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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Bromo-5-phenyloxazole, is researched, Molecular C9H6BrNO, CAS is 740806-67-1, about Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping.SDS of cas: 740806-67-1.

Oxazoles were rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethyl isocyanide, with esters followed by sulfanyl-lithium exchange-trapping. Deprotonattion of Asmic afforded a metalated isocyanide that efficiently trapped esters to afford oxazoles bearing a versatile C-4 anisylsulfanyl substituent. Interchange of the anisylsulfanyl substituent was readily achieved through a first-in-class sulfur-lithium exchange-electrophilic trapping sequence whose versatility was illustrated in the three-step synthesis of the bioactive natural product streptochlorin.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Goya-Jorge, Elizabeth; Abdmouleh, Fatma; Carpio, Laureano E.; Giner, Rosa M.; Sylla-Iyarreta Veitia, Maite researched the compound: 2-Bromobenzo[d]thiazol-6-amine( cas:945400-80-6 ).Product Details of 945400-80-6.They published the article 《Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities》 about this compound( cas:945400-80-6 ) in European Journal of Pharmaceutical Sciences. Keywords: aryl pyridinylbenzothiazole hydrocarbon receptor antimicrobial agonistic activity; Agonism; Ah receptor; Antibacterial; Antibiofilm; Antifungal; Benzothiazole. We’ll tell you more about this compound (cas:945400-80-6).

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ.

After consulting a lot of data, we found that this compound(945400-80-6)Product Details of 945400-80-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Reference of 4-Bromo-5-phenyloxazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Bromo-5-phenyloxazole, is researched, Molecular C9H6BrNO, CAS is 740806-67-1, about Regioselective Palladium Cross-Coupling of 2,4-Dihalooxazoles: Convergent Synthesis of Trisoxazoles. Author is Flegeau, Emmanuel Ferrer; Popkin, Matthew E.; Greaney, Michael F..

A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles, e.g. I, in high yield and in a min. number of steps.

Although many compounds look similar to this compound(740806-67-1)Reference of 4-Bromo-5-phenyloxazole, numerous studies have shown that this compound(SMILES:BrC1=C(C2=CC=CC=C2)OC=N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping, published in 2021-02-19, which mentions a compound: 740806-67-1, mainly applied to anisylsulfanylacetonitrile alkyl carboxylate tandem deprotonation asmic ester condensation alkylation; anisylsulfanyl oxazole halide tandem deprotonation asmic ester condensation alkylation; oxazole preparation, Application of 740806-67-1.

Oxazoles were rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethyl isocyanide, with esters followed by sulfanyl-lithium exchange-trapping. Deprotonattion of Asmic afforded a metalated isocyanide that efficiently trapped esters to afford oxazoles bearing a versatile C-4 anisylsulfanyl substituent. Interchange of the anisylsulfanyl substituent was readily achieved through a first-in-class sulfur-lithium exchange-electrophilic trapping sequence whose versatility was illustrated in the three-step synthesis of the bioactive natural product streptochlorin.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Safety of 4-Bromo-5-phenyloxazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Bromo-5-phenyloxazole, is researched, Molecular C9H6BrNO, CAS is 740806-67-1, about Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping. Author is Mueller, Louis G. Jr.; Chao, Allen; Alwedi, Embarek; Natrajan, Maanasa; Fleming, Fraser F..

Oxazoles were rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethyl isocyanide, with esters followed by sulfanyl-lithium exchange-trapping. Deprotonattion of Asmic afforded a metalated isocyanide that efficiently trapped esters to afford oxazoles bearing a versatile C-4 anisylsulfanyl substituent. Interchange of the anisylsulfanyl substituent was readily achieved through a first-in-class sulfur-lithium exchange-electrophilic trapping sequence whose versatility was illustrated in the three-step synthesis of the bioactive natural product streptochlorin.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions, published in 2013-09-02, which mentions a compound: 945400-80-6, Name is 2-Bromobenzo[d]thiazol-6-amine, Molecular C7H5BrN2S, Name: 2-Bromobenzo[d]thiazol-6-amine.

In positron emission tomog. [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer’s disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [18F] precursor derivatives of PIB containing a nitro function.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

COA of Formula: C7H5BrN2S. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromobenzo[d]thiazol-6-amine, is researched, Molecular C7H5BrN2S, CAS is 945400-80-6, about Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions. Author is Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde.

In positron emission tomog. [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer’s disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [18F] precursor derivatives of PIB containing a nitro function.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Flegeau, Emmanuel Ferrer; Popkin, Matthew E.; Greaney, Michael F. published an article about the compound: 4-Bromo-5-phenyloxazole( cas:740806-67-1,SMILESS:BrC1=C(C2=CC=CC=C2)OC=N1 ).Computed Properties of C9H6BrNO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:740806-67-1) through the article.

A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles, e.g. I, in high yield and in a min. number of steps.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities, published in 2020-08-01, which mentions a compound: 945400-80-6, Name is 2-Bromobenzo[d]thiazol-6-amine, Molecular C7H5BrN2S, Reference of 2-Bromobenzo[d]thiazol-6-amine.

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Bromo-5-phenyloxazole(SMILESS: BrC1=C(C2=CC=CC=C2)OC=N1,cas:740806-67-1) is researched.Reference of 2-Bromobenzo[d]thiazol-6-amine. The article 《Regioselective Palladium Cross-Coupling of 2,4-Dihalooxazoles: Convergent Synthesis of Trisoxazoles》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:740806-67-1).

A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles, e.g. I, in high yield and in a min. number of steps.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider