Tag: M.W:200-300

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: quinoxaline. Introducing a new discovery about 82031-32-1, Name is 7-Bromoquinoxalin-2(1H)-one

Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes

The direct synthesis of C(CF3)Me2-substituted heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation of heteroarenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported. This method does not need the transition-metal catalyst, and the base is crucial for this reaction. A series of previously unknown C(CF3)Me2-containing heteroarenes were obtained in high yields and have potential applications in the drug discovery process.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: quinoxaline, you can also check out more blogs about82031-32-1

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1790 | ChemSpider

Related Products of 55686-94-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.55686-94-7, Name is 2-Chloro-7-nitroquinoxaline, molecular formula is C8H4ClN3O2. In a article£¬once mentioned of 55686-94-7

Regioselectivity of the Amination of Some Nitroquinoxalines by Liquid Ammonia/Potassium Permanganate

5- and 6-Nitroquinoxalines and some of their derivatives are aminated in a liquid ammonia solution of potassium permanganate to yield the corresponding 2- and/or 3- and/or 5-amino compounds.Quantum-chemical calculations are made to explain the regioselectivity of the amination reactions. Key Words: Amination / Nitroquinoxalines / Reactivity indices / Calculations, MNDO / Quinoxalines

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 55686-94-7

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1742 | ChemSpider

Electric Literature of 55687-34-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 55687-34-8, molcular formula is C8H5BrN2O, introducing its new discovery.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile – Part 1

Nonstructural protein 5A (NS5A) represents a novel target for the treatment of hepatitis C virus (HCV). Daclatasvir, recently reported by Bristol-Myers-Squibb, is a potent NS5A inhibitor currently under investigation in phase 3 clinical trials. While the performance of daclatasvir has been impressive, the emergence of resistance could prove problematic and as such, improved analogues are being sought. By varying the biphenyl-imidazole unit of daclatasvir, novel inhibitors of HCV NS5A were identified with an improved resistance profile against mutant strains of the virus while retaining the picomolar potency of daclatasvir. One compound in particular, methyl ((S)-1-((S)-2-(4-(4-(6-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl) -1H-imidazol-5-yl)quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl) -3-methyl-1-oxobutan-2-yl)carbamate (17), exhibited very promising activity and showed good absorption and a long predicted human pharmacokinetic half-life. This compound represents a promising lead that warrants further evaluation. Resisting resistance: An investigation into the anti-hepatitis C virus (HCV) replicon activity of a series of biaryl-linked pyrrolidine NS5A inhibitors explored a diverse range of core structure modifications as key determinants of antiviral activity and susceptibility to common resistance mutations. Further evaluation of several core structure designs identified a compound with excellent pharmacokinetics, suitable for once daily dosing.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 55687-34-8 is helpful to your research. Electric Literature of 55687-34-8

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1815 | ChemSpider

106595-91-9, Name is 4-Benzyl-1,3-dihydroquinoxalin-2-one, belongs to quinoxaline compound, is a common compound. HPLC of Formula: C15H14N2OIn an article, once mentioned the new application about 106595-91-9.

Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography

Soluble epoxide hydrolase (sEH) is a component of the arachidonic acid cascade and is a candidate target for therapies for hypertension or inflammation. Although many sEH inhibitors are available, their scaffolds are not structurally diverse, and knowledge of their specific interactions with sEH is limited. To obtain detailed structural information about protein-ligand interactions, we conducted fragment screening of sEH, analyzed the fragments using high-throughput X-ray crystallography, and determined 126 fragment-bound structures at high resolution. Aminothiazole and benzimidazole derivatives were identified as novel scaffolds that bind to the catalytic triad of sEH with good ligand efficiency. We further identified fragment hits that bound to subpockets of sEH called the short and long branches. The water molecule conserved in the structure plays an important role in binding to the long branch, whereas Asp496 and the main chain of Phe497 form hydrogen bonds with fragment hits in the short branch. Fragment hits and their crystal structures provide structural insights into ligand binding to sEH that will facilitate the discovery of novel and potent inhibitors of sEH.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 106595-91-9

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1913 | ChemSpider

Reference of 49679-45-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a Patent£¬once mentioned of 49679-45-0

Quinoxaline signal pathway inhibitor as well as preparation method and application thereof (by machine translation)

The invention belongs to the field, of pharmaceutical chemistry and particularly provides a quinoxaline signal pathway inhibitor as well as a preparation method and application, of the quinoxaline signal pathway inhibitor. , The preparation method can prepare more quinoxaline compounds, has good anti-cancer effect, both in vitro and in vivo, and has good application prospects, in the aspects of anticancer new drug research and development and the like. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 49679-45-0

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1883 | ChemSpider

Related Products of 25983-13-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 25983-13-5, 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione, introducing its new discovery.

PHOSPHONOCEPHEM COMPOUND

A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior quality such as high solid stability, possible long-term stable preservation and the like.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 25983-13-5. In my other articles, you can also check out more blogs about 25983-13-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1846 | ChemSpider

Synthetic Route of 1210048-05-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1210048-05-7, Name is 7-Bromo-5-fluoroquinoxaline, molecular formula is C8H4BrFN2. In a Patent£¬once mentioned of 1210048-05-7

SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF

The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 1210048-05-7. In my other articles, you can also check out more blogs about 1210048-05-7

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1819 | ChemSpider

Reference of 41213-32-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 41213-32-5, 2-Chloro-6-(trifluoromethyl)quinoxaline, introducing its new discovery.

