Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. 2379-56-8, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 2379-56-8

Glycine receptor antagonists and the use thereof

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease and Down’s syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia and treating psychosis are disclosed by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Also disclosed are novel 1,4-dihydroquinoxaline-2,3-diones, and pharmaceutical compositions thereof. Also disclosed are highly soluble ammonium salts of 1,4-dihydroquinoxaline-2,3-diones.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1695 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. 55686-94-7. Introducing a new discovery about 55686-94-7, Name is 2-Chloro-7-nitroquinoxaline

From simple quinoxalines to potent oxazolo[5,4-: F] quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)

2,7-Disubstituted oxazolo[5,4-f]quinoxalines were synthesized from 6-amino-2-chloroquinoxaline in four steps (iodination at C5, substitution of the chloro group, amidation and copper-catalysed cyclization) affording 28 to 44% overall yields. 2,8-Disubstituted oxazolo[5,4-f]quinoxaline was similarly obtained from 6-amino-3-chloroquinoxaline (39% overall yield). For the synthesis of other oxazolo[5,4-f]quinoxalines, amidation was rather performed before substitution; moreover, time-consuming purification steps were avoided between the amines and the final products (38 to 54% overall yields). Finally, a more efficient method involving merging of the last two steps in a sequential process was developed to access more derivatives (37 to 65% overall yields). Most of the oxazolo[5,4-f]quinoxalines were evaluated for their activity on a panel of protein kinases, and a few 2,8-disubstituted derivatives proved to inhibit GSK3 kinase. While experiments showed an ATP-competitive inhibition on GSK3beta, structure-activity relationships allowed us to identify 2-(3-pyridyl)-8-(thiomorpholino)oxazolo[5,4-f]quinoxaline as the most potent inhibitor with an IC50 value of about 5 nM on GSK3alpha.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1736 | ChemSpider

55687-34-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.55687-34-8, Name is 6-Bromoquinoxalin-2(1H)-one, molecular formula is C8H5BrN2O. In a Article, authors is Sakata, Gozyo£¬once mentioned of 55687-34-8

The facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones

Facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones and these reaction mechanisms are described.The intramolecular cyclization reaction of 4′-substituted 2′-nitroacetoacetanilides in aqueous basic medium and the reduction of 6-substituted 2(1H)-quinoxalinone-4-oxide wit sodium borohydride or sodium hydrogensulfite were studied in detail

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1812 | ChemSpider

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 89891-65-6, molcular formula is C8H4BrClN2, introducing its new discovery. , 89891-65-6

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase alpha and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 89891-65-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 89891-65-6

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1964 | ChemSpider

82031-32-1, In an article, published in an article,authors is Carter, Kelsey K., once mentioned the application of 82031-32-1, Name is 7-Bromoquinoxalin-2(1H)-one,molecular formula is C8H5BrN2O, is a conventional compound. this article was the specific content is as follows.

Improving Hg-triggered gelation via structural modifications

The relationship between chemical structure and gelation ability was examined for a series of nine Hg-containing compounds. Both solid-state properties (dissolution enthalpies/entropies and packing structure) and gel properties (strength, morphology, cation selectivity, and anion tolerance) were examined. Overall, the results reveal a complex relationship between chemical structure and properties. The remediation potential of these Hg-triggered gelations was also investigated, revealing that >98% of the Hg2+ in water can be removed through gel formation.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1787 | ChemSpider

2379-56-8, In an article, published in an article,authors is Cai, Sui Xiong, once mentioned the application of 2379-56-8, Name is 6-Nitroquinoxaline-2,3-dione,molecular formula is C8H3N3O4, is a conventional compound. this article was the specific content is as follows.

