Tag: M.W=150-200

Minisci, Francesco; Citterio, Attilio; Vismara, Elena; Giordano, Claudio published the artcile< Polar effects in free-radical reactions. New synthetic developments in the functionalization of heteroaromatic bases by nucleophilic radicals>, Related Products of 5182-90-1, the main research area is lepidine alc nucleophilic radical substitution; hydroxylaminium salt titanium substitution catalyst; hydroxyalkyllepidine; substitution catalyst benzoyl peroxide hydrogen; carbamoylation quinoline acridine pyrazine benzothiazole; heteroaromatic base carbamoylation peroxide catalyst; dioxane hydrofuran lepidine radical substitution.

Direct substitution of protonated heteroaromatic bases by nucleophilic carbon-centered radicals involved use of the redox system N+H3OH/Ti(III) in several solvents, use of benzoyl peroxide in alcs., and carbamoylation by HCONH2 and H2O2 in the presence of catalytic Fe(II). Thus lepidine I (R = H) in MeOH gave 98% I (R = CH2OH) in the presence of benzoyl peroxide. These systems gave hitherto unobtainable substitution products and reactions of industrial interest. Polar effects determine reactivity, selectivity and synthetic applications; in particular the role of the strongly nucleophilic intermediate radicals of pyridinyl type in the rearomatization step is emphasized.

Tetrahedron published new progress about Carbamoylation. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Related Products of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

do Amaral, Daniel N.; Alves, Fernando R. de Sa; Barreiro, Eliezer J.; Laufer, Stefan A.; Lima, Lidia M. published the artcile< Multi-gram preparation of 7-nitroquinoxalin-2-amine>, SDS of cas: 89898-96-4, the main research area is nitro quinoxalinamine regioselective preparation.

Methodologies to obtain quinoxaline compounds regioselectively were rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives were desirable to explore the entire potential of these scaffolds for academic and/or com. application. A facile and multi-gram methodol. was described to obtain compound 7-nitroquinoxalin-2-amine I using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatog.

Journal of the Brazilian Chemical Society published new progress about Quinoxalines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, SDS of cas: 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Hoang, Thanh T.; To, Tuong A.; Cao, Vi T. T.; Nguyen, Anh T.; Nguyen, Tung T.; Phan, Nam T. S. published the artcile< Direct oxidative C-H amination of quinoxalinones under copper-organic framework catalysis>, Related Products of 89898-96-4, the main research area is copper organic framework catalyst preparation green chem; quinoxalinone amine carbon hydrogen activation amination; aminoquinoxalinone preparation.

A copper-organic framework Cu-CPO-27 was synthesized, and utilized as a recyclable heterogeneous catalyst for the direct C-H amination of quinoxalin-2(1H)-ones with amines to produce 3-aminoquinoxalin-2(1H)-ones, e.g., I. High yields were achieved in the presence of mol. oxygen as the oxidant. This framework was more catalytically active than a number of MOF-based catalysts. The Cu-CPO-27 also displayed higher performance than CuFe2O4 nanoparticles. The copper-organic framework catalyst could be reutilized in the synthesis of 3-aminoquinoxalin-2(1H)-ones via the direct C-H amination reaction without a remarkable deterioration in catalytic performance. This is the first heterogeneous catalytic protocol to generate 3-aminoquinoxalin-2(1H)-ones.

Catalysis Communications published new progress about Amination. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Related Products of 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lewis, Susan J.; Mirrlees, Margaret S.; Taylor, Peter J. published the artcile< Rationalizations among heterocyclic partition coefficients. Part 2: The azines>, Safety of 6-Quinoxalinecarbonitrile, the main research area is azine structure partition coefficient; LFER azine.

π-Values (partition substituent constants) of 246 azines are given and discussed in terms of Δπ, the difference in π-value from that expected for C6H6. It is shown that Δπ is close to zero for alkyl and most halogen groups, but for polar substituents capable of H bonding it may be as high as φ1.6. Except for peri-positions, these Δπ-values may be correlated by a set of equations specific for different types of substituent position and containing terms which sep. parameterize proton-donor and -acceptor ability. The rationale behind this treatment is justified in terms of the nature of the octanol-H2O partitioning process and the manner in which electronic effects are expected to operate, in this context and that of the individual mol. Other topics discussed include: reasons for deviations among “”irregular”” substituents; the special problems of peri-positions; multisubstitution; and some consequences of this anal. for other types of compound

Quantitative Structure-Activity Relationships published new progress about Molecular structure-property relationship, partition. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Safety of 6-Quinoxalinecarbonitrile.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Xingjie; Xia, Aiyou; Chen, Haoyi; Liu, Yuanhong published the artcile< General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP>, Related Products of 23088-24-6, the main research area is aryl halide zinc cyanide nickel DMAP; cyanoarene preparation; heteroaryl halide zinc cyanide nickel DMAP; cyanoheteroarene preparation; nickel cyanation catalyst; DMAP cyanation mediator.

