnetic materials, which possess addnl. properties such as conductivity, photoreactivity, or optical properties, is discussed. The synthesis and crystal structure and optical and magnetic properties of a new 2D fully chiral ferrimagnet; [{Cr(CN)6}{Mn(S)-pnH(H2O)}](H2O), where [(S)-pn=(S)-1,2-diaminopropane], is described. X-ray structural anal. found an orthorhombic unit cell and the structure revealed the formation of a two-dimensional chiral network. The magnetic transition temperature at 38K was relatively high. Field cooled and zero field cooled susceptibility χmolT and magnetic moments were determined The MCD spectra and Faraday effect was shown.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1127-45-3, is researched, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2Journal, Article, Acta Crystallographica, Section E: Structure Reports Online called catena-Poly[[[diaquabis(8-hydroxyquinoline N-oxide-κO1)cobalt(II)]-μ-2,5-dimethylpyrazine 1,4-dioxide-κ2O1:O4] bis(perchlorate)], Author is Gu, Li Qin; Li, Jin Min, the main research direction is cobalt hydroxylquinolineoxide dimethylpyrazinedioxide aqua complex perchlorate crystal structure; supramol mol structure cobalt hydroxylquinolineoxide dimethylpyrazinedioxide aqua complex perchlorate; hydrogen bond cobalt hydroxylquinolineoxide dimethylpyrazinedioxide aqua complex perchlorate; pi stacking cobalt hydroxylquinolineoxide dimethylpyrazinedioxide aqua complex perchlorate.Name: 8-Hydroxyquinoline 1-oxide.

In the title complex, {[Co(C6H8N2O2)(C9H7NO2)(H2O)2](ClO4)2}n, the CoII ion lies on an inversion center and is coordinated in a slightly distorted octahedral environment. The 2,5-dimethylpyrazine 1,4-dioxide ligand, which also lies on an inversion center, acts as a bridging ligand, linking symmetry-related CoII ions [Co…Co = 8.669 (3) Å] and forming one-dimensional chains along the b axis. In the crystal structure, these chains are linked by intermol. aqua-perchlorate O-H…O hydrogen bonds, forming two-dimensional layers which are in turn connected into a three-dimensional network via π-π stacking interactions between quinoline rings, with a centroid-centroid distance of 3.580 (3) Å. An intermol. O-H…Cl interaction is also present. Crystallog. data are given.

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91895-29-3, 6,7-Difluoroquinoxaline-2,3(1H,4H)-dione is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 88 Preparation of 6,7-Difluoro-5-nitro-1,4-dihydro-2,3-quinoxalinedione To a suspension of 6,7-difluoro-1,4-dihydro-2,3-quinoxalinedione (837 mg, 4.23 mmol) in trifluoracetic acid (30 mL) was added KNO3 (512 mg, 5.07 mmol). The mixture was stirred at 55 C. for 20 h at the end of this time, 256 mg (2.50 mmol) of KNO3 was added and the reaction mixture was stirred at 55 C. for 20 h, then another 256 mg (2.50 mmol) of KNO3 was added and the mixture was stirred at 55 C. for 20 h. The reaction mixture was then rota-evaporated to dryness. To the residual solid was added ice-cold water (about 15 mL), the solid was collected by vacuum filtration, washed with ice-cold water (5*5 mL), and dried at 40 C. under 1 mm Hg for 14 h, giving 700 mg (68%) of the title compound as a yellow powder. Mp 288-90 C. (dec.). IR (KBr) 3424, 3226, 1752, 1717, 1554, 1356, 1304 cm-1. 1 H NMR (DMSO-d6): 12.249 (s, 1H), 11.864 (bs, 1H), 7.330 (dd, 1H, J=10.5, 7.8 Hz). Analysis for C8 H3 F2 N3 O4, calcd: C, 39.50, H, 1.24, N, 17.29; found: C, 39.42, H, 1.26, N, 17.08., 91895-29-3

91895-29-3 6,7-Difluoroquinoxaline-2,3(1H,4H)-dione 822839, aquinoxaline compound, is more and more widely used in various fields.

Reference：
Patent; The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California; US5514680; (1996); A;,
Quinoxaline – Wikipedia
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