Tag: M.W:200-300

Related Products of 108258-54-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.108258-54-4, Name is Methyl 2,3-dichloroquinoxaline-6-carboxylate, molecular formula is C10H6Cl2N2O2. In a Article£¬once mentioned of 108258-54-4

Synthesis and Fungicidal Activity of 1,4-Dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles

A series of eleven 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles was prepared by reaction of 2,3-dichloroquinoxalines with disodium (Z)-2,3-dimercapto-2-butenedinitrile in N,N-dimethylformamide. These products were tested for in-vitro fungicidal activity by a Minimum Inhibitory Concentration (MIC) method. Several of these compounds showed broad-spectrum fungicidal activity. The activity exhibited by these compounds was greatly dependent upon the substituents of the quinoxaline ring, with the nitro-substituted derivatives showing the higest levels of antifungal activity. None of the compounds prepared, however, showed fungicidal activity comparable to that of the commercial fungicides screened.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1988 | ChemSpider

Electric Literature of 82019-32-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 82019-32-7, Name is 7-Bromo-1-methyl-1H-quinoxalin-2-one, molecular formula is C9H7BrN2O. In a Article£¬once mentioned of 82019-32-7

Transition-Metal and Solvent-Free Oxidative C-H Fluoroalkoxylation of Quinoxalinones with Fluoroalkyl Alcohols

The first example of oxidative C-H fluoroalkoxylation of quinoxalinones with fluoroalkyl alcohols under transition-metal and solvent-free conditions is described. This approach provides the synthesis of fluoroalkoxylated quinoxaline derivatives with good to excellent yields under mild reactions conditions. This method can also be extended to the facile and efficient synthesis of histamine-4 receptor.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 82019-32-7. In my other articles, you can also check out more blogs about 82019-32-7

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1930 | ChemSpider

Application of 108229-82-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.108229-82-9, Name is 6-Bromo-2,3-dichloroquinoxaline, molecular formula is C8H3BrCl2N2. In a article£¬once mentioned of 108229-82-9

COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS

The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1997 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of 2,3-Dichloro-6,7-dimethylquinoxaline, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 63810-80-0, name is 2,3-Dichloro-6,7-dimethylquinoxaline. In an article£¬Which mentioned a new discovery about 63810-80-0

The syntheses of pyrazino-containing sultines and their application in Diels-Alder reactions with electron-poor olefins and [60]fullerene

The Diels-Alder reactions of heterocyclic o-quinodimethanes, generated in situ from 6,7-disubstituted quinoxalino[2,3-d]-[1,2lambda4]oxathiine 2-oxides (6a-c), 2,3-disubstituted-8,9-dihydro-6H-8lambda 4-[1,2]oxathiino[4,5-g]quinoxalin-8-one (7a-c) (sultines), and pyrazinosultine (22), with electron-poor olefins and [60]fullerene are described. The heterocyclic-fused sultines 7a-c and 22 are readily prepared from the corresponding dibromides 9a-c and 24 with the commercially available Rongalite (sodium formaldehyde sulfoxylate). When heated in the presence of electron-poor dienophiles and [60]fullerene, all of the sultines underwent extrusion of SO2, and the resulting heterocyclic o-quinodimethanes (3a-d, 4a-c, and 25) were intercepted as the 1:1 adducts in good to excellent yields. The temperature-dependent 1H NMR spectra of fullerene derivatives 31-38 show a dynamic process for the methylene protons. The activation free energies (DeltaGc?) determined for the boat-to-boat inversion of these pyrazino-containing C60 compounds (31-34 and 38) are found to be in the range of 14.1-14.8 kcal/mol, but they are in the range of 15.2 to >17.1 kcal/mol for adducts 35-37. The activation free energies (DeltaGC?) are significantly affected by (1) the orientations and (2) the substituents of the quinoxaline rings and (3) the extended benzannulation in the arenes of C60 adducts (see Table 2), which implies that both electronic interactions and steric effects between the aromatic addends and C60 are important. Tautomerization of methylquinoxaline to its enamine is invoked as a rationalization for the lowering of DeltaGC? in some of the fulleroadducts.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 63810-80-0, help many people in the next few years.Application In Synthesis of 2,3-Dichloro-6,7-dimethylquinoxaline

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1830 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C10H10N2O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 16915-79-0, Name is 2-(Hydroxymethyl)-3-methylquinoxaline 1,4-dioxide, molecular formula is C10H10N2O3

A Wolf-containing, fructus Rosae Laevigatae and sulfamonomethoxine sodium for livestock and poultry compound (by machine translation)

The invention relates to a containing Wolf, fructus Rosae Laevigatae and sulfamonomethoxine sodium for livestock and poultry compound drug, by sulfamonomethoxine sodium and Wolf, a gold Matsui, sulfamonomethoxine sodium and Wolf, embodies the weight ratio of 1:20 – 25:2 – 5. The invention also calls for protection of the compound from the above-mentioned for livestock and poultry preparation into the compound preparation. The invention has the advantages of: the experimental research proved, sulfamonomethoxine sodium and Wolf, Cherokee rose to specific weight ratio of joint use, has synergistic effects obviously, curative effect fast, low cost and the like. (by machine translation)

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1720 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: quinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 887590-25-2, Name is tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate, molecular formula is C13H18N2O2

SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2)

Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1868 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C8H3N3O4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 2379-56-8

Design and synthesis of small molecule RhoA inhibitors: A new promising therapy for cardiovascular diseases?

