Tag: M.W:200-300

An article , which mentions 25983-13-5, molecular formula is C8H4Cl2N2O2. The compound – 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione played an important role in people’s production and life., 25983-13-5

Synthesis and antimicrobial evaluation of novel sulphur bridged 2-oxo-1,2,3,4-tetrahydropyrimidine derivatives

In this study, novel series of eleven 2-oxo-6-(4-pyridin-4-yl-thiazol-2-yl sulfanylmethyl)-1,2,3,4-tetrahydropyrimidine derivatives (3a-k) was synthesized by reacting 4-(pyridin-4-yl)-1, 3-thiazol-2-thiol (1) and ethyl-4-chloroacetocetate in dimethylformamide. To this reaction mixture, anhydrous potassium carbonate was added and the reaction mixture stirred at room temperature afforded ethyl 3-oxo-4-[(4-pyridin-4-yl-1,3-thiazol-2-yl)thio]butanoate (2) as intermediate. This on subsequent treatment with urea and substituted aryl aldehyde afforded the titled compounds (3a-k). The structural features of the synthesized compounds were characterized by elemental, IR, 1H NMR, 13C NMR and Mass spectral analysis. All the compounds were evaluated for their antimicrobial activity against four bacterial strains (E. coli, S. aureus, K. pneumonia and B. subtilis) and two fungal strains (C. albicans and A. Niger). Docking studies were also performed against glucosamine-6-phosphate synthase enzyme in order to study the putative binding mode of the active compounds.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1847 | ChemSpider

16915-79-0, An article , which mentions 16915-79-0, molecular formula is C10H10N2O3. The compound – 2-(Hydroxymethyl)-3-methylquinoxaline 1,4-dioxide played an important role in people’s production and life.

Facile synthesis of tetrahydroprotoberberine and protoberberine alkaloids from protopines and study on their antibacterial activities

A series of isoquinoline alkaloids including tetrahydroprotoberberines, N-methyl tetrahydroprotoberberines and protoberberines were facile synthesised with protopines as the starting material. All compounds were evaluated for their antibacterial activities against four pathogenic bacteria Escherichia coli, Staphyloccocus aureus, Staphylococcus gallinarum and Salmonella choleraesuis. Experimental results indicated that protoberberines were the most active compounds to the target bacteria among the tested alkaloids. It was suggested that planar molecule with high aromatisation level (e.g. coptisine 5 and berberine 6) or a positive charge of the molecules (e.g. N-methyl tetrahydroprotoberberines 11 and 12) had a positive influence on the antibacterial effects.

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Quinoxaline | C8H6N1727 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. 49679-45-0, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 49679-45-0

PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS

The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered mono- cyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6- membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O-, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor

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Quinoxaline | C8H6N1886 | ChemSpider

148231-12-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 148231-12-3, Name is 5,8-Dibromoquinoxaline,introducing its new discovery.

Efficient quasi-solid-state dye-sensitized solar cells based on organic sensitizers containing fluorinated quinoxaline moiety

Two novel organic sensitizers (FNE55 and FNE56) containing a 6,7-difluoroquinoxaline moiety have been designed and synthesized for quasi-solid-state dye-sensitized solar cells (DSSCs). For comparison, an organic dye, FNE54, without fluorine has also been synthesized. The effects of the introduction of fluorine on the absorption, electrochemical and photovoltaic properties have been systematically investigated. Upon the incorporation of fluorine in the quinoxaline unit, the electron-withdrawing ability is strengthened, which results in the enhanced push-pull interactions and thus narrows the energy band gap. The absorption maximum wavelength in toluene solution bathochromically shifts from 504 nm for FNE54 to 511 nm for FNE55, and further to 525 nm for FNE56. However, although the lowest unoccupied molecular orbitals (LUMOs) are lowered down after the introduction of fluorines, the driving force for the photo-excited electrons from their excited states to the semiconductor conduction band is still sufficient. Consequently, the quasi-solid-state DSSC based on FNE56 exhibits a highest power conversion efficiency of 8.2%, which is 37% higher than that for FNE54 based quasi-solid-state DSSCs.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 148231-12-3, and how the biochemistry of the body works.148231-12-3

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2031 | ChemSpider

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 887590-25-2, molcular formula is C13H18N2O2, introducing its new discovery. , 887590-25-2

BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q1 is: (i) C1, Br, I, -CN, -CH3, or -CF3; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Ra and zero to 1 Rb; and R1, R2, R3, R4, R5, R6, Ra, and Rb are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1865 | ChemSpider

106595-91-9, Name is 4-Benzyl-1,3-dihydroquinoxalin-2-one, belongs to quinoxaline compound, is a common compound. 106595-91-9In an article, authors is Akula, Pavan Sudheer, once mentioned the new application about 106595-91-9.

Visible-light-induced C(sp3)-H activation for a C-C bond forming reaction of 3,4-dihydroquinoxalin-2(1: H)-one with nucleophiles using oxygen with a photoredox catalyst or under catalyst-free conditions

A convenient photocatalyzed oxidative coupling reaction of 4-alkyl-3,4-dihydroquinoxalin-2(1H)-one and its derivatives with a variety of nucleophiles was developed with a ruthenium photoredox catalyst and oxygen under a household compact fluorescent light. With a slower reaction rate, the cross coupling transformation can be achieved in the absence of an external photocatalyst with a similar isolated yield. An application to the synthesis of natural product cephalandole A was also demonstrated.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1912 | ChemSpider

63810-80-0, Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 63810-80-0, Name is 2,3-Dichloro-6,7-dimethylquinoxaline

Metal catalyst free cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines in TFA alone: a new synthesis of indolophenazines

TFA alone was found to be remarkably effective for the intramolecular hydroarylation (IMHA) of alkynes when employed as a solvent in the cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines. This simple and metal free cyclization method afforded a range of indolophenazines as new and potential cytotoxic agents. The use of excess TFA was found to be crucial for the success of this reaction.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1825 | ChemSpider

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2379-56-8, Name is 6-Nitroquinoxaline-2,3-dione, molecular formula is C8H3N3O4, 2379-56-8, In a Article, authors is Obefami, Craig A.£¬once mentioned of 2379-56-8

Synthesis and Some Reactions of 3-Chloro-2-(cyanomethylene)-1,2-dihydroquinoxalines

2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and ethyl cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene)-1,2-dihydroquinoxaline derivatives. The reaction of 3-chloro-2-(dicyanomethylene)-1,2-dihydroquinoxaline (2e) with pyridine and its methyl derivatives led to the zwitterionic structures 6a-c. The structures of the newly synthesized compounds were assigned by spectroscopic data and elemental analyses.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1710 | ChemSpider

2379-56-8, An article , which mentions 2379-56-8, molecular formula is C8H3N3O4. The compound – 6-Nitroquinoxaline-2,3-dione played an important role in people’s production and life.

Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening

N-Ureido-quinoxalinedione derivatives have been discovered as leads for a novel series of dipeptidyl peptidase-IV (DPP-IV) inhibitors through high-throughput screening of our chemical library. A brief structure-activity relationship of the compounds was investigated. Among them, entry 5 showed the most potent inhibitory activity. The nitro group in quinoxaline moiety and the aromatic sulfonyl substituted ureido functional group seem to be important to increase the potency dramatically.

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Quinoxaline | C8H6N1698 | ChemSpider

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate,introducing its new discovery., 49679-45-0

Rapid and convenient synthesis of original 5-substituted quinolino[3,4- b ]quinoxalin-6(5 H)-ones under eco-friendly conditions

We report herein the synthesis of 5-(substituted)quinolino[3,4-b]quinoxalin-6(5H)-one derivatives from ethyl 3-(2-bromophenyl)quinoxaline-2-carboxylate under one-pot Buchwald-Hartwig coupling-lactamization reaction.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 49679-45-0, and how the biochemistry of the body works.49679-45-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1898 | ChemSpider