THE FACILE SYNTHESIS OF QUINOXALINYL-2-OXYPHENOLS

Facile synthesis of quinoxalinyl-2-oxyphenols are described.The condensation of 2-chloroquinoxalines with three molar equivalent of dihydroxybenzene in basic medium gave preferentially quinoxalinyl-2-oxyphenols, which involves nucleophilic cleavage of the initially formed bis(quinoxalinyl-2-oxy)benzenes by an excess of dihydroxybenzene.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 41213-32-5. In my other articles, you can also check out more blogs about 41213-32-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1863 | ChemSpider

63810-80-0, Name is 2,3-Dichloro-6,7-dimethylquinoxaline, belongs to quinoxaline compound, is a common compound. HPLC of Formula: C10H8Cl2N2In an article, once mentioned the new application about 63810-80-0.

Kynurenic Acid Derivatives. Structure-Activity Relationships for Excitatory Amino Acid Antagonism and Identification of Potent and Selective Antagonists at the Glycine Site of the N-Methyl-D-aspartate Receptor

Derivatives of the nonselective excitatory amino acid antagonist kynurenic acid (4-oxo-1,4-dihydroquinoline-2-carboxylic acid, 1) have been synthesized and evaluated for in vitro antagonist activity at the excitatory amino acid receptors sensitive to N-methyl-D-aspartic acid (NMDA), quisqualic acid (QUIS or AMPA), and kainic acid (KA).Introduction of substituents at the 5-, 7-, and 5,7-positions resulted in analogues having selective NMDA antagonist action, as a result of blockade of the glycine modulatory (or coagonist) site on the NMDA receptor.Regression analysis suggested a requirement for op timally sized, hydrophobic 5- and 7-substituents, with bulk tolerance being greater at the 5-position.Optimization led to the 5-iodo-7-chloro derivative (53), which is the most potent and selective glycine/NMDA antagonist to date (IC50 vs <3H>glycine binding, 32 nM; IC50’s for other excitatory amino acid receptor sites, >100 muM).Substitution of 1 at the 6-position resulted in compounds having selective non-NMDA antagonism and 8-substituted compounds were inactive at all receptors.The retention of glycine/NMDA antagonist activity in heterocyclic ring modified analogues, such as the oxanilide 69 and the 2-carboxybenzimidazole 70, suggests that the 4-oxo tautomer of 1 and its derivatives is required for activity.Structurally related quinoxaline-2,3-diones are also glycine/NMDA antagonists, but are not selective and are less potent than the 1 derivatives, and additionally show different structure-activity requirements for aromatic ring substitution.On the basis of these results, a model accounting for glycine receptor binding of the 1 derived antagonists is proposed, comprising (a) size-limited, hydrophobic binding of the benzene ring, (b) hydrogen- bond acceptance by the 4-oxo group, (c) hydrogen-bond donation by the 1-amino group, and (d) a Coulombic attraction of the 2-carboxylate.The model can also account for the binding of quinoxaline-2,3-diones, quinoxalic acids, and 2-carboxybenzimidazoles.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 63810-80-0

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1828 | ChemSpider

Synthetic Route of 49679-45-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate, introducing its new discovery.

AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE

The present invention provides aromatic nitrogen-containing 6-membered ring compounds having execellent PDE10 inhibitory activity. The present invention relates to an aromatic nitrogen-containing 6-membered ring compound represented by the following formula [I 0 ] or a pharmaceutically acceptable salt thereof, a method for preparing the same, and use of said compounds for PDE10 inhibitors, and a pharmaceutical composition comprising said compounds as an active ingredient: Formula [I 0 ] wherein: X 1 , X 2 and X 3 each independently are N or CH, and at least two of X 1 , X 2 and X 3 are N; A is *-CH=CH-, *-C(Alk)=CH-, *-CH 2 -CH 2 – or *-O-CH 2 – (* is a bond with R 1 ); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R 1 is an optionally substituted nitrogen-containing heterocyclic group, a nitrogen-containing heterocyclic moiety of which is a moiety selected from the group consisting of quinoxalinyl, quinolyl, isoquinolyl, quinazolinyl, pyrazinyl, pyrimidinyl and a moiety thereof fused with a 5 to 6-membered aliphatic ring thereto; Y 0 is a group selected from the group consisting of the following (1) to (5): (1) an optionally substituted phenyl or an optionally substituted aromatic monocyclic 5 to 6-membered heterocyclic group; (2) an optionally substituted aminocarbonyl; (3) an optionally substituted amino lower alkyl; (4) -O-R 2 wherein R 2 is hydrogen, an optionally substituted lower alkyl, lower cycloalkyl, aliphatic monocyclic 5 to 6-membered heterocyclic group, or Formula [AA]; (5) mono- or di-substituted amino; provided that, when Y 0 is mono- or di-substituted amino, the nitrogen-containing heterocyclic moiety of R 1 is not quinoxalinyl or quinolyl

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 49679-45-0. In my other articles, you can also check out more blogs about 49679-45-0

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1887 | ChemSpider