RhoA is a member of Rho GTPases, a subgroup of the Ras superfamily of small GTP-binding proteins. RhoA, as an important regulator of diverse cellular signaling pathways, plays significant roles in cytoskeletal organization, transcription, and cell-cycle progression. The RhoA/ROCK inhibitors have emerged as a new promising treatment for cardiovascular diseases. However, to date, RhoA inhibitors are macromolecules, and to our knowledge, small molecular-based inhibitors have not been reported. In this study, a series of first-in-class small molecular RhoA inhibitors have been discovered by using structure-based virtual screening in conjunction with chemical synthesis and bioassay. Virtual screening of ?200,000 compounds, followed by SPR-based binding affinity assays resulted in three compounds with binding affinities to RhoA at the micromolar level (compounds 1-3). Compound 1 was selected for further structure modifications in considering binding activity and synthesis ease. Fourty-one new compounds (1, 12a-v, 13a-h, and 14a-j) were designed and synthesized accordingly. It was found that eight (12a, 12j, 14a, 14b, 14d, 14e, 14 g, and 14h) showed high RhoA inhibition activities with IC50 values of 1.24 to 3.00 muM. A pharmacological assay indicated that two compounds (14g and 14 h) demonstrated noticeable vasorelaxation effects against PE-induced contraction in thoracic aorta artery rings and served as good leads for developing more potent cardiovascular agents.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1700 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of Ethyl 3-chloroquinoxaline-2-carboxylate. Introducing a new discovery about 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate

Quinoxaline chemistry. Part 8. 2-[anilino]-3- [carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared In order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6 M for a few compounds. One single compound exhibited good activity against Candida albicans.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1899 | ChemSpider

Reference of 148231-12-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 148231-12-3, Name is 5,8-Dibromoquinoxaline, molecular formula is C8H4Br2N2. In a Article£¬once mentioned of 148231-12-3

Synthesis and characterization of new fluorene-acceptor alternating and random copolymers for light-emitting applications

A series of novel light-emitting copolymers consisted of 9,9-dihexylfluorene (F) and different acceptor segments, including quinoxaline (Q), 2,1,3-benzothiadiazole (BT) and thieno[3,4-b]-pyrazine (TP), were synthesized by the palladium-catalyzed Suzuki coupling reaction. Three fluorene-acceptor alternating copolymers (PFQ, PFBT, PFTP) and six F-TP (PFTP0.5-PFTP35) random copolymers were investigated and compared with the parent polyfluorene (PF). The experimental results suggest that the acceptor strength or content significantly affect the electronic and optoelectronic properties. The optical absorption maxima of the PF, PFQ, PFBT, and PFTP are 368, 416, 470, and 578 nm, respectively, which indicates the significance of intramolecular charge transfer. The electrochemical band gap also shows a similar trend. The incorporation of the acceptor into the PF lowers the LUMO level and thus could improve the electron-accepting ability of the PF. The emission maxima on the photoluminescence (PL) spectra of the PF, PFQ, PFBT, and PFTP films are 424, 493, 540, and 674 nm, which correspond to the color of blue, green, yellow, and red, respectively. It suggests that the full color of emission can be achieved by different acceptors. The significant positive solvatochromism on the PL spectra in different polar solvents suggests the efficient intramolecular charge transfer in PFTP. However, such charge transfer or heavy-atom effect results in fluorescence quenching and thus reduces the PL efficiencies. By random copolymerizing the TP into the PF, the PL efficiency could be improved. A significantly reduction on the PF emission peak with increasing the TP content suggests the energy transfer between the PF and TP segments. Besides, the characteristics on the electroluminescence (EL) devices of ITO/PEDOT:PSS/emissive layer/Ca/Ag suggest that such energy transfer results in the complete quenching of the PF emission at only 1% TP content in the PFTP01. The maximum external quantum efficiency (EQE) of the EL device based on the PFTP01 is superior to that of the PF due to the reduced LUMO level in matching with the Ca. The CIE 1931 coordinates of the PFTP01 based EL device under the condition of maximum EQE is (0.66, 0.31), which is close to the standard red of (0.66, 0.34) demanded by the National Television System Committee (NTSC). The luminescence characteristics based on the prepared polymers depend on the Foerster energy transfer or the intramolecular charge transfer, or heavy-atom fluorescence quenching. The present study suggests that the tuning of the electronic and optoelectronic properties could be achieved by incorporating various acceptors or content into the polyfluorenes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 148231-12-3. In my other articles, you can also check out more blogs about 148231-12-3

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2050 | ChemSpider

98416-72-9, Name is 6-Bromo-2-chloro-3-methylquinoxaline, belongs to quinoxaline compound, is a common compound. Product Details of 98416-72-9In an article, once mentioned the new application about 98416-72-9.

TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1989 | ChemSpider