5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: Novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors

A group of 5-aza-7-substituted-1,4-dihydroquinoxaline-2,3-diones (QXs) and the corresponding 5-(N. oxyaza)-7-substituted QXs were prepared and evaluated as antagonists of ionotropic glutamate receptors. The in vitro potency of these QXs was determined by inhibition of [3H]-5,7- dichlorokynurenic acid ([3H]DCKA) binding to N-methyl-D-aspartate (NMDA)/glycine receptors, [3H]-(S)-alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid ([3H]AMPA) binding to AMPA receptors, and [3H]kainate ([3H]KA) binding to KA receptors in rat brain membranes. 5-(N- Oxyaza)-QXs 12a-e all have low micromolar or submicromolar potency for NMDA/glycine receptors and low micromolar potencies for AMPA and KA receptors. QXs 12a-e display 2-12-fold selectivity for NMDA/glycine receptors compared to AMPA receptors, and ~2-fold difference between AMPA and KA potency. In contrast to other QXs that either show high selectivity for NMDA (such as ACEA 1021) or AMPA (such as NBQX) receptors, these molecules are broad spectrum antagonists of ionotropic glutamate receptors. 7-Nitro-5-(N- axyaza)-QX (12e) is the most potent inhibitor among 12a-e, having IC50 values of 0.69, 1.3, and 2.4 muM at NMDA, AMPA, and KA receptors, respectively. In functional assays on glutamate receptors expressed in oocytes by rat cerebral cortex poly(A+) RNA, 7-chloro-5-(N-oxyaza)-QX (12a) and 7-nitro-5(N-oxyaza)-QX (12e) have K(b) values of 0.63 and 0.31 muM for NMDA/glycine receptors, and are 6- and 4-fold selective for NMDA over AMPA receptors, respectively. 5-(N-Oxyaza)-7-substituted-QXs 12a-e all have surprisingly high in vivo potency as anticonvulsants in a mouse maximal electroshock-induced seizure (MES) model. 7-Chloro-5-(N-oxyaza)-QX (12a), 7- bromo-5-(N-oxyaza)-QX (12b), and 7-methyl-5-(N-oxyaza)-QX (12c) have ED50 values of 0.82, 0.87, and 0.97 mg/kg iv, respectively. The high in vivo potency of QXs 12a-e is particularly surprising given their low log P values (~ -2.7). Separate studies indicate that QXs 12a and 12e are also active in vive as neuroprotectants and also have antinociceptive activity in animal pain models. In terms of in vivo activity, these 5-(N-oxyaza)-7-substituted- QXs are among the most potent broad spectrum ionotropic glutamate antagonists reported.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1696 | ChemSpider

49679-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article£¬once mentioned of 49679-45-0

Quinoxaline chemistry. Part 12. 3-Carboxy-2[phenoxyl-6(7)substituted quinoxalines and N-[4-(6(7) substituted-3-carboxyquinoxalin- 2-yl)hydroxy]-benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity

Thirty quinoxalines bearing a substituted phenoxy or hydroxybenzoylglutamate group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate the in vitro anticancer activity. Screening over 21 compounds selected at the National Cancer Institute (Bethesda, MD) showed that only few derivatives exhibited a moderate growth inhibition activity on various tumor panel cell lines at 10-4 molar concentration. The acid derivatives showed no growth inhibition activity. The results obtained in this series seem to indicate that in general carboxy or carboethoxy groups close to O-link with phenyl or benzoyl glutamates on position 2 are detrimental for anticancer activity.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1910 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 1910-90-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1910-90-3, name is 6-Bromoquinoxaline-2,3(1H,4H)-dione. In an article£¬Which mentioned a new discovery about 1910-90-3

A One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a?n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a?3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i?3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1945 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 148231-12-3, name is 5,8-Dibromoquinoxaline, introducing its new discovery. 148231-12-3

NOVEL HETEROARYL HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), ab (I), wherein R1 to R3 and L are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.148231-12-3, you can also check out more blogs about148231-12-3

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2011 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 82031-32-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 82031-32-1, name is 7-Bromoquinoxalin-2(1H)-one. In an article£¬Which mentioned a new discovery about 82031-32-1

Silver-catalyzed decarboxylative acylation of quinoxalin-2(1: H)-ones with alpha-oxo-carboxylic acids

A novel silver-catalyzed decarboxylative acylation of alpha-oxo-carboxylic acids was developed, by which various 3-acyl quinoxalin-2(1H)-ones were synthesized by direct C-H bond acylation of quinoxalin-2(1H)-ones. In this method, alpha-oxo-carboxylic acids served as efficient acylating reagents to in situ generate the required active acyl radical. Its excellent chemoselectivity allowed the molecular diversity of 3-acyl quinoxalin-2(1H)-ones to be achieved by convenient functionalizations of both N1- and C3-positions.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1793 | ChemSpider