Zhang, Xingjie; Xia, Aiyou; Chen, Haoyi; Liu, Yuanhong published the artcile< General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP>, Synthetic Route of 23088-24-6, the main research area is aryl halide zinc cyanide nickel DMAP; cyanoarene preparation; heteroaryl halide zinc cyanide nickel DMAP; cyanoheteroarene preparation; nickel cyanation catalyst; DMAP cyanation mediator.
A new and general nickel-catalyzed cyanation of hetero(aryl) chlorides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction relies on the use of inexpensive NiCl2·6H2O/dppf/Zn as the catalytic system and DMAP as the additive, allowing the cyanation to occur under mild reaction conditions (50-80 °C) with wide functional group tolerance. DMAP was found to be crucial for successful transformation, and the reaction likely proceeds via a Ni(0)/Ni(II) catalysis based on mechanistic studies. The method was also successfully extended to aryl bromides and aryl iodides.
Organic Letterspublished new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Synthetic Route of 23088-24-6.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider