Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 6-Nitroquinoxaline-2,3-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 2379-56-8

Ytterbium triflate catalyzed heterocyclization of 1,2-phenylenediamines and alkyl oxalates under solvent-free conditions via phillips reaction: A facile synthesis of quinoxaline-2,3-diones derivatives

Ytterbium triflate are found to catalyze efficiently the Phillips-type heterocyclization reactions of 1,2-phenylenediamine and alkyl oxalate under solvent-free and mild conditions to afford the corresponding quinoxaline-2,3-dione derivatives in high yields. The catalyst could be recovered almost quantitatively from the aqueous layer after the reaction was completed and it could be reused in subsequent reaction without decrease in activity.

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Quinoxaline | C8H6N1717 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C8H4Br2N2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 148231-12-3

Synthesis of organosilicon polymers containing donor-acceptor type pi-conjugated units and their applications to dye-sensitized solar cells

Novel organosilicon polymers having donor-acceptor type pi-conjugated units in the backbone were prepared by Stille-coupling reactions of bis(tributylstannylthienyl)silanes with diiodoquinoxialine, benzothiadiazole, and benzothiaselenazole. Dehaloganative copolymerization of di(bromothienyl)silanes and dibromoquinoxaline was also studied, which gave the corresponding random copolymer. Applications of these polymers to dye-sensitized solar cells (DSSCs) were examined and it was found that the polymer containing benzoselenadiazole units as the acceptor exhibited the best performance as the sensitizer among the present polymers.

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Quinoxaline | C8H6N2040 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: quinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 148231-12-3, Name is 5,8-Dibromoquinoxaline, molecular formula is C8H4Br2N2

SULFONE DERIVATIVES AND THEIR USE AS PKM2 MODULATORS FOR THE TREATMENT OF CANCER

Provided herein is novel compound of the general formula (I), its tautomeric forms, its stereoisomers, its analogs, its prodrugs, its isotopes, its N- oxides, its metabolites, its pharmaceutically acceptable salts, its polymorphs, its solvates, its optical isomers, its clathrates, its co-crystals, its combinations with suitable medicament and pharmaceutical compositions comprising the same. Also provided is method of treating a disease responsive to activation of human PKM2 by administration of said compound and its use as PKM2 modulator in various pathological conditions.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: quinoxaline, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 148231-12-3

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Quinoxaline | C8H6N2015 | ChemSpider

Application of 89891-65-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.89891-65-6, Name is 7-Bromo-2-chloroquinoxaline, molecular formula is C8H4BrClN2. In a article£¬once mentioned of 89891-65-6

THE FACILE SYNTHESIS OF QUINOXALINYL-2-OXYPHENOLS

Facile synthesis of quinoxalinyl-2-oxyphenols are described.The condensation of 2-chloroquinoxalines with three molar equivalent of dihydroxybenzene in basic medium gave preferentially quinoxalinyl-2-oxyphenols, which involves nucleophilic cleavage of the initially formed bis(quinoxalinyl-2-oxy)benzenes by an excess of dihydroxybenzene.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 89891-65-6

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1977 | ChemSpider

148231-12-3, Name is 5,8-Dibromoquinoxaline, belongs to quinoxaline compound, is a common compound. Safety of 5,8-DibromoquinoxalineIn an article, once mentioned the new application about 148231-12-3.

Toward a rational design of poly(2,7-carbazole) derivatives for solar cells

On the basis of theoretical models and calculations, several alternating polymeric structures have been investigated to develop optimized poly(2,7-carbazole) derivatives for solar cell applications. Selected low band gap alternating copolymers have been obtained via a Suzuki coupling reaction. A good correlation between DFT theoretical calculations performed on model compounds and the experimental HOMO, LUMO, and band gap energies of the corresponding polymers has been obtained. This study reveals that the alternating copolymer HOMO energy level is mainly fixed by the carbazole moiety, whereas the LUMO energy level is mainly related to the nature of the electron-withdrawing comonomer. However, solar cell performances are not solely driven by the energy levels of the materials. Clearly, the molecular weight and the overall organization of the polymers are other important key parameters to consider when developing new polymers for solar cells. Preliminary measurements have revealed hole mobilities of about 1 ¡Á 10-3 cm2¡¤V-1¡¤s-1 and a power conversion efficiency (PCE) up to 3.6%. Further improvements are anticipated through a rational design of new symmetric low band gap poly(2,7-carbazole) derivatives.

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Quinoxaline | C8H6N2022 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 2379-56-8, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2379-56-8, name is 6-Nitroquinoxaline-2,3-dione. In an article£¬Which mentioned a new discovery about 2379-56-8

Glycine receptor antagonists and the use thereof

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease and Down’s syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia and treating psychosis are disclosed by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Also disclosed are novel 1,4-dihydroquinoxaline-2,3-diones, and pharmaceutical compositions thereof. Also disclosed are highly soluble ammonium salts of 1,4-dihydroquinoxaline-2,3-diones.

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Quinoxaline | C8H6N1695 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate. Introducing a new discovery about 887590-25-2, Name is tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate

IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof: wherein: “Z” and R1 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson’s disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson’s disease.

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Quinoxaline | C8H6N1867 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C8H4BrClN2. Introducing a new discovery about 89891-65-6, Name is 7-Bromo-2-chloroquinoxaline

HETEROCYCLIC CARBOXYLIC ACID AMIDES AS PDK1 INIHIBITORS

The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, Land n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C8H4BrClN2, you can also check out more blogs about89891-65-6

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Quinoxaline | C8H6N1952 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 55686-94-7, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 55686-94-7, Name is 2-Chloro-7-nitroquinoxaline, molecular formula is C8H4ClN3O2

Quinoxaline chemistry. Part 4. 2-(R)-anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity

Thirty-five quinoxalines bearing a substituted amiline group on position 2 and various substituents on positions 3, 6, 7 and 8 were prepared in order to evaluate in vitro anticancer activity. Structural elucidation of some isomeric quinoxalinones formed by ring closure of 4-substituted-1,2-diaminobenzenes with dicarbonyl compounds was achieved by comparison with one isomer coming from an unambiguous independent route. Preliminary in vitro screening at NCI showed that many compounds exhibited a moderate to strong growth inhibition activity on various cell lines between 10-5 and 10-4 molar concentrations.

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Quinoxaline | C8H6N1738 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: 2-Chloro-7-nitroquinoxaline. Introducing a new discovery about 55686-94-7, Name is 2-Chloro-7-nitroquinoxaline

Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469)

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

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Quinoxaline | C8H6N1735 | ChemSpider