A new and general nickel-catalyzed cyanation of hetero(aryl) chlorides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction relies on the use of inexpensive NiCl2·6H2O/dppf/Zn as the catalytic system and DMAP as the additive, allowing the cyanation to occur under mild reaction conditions (50-80 °C) with wide functional group tolerance. DMAP was found to be crucial for successful transformation, and the reaction likely proceeds via a Ni(0)/Ni(II) catalysis based on mechanistic studies. The method was also successfully extended to aryl bromides and aryl iodides.

Organic Letters published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Related Products of 23088-24-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gobec, S.; Urleb, U. published the artcile< Product class 15: quinoxalines>, Formula: C8H5N3O3, the main research area is review quinoxaline preparation cyclization ring transformation aromatization.

A review. Methods for preparing quinoxalines are reviewed including cyclization, ring transformation, aromatization, and substituent modification.

Science of Synthesis published new progress about Aromatization. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Formula: C8H5N3O3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Izzo, Francesca Caterina; Vitale, Valentina; Fabbro, Chiara; Van Keulen, Henk published the artcile< Multi-analytical investigation on felt-tip pen inks: Formulation and preliminary photo-degradation study>, COA of Formula: C9H7N3O, the main research area is photodegradation felt tip pen ink archaeol.

We present a multi-anal. study on the formulation of com. felt-tip pens, introduced in the second half of the 20th century and commonly used by modern and contemporary artists. These media of both drawing and writing have not yet been fully investigated, but the degradation processes they might undergo, such as fading, are well-known and rather apparent.Twelve water-based felt-tip pens were investigated by the joint use of complementary anal. techniques, such as Thin Layer Chromatog., NMR, Fourier transformed IR spectroscopy, X-ray fluorescence spectrometry and Pyrolysis-Gas Chromatog./Mass Spectrometry.The obtained results provided crucial, preliminary data for the identification of dyes, solvents and additives present in the inks’ formulations. Numerous synthetic food coloring agents and pigments were identified, such as Acid Yellow 23, Acid Red 18, Acid Blue 9, and Pigment Blue 15. In addition, glycols, fatty acids, 2-phenoxyethanol, colophony, benzotriazole derivatives and other solvents and additives were detected in the manufactured inks.Furthermore, the effects of photo-degradation on one emblematic ink sample were studied, highlighting in particular visual and aesthetical changes due to discoloration.This study demonstrates a methodol. based upon the use of an integrated anal. approach for the characterization of com. ink-based artistic media and their viable degradation patterns, which aims to develop suitable conservation treatments to assess modern and contemporary drawings and writings.

Microchemical Journal published new progress about Archaeology. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, COA of Formula: C9H7N3O.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gobec, S.; Urleb, U. published the artcile< Product class 15: quinoxalines>, Electric Literature of 5182-90-1, the main research area is review quinoxaline preparation cyclization ring transformation aromatization.

A review. Methods for preparing quinoxalines are reviewed including cyclization, ring transformation, aromatization, and substituent modification.

Science of Synthesis published new progress about Aromatization. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Electric Literature of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Takai, Hitoshi; Odani, Akira; Sasaki, Yoshio published the artcile< Studies on heterocyclic carbon-13 magnetic resonance spectroscopy. XI. Nitrogen heterocycles. (1). 6-Substituted quinoline and quinoxaline derivatives>, COA of Formula: C9H5N3, the main research area is carbon NMR quinoline quinoxaline; LFER NMR heterocycle.

The assignment of 13C NMR chem. shifts of 6-substituted quinoline and quinoxaline derivatives were confirmed, and the additivity rules of 13C chem. shifts of 2-substituted naphthalene derivatives were approved for both 6-substituted quinoline and quinoxaline derivatives The correlation coefficient of meta-like positions is promoted by the linear combinations of chem. shifts at the corresponding meta position of 2-substituted naphthalene derivatives and substituent constants σπ.

Chemical & Pharmaceutical Bulletin published new progress about Linear free energy relationship. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, COA of Formula: C9H5N3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nasielski, J.; Rypens, C. published the artcile< 6-Nitro-2,3-dipiperidinoquinoxaline: its unexpected formation from 2-chloro-7-nitroquinoxaline>, SDS of cas: 89898-96-4, the main research area is chloronitroquinoxaline substitution piperidine; nitrodipiperidinoquinoxaline.

Excess piperidine and 2-chloro-7-nitroquinoxaline I (R=Cl, R1=H) in di-Et ether give large amounts of the unexpected disubstitution product 6-nitro-2,3-dipiperidinoquinoxaline I (R=R1=piperidino). The mechanism of this very unusual nucleophilic substitution of hydrogen is suggested to involve the oxidation of the dipiperidinodihydroquinoxaline II ( R = piperidino) by dissolved oxygen.

Tetrahedron Letters published new progress about Substitution reaction. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, SDS of cas